{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:18:07Z","timestamp":1763018287772,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009703","name":"Fondazione per la Ricerca Biomedica","doi-asserted-by":"publisher","award":["FRRB 2015-043"],"award-info":[{"award-number":["FRRB 2015-043"]}],"id":[{"id":"10.13039\/501100009703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.jcv.2021.104734","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T08:39:07Z","timestamp":1610440747000},"page":"104734","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Early T cell reconstitution and cytokine profile may help to guide a personalized management of human cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1016","volume":"135","author":[{"given":"Elisa","family":"Gabanti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Borsani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Caldera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3045-1198","authenticated-orcid":false,"given":"Anna Amelia","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia Valeria","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio Paolo","family":"Alessandrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Gerna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Bernasconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Lilleri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jcv.2021.104734_bib0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.hoc.2010.11.011","article-title":"Cytomegalovirus in hematopoietic stem cell transplant recipients","volume":"25","author":"Ljungman","year":"2011","journal-title":"Hematol. Oncol. Clin. North Am."},{"issue":"3","key":"10.1016\/j.jcv.2021.104734_bib0010","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/S2352-3026(15)00289-6","article-title":"Cytomegalovirus viral load and mortality after haemopoietic stem cell transplantation in the era of pre-emptive therapy: a retrospective cohort study","volume":"3","author":"Green","year":"2016","journal-title":"Lancet Haematol."},{"issue":"3","key":"10.1016\/j.jcv.2021.104734_bib0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.7326\/0003-4819-118-3-199302010-00003","article-title":"Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant","volume":"118","author":"Goodrich","year":"1993","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.jcv.2021.104734_bib0020","doi-asserted-by":"crossref","first-page":"179","DOI":"10.7326\/0003-4819-118-3-199302010-00004","article-title":"Ganciclovir prophylaxis of cytomegalovirus infection and disease in allogeneic bone marrow transplant recipients. Results of a placebo-controlled, double-blind trial","volume":"118","author":"Winston","year":"1993","journal-title":"Ann. Intern. Med."},{"issue":"6","key":"10.1016\/j.jcv.2021.104734_bib0025","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1086\/367836","article-title":"Randomized comparison of oral valacyclovir and intravenous ganciclovir for prevention of cytomegalovirus disease after allogeneic bone marrow transplantation","volume":"36","author":"Winston","year":"2003","journal-title":"Clin. Infect. Dis."},{"year":"2019","series-title":"The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies","author":"Carreras","key":"10.1016\/j.jcv.2021.104734_bib0030"},{"issue":"25","key":"10.1016\/j.jcv.2021.104734_bib0035","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1056\/NEJMoa1706640","article-title":"Letermovir prophylaxis for cytomegalovirus in hematopoietic-cell transplantation","volume":"377","author":"Marty","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"23","key":"10.1016\/j.jcv.2021.104734_bib0040","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1182\/blood-2008-10-143560","article-title":"How we treat cytomegalovirus in hematopoietic cell transplant recipients","volume":"113","author":"Boeckh","year":"2009","journal-title":"Blood"},{"issue":"2 Suppl","key":"10.1016\/j.jcv.2021.104734_bib0045","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/j.bbmt.2014.12.034","article-title":"Reprint of: recent advances in cytomegalovirus: an update on pharmacologic and cellular therapies","volume":"21","author":"Boeckh","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"3","key":"10.1016\/j.jcv.2021.104734_bib0050","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.blre.2017.01.002","article-title":"The clinical impact of cytomegalovirus infection following allogeneic hematopoietic cell transplantation: why the quest for meaningful prophylaxis still matters","volume":"31","author":"Chan","year":"2017","journal-title":"Blood Rev."},{"issue":"5","key":"10.1016\/j.jcv.2021.104734_bib0055","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1182\/blood.V97.5.1232","article-title":"Direct visualization of cytomegalovirus-specific T cell reconstitution after allogeneic stem cell transplantation","volume":"97","author":"Cwynarski","year":"2001","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.jcv.2021.104734_bib0060","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1182\/blood.V98.5.1358","article-title":"Tetramer-based quantification of cytomegalovirus (CMV)-specific CD8+ T lymphocytes in T cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection","volume":"98","author":"Gratama","year":"2001","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.jcv.2021.104734_bib0065","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.1182\/blood.V99.10.3830","article-title":"Sensitive detection of human cytomegalovirus peptide-specific cytotoxic T-lymphocyte responses by interferon-gamma-enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation","volume":"99","author":"Hebart","year":"2002","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.jcv.2021.104734_bib0070","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1016\/j.bbmt.2015.08.002","article-title":"Reconstitution of human cytomegalovirus-specific CD4+ t cells is critical for control of virus reactivation in hematopoietic stem cell transplant recipients but does not prevent organ infection","volume":"21","author":"Gabanti","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"6","key":"10.1016\/j.jcv.2021.104734_bib0075","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1093\/infdis\/jiy592","article-title":"The ability of a cytomegalovirus ELISPOT assay to predict outcome of low-level CMV reactivation in hematopoietic cell transplant recipients","volume":"219","author":"El Haddad","year":"2019","journal-title":"J. Infect. Dis."},{"issue":"5","key":"10.1016\/j.jcv.2021.104734_bib0080","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/CVI.05633-11","article-title":"Performance of the QuantiFERON-cytomegalovirus (CMV) assay for detection and estimation of the magnitude and functionality of the CMV-specific gamma interferon-producing CD8(+) T cell response in allogeneic stem cell transplant recipients","volume":"19","author":"Clari","year":"2012","journal-title":"Clin. Vaccine Immunol."},{"issue":"11","key":"10.1016\/j.jcv.2021.104734_bib0085","doi-asserted-by":"crossref","first-page":"e3634","DOI":"10.1371\/journal.pone.0003634","article-title":"Levels of CMV specific CD4 T cells are dynamic and correlate with CMV viremia after allogeneic stem cell transplantation","volume":"3","author":"Widmann","year":"2008","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jcv.2021.104734_bib0090","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3324\/haematol.11912","article-title":"Human cytomegalovirus-specific CD4+ and CD8+ T cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection","volume":"93","author":"Lilleri","year":"2008","journal-title":"Haematologica."},{"issue":"12","key":"10.1016\/j.jcv.2021.104734_bib0095","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1093\/cid\/cis818","article-title":"State-of-the-art monitoring of cytomegalovirus-specific cell-mediated immunity after organ transplant: a primer for the clinician","volume":"55","author":"Egli","year":"2012","journal-title":"Clin. Infect. Dis."},{"issue":"8","key":"10.1016\/j.jcv.2021.104734_bib0100","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/bmt.2010.261","article-title":"Signature profiles of CMV-specific T cells in patients with CMV reactivation after hematopoietic SCT","volume":"46","author":"Kr\u00f3l","year":"2011","journal-title":"Bone Marrow Transplant."},{"issue":"9","key":"10.1016\/j.jcv.2021.104734_bib0105","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1099\/vir.0.000203","article-title":"Role of cytomegalovirus (CMV)-specific polyfunctional CD8+ T cells and antibodies neutralizing virus epithelial infection in the control of CMV infection in an allogeneic stem-cell transplantation setting","volume":"96","author":"Gim\u00e9nez","year":"2015","journal-title":"J. Gen. Virol."},{"issue":"11","key":"10.1016\/j.jcv.2021.104734_bib0110","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1093\/infdis\/jix192","article-title":"Identifying cytomegalovirus complications using the Quantiferon-CMV assay after allogeneic hematopoietic stem cell transplantation","volume":"215","author":"Yong","year":"2017","journal-title":"J. Infect. Dis."},{"issue":"8","key":"10.1016\/j.jcv.2021.104734_bib0115","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1182\/blood-2018-10-878918","article-title":"Deep functional immunophenotyping predicts risk of cytomegalovirus reactivation after hematopoietic cell transplantation","volume":"133","author":"Camargo","year":"2019","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jcv.2021.104734_bib0120","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/jmv.22254","article-title":"Functional profile of cytomegalovirus (CMV)-specific CD8+ T cells and kinetics of NKG2C+ NK cells associated with the resolution of CMV DNAemia in allogeneic stem cell transplant recipients","volume":"84","author":"Mu\u00f1oz-Cobo","year":"2012","journal-title":"J. Med. Virol."},{"issue":"8","key":"10.1016\/j.jcv.2021.104734_bib0125","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/infdis\/jix357","article-title":"Cytomegalovirus-specific t cell transfer for refractory cytomegalovirus infection after haploidentical stem cell transplantation: the quantitative and qualitative immune recovery for cytomegalovirus","volume":"216","author":"Pei","year":"2017","journal-title":"J. Infect. Dis."},{"issue":"5","key":"10.1016\/j.jcv.2021.104734_bib0130","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/cyto.b.21348","article-title":"Appearance of cytomegalovirus-specific T cells predicts fast resolution of viremia post hematopoietic stem cell transplantation","volume":"92","author":"Pel\u00e1k","year":"2017","journal-title":"Cytometry B Clin. Cytom."},{"issue":"3","key":"10.1016\/j.jcv.2021.104734_bib0135","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/jmv.20555","article-title":"Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on the lower respiratory tract infections of lung transplant recipients","volume":"78","author":"Gerna","year":"2006","journal-title":"J. Med. Virol."},{"issue":"4","key":"10.1016\/j.jcv.2021.104734_bib0140","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jcv.2012.08.017","article-title":"Kinetics of human cytomegalovirus (HCMV) DNAemia in transplanted patients expressed in international units as determined with the Abbott RealTime CMV assay and an in-house assay","volume":"55","author":"Furione","year":"2012","journal-title":"J. Clin. Virol."},{"issue":"6","key":"10.1016\/j.jcv.2021.104734_bib0145","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/eji.200526023","article-title":"Simultaneous quantification of human cytomegalovirus (HCMV)-specific CD4+ and CD8+ T cells by a novel method using monocyte-derived HCMV-infected immature dendritic cells","volume":"35","author":"Lozza","year":"2005","journal-title":"Eur. J. Immunol."},{"issue":"4","key":"10.1016\/j.jcv.2021.104734_bib0150","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4","article-title":"Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors","volume":"15","author":"Harrell","year":"1996","journal-title":"Stat. Med."},{"issue":"10","key":"10.1016\/j.jcv.2021.104734_bib0155","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/sj.bmt.1705986","article-title":"Validation of a DNAemia cutoff for preemptive therapy of cytomegalovirus infection in adult hematopoietic stem cell transplant recipients","volume":"41","author":"Gerna","year":"2008","journal-title":"Bone Marrow Transplant."},{"issue":"10","key":"10.1016\/j.jcv.2021.104734_bib0160","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1086\/508495","article-title":"Functional comparison of T cells recognizing cytomegalovirus pp65 and intermediate-early antigen polypeptides in hematopoietic stem-cell transplant and solid organ transplant recipients","volume":"194","author":"Lacey","year":"2006","journal-title":"J. Infect. Dis."},{"issue":"25","key":"10.1016\/j.jcv.2021.104734_bib0165","doi-asserted-by":"crossref","first-page":"6465","DOI":"10.1182\/blood-2009-02-203307","article-title":"Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipients","volume":"113","author":"Zhou","year":"2009","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.jcv.2021.104734_bib0170","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1111\/j.1600-6143.2007.01890.x","article-title":"Inconsistent responses of cytomegalovirus-specific T cells to pp65 and IE-1 versus infected dendritic cells in organ transplant recipients","volume":"7","author":"Lilleri","year":"2007","journal-title":"Am. J. Transplant."},{"issue":"11","key":"10.1016\/j.jcv.2021.104734_bib0175","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1128\/JVI.78.11.5535-5545.2004","article-title":"Memory CD8 T cell differentiation during viral infection","volume":"78","author":"Wherry","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2021.104734_bib0180","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.0105-2896.2006.00395.x","article-title":"Functional signatures of protective antiviral T cell immunity in human virus infections","volume":"211","author":"Harari","year":"2006","journal-title":"Immunol. Rev."}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653221000019?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653221000019?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T03:13:08Z","timestamp":1761361988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653221000019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":36,"alternative-id":["S1386653221000019"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2021.104734","relation":{},"ISSN":["1386-6532"],"issn-type":[{"type":"print","value":"1386-6532"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early T cell reconstitution and cytokine profile may help to guide a personalized management of human cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2021.104734","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104734"}}