{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:43:56Z","timestamp":1792172636217,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["journalofclinicalvirology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.jcv.2017.06.009","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T16:31:43Z","timestamp":1499272303000},"page":"8-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Compartmental HBV evolution and replication in liver and extrahepatic sites after nucleos\/tide analogue therapy in chronic hepatitis B carriers"],"prefix":"10.1016","volume":"94","author":[{"given":"Shan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Ping","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van der Meer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Osiowy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"van Marle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla S.","family":"Coffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2017.06.009_bib0005","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/hep.22841","article-title":"Long\u2010term monitoring shows hepatitis B virus resistance to entecavir in nucleoside\u2010na\u00efve patients is rare through 5 years of therapy","volume":"49","author":"Tenney","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2017.06.009_bib0010","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/hep.26686","article-title":"No detectable resistance to tenofovir disoproxil fumarate after 6 years of therapy in patients with chronic hepatitis B","volume":"59","author":"Kitrinos","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2017.06.009_bib0015","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.4254\/wjh.v7.i8.1086","article-title":"Clinical relevance of hepatitis B virus variants","volume":"7","author":"Gao","year":"2015","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0020","series-title":"Seminars in Liver Disease: Copyright\u00a9 2002 by Thieme Medical Publishers, Inc.","first-page":"005","article-title":"The hepatitis B virus and common mutants","author":"Locarnini","year":"2003"},{"key":"10.1016\/j.jcv.2017.06.009_bib0025","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.antiviral.2012.12.023","article-title":"Jenny heathcote E, Simon K, et al: hepatitis B e antigen levels and response to peginterferon: influence of precore and basal core promoter mutants","volume":"97","author":"Sonneveld","year":"2013","journal-title":"Antiviral Res."},{"key":"10.1016\/j.jcv.2017.06.009_bib0030","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.meegid.2015.05.014","article-title":"A novel baseline hepatitis B virus sequencing-based strategy for predicting adefovir antiviral response Infection, genetics and evolution","volume":"33","author":"Wang","year":"2015","journal-title":"J. Mol. Epidemiol. Evol. Genet. Infect. Dis."},{"key":"10.1016\/j.jcv.2017.06.009_bib0035","first-page":"1","article-title":"Deep sequencing shows that HBV basal core promoter and precore variants reduce the likelihood of HBsAg loss following tenofovir disoproxil fumarate therapy in HBeAg-positive chronic hepatitis B","author":"Bayliss","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.jcv.2017.06.009_bib0040","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/hep.1840180406","article-title":"Hepatitis B virus replication in diverse cell types during chronic hepatitis B virus infection","volume":"18","author":"Mason","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2017.06.009_bib0045","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1128\/JVI.71.7.5399-5407.1997","article-title":"Transcription of hepatitis B virus in peripheral blood mononuclear cells from persistently infected patients","volume":"71","author":"Stoll-Becker","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0050","doi-asserted-by":"crossref","first-page":"9983","DOI":"10.1128\/JVI.01905-08","article-title":"Genetic characterization of hepatitis B virus in peripheral blood leukocytes: evidence for selection and compartmentalization of viral variants with the immune escape G145R mutation","volume":"83","author":"Datta","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0055","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jhep.2005.01.016","article-title":"Hepatitis B virus infection in lymphatic tissues in inactive hepatitis B carriers","volume":"42","author":"Umeda","year":"2005","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0060","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/lt.22312","article-title":"HepatitisB virus quasispecies in hepatic and extrahepatic viral reservoirs in liver transplant recipients on prophylactic therapy","volume":"17","author":"Coffin","year":"2011","journal-title":"Liver Transpl."},{"key":"10.1016\/j.jcv.2017.06.009_bib0065","doi-asserted-by":"crossref","first-page":"e0137568","DOI":"10.1371\/journal.pone.0137568","article-title":"Detection of hepatitis B virus (HBV) genomes and HBV drug resistant variants by deep sequencing analysis of HBV genomes in immune cell subsets of HBV mono-Infected and\/or human immunodeficiency virus type-1 (HIV-1) and HBV Co-Infected individuals","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jcv.2017.06.009_bib0070","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.diagmicrobio.2015.09.017","article-title":"Correlation of the content of hepatitis B core antigen in peripheral blood mononuclear cells with HBV virus load","volume":"85","author":"Peng","year":"2016","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.jcv.2017.06.009_bib0075","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1053\/jhep.2003.50294","article-title":"HBV DNA persistence 10 years after liver transplantation despite successful anti-HBS passive immunoprophylaxis","volume":"38","author":"Roche","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2017.06.009_bib0080","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0168-8278(97)80035-9","article-title":"Evidence for selection of hepatitis B mutants after liver transplantation through peripheral blood mononuclear cell infection","volume":"26","author":"Brind","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0085","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1097\/00007890-199006000-00025","article-title":"Persistent hepatitis B virus infection of mononuclear blood cells without concomitant liver infection. The liver transplantation model","volume":"49","author":"Feray","year":"1990","journal-title":"Transplantation"},{"key":"10.1016\/j.jcv.2017.06.009_bib0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jcv.2014.04.021","article-title":"Virological characteristics of occult hepatitis B virus in a North American cohort of human immunodeficiency virus type 1-positive patients on dual active anti-HBV\/HIV therapy","volume":"60","author":"Coffin","year":"2014","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0095","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1053\/jhep.2000.8541","article-title":"Molecular analysis of hepatitis B virus DNA in serum and peripheral blood mononuclear cells from hepatitis B surface antigen-negative cases","volume":"32","author":"Cabrerizo","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2017.06.009_bib0100","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1126\/science.2410981","article-title":"Hepatitis B virus DNA sequences in lymphoid cells from patients with AIDS and AIDS-related complex","volume":"229","author":"Laure","year":"1985","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.jcv.2017.06.009_bib0105","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0168-8278(90)90050-2","article-title":"Presence of HBV-DNA in peripheral blood mononuclear cells from anti-HIV symptomless carriers","volume":"10","author":"Bartolome","year":"1990","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0110","doi-asserted-by":"crossref","first-page":"266","DOI":"10.7150\/ijbs.10813","article-title":"Peripheral blood mononuclear cell traffic plays a crucial role in mother-to-infant transmission of hepatitis B virus","volume":"11","author":"Xu","year":"2015","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.jcv.2017.06.009_bib0115","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1128\/JVI.01363-12","article-title":"Repeated exposure to trace amounts of woodchuck hepadnavirus induces molecularly evident infection and virus-specific T cell response in the absence of serological infection markers and hepatitis","volume":"87","author":"Gujar","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0120","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1128\/JVI.78.4.1730-1738.2004","article-title":"Low doses of hepadnavirus induce infection of the lymphatic system that does not engage the liver","volume":"78","author":"Michalak","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0125","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1172\/JCI5048","article-title":"Persistence of infectious hepadnavirus in the offspring of woodchuck mothers recovered from viral hepatitis","volume":"104","author":"Coffin","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jcv.2017.06.009_bib0130","doi-asserted-by":"crossref","first-page":"7540","DOI":"10.1128\/JVI.00405-08","article-title":"Repeated passage of wild-type woodchuck hepatitis virus in lymphoid cells does not generate cell type-specific variants or alter virus infectivity","volume":"82","author":"Mulrooney-Cousins","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0135","doi-asserted-by":"crossref","first-page":"e1004332","DOI":"10.1371\/journal.ppat.1004332","article-title":"Primary seronegative but molecularly evident hepadnaviral infection engages liver and induces hepatocarcinoma in the woodchuck model of hepatitis B","volume":"10","author":"Mulrooney-Cousins","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jcv.2017.06.009_bib0140","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/jvh.12308","article-title":"Hepatitis B virus (HBV) variants fluctuate in paired plasma and peripheral blood mononuclear cells among patient cohorts during different chronic hepatitis B (CHB) disease phases","volume":"22","author":"Coffin","year":"2015","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.jcv.2017.06.009_bib0145","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s12072-012-9365-4","article-title":"Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update","volume":"6","author":"Liaw","year":"2012","journal-title":"Hepatol. Int."},{"key":"10.1016\/j.jcv.2017.06.009_bib0150","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1172\/JCI116950C1","article-title":"Hepatitis B virus persistence after recovery from acute viral hepatitis","volume":"94","author":"Michalak","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jcv.2017.06.009_bib0155","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2893.2010.01321.x","article-title":"Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy","volume":"18","author":"Coffin","year":"2011","journal-title":"Viral Hepat."},{"key":"10.1016\/j.jcv.2017.06.009_bib0160","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/hep.20353","article-title":"Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients","volume":"40","author":"Wong","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2017.06.009_bib0165","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1111\/j.1365-2893.2010.01356.x","article-title":"Distinct geographical and demographic distribution of hepatitis B virus genotypes in the Canadian Arctic as revealed through an extensive molecular epidemiological survey","volume":"18","author":"Osiowy","year":"2011","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.jcv.2017.06.009_bib0170","article-title":"HBsAg seroclearance after nucleoside analogue therapy in patients with chronic hepatitis B: clinical outcomes and durability","author":"Kim","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.jcv.2017.06.009_bib0175","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.coviro.2016.06.003","article-title":"HBV cure: why, how, when?","volume":"18","author":"Levrero","year":"2016","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0180","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jviromet.2006.07.019","article-title":"Real-time PCR quantitation of hepatitis B virus total DNA and covalently closed circular DNA in peripheral blood mononuclear cells from hepatitis B virus-infected patients","volume":"138","author":"Mazet-Wagner","year":"2006","journal-title":"J. Virol. Methods"},{"key":"10.1016\/j.jcv.2017.06.009_bib0185","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1053\/jhep.2000.8541","article-title":"Molecular analysis of hepatitis B virus DNA in serum and peripheral blood mononuclear cells from hepatitis B surface antigen-negative cases","volume":"32","author":"Cabrerizo","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2017.06.009_bib0190","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.clinre.2012.11.002","article-title":"Distribution of total DNA and cccDNA in serum and PBMCs may reflect the HBV immune status in HBsAg+ and HBsAg- patients coinfected or not with HIV or HCV","volume":"37","author":"Loustaud-Ratti","year":"2013","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0195","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1365-2893.2008.01054.x","article-title":"Intracellular levels of hepatitis B virus DNA and pregenomic RNA in peripheral blood mononuclear cells of chronically infected patients","volume":"16","author":"Lu","year":"2009","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.jcv.2017.06.009_bib0200","first-page":"E1","article-title":"Different variants in reverse transcriptase domain determined by ultra-deep sequencing in treatment-naive and treated indonesian patients infected with hepatitis B virus","volume":"62","author":"Wasityastuti","year":"2016","journal-title":"Kobe J. Med. Sci."},{"key":"10.1016\/j.jcv.2017.06.009_bib0205","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1159\/000366420","article-title":"A deep-sequencing method detects drug-resistant mutations in the hepatitis B virus in Indonesians","volume":"57","author":"Widasari","year":"2014","journal-title":"Intervirology"},{"key":"10.1016\/j.jcv.2017.06.009_bib0210","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1440-1746.2009.05864.x","article-title":"Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients","volume":"24","author":"Han","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0215","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1136\/gutjnl-2014-306977","article-title":"Higher proportion of viral basal core promoter mutant increases the risk of liver cirrhosis in hepatitis B carriers","volume":"64","author":"Tseng","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.jcv.2017.06.009_bib0220","first-page":"52","article-title":"Hepatitis B virus genotypes, precore mutations, and basal core promoter mutations in HBV-infected Chinese patients with persistently normal alanine aminotransferase and low serum HBV-DNA levels","volume":"16","author":"Shi","year":"2012","journal-title":"Braz. J. Infect. Dis."},{"key":"10.1016\/j.jcv.2017.06.009_bib0225","doi-asserted-by":"crossref","first-page":"e0131337","DOI":"10.1371\/journal.pone.0131337","article-title":"Deep sequencing analysis of HBV genotype shift and correlation with antiviral efficiency during adefovir dipivoxil therapy","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jcv.2017.06.009_bib0230","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1086\/342599","article-title":"Genotype mixtures of hepatitis B virus in patients treated with interferon","volume":"186","author":"Hannoun","year":"2002","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jcv.2017.06.009_bib0235","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jhep.2008.03.030","article-title":"Analysis of hepatitis B genotype changes in chronic hepatitis B infection: influence of antiviral therapy","volume":"49","author":"Jardi","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jcv.2017.06.009_bib0240","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/viro.1998.9126","article-title":"The hepatitis B virus seroconversion to anti-HBe is frequently associated with HBV genotype changes and selection of preS2-defective particles in chronically infected children","volume":"245","author":"Gerner","year":"1998","journal-title":"Virology"}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653217301853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653217301853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T12:29:18Z","timestamp":1602419358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653217301853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":48,"alternative-id":["S1386653217301853"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2017.06.009","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compartmental HBV evolution and replication in liver and extrahepatic sites after nucleos\/tide analogue therapy in chronic hepatitis B carriers","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2017.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}