{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:14:39Z","timestamp":1760015679829,"version":"3.40.5"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III (ISCIII)","award":["PI14CIII\/00011","PI15CIII\/00024"],"award-info":[{"award-number":["PI14CIII\/00011","PI15CIII\/00024"]}]},{"DOI":"10.13039\/501100004587","name":"ISCIII","doi-asserted-by":"crossref","award":["CD13\/00013","CP14\/0010"],"award-info":[{"award-number":["CD13\/00013","CP14\/0010"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journalofclinicalvirology.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jcv.2018.04.008","type":"journal-article","created":{"date-parts":[[2018,4,12]],"date-time":"2018-04-12T18:09:05Z","timestamp":1523556545000},"page":"71-74","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study"],"prefix":"10.1016","volume":"103","author":[{"given":"Mar\u00eda \u00c1ngeles","family":"Jim\u00e9nez-Sousa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Zaida","family":"G\u00f3mez-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Pineda-Tenor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"S\u00e1nchez-Ruano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Artaza-Varasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"G\u00f3mez-Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Mart\u00edn-Vicente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"V\u00e1zquez-Mor\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-0450","authenticated-orcid":false,"given":"Salvador","family":"Resino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2018.04.008_bib0005","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.jhep.2014.07.012","article-title":"Natural history of hepatitis C","volume":"61","author":"Westbrook","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jcv.2018.04.008_bib0010","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jcv.2018.04.008_bib0015","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1136\/gutjnl-2014-306997","article-title":"Impact of common risk factors of fibrosis progression in chronic hepatitis C","volume":"64","author":"Rueger","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.jcv.2018.04.008_bib0020","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.jhep.2016.07.037","article-title":"Host \u2013 hepatitis C viral interactions: the role of genetics","volume":"65","author":"Heim","year":"2016","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jcv.2018.04.008_bib0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cgh.2015.08.018","article-title":"A variant in PNPLA3 associated with fibrosis progression but not hepatocellular carcinoma in patients with hepatitis C virus infection","volume":"14","author":"Ali","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jcv.2018.04.008_bib0030","doi-asserted-by":"crossref","first-page":"456","DOI":"10.5009\/gnl15261","article-title":"PNPLA3 rs738409 polymorphism associated with hepatic steatosis and advanced fibrosis in patients with chronic hepatitis C virus: a meta-analysis","volume":"10","author":"Fan","year":"2016","journal-title":"Gut Liver"},{"key":"10.1016\/j.jcv.2018.04.008_bib0035","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/hep.24350","article-title":"Impact of patatin-like phospholipase-3 (rs738409 C\u202f>\u202fG) polymorphism on fibrosis progression and steatosis in chronic hepatitis C","volume":"54","author":"Trepo","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2018.04.008_bib0040","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/hep.24123","article-title":"Patatin-like phospholipase domain-containing 3 I148\u202fM polymorphism, steatosis, and liver damage in chronic hepatitis C","volume":"53","author":"Valenti","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2018.04.008_bib0045","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1478-3231.2011.02703.x","article-title":"2011 European Association of the Study of the Liver hepatitis C virus clinical practice guidelines","volume":"32","author":"Calvaruso","year":"2012","journal-title":"Liver Int."},{"key":"10.1016\/j.jcv.2018.04.008_bib0050","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jhep.2013.11.003","article-title":"EASL Clinical Practice Guidelines: management of hepatitis C virus infection","volume":"60","year":"2014","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jcv.2018.04.008_bib0055","series-title":"SNP Genotyping Using the Sequenom MassARRAY iPLEX Platform. Current Protocols in Human Genetics","first-page":"12","author":"Gabriel","year":"2009"},{"key":"10.1016\/j.jcv.2018.04.008_bib0060","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ultrasmedbio.2003.07.001","article-title":"Transient elastography: a new noninvasive method for assessment of hepatic fibrosis","volume":"29","author":"Sandrin","year":"2003","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.jcv.2018.04.008_bib0065","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/j.gastro.2004.11.018","article-title":"Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C","volume":"128","author":"Castera","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcv.2018.04.008_bib0070","doi-asserted-by":"crossref","first-page":"e0168265","DOI":"10.1371\/journal.pone.0168265","article-title":"The PNPLA3 genetic variant rs738409 influences the progression to cirrhosis in HIV\/hepatitis C virus coinfected patients","volume":"11","author":"Nunez-Torres","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jcv.2018.04.008_bib0075","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/QAD.0000000000000908","article-title":"Impact of patatin-like phospholipase domain-containing 3 gene polymorphism (rs738409) on severity of liver disease in HIV\/hepatitis C virus-coinfected patients","volume":"30","author":"Jimenez-Sousa","year":"2016","journal-title":"AIDS"},{"key":"10.1016\/j.jcv.2018.04.008_bib0080","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/ajg.2013.476","article-title":"The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis","volume":"109","author":"Singal","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jcv.2018.04.008_bib0085","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/hep.29273","article-title":"The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation","volume":"66","author":"BasuRay","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jcv.2018.04.008_bib0090","doi-asserted-by":"crossref","first-page":"5250","DOI":"10.2174\/13816128113199990344","article-title":"Pathophysiology of NASH: perspectives for a targeted treatment","volume":"19","author":"Marra","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.jcv.2018.04.008_bib0095","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1053\/j.gastro.2006.03.014","article-title":"Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data","volume":"130","author":"Leandro","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jcv.2018.04.008_bib0100","doi-asserted-by":"crossref","first-page":"G66","DOI":"10.1152\/ajpgi.00335.2013","article-title":"Metabolic profiling reveals that PNPLA3 induces widespread effects on metabolism beyond triacylglycerol remodeling in Huh-7 hepatoma cells","volume":"307","author":"Min","year":"2014","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jcv.2018.04.008_bib0105","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.cmi.2016.09.017","article-title":"Role of assessing liver fibrosis in management of chronic hepatitis C virus infection","volume":"22","author":"Carmona","year":"2016","journal-title":"Clin. Microbiol. Infect."}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653218301008?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653218301008?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T08:15:15Z","timestamp":1589876115000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653218301008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":21,"alternative-id":["S1386653218301008"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2018.04.008","relation":{},"ISSN":["1386-6532"],"issn-type":[{"type":"print","value":"1386-6532"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PNPLA3 rs738409 polymorphism is associated with liver fibrosis progression in patients with chronic hepatitis C: A repeated measures study","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2018.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}