{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:15:16Z","timestamp":1790252116533,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofclinicalvirology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.jcv.2016.02.019","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T08:37:33Z","timestamp":1456475853000},"page":"47-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["HHV-8 DNA replication correlates with the clinical status in AIDS-related Kaposi\u2019s sarcoma"],"prefix":"10.1016","volume":"78","author":[{"given":"Francesco","family":"Broccolo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Tassan","family":"Din","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Grazia","family":"Vigan\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Rutigliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Lusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tambussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro S.","family":"Malnati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2016.02.019_bib0005","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/jnci\/dji072","article-title":"Cancer risk in the Swiss HIV Cohort Study: associations with immunodeficiency smoking, and highly active antiretroviral therapy","volume":"97","author":"Clifford","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.jcv.2016.02.019_bib0010","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0140-6736(06)68649-2","article-title":"A prognostic index for AIDS-associated Kaposi's sarcoma in the era of highly active antiretroviral therapy","volume":"367","author":"Stebbing","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jcv.2016.02.019_bib0015","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/jinf.2001.0810","article-title":"The changing pattern of AIDS-defining illnesses with the introduction of highly active antiretroviral therapy (HAART) in a London clinic","volume":"42","author":"Ives","year":"2001","journal-title":"J. Infect."},{"key":"10.1016\/j.jcv.2016.02.019_bib0020","doi-asserted-by":"crossref","unstructured":"Highly active antiretroviral therapy and incidence of cancer in human immunodeficiency virus-infected adults. J. Natl. Cancer. Inst. 92 2000 1823-1830.","DOI":"10.1093\/jnci\/92.22.1823"},{"key":"10.1016\/j.jcv.2016.02.019_bib0025","doi-asserted-by":"crossref","first-page":"F45","DOI":"10.1097\/00002030-199807000-00002","article-title":"Clinical and biological impact of antiretroviral therapy with protease inhibitors on HIV-related Kaposi's sarcoma","volume":"12","author":"Lebbe","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.jcv.2016.02.019_bib0030","first-page":"1717","article-title":"Complete regression of AIDS-related Kaposi's sarcoma-associated human herpesvirus-8 during therapy with indinavir","volume":"12","author":"Martinelli","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.jcv.2016.02.019_bib0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1586\/era.12.179","article-title":"Do we still need chemotherapy for AIDS associated Kaposi's sarcoma?","author":"Dalla Pria","year":"2013","journal-title":"Anticancer Ther. Expert. Rev."},{"key":"10.1016\/j.jcv.2016.02.019_bib0040","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1053\/hupa.2001.21131","article-title":"Colocalization of the viral interleukin-6 with latent nuclear antigen-1 of human herpesvirus-8 in endothelial spindle cells of Kaposi's sarcoma and lymphoid cells of multicentric Castleman's disease","volume":"32","author":"Brousset","year":"2001","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.jcv.2016.02.019_bib0045","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1086\/314956","article-title":"Heterogeneity of viral IL-6 expression in HHV-8-associated diseases","volume":"180","author":"Cannon","year":"1999","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jcv.2016.02.019_bib0050","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1126\/science.274.5293.1739","article-title":"Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV","volume":"274","author":"Moore","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jcv.2016.02.019_bib0055","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1182\/blood.V96.6.2069","article-title":"High levels of human herpesvirus 8 viral load, human interleukin-6, interleukin-10, and C reactive protein correlate with exacerbation of multicentric castleman disease in HIV-infected patients","volume":"96","author":"Oksenhendler","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.jcv.2016.02.019_bib0060","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1182\/blood-2003-03-0951","article-title":"Rituximab therapy for HIV-associated Castleman disease","volume":"102","author":"Marcelin","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jcv.2016.02.019_bib0065","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1097\/00002030-200308150-00015","article-title":"Detection and quantification of Kaposi's sarcoma-associated herpesvirus to predict AIDS-associated Kaposi's sarcoma","volume":"17","author":"Engels","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.jcv.2016.02.019_bib0070","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1086\/341088","article-title":"Prognostic value of quantitative Kaposi sarcoma-associated herpesvirus load in posttransplantation Kaposi sarcoma","volume":"186","author":"Pellet","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jcv.2016.02.019_bib0075","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1128\/JCM.39.12.4269-4273.2001","article-title":"Viral load of human herpesvirus 8 in peripheral blood of human immunodeficiency virus-infected patients with Kaposi's sarcoma","volume":"39","author":"Tedeschi","year":"2001","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jcv.2016.02.019_bib0080","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1097\/QAD.0b013e3282202b7d","article-title":"Human herpesvirus 8 presence and viral load are associated with the progression of AIDS-associated Kaposi's sarcoma","volume":"21","author":"Laney","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.jcv.2016.02.019_bib0085","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1086\/654800","article-title":"Evaluation of plasma human herpesvirus 8 DNA as a marker of clinical outcomes during antiretroviral therapy for AIDS-related Kaposi sarcoma in Zimbabwe","volume":"51","author":"Borok","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jcv.2016.02.019_bib0090","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1086\/374599","article-title":"Relationship of Kaposi sarcoma (KS)-associated herpesvirus viremia and KS disease in Zimbabwe","volume":"36","author":"Campbell","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.jcv.2016.02.019_bib0095","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.canlet.2007.12.025","article-title":"Human herpesvirus 8 load and progression of AIDS-related Kaposi sarcoma lesions","volume":"263","author":"Nsubuga","year":"2008","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jcv.2016.02.019_bib0100","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/jmv.20192","article-title":"Retrospective: longitudinal analysis of serum human herpesvirus-8 viral DNA load in AIDS-related Kaposi's sarcoma patients before and after diagnosis","volume":"74","author":"Polstra","year":"2004","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jcv.2016.02.019_bib0105","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1128\/JCM.40.12.4652-4658.2002","article-title":"Calibrated real-time PCR assay for quantitation of human herpesvirus 8 DNA in biological fluids","volume":"40","author":"Broccolo","year":"2002","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jcv.2016.02.019_bib0110","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1084\/jem.184.1.283","article-title":"The Kaposi's sarcoma-associated herpesvirus (KSHV) is present as an intact latent genome in KS tissue but replicates in the peripheral blood mononuclear cells of KS patients","volume":"184","author":"Decker","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jcv.2016.02.019_bib0115","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1172\/JCI119380","article-title":"Sensitivity of Kaposi's sarcoma-associated herpesvirus replication to antiviral drugs: implications for potential therapy","volume":"99","author":"Kedes","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jcv.2016.02.019_bib0120","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1128\/AAC.41.12.2754","article-title":"Antiviral drug susceptibility of human herpesvirus 8","volume":"41","author":"Neyts","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jcv.2016.02.019_bib0125","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1097\/00002030-199711000-00006","article-title":"In vitro antiviral drug sensitivity of the Kaposi's sarcoma-associated herpesvirus","volume":"11","author":"Medveczky","year":"1997","journal-title":"AIDS"},{"key":"10.1016\/j.jcv.2016.02.019_bib0130","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.7855583","article-title":"AIDS-associated Kaposi's sarcoma","volume":"267","author":"Jones","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.jcv.2016.02.019_bib0135","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/infdis\/173.6.1477","article-title":"Use of antiherpes drugs and the risk of Kaposi's sarcoma: data from the multicenter AIDS cohort study","volume":"173","author":"Glesby","year":"1996","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jcv.2016.02.019_bib0140","first-page":"1101","article-title":"Anti-herpesvirus treatment and risk of Kaposi's sarcoma in HIV infection","volume":"10","author":"Mocroft","year":"1996","journal-title":"AIDS"},{"key":"10.1016\/j.jcv.2016.02.019_bib0145","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1056\/NEJM199904083401402","article-title":"Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant","volume":"340","author":"Martin","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jcv.2016.02.019_bib0150","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00042560-199901010-00005","article-title":"Effect of antiviral drugs used to treat cytomegalovirus end-organ disease on subsequent course of previously diagnosed Kaposi's sarcoma in patients with AIDS","volume":"20","author":"Robles","year":"1999","journal-title":"J. Acquir. Immune Defic. Syndr. Hum. Retrovirol."},{"key":"10.1016\/j.jcv.2016.02.019_bib0155","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1097\/00002030-200110190-00026","article-title":"Efficacy of cidofovir on human herpesvirus 8 viraemia and Kaposi's sarcoma progression in two patients with AIDS","volume":"15","author":"Mazzi","year":"2001","journal-title":"AIDS"},{"key":"10.1016\/j.jcv.2016.02.019_bib0160","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1097\/00002030-199818000-00018","article-title":"Seroconversion for human herpesvirus 8 during HIV infection is highly predictive of Kaposi's sarcoma","volume":"12","author":"Renwick","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.jcv.2016.02.019_bib0165","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1056\/NEJM199607253350403","article-title":"Seroconversion to antibodies against Kaposi's sarcoma-associated herpes virus-related latent nuclear antigens before the development of Kaposi's sarcoma","volume":"335","author":"Gao","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jcv.2016.02.019_bib0170","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1086\/315503","article-title":"Interaction of human immunodeficiency virus type 1 and human herpesvirus type 8 infections of the incidence of Kaposi's sarcoma","volume":"181","author":"Jacobson","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jcv.2016.02.019_bib0175","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00504-13","article-title":"Calibration technologies for correct determination of Epstein\u2013Barr virus human herpesvirus 6 (HHV-6), and HHV-8 antiviral drug susceptibilities by use of real-time-PCR-based assays","volume":"51","author":"Broccolo","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jcv.2016.02.019_bib0180","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1200\/JCO.2008.20.1707","article-title":"Effects of chemotherapy in AIDS-associated non-Hodgkin's lymphoma on Kaposi's sarcoma herpesvirus DNA in blood","volume":"27","author":"Lin","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jcv.2016.02.019_bib0185","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1128\/JCM.41.8.3897-3900.2003","article-title":"Evaluation of susceptibility of human herpesvirus 8 to antiviral drugs by quantitative real-time PCR","volume":"41","author":"Seregerie","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jcv.2016.02.019_bib0190","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1056\/NEJMoa042850","article-title":"A relapsing inflammatory syndrome and active human herpesvirus 8 infection","volume":"353","author":"Dagna","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jcv.2016.02.019_bib0195","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1086\/340652","article-title":"Elevated virus loads of Kaposi's sarcoma-associated human herpesvirus 8 predict Kaposi's sarcoma disease progression: but elevated levels of human immunodeficiency virus type 1 do not","volume":"185","author":"Quinlivan","year":"2002","journal-title":"J. Infect. Dis."}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653216300117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653216300117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T03:42:17Z","timestamp":1600227737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653216300117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":39,"alternative-id":["S1386653216300117"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2016.02.019","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HHV-8 DNA replication correlates with the clinical status in AIDS-related Kaposi\u2019s sarcoma","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2016.02.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}