{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:17:03Z","timestamp":1792318623732,"version":"4.4.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofclinicalvirology.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jcv.2014.12.001","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T18:46:19Z","timestamp":1417718779000},"page":"42-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"special_numbering":"C","title":["Cytokine modulation correlates with severity of monkeypox disease in humans"],"prefix":"10.1016","volume":"63","author":[{"given":"Sara C.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer W.","family":"Stonier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny L.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neville K.","family":"Kisalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa E.","family":"Hensley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne W.","family":"Rimoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2014.12.001_bib0005","doi-asserted-by":"crossref","first-page":"16262","DOI":"10.1073\/pnas.1005769107","article-title":"Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo","volume":"107","author":"Rimoin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jcv.2014.12.001_bib0010","doi-asserted-by":"crossref","first-page":"15190","DOI":"10.1073\/pnas.0405759101","article-title":"The host response to smallpox: analysis of the gene expression program in peripheral blood cells in a nonhuman primate model","volume":"101","author":"Rubins","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jcv.2014.12.001_bib0015","doi-asserted-by":"crossref","first-page":"15196","DOI":"10.1073\/pnas.0405954101","article-title":"Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox","volume":"101","author":"Jahrling","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jcv.2014.12.001_bib0020","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/milmed\/167.6.546","article-title":"The cause of death in smallpox: an examination of the pathology record","volume":"167","author":"Martin","year":"2002","journal-title":"Mil. Med."},{"key":"10.1016\/j.jcv.2014.12.001_bib0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1128\/MMBR.05015-11","article-title":"Into the eye of the cytokine storm","volume":"76","author":"Tisoncik","year":"2012","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.jcv.2014.12.001_bib0030","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3201\/eid2002.130118","article-title":"Genomic variability of monkeypox virus among humans, Democratic Republic of the Congo","volume":"20","author":"Kugelman","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jcv.2014.12.001_bib0035","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1128\/JVI.78.9.4433-4443.2004","article-title":"Smallpox DNA vaccine protects nonhuman primates against lethal monkeypox","volume":"78","author":"Hooper","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0040","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.1128\/JVI.70.10.7103-7107.1996","article-title":"Interleukin-4 mediates down regulation of antiviral cytokine expression and cytotoxic T-lymphocyte responses and exacerbates vaccinia virus infection in vivo","volume":"70","author":"Sharma","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0045","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.immuni.2006.02.006","article-title":"Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus","volume":"24","author":"Howell","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jcv.2014.12.001_bib0050","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4049\/jimmunol.164.1.371","article-title":"IL-4 and IL-10 antagonize IL-12-mediated protection against acute vaccinia virus infection with a limited role of IFN-gamma and nitric oxide synthetase 2","volume":"164","author":"van Den Broek","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0055","doi-asserted-by":"crossref","first-page":"91","DOI":"10.5500\/wjt.v3.i4.91","article-title":"Role of IL-10 in the progression of kidney disease","volume":"3","author":"Sinuani","year":"2013","journal-title":"World J. Transplant."},{"key":"10.1016\/j.jcv.2014.12.001_bib0060","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1189\/jlb.1209772","article-title":"Regulation of the T helper cell type 2 (Th2)\/T regulatory cell (Treg) balance by IL-4 and STAT6","volume":"87","author":"Chapoval","year":"2010","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0065","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.immuni.2009.04.010","article-title":"Mechanisms of foxp3+ T regulatory cell-mediated suppression","volume":"30","author":"Shevach","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jcv.2014.12.001_bib0070","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/nm745","article-title":"Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity","volume":"8","author":"Akbari","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.jcv.2014.12.001_bib0075","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1084\/jem.20020620","article-title":"Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells","volume":"196","author":"Wurster","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jcv.2014.12.001_bib0080","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.4049\/jimmunol.1101649","article-title":"Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction","volume":"187","author":"Kastenmuller","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0085","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.4049\/jimmunol.174.6.3344","article-title":"Regulatory T cells suppress CD8+ T cell responses induced by direct priming and cross-priming and moderate immunodominance disparities","volume":"174","author":"Haeryfar","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0090","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/intimm\/dxn147","article-title":"GM-CSF-induced CD11c+CD8a\u2212 dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis","volume":"21","author":"Ganesh","year":"2009","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0095","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.4049\/jimmunol.177.8.5296","article-title":"Suppression of experimental autoimmune myasthenia gravis by granulocyte-macrophage colony-stimulating factor is associated with an expansion of FoxP3+ regulatory T cells","volume":"177","author":"Sheng","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0100","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.clim.2008.03.509","article-title":"Regulatory T cells induced by GM-CSF suppress ongoing experimental myasthenia gravis","volume":"128","author":"Sheng","year":"2008","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0105","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1365-3083.2009.02268.x","article-title":"CD25 shedding by human natural occurring CD4+CD25+ regulatory T cells does not inhibit the action of IL-2","volume":"70","author":"Pedersen","year":"2009","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0110","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.188.2.287","article-title":"CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production","volume":"188","author":"Thornton","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jcv.2014.12.001_bib0115","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/ni1536","article-title":"CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells","volume":"8","author":"Pandiyan","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jcv.2014.12.001_bib0120","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nri1485","article-title":"Regulatory T cells: friend or foe in immunity to infection?","volume":"4","author":"Mills","year":"2004","journal-title":"Nat. Rev. Immunol."}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653214004636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653214004636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T11:14:38Z","timestamp":1598526878000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653214004636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":24,"alternative-id":["S1386653214004636"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2014.12.001","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokine modulation correlates with severity of monkeypox disease in humans","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2014.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}