{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:48:39Z","timestamp":1791413319583,"version":"4.3.3"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,11,13]],"date-time":"2016-11-13T00:00:00Z","timestamp":1478995200000},"content-version":"vor","delay-in-days":348,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofclinicalvirology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.jcv.2015.10.020","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T22:47:34Z","timestamp":1446763654000},"page":"89-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["In silico prediction of ebolavirus RNA polymerase inhibition by specific combinations of approved nucleotide analogues"],"prefix":"10.1016","volume":"73","author":[{"given":"Formijn J.","family":"van Hemert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans L.","family":"Zaaijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Berkhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2015.10.020_bib0005","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1007\/s00018-014-1695-z","article-title":"Common and unique features of viral RNA-dependent polymerases","volume":"71","author":"Te Velthuis","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jcv.2015.10.020_bib0010","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.sbi.2005.12.002","article-title":"A comparison of viral RNA-dependent RNA polymerases","volume":"16","author":"Ferrer-Orta","year":"2006","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.jcv.2015.10.020_bib0015","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1073\/pnas.0400660101","article-title":"The structure of the RNA-dependent RNA polymerase from bovine viral diarrhea virus establishes the role of GTP in de novo initiation","volume":"101","author":"Choi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jcv.2015.10.020_bib0020","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s13238-010-0061-7","article-title":"Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China","volume":"1","author":"Wu","year":"2010","journal-title":"Protein Cell"},{"key":"10.1016\/j.jcv.2015.10.020_bib0025","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.1073\/pnas.0700518104","article-title":"Sequential structures provide insights into the fidelity of RNA replication","volume":"104","author":"Ferrer-Orta","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jcv.2015.10.020_bib0030","doi-asserted-by":"crossref","first-page":"W363","DOI":"10.1093\/nar\/gki481","article-title":"PatchDock and SymmDock: servers for rigid and symmetric docking","volume":"33","author":"Schneidman-Duhovny","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jcv.2015.10.020_bib0035","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1021\/ci0502146","article-title":"PEARLS: program for energetic analysis of receptor-ligand system","volume":"46","author":"Han","year":"2006","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.jcv.2015.10.020_bib0040","first-page":"137","article-title":"Structure-function relationships among RNA-dependent RNA polymerases","volume":"320","author":"Ng","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.jcv.2015.10.020_bib0045","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nprot.2009.2","article-title":"Protein structure prediction on the Web: a case study using the Phyre server","volume":"4","author":"Kelley","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jcv.2015.10.020_bib0050","doi-asserted-by":"crossref","first-page":"e106324","DOI":"10.1371\/journal.pone.0106324","article-title":"Differential binding of tenofovir and adefovir to reverse transcriptase of hepatitis B virus","volume":"9","author":"van Hemert","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcv.2015.10.020_bib0055","doi-asserted-by":"crossref","first-page":"23261","DOI":"10.1074\/jbc.272.37.23261","article-title":"One of two NTP binding sites in poliovirus RNA polymerase required for RNA replication","volume":"272","author":"Richards","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jcv.2015.10.020_bib0060","doi-asserted-by":"crossref","first-page":"17361","DOI":"10.1073\/pnas.0408168101","article-title":"Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center","volume":"101","author":"Batada","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jcv.2015.10.020_bib0065","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1093\/nar\/gki570","article-title":"The highly conserved glutamic acid 791 of Rpb2 is involved in the binding of NTP and Mg(B) in the active center of human RNA polymerase II","volume":"33","author":"Langelier","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jcv.2015.10.020_bib0070","doi-asserted-by":"crossref","first-page":"18677","DOI":"10.1074\/jbc.M600543200","article-title":"Kinetic investigation of E. coli RNA polymerase mutants that influence nucleotide discrimination and transcription fidelity","volume":"281","author":"Holmes","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jcv.2015.10.020_bib0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.antiviral.2014.02.014","article-title":"Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model","volume":"105","author":"Oestereich","year":"2014","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jcv.2015.10.020_bib0080","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.2174\/138161205774580642","article-title":"The antiviral activity, mechanism of action, clinical significance and resistance of abacavir in the treatment of pediatric AIDS","volume":"11","author":"Melroy","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jcv.2015.10.020_bib0085","doi-asserted-by":"crossref","first-page":"D1091","DOI":"10.1093\/nar\/gkt1068","article-title":"DrugBank 4. 0: shedding new light on drug metabolism","volume":"42","author":"Law","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jcv.2015.10.020_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3851\/IMP2125","article-title":"The application and mechanism of action of ribavirin in therapy of hepatitis C","volume":"23","author":"Thomas","year":"2013","journal-title":"Antivir. Chem. Chemother."},{"key":"10.1016\/j.jcv.2015.10.020_bib0095","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.antiviral.2013.09.015","article-title":"Favipiravir (T-705), a novel viral RNA polymerase inhibitor","volume":"100","author":"Furuta","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jcv.2015.10.020_bib0100","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.2174\/1568026043388358","article-title":"Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase","volume":"4","author":"Painter","year":"2004","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.jcv.2015.10.020_bib0105","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1073\/pnas.94.5.1619","article-title":"Choosing the right sugar: how polymerases select a nucleotide substrate","volume":"94","author":"Joyce","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jcv.2015.10.020_bib0110","doi-asserted-by":"crossref","first-page":"31650","DOI":"10.1074\/jbc.M111.253401","article-title":"Molecular insights into DNA polymerase deterrents for ribonucleotide insertion","volume":"286","author":"Cavanaugh","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jcv.2015.10.020_bib0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature13777","article-title":"Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp","volume":"514","author":"Qiu","year":"2014","journal-title":"Nature"}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653215007155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653215007155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T05:08:06Z","timestamp":1567314486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653215007155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":23,"alternative-id":["S1386653215007155"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2015.10.020","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In silico prediction of ebolavirus RNA polymerase inhibition by specific combinations of approved nucleotide analogues","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2015.10.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}