{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:01:37Z","timestamp":1758819697299,"version":"3.37.3"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81272337"],"award-info":[{"award-number":["81272337"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jcv.2018.08.008","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T22:11:16Z","timestamp":1535494276000},"page":"6-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The association between human papillomavirus 16, 18 DNA load and E6 protein expression in cervical intraepithelial neoplasia and cancer"],"prefix":"10.1016","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1874-2649","authenticated-orcid":false,"given":"Zeni","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-0871","authenticated-orcid":false,"given":"Youlin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"2014","series-title":"World Cancer Report 2014","author":"Stewart","key":"10.1016\/j.jcv.2018.08.008_bib0005"},{"key":"10.1016\/j.jcv.2018.08.008_bib0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/00004347-200001000-00004","article-title":"Human papillomaviruses and cervical neoplasia: a model for carcinogenesis","volume":"19","author":"Stoler","year":"2000","journal-title":"Int. J. Gynecol. Pathol."},{"key":"10.1016\/j.jcv.2018.08.008_bib0015","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S1470-2045(10)70256-4","article-title":"Performance of high-risk human papillomavirus DNA testing as a primary screen for cervical cancer: a pooled analysis of individual patient data from 17 population-based studies from China","volume":"11","author":"Zhao","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jcv.2018.08.008_bib0020","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.cmi.2015.04.015","article-title":"Which high-risk HPV assays fulfil criteria for use in primary cervical cancer screening?","volume":"21","author":"Arbyn","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"issue":"Suppl 1","key":"10.1016\/j.jcv.2018.08.008_bib0025","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.vaccine.2005.09.002","article-title":"Immune responses to human papillomavirus","volume":"24","author":"Stanley","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.jcv.2018.08.008_bib0030","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1128\/JCM.37.4.1030-1034.1999","article-title":"Human papillomavirus (HPV) DNA copy number is dependent on grade of cervical disease and HPV type","volume":"37","author":"Swan","year":"1999","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jcv.2018.08.008_bib0035","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/jmv.23487","article-title":"Comparison of oncogenic HPV type-specific viral DNA load and E6\/E7 mRNA detection in cervical samples: results from a multicenter study","volume":"85","author":"Broccolo","year":"2013","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jcv.2018.08.008_bib0040","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1002\/ijc.30594","article-title":"Type-dependent association between risk of cervical intraepithelial neoplasia and viral load of oncogenic human papillomavirus types other than types 16 and 18","volume":"140","author":"Fu Xi","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jcv.2018.08.008_bib0045","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/jmv.24645","article-title":"Association between human papillomavirus (HPV) 16, HPV18, and other HR-HPV viral load and the histological classification of cervical lesions: results from a large-scale cross-sectional study","volume":"89","author":"Wu","year":"2017","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jcv.2018.08.008_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11262-009-0412-8","article-title":"The biological properties of E6 and E7 oncoproteins from human papillomaviruses","volume":"40","author":"Ghittoni","year":"2010","journal-title":"Virus Genes"},{"key":"10.1016\/j.jcv.2018.08.008_bib0055","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.virol.2013.04.026","article-title":"Papillomavirus E6 oncoproteins","volume":"445","author":"Vande Pol","year":"2013","journal-title":"Virology"},{"key":"10.1016\/j.jcv.2018.08.008_bib0060","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1038\/sj.onc.1208701","article-title":"Crosstalk between the human papillomavirus E2 transcriptional activator and the E6 oncoprotein","volume":"24","author":"Grm","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.jcv.2018.08.008_bib0065","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/LGT.0b013e3181f6c84d","article-title":"Association of elevated E6 oncoprotein with grade of cervical neoplasia using PDZ interaction-mediated precipitation of E6","volume":"15","author":"Sellors","year":"2011","journal-title":"J. Low Genit. Tract. Dis."},{"key":"10.1016\/j.jcv.2018.08.008_bib0070","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1158\/1940-6207.CAPR-13-0091","article-title":"An evaluation of novel, lower-cost molecular screening tests for human papillomavirus in rural China","volume":"6","author":"Zhao","year":"2013","journal-title":"Cancer Prev. Res. (Phila)"},{"key":"10.1016\/j.jcv.2018.08.008_bib0075","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1128\/JCM.01315-10","article-title":"Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer","volume":"48","author":"Schweizer","year":"2010","journal-title":"J. Clin. Microbiol."},{"issue":"Suppl 1","key":"10.1016\/j.jcv.2018.08.008_bib0080","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.jcv.2004.12.006","article-title":"The papillomavirus life cycle","volume":"32","author":"Doorbar","year":"2005","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.jcv.2018.08.008_bib0085","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jviromet.2018.02.009","article-title":"Immunogold-agglutination assay for direct detection of HPV-16 E6 and L1 proteins from clinical specimens","volume":"255","author":"Bhattarakosol","year":"2018","journal-title":"J. Virol. Methods"},{"issue":"Suppl 5","key":"10.1016\/j.jcv.2018.08.008_bib0090","doi-asserted-by":"crossref","first-page":"F55","DOI":"10.1016\/j.vaccine.2012.06.083","article-title":"The biology and life-cycle of human papillomaviruses","volume":"30","author":"Doorbar","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.jcv.2018.08.008_bib0095","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1007\/s10552-009-9422-z","article-title":"Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18","volume":"20","author":"Chen","year":"2009","journal-title":"Cancer Causes Control"},{"key":"10.1016\/j.jcv.2018.08.008_bib0100","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1002\/ijc.30401","article-title":"The variable clinicopathological categories and role of human papillomavirus in cervical adenocarcinoma: a hospital based nation-wide multi-center retrospective study across China","volume":"139","author":"Chen","year":"2016","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jcv.2018.08.008_bib0105","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(08)70103-7","article-title":"Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study","volume":"9","author":"McCredie","year":"2008","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jcv.2018.08.008_bib0110","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(04)16674-9","article-title":"The cervical cancer epidemic that screening has prevented in the UK","volume":"364","author":"Peto","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jcv.2018.08.008_bib0115","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1158\/1055-9965.EPI-15-1057","article-title":"Elevated expression of human papillomavirus-16\/18 E6 oncoprotein associates with persistence of viral infection: a 3-year prospective study in China","volume":"25","author":"Yu LL","year":"2016","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.jcv.2018.08.008_bib0120","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/ijc.30807","article-title":"Risk stratification and long-term risk prediction of E6 oncoprotein in a prospective screening cohort in China","volume":"141","author":"Zhang","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jcv.2018.08.008_bib0125","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/aje\/kwn036","article-title":"Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis","volume":"168","author":"Koshiol","year":"2008","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jcv.2018.08.008_bib0130","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0140-6736(13)60022-7","article-title":"Human papillomavirus and cervical cancer","volume":"382","author":"Crosbie","year":"2013","journal-title":"Lancet"}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653218302178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653218302178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T11:14:31Z","timestamp":1604834071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653218302178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":26,"alternative-id":["S1386653218302178"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2018.08.008","relation":{},"ISSN":["1386-6532"],"issn-type":[{"type":"print","value":"1386-6532"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association between human papillomavirus 16, 18 DNA load and E6 protein expression in cervical intraepithelial neoplasia and cancer","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2018.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}