{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:53:21Z","timestamp":1789019601385,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofclinicalvirology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.jcv.2014.06.022","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T05:47:43Z","timestamp":1404280063000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["CD8+ T cell responses specific for hepatitis B virus core protein in patients with chronic hepatitis B virus infection"],"prefix":"10.1016","volume":"61","author":[{"given":"Wei","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2014.06.022_bib0005","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1099\/vir.0.81920-0","article-title":"The immune response during hepatitis B virus infection","volume":"87","author":"Bertoletti","year":"2006","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jcv.2014.06.022_bib0010","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1084\/jem.191.8.1269","article-title":"The role of virus-specific CD8 cells in liver damage and viral control during persistent hepatitis B virus infection","volume":"191","author":"Maini","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.jcv.2014.06.022_bib0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.iy.13.040195.000333","article-title":"Hepatitis B virus immunopathogenesis","volume":"13","author":"Chisari","year":"1995","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jcv.2014.06.022_bib0020","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1172\/JCI119559","article-title":"Human histocompatibility leucocyte antigen-binding supermotifs predict broadly cross-reactive cytotoxic T lymphocyte responses in patients with acute hepatitis","volume":"100","author":"Bertoni","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcv.2014.06.022_bib0025","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1128\/JVI.78.11.5707-5719.2004","article-title":"Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy","volume":"78","author":"Webster","year":"2004","journal-title":"J Virol"},{"issue":"9","key":"10.1016\/j.jcv.2014.06.022_bib0030","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.4049\/jimmunol.173.9.5863","article-title":"Cellular immune responses to the hepatitis B virus polymerase","volume":"173","author":"Mizukoshi","year":"2004","journal-title":"J Immunol"},{"issue":"13","key":"10.1016\/j.jcv.2014.06.022_bib0035","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.3748\/wjg.v10.i13.1902","article-title":"Therapeutic polypeptides based on HBV core 18\u201327 epitope can induce CD8+ CTL-mediated cytotoxicity in HLA-A2+ human PBMCs","volume":"10","author":"Shi","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jcv.2014.06.022_bib0040","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1744-313X.1996.tb00122.x","article-title":"HLA-A2 polymorphism and immune functions","volume":"23","author":"Krausa","year":"1996","journal-title":"Eur J Immunogenet"},{"issue":"22","key":"10.1016\/j.jcv.2014.06.022_bib0045","doi-asserted-by":"crossref","first-page":"10986","DOI":"10.1128\/JVI.01124-08","article-title":"Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire","volume":"82","author":"Tan","year":"2008","journal-title":"J Virol"},{"issue":"1","key":"10.1016\/j.jcv.2014.06.022_bib0050","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.immuni.2005.05.005","article-title":"Oscillating CD8+ T cell effector functions after antigen recognition in the liver","volume":"23","author":"Isogawa","year":"2005","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jcv.2014.06.022_bib0055","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.21844","article-title":"The phenotype of hepatitis B virus-specific T cells differ in the liver and blood in chronic hepatitis B virus infection","volume":"46","author":"Chang","year":"2007","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.jcv.2014.06.022_bib0060","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1128\/JVI.02844-06","article-title":"Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection","volume":"81","author":"Boni","year":"2007","journal-title":"J Virol"},{"issue":"7","key":"10.1016\/j.jcv.2014.06.022_bib0065","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.4049\/jimmunol.178.7.4112","article-title":"Four functionally distinct populations of human effector-memory CD8+ T lymphocytes","volume":"178","author":"Romero","year":"2007","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.jcv.2014.06.022_bib0070","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nm0402-379","article-title":"Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections","volume":"8","author":"Appay","year":"2002","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.jcv.2014.06.022_bib0075","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1172\/JCI13543","article-title":"Rules of chemokine receptor association with T cell polarization in vivo","volume":"108","author":"Kim","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcv.2014.06.022_bib0080","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1126\/science.1058867","article-title":"Preferential localization of effector memory cells in nonlymphoid tissue","volume":"291","author":"Masopust","year":"2001","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.jcv.2014.06.022_bib0085","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0167-5699(94)90077-9","article-title":"CD27: marker and mediator of T cell activation","volume":"15","author":"Hintzen","year":"1994","journal-title":"Immunol Today"},{"issue":"3","key":"10.1016\/j.jcv.2014.06.022_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.23190","article-title":"AASLD practice guidelines chronic hepatitis B: update 2009","volume":"50","author":"Lok","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2014.06.022_bib0095","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1136\/gutjnl-2011-301073","article-title":"Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection","volume":"61","author":"Bertoletti","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.jcv.2014.06.022_bib0100","doi-asserted-by":"crossref","first-page":"287","DOI":"10.4049\/jimmunol.0902761","article-title":"CD8+ T cell control of hepatitis B virus replication: direct comparison between cytolytic and noncytolytic Functions","volume":"184","author":"Sandra","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.jcv.2014.06.022_bib0105","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1053\/j.gastro.2009.09.052","article-title":"Antiviral intrahepatic T- cell responses can be restored by blocking programmed death-1 pathway in chronic hepatitis B","volume":"138","author":"Fisicaro","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcv.2014.06.022_bib0110","doi-asserted-by":"crossref","first-page":"S218","DOI":"10.1111\/j.1440-1746.1997.tb00503.x","article-title":"Natural history of chronic hepatitis B virus infection: an immunopathological study","volume":"12","author":"Chu","year":"1997","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jcv.2014.06.022_bib0115","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1743-422X-2-82","article-title":"Hepatitis B virus: inactive carriers","author":"Sharma","year":"2005","journal-title":"Virol J"},{"key":"10.1016\/j.jcv.2014.06.022_bib0120","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1053\/jhep.2002.33638","article-title":"Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B","volume":"35","author":"Hsu","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2014.06.022_bib0125","doi-asserted-by":"crossref","first-page":"191","DOI":"10.7326\/0003-4819-118-3-199302010-00006","article-title":"The natural history of asymptomatic hepatitis B surface antigen carriers","volume":"118","author":"De Franchis","year":"1993","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.jcv.2014.06.022_bib0130","first-page":"19","article-title":"Long term follow-up of a large cohort of inactive HBsAg (+)\/HBeAg (\u2013)\/anti-HBe (+) carriers in Greece","volume":"16","author":"Gigi","year":"2007","journal-title":"J Gastrointestin Liver Dis"},{"key":"10.1016\/j.jcv.2014.06.022_bib0135","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1053\/gast.2001.22461","article-title":"Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease","volume":"120","author":"Perillo","year":"2001","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.jcv.2014.06.022_bib0140","first-page":"179","article-title":"Report of HLA distribution of Chinese bone marrow bank (Shanghai)","volume":"22","author":"Zhang","year":"2001","journal-title":"Chin J Organ Transplan"},{"issue":"8","key":"10.1016\/j.jcv.2014.06.022_bib0145","first-page":"473","article-title":"Study of HLA polymorphism in the 6965 han bone marrow registry donors","volume":"25","author":"Wu","year":"2004","journal-title":"Chin J Hematol"},{"issue":"6","key":"10.1016\/j.jcv.2014.06.022_bib0150","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/j.1440-1746.2008.05385.x","article-title":"Understanding the immunopathogenesis of chronic hepatitis B virus: an Asian prospective","volume":"23","author":"Tan","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.jcv.2014.06.022_bib0155","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/eji.200324478","article-title":"Phenotypic classification of human CD8+ T cells reflecting their function: inverse correlation between quantitative expression of CD27 and cytotoxic effector function","volume":"34","author":"Tomiyama","year":"2004","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.jcv.2014.06.022_bib0160","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1053\/j.gastro.2012.07.014","article-title":"Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues","volume":"143","author":"Boni","year":"2012","journal-title":"Gastroenterology"}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653214002558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653214002558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T16:44:50Z","timestamp":1746290690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653214002558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S1386653214002558"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2014.06.022","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD8+ T cell responses specific for hepatitis B virus core protein in patients with chronic hepatitis B virus infection","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2014.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}