{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T07:54:49Z","timestamp":1777535689155,"version":"3.51.4"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza University of Rome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journalofclinicalvirology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.jcv.2018.03.003","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T20:15:31Z","timestamp":1520712931000},"page":"101-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity"],"prefix":"10.1016","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-360X","authenticated-orcid":false,"given":"Alessandra","family":"Pierangeli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Statzu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-3462","authenticated-orcid":false,"given":"Raffaella","family":"Nenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Santinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Petrarca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Frassanito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Antonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Midulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1044-1478","authenticated-orcid":false,"given":"Carolina","family":"Scagnolari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2018.03.003_bib0005","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/pai.12716","article-title":"Respiratory syncytial virus-host interaction in the pathogenesis of bronchiolitis and its impact on respiratory morbidity in later life","volume":"28","author":"Rossi","year":"2017","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0010","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jaci.2017.08.003","article-title":"Role of viral infections in the development and exacerbation of asthma in children","volume":"140","author":"Jartti","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0015","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.virusres.2011.07.011","article-title":"Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells","volume":"160","author":"Okabayashi","year":"2011","journal-title":"Virus Res."},{"key":"10.1016\/j.jcv.2018.03.003_bib0020","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1398-9995.2008.01826.x","article-title":"Respiratory virus induction of alpha- beta- and lambda-interferons in bronchial epithelial cells and peripheral blood mononuclear cells","volume":"64","author":"Khaitov","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.jcv.2018.03.003_bib0025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.virol.2017.01.017","article-title":"Respiratory syncytial virus infection induces a subset of types I and III interferons in human dendritic cells","volume":"504","author":"Hillyer","year":"2017","journal-title":"Virology"},{"key":"10.1016\/j.jcv.2018.03.003_bib0030","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nm1462","article-title":"Role of deficient type III interferon-lambda production in asthma exacerbations","volume":"12","author":"Contoli","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.jcv.2018.03.003_bib0035","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1128\/JVI.00272-10","article-title":"Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections","volume":"84","author":"Mordstein","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0040","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1136\/thoraxjnl-2011-200405","article-title":"Impaired type I and type III interferon induction and rhinovirus control in human cystic fibrosis airway epithelial cells","volume":"67","author":"Vareille","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.jcv.2018.03.003_bib0045","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.jaci.2012.08.005","article-title":"Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma","volume":"130","author":"Baraldo","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0050","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/thoraxjnl-2012-202909","article-title":"Rhinovirus-induced interferon production is not deficient in well controlled asthma","volume":"69","author":"Sykes","year":"2014","journal-title":"Thorax"},{"key":"10.1016\/j.jcv.2018.03.003_bib0055","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/thoraxjnl-2013-204908","article-title":"Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy","volume":"69","author":"Spann","year":"2014","journal-title":"Thorax"},{"key":"10.1016\/j.jcv.2018.03.003_bib0060","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.jaci.2014.07.013","article-title":"Interferon response and respiratory virus control are preserved in bronchial epithelial cells in asthma","volume":"134","author":"Patel","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0065","doi-asserted-by":"crossref","first-page":"e01939","DOI":"10.1128\/mBio.01939-15","article-title":"Lambda interferon restructures the nasal microbiome and increases susceptibility to Staphylococcus aureus superinfection","volume":"7","author":"Planet","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.jcv.2018.03.003_bib0070","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.immuni.2017.04.025","article-title":"Interferon-\u03bb mediates non-redundant front-line antiviral protection against influenza virus infection without compromising host fitness","volume":"46","author":"Galani","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.jcv.2018.03.003_bib0075","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00969-2016","article-title":"IFN-\u00df\/IFN-\u03b1 responses to respiratory viruses in paediatric asthma","volume":"49","author":"Bergauer","year":"2017","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jcv.2018.03.003_bib0080","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ebiom.2017.03.033","article-title":"A comprehensive evaluation of nasal and bronchial cytokines and chemokines following experimental rhinovirus infection in allergic asthma: increased interferons (IFN-\u03b3 and IFN-\u03bb) and type 2 inflammation (IL-5 and IL-13)","volume":"19","author":"Hansel","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jcv.2018.03.003_bib0085","doi-asserted-by":"crossref","first-page":"5894","DOI":"10.1093\/emboj\/16.19.5894","article-title":"Identification and functional characterization of a second chain of the interleukin-10 receptor complex","volume":"16","author":"Kotenko","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.jcv.2018.03.003_bib0090","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ni873","article-title":"IL-28, IL-29 and their class II cytokine receptor IL-28R","volume":"4","author":"Sheppard","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0095","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1042\/bj20021935","article-title":"Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3","volume":"370","author":"Dumoutier","year":"2003","journal-title":"Biochem. J"},{"key":"10.1016\/j.jcv.2018.03.003_bib0100","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.intimp.2004.01.003","article-title":"Full house: 12 receptors for 27 cytokines","volume":"4","author":"Kotenko","year":"2004","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0105","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/sj.gene.6364382","article-title":"Human interferon lambda-1 (IFN-lambda1\/IL-29) modulates the Th1\/Th2 response","volume":"8","author":"Jordan","year":"2007","journal-title":"Genes Immun."},{"key":"10.1016\/j.jcv.2018.03.003_bib0110","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3389\/fimmu.2014.00466","article-title":"Immunity to RSV in early-life","volume":"5","author":"Lambert","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0115","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/jir.2010.0078","article-title":"Interferon-lambda: a new addition to an old family","volume":"30","author":"Donnelly","year":"2010","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.jcv.2018.03.003_bib0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.immuni.2015.07.001","article-title":"Interferon-lambda: immune functions at barrier surfaces and beyond","volume":"43","author":"Lazear","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jcv.2018.03.003_bib0125","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1136\/adc.2008.153361","article-title":"Respiratory syncytial virus, human bocavirus and rhinovirus bronchiolitis in infants","volume":"95","author":"Midulla","year":"2010","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.jcv.2018.03.003_bib0130","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/jmv.20832","article-title":"Detection and typing by molecular techniques of respiratory viruses in children hospitalized for acute respiratory infection in Rome Italy","volume":"79","author":"Pierangeli","year":"2007","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0135","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00430-013-0296-z","article-title":"Molecular epidemiology and genetic diversity of human rhinovirus affecting hospitalized children in Rome","volume":"202","author":"Pierangeli","year":"2013","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0140","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jinf.2013.12.010","article-title":"Interferon lambda 1\u20133 expression in infants hospitalized for RSV or HRV associated bronchiolitis","volume":"68","author":"Selvaggi","year":"2014","journal-title":"J. Infect."},{"issue":"31","key":"10.1016\/j.jcv.2018.03.003_bib0145","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cyto.2005.04.003","article-title":"Biological activity of interleukins-28 and -29: comparison with type I interferons","volume":"21","author":"Meager","year":"2005","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.jcv.2018.03.003_bib0150","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2<DELTA><DELTA>C(T) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"211","key":"10.1016\/j.jcv.2018.03.003_bib0155","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1084\/jem.20131557","article-title":"IFN-\u03bb receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-\u03bb3 genotype and with nonresponsiveness to IFN-\u03b1 therapies","volume":"5","author":"Duong","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jcv.2018.03.003_bib0160","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1128\/CVI.00445-08","article-title":"Gene expression of nucleic acid-sensing pattern recognition receptors in children hospitalized for respiratory syncytial virus-associated acute bronchiolitis","volume":"16","author":"Scagnolari","year":"2009","journal-title":"Clin. Vaccine Immunol."},{"issue":"10","key":"10.1016\/j.jcv.2018.03.003_bib0165","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.3181\/0705-BC-124","article-title":"Upregulation of interferon-induced genes in infants with virus-associated acute bronchiolitis","volume":"232","author":"Scagnolari","year":"2007","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.jcv.2018.03.003_bib0170","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1084\/jem.20121401","article-title":"Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon \u03bb and antiviral defense in airway epithelium","volume":"210","author":"Ueki","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jcv.2018.03.003_bib0175","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2017.05.169","article-title":"The suppression of innate immune response by human rhinovirus C","volume":"490","author":"Pang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jcv.2018.03.003_bib0180","first-page":"807","article-title":"Integrative genomic analyses on IL28RA the common receptor of interferon-lambda1, -lambda2 and -lambda3","volume":"25","author":"Yang","year":"2010","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jcv.2018.03.003_bib0185","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1749-6632.2011.06339.x","article-title":"IL-10 and IL-10 receptor defects in humans","volume":"1246","author":"Glocker","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jcv.2018.03.003_bib0190","first-page":"4","article-title":"Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells","volume":"17","author":"Ma","year":"2015","journal-title":"F1000Res"},{"key":"10.1016\/j.jcv.2018.03.003_bib0195","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/INF.0000000000000825","article-title":"Viral load in infants hospitalized for respiratory syncytial virus bronchiolitis correlates with recurrent wheezing at thirty-six-month follow-up","volume":"34","author":"Nenna","year":"2015","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"8","key":"10.1016\/j.jcv.2018.03.003_bib0200","doi-asserted-by":"crossref","first-page":"989","DOI":"10.3389\/fimmu.2017.00989","article-title":"The unresolved role of interferon-\u00f6 in asthma bronchiale","volume":"15","author":"Sopel","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0205","doi-asserted-by":"crossref","first-page":"5032","DOI":"10.1128\/JVI.80.10.5032-5040.2006","article-title":"Alpha and lambda interferon together mediate suppression of CD4T cells induced by respiratory syncytial virus","volume":"80","author":"Chi","year":"2006","journal-title":"J. Virol."},{"issue":"201","key":"10.1016\/j.jcv.2018.03.003_bib0210","first-page":"348","article-title":"IL-28A (IFN-lambda2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease","volume":"3","author":"Koltsida","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.jcv.2018.03.003_bib0215","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1164\/rccm.201202-0330OC","article-title":"Human rhinovirus species and season of infection determine illness severity","volume":"186","author":"Lee","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jcv.2018.03.003_bib0220","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1097\/INF.0b013e31821b8c71","article-title":"Clinical spectrum of human rhinovirus infections in hospitalized Hong Kong children","volume":"30","author":"Mak","year":"2011","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.jcv.2018.03.003_bib0225","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.3201\/eid1411.080386","article-title":"Novel human rhinoviruses and exacerbation of asthma in children","volume":"14","author":"Khetsuriani","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.jcv.2018.03.003_bib0230","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/eji.200324610","article-title":"Viral infection and Toll-like receptor agonists induce a differential expression of type I and lambda interferons in human plasmacytoid and monocyte-derived dendritic cells","volume":"34","author":"Coccia","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0235","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1099\/vir.0.80904-0","article-title":"Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model","volume":"86","author":"Bartlett","year":"2005","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0240","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1128\/JVI.80.9.4501-4509.2006","article-title":"Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo","volume":"80","author":"Ank","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0245","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.4049\/jimmunol.180.4.2474","article-title":"An important role for type III interferon (IFN-lambda\/IL-28) in TLR-induced antiviral activity","volume":"180","author":"Ank","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0250","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1189\/jlb.0807525","article-title":"Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes","volume":"83","author":"Wolk","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0255","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.3390\/v2081589","article-title":"Interferon-lambda in HCV infection and therapy","volume":"2","author":"Pagliaccetti","year":"2010","journal-title":"Viruses"},{"key":"10.1016\/j.jcv.2018.03.003_bib0260","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1182\/blood-2009-09-246157","article-title":"IL-4 enhances IFN-lambda1 (IL-29) production by plasmacytoid DCs via monocyte secretion of IL-1Ra","volume":"115","author":"Megjugorac","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jcv.2018.03.003_bib0265","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.4049\/jimmunol.1003389","article-title":"Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN","volume":"186","author":"Zhang","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0270","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cyto.2012.01.003","article-title":"Eosinophil-derived interferon-lambda contributes to initiation of allergen-related inflammation in the intestine","volume":"58","author":"He","year":"2012","journal-title":"Cytokine"},{"key":"10.1016\/j.jcv.2018.03.003_bib0275","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.4049\/jimmunol.1102038","article-title":"Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells","volume":"189","author":"Yin","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0280","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.4049\/jimmunol.1103507","article-title":"IFNs and plasmacytoid dendritic cells constrain Th2 cytokine responses to rhinovirus: a regulatory mechanism with relevance to asthma","volume":"188","author":"Pritchard","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0285","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1128\/CVI.00414-15","article-title":"Understanding the association of human rhinovirus with asthma","volume":"23","author":"Stone","year":"2015","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0290","doi-asserted-by":"crossref","first-page":"e6787","DOI":"10.1097\/MD.0000000000006787","article-title":"Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis","volume":"96","author":"Garc\u00eda-Garc\u00eda","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jcv.2018.03.003_bib0295","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/apa.12720","article-title":"Recurrent wheezing 36 months after bronchiolitis is associated with rhinovirus infections and blood eosinophilia","volume":"103","author":"Midulla","year":"2014","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.jcv.2018.03.003_bib0300","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s40121-016-0142-x","article-title":"Defining the risk and associated morbidity and mortality of severe respiratory syncytial virus infection among infants with congenital heart disease","volume":"6","author":"Checchia","year":"2017","journal-title":"Infect. Dis. Ther."},{"issue":"December (4)","key":"10.1016\/j.jcv.2018.03.003_bib0305","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s40121-016-0130-1","article-title":"Defining the risk and associated morbidity and mortality of severe respiratory syncytial virus infection among preterm infants without chronic lung disease or congenital heart disease","volume":"5","author":"Figueras-Aloy","year":"2016","journal-title":"Infect. Dis. Ther."},{"key":"10.1016\/j.jcv.2018.03.003_bib0310","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s40121-017-0160-3","article-title":"Defining the incidence and associated morbidity and mortality of severe respiratory syncytial virus infection among children with chronic diseases","volume":"6","author":"Manzoni","year":"2017","journal-title":"Infect. Dis. Ther."},{"key":"10.1016\/j.jcv.2018.03.003_bib0315","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/01.mph.0000210061.96075.8e","article-title":"Respiratory virus infections in children with cancer or HIV infection","volume":"28","author":"Mendoza","year":"2006","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0320","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1097\/PCC.0b013e3182417848","article-title":"An investigation into the prevalence and outcome of patients admitted to pediatric intensive care unit with viral respiratory tract infections in Cape Town, South Africa","volume":"13","author":"Ghani","year":"2012","journal-title":"Pediatr. Crit. Care Med."},{"key":"10.1016\/j.jcv.2018.03.003_bib0325","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.resinv.2013.08.005","article-title":"Viral infections in asthma and COPD","volume":"52","author":"Matsumoto","year":"2014","journal-title":"Respir. Investig."},{"key":"10.1016\/j.jcv.2018.03.003_bib0330","doi-asserted-by":"crossref","first-page":"e0184318","DOI":"10.1371\/journal.pone.0184318","article-title":"Distinct patterns of innate immune activation by clinical isolates of respiratory syncytial virus","volume":"12","author":"Levitz","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jcv.2018.03.003_bib0335","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2016.10.018","article-title":"Host and environmental factors influencing individual human cytokine responses","volume":"167","author":"Ter Horst","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jcv.2018.03.003_bib0340","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/icb.2012.9","article-title":"The interferons and their receptors\u2014distribution and regulation","volume":"90","author":"de Weerd","year":"2012","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0345","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1128\/JVI.02502-15","article-title":"Parainfluenza virus 3 blocks antiviral mediators downstream of the interferon lambda receptor by modulating stat1 phosphorylation","volume":"90","author":"Eberle","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2018.03.003_bib0350","doi-asserted-by":"crossref","first-page":"7418","DOI":"10.1128\/JVI.02290-09","article-title":"The ABCs of rhinoviruses wheezing, and asthma","volume":"84","author":"Gern","year":"2010","journal-title":"J. Virol."}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653218300660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653218300660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T05:53:51Z","timestamp":1535003631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653218300660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":70,"alternative-id":["S1386653218300660"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2018.03.003","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2018.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}