{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:33:52Z","timestamp":1793144032944,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,13]],"date-time":"2016-12-13T00:00:00Z","timestamp":1481587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journalofclinicalvirology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.jcv.2016.12.004","type":"journal-article","created":{"date-parts":[[2016,12,11]],"date-time":"2016-12-11T15:00:54Z","timestamp":1481468454000},"page":"23-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Aptima HPV Assay versus Hybrid Capture\u00ae 2 HPV test for primary cervical cancer screening in the HPV FOCAL trial"],"prefix":"10.1016","volume":"87","author":[{"given":"Darrel A.","family":"Cook","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie W.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"van Niekerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Ceballos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lovedeep","family":"Gondara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo L.","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Coldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina S.","family":"Ogilvie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Chernesky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mel","family":"Krajden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jcv.2016.12.004_bib0005","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1056\/NEJMoa021641","article-title":"International Agency for Research on Cancer Multicenter Cervical Cancer Study Group: epidemiologic classification of human papillomavirus types associated with cervical cancer","volume":"348","author":"Munoz","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jcv.2016.12.004_bib0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F","article-title":"Human papillomavirus is a necessary cause of invasive cervical cancer worldwide","volume":"189","author":"Walboomers","year":"1999","journal-title":"J. Pathol."},{"key":"10.1016\/j.jcv.2016.12.004_bib0015","doi-asserted-by":"crossref","first-page":"F88","DOI":"10.1016\/j.vaccine.2012.06.095","article-title":"Evidence regarding human papillomavirus testing in secondary prevention of cervical cancer","volume":"30","author":"Arbyn","year":"2012","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.jcv.2016.12.004_bib0020","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju153","article-title":"Reassurance against future risk of precancer and cancer conferred by a negative human papillomavirus test","volume":"106","author":"Gage","year":"2014","journal-title":"J. Nat. Cancer Inst."},{"issue":"2","key":"10.1016\/j.jcv.2016.12.004_bib0025","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1002\/ijc.29381","article-title":"Primary human papillomavirus DNA screening for cervical cancer prevention: can the screening interval be safely extended?","volume":"137","author":"Vink","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"6","key":"10.1016\/j.jcv.2016.12.004_bib0030","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1002\/ijc.27828","article-title":"Patterns of persistent genital human papillomavirus infection among women worldwide: a literature review and meta-analysis","volume":"133","author":"Rositch","year":"2013","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jcv.2016.12.004_bib0035","doi-asserted-by":"crossref","first-page":"i3633","DOI":"10.1136\/bmj.i3633","article-title":"Adverse obstetric outcomes after local treatment for cervical preinvasive and early invasive disease to cone depth: systematic review and meta-analysis","volume":"354","author":"Kyrgiou","year":"2016","journal-title":"Br. Med. J."},{"issue":"9916","key":"10.1016\/j.jcv.2016.12.004_bib0040","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0140-6736(13)62218-7","article-title":"Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials","volume":"383","author":"Ronco","year":"2013","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.jcv.2016.12.004_bib0045","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/bjc.2012.489","article-title":"Primary cervical cancer screening with HPV testing compared with liquid-based cytology: results of round 1 of a randomised controlled trial \u2013 the HPV FOCAL Study","volume":"107","author":"Ogilvie","year":"2012","journal-title":"Br. J. Cancer"},{"issue":"20","key":"10.1016\/j.jcv.2016.12.004_bib0050","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1093\/jnci\/djt235","article-title":"Screening for cervical cancer precursors with p16\/Ki-67 dual-stained cytology: results of the PALMS study","volume":"105","author":"Ikenberg","year":"2013","journal-title":"J. Nat. Cancer Inst."},{"issue":"12","key":"10.1016\/j.jcv.2016.12.004_bib0055","doi-asserted-by":"crossref","first-page":"djv257","DOI":"10.1093\/jnci\/djv257","article-title":"P16\/Ki-67 dual stain cytology for detection of cervical precancer in HPV-positive women","volume":"107","author":"Wentzensen","year":"2015","journal-title":"J. Nat. Cancer Inst."},{"issue":"2","key":"10.1016\/j.jcv.2016.12.004_bib0060","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ygyno.2014.11.076","article-title":"Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test","volume":"136","author":"Wright","year":"2015","journal-title":"Gynecol. Oncol."},{"issue":"7","key":"10.1016\/j.jcv.2016.12.004_bib0065","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1128\/JCM.02570-10","article-title":"Sensitivity, specificity, and clinical value of human papillomavirus (HPV) E6\/E7 mRNA assay as a triage test for cervical cytology and HPV DNA test","volume":"49","author":"Benevolo","year":"2011","journal-title":"J. Clin. Microbiol."},{"issue":"6","key":"10.1016\/j.jcv.2016.12.004_bib0070","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrc3728","article-title":"Clinical implications of (epi)genetic changes in HPV-induced cervical precancerous lesions","volume":"14","author":"Steenbergen","year":"2014","journal-title":"Nat. Rev. Cancer"},{"issue":"11","key":"10.1016\/j.jcv.2016.12.004_bib0075","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1002\/ijc.30008","article-title":"Validation of a DNA methylation HPV triage classifier in a screening sample","volume":"138","author":"Lorincz","year":"2016","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.jcv.2016.12.004_bib0080","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/bjc.2013.22","article-title":"Comparing the performance of six human papillomavirus tests in a screening population","volume":"108","author":"Cuzick","year":"2013","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.jcv.2016.12.004_bib0085","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/ijc.27636","article-title":"The APTIMA HPV assay versus the hybrid capture 2 test in triage of women with ASC-US or LSIL cervical cytology: a meta-analysis of the diagnostic accuracy","volume":"132","author":"Arbyn","year":"2013","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.jcv.2016.12.004_bib0090","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/1471-2407-10-111","article-title":"A randomized controlled trial of Human Papillomavirus (HPV) testing for cervical cancer screening: trial design and preliminary results (HPV FOCAL Trial)","volume":"10","author":"Ogilvie","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jcv.2016.12.004_bib0095","series-title":"More than Just the Kappa Coefficient: A Program to Fully Characterize Inter-Rater Reliability Between Two Raters SAS Global Forum 2009","author":"Cunningham","year":"2009"},{"issue":"3","key":"10.1016\/j.jcv.2016.12.004_bib0100","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1002\/ijc.25726","article-title":"Evaluation of oncogenic human papillomavirus RNA and DNA tests with liquid-based cytology in primary cervical cancer screening: the FASE study","volume":"129","author":"Monsonego","year":"2011","journal-title":"Int. J. Cancer"},{"issue":"8","key":"10.1016\/j.jcv.2016.12.004_bib0105","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1128\/JCM.01013-15","article-title":"Head-to-Head comparison of the RNA-based Aptima Human Papillomavirus (HPV) Assay and the DNA-based hybrid capture 2 HPV Test in a routine screening population of women aged 30 to 60 years in Germany","volume":"53","author":"Iftner","year":"2015","journal-title":"J. Clin. Microbiol."},{"issue":"8","key":"10.1016\/j.jcv.2016.12.004_bib0110","first-page":"1411","article-title":"Human papillomavirus messenger RNA assay for cervical cancer screening: the Shenzhen cervical cancer screening trial I","volume":"20","author":"Wu","year":"2010","journal-title":"Int. J. Gynecol. Cancer"},{"issue":"1","key":"10.1016\/j.jcv.2016.12.004_bib0115","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/AOG.0b013e31818f5008","article-title":"Evidence for frequent regression of Cervical Intraepithelial Neoplasia\u2013Grade 2","volume":"113","author":"Castle","year":"2009","journal-title":"Obstet. Gynecol."},{"issue":"3","key":"10.1016\/j.jcv.2016.12.004_bib0120","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1309\/AJCPHVD7MIP3FYVV","article-title":"Human papillomavirus oncogenic mRNA testing for cervical cancer screening; baseline and longitudinal results from the CLEAR study","volume":"144","author":"Reid","year":"2015","journal-title":"Am. J. Clin. Pathol."},{"issue":"Suppl. 1","key":"10.1016\/j.jcv.2016.12.004_bib0125","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.jcv.2015.10.027","article-title":"A review of the clinical performance of the Aptima HPV assay","volume":"76","author":"Haedicke","year":"2016","journal-title":"J. Clin. Virol."},{"issue":"9","key":"10.1016\/j.jcv.2016.12.004_bib0130","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.cmi.2015.04.015","article-title":"Which high-risk HPV assays fulfill criteria for use in primary cervical cancer screening?","volume":"21","author":"Arbyn","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"issue":"1","key":"10.1016\/j.jcv.2016.12.004_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-015-1959-5","article-title":"Comparison of the Roche cobas\u00ae 4800 and Digene Hybrid Capture\u00ae 2 HPV tests for primary cervical cancer screening in the HPV FOCAL trial","volume":"15","author":"Cook","year":"2015","journal-title":"BMC Cancer"},{"issue":"11","key":"10.1016\/j.jcv.2016.12.004_bib0140","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1128\/JCM.01321-16","article-title":"Differential detection of Human Papillomavirus genotypes and Cervical Intraepithelial Neoplasia by four commercial assays","volume":"54","author":"Rebolj","year":"2016","journal-title":"J. Clin. Microbiol."},{"issue":"5","key":"10.1016\/j.jcv.2016.12.004_bib0145","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/cyt.12083","article-title":"Understanding HPV tests and their appropriate applications","volume":"24","author":"Cubie","year":"2013","journal-title":"Cytopathology"}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653216306175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653216306175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T03:48:39Z","timestamp":1718941719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653216306175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":29,"alternative-id":["S1386653216306175"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2016.12.004","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aptima HPV Assay versus Hybrid Capture\u00ae 2 HPV test for primary cervical cancer screening in the HPV FOCAL trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2016.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}