{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:14:09Z","timestamp":1781576049296,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jcv.2025.105799","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T13:57:23Z","timestamp":1745157443000},"page":"105799","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Human cytomegalovirus (HCMV) glycoprotein M occurs in three distinct genotypes in laboratory strains and clinical isolates"],"prefix":"10.1016","volume":"178","author":[{"given":"Alia","family":"Al-Alfard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahrah","family":"Buhamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Duffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lovell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Klapper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7712-9131","authenticated-orcid":false,"given":"Pamela","family":"Vallely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"21","key":"10.1016\/j.jcv.2025.105799_bib1","doi-asserted-by":"crossref","first-page":"10841","DOI":"10.1128\/JVI.76.21.10841-10848.2002","article-title":"The genes encoding the gCIII complex of human cytomegalovirus exist in highly diverse combinations in clinical isolates","volume":"76","author":"Rasmussen","year":"2002","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.jcv.2025.105799_bib2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.idc.2015.05.009","article-title":"Strain variation and disease severity in congenital cytomegalovirus infection: in search of a viral marker","volume":"29","author":"Arav-Boger","year":"2015","journal-title":"Inf. Dis. Clin. N. Am."},{"issue":"36","key":"10.1016\/j.jcv.2025.105799_bib3","doi-asserted-by":"crossref","first-page":"18021","DOI":"10.1073\/pnas.1907447116","article-title":"Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability","volume":"116","author":"Tang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"10.1016\/j.jcv.2025.105799_bib4","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3390\/v13061106","article-title":"Common polymorphisms in the glycoproteins of human cytomegalovirus and associated strain-specific immunity","volume":"13","author":"Wang","year":"2021","journal-title":"Viruses"},{"issue":"7","key":"10.1016\/j.jcv.2025.105799_bib5","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1099\/0022-1317-67-7-1469","article-title":"Characterization of glycoprotein complexes present in human cytomegalovirus envelopes","volume":"67","author":"Farrar","year":"1986","journal-title":"J. Gen. Virol."},{"issue":"6","key":"10.1016\/j.jcv.2025.105799_bib6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/rmv.438","article-title":"Genetic polymorphisms among human cytomegalovirus (HCMV) wild-type strains","volume":"14","author":"Pignatelli","year":"2004","journal-title":"Rev. Med. Virol."},{"issue":"1","key":"10.1016\/j.jcv.2025.105799_bib7","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s12985-015-0428-8","article-title":"Combined genetic variants of human cytomegalovirus envelope glycoproteins as congenital infection markers","volume":"12","author":"Arcangeletti","year":"2015","journal-title":"Virol. J."},{"issue":"3","key":"10.1016\/j.jcv.2025.105799_bib8","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000100564","article-title":"Human cytomegalovirus glycoprotein B genotype correlates with different symptoms of infected infants","volume":"50","author":"Jin","year":"2007","journal-title":"Intervirology"},{"issue":"4","key":"10.1016\/j.jcv.2025.105799_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofv151","article-title":"Cytomegalovirus genotype distribution among congenitally and postnatally infected patients: association of particular glycoprotein (g)B and gN types with symptomatic disease","volume":"2","author":"Bra\u00f1as","year":"2015","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.jcv.2025.105799_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2023.1112645","article-title":"Distribution of CMV envelope glycoprotein B, H and N genotypes in infants with congenital cytomegalovirus symptomatic infection","volume":"11","author":"Dong","year":"2023","journal-title":"Front. Pediatr."},{"issue":"1","key":"10.1016\/j.jcv.2025.105799_bib11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1086\/653423","article-title":"Cytomegalovirus gN genotypes distribution among congenitally infected newborns and their relationship with symptoms at birth and sequelae","volume":"51","author":"Pignatelli","year":"2010","journal-title":"Clin. Infect. Dis."},{"issue":"1\u20132","key":"10.1016\/j.jcv.2025.105799_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0166-0934(98)00173-6","article-title":"Identification of human cytomegalovirus variants by analysis of single strand conformation polymorphism and DNA sequencing of the envelope glycoprotein B gene region-distribution frequency in liver transplant recipients","volume":"78","author":"Binder","year":"1999","journal-title":"J. Virol. Methods"},{"issue":"1","key":"10.1016\/j.jcv.2025.105799_bib13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/(SICI)1096-9071(199909)59:1<98::AID-JMV16>3.0.CO;2-A","article-title":"Human cytomegalovirus glycoprotein B genotypes in blood of AIDS patients: lack of association with either the viral DNA load in leukocytes or presence of retinitis","volume":"59","author":"Gilbert","year":"1999","journal-title":"J. Med. Virol."},{"issue":"3","key":"10.1016\/j.jcv.2025.105799_bib14","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1086\/315770","article-title":"Intrauterine cytomegalovirus Infection and glycoprotein B genotypes","volume":"182","author":"Bale","year":"2000","journal-title":"J. Infect. Dis."},{"issue":"12","key":"10.1016\/j.jcv.2025.105799_bib15","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/pd.942","article-title":"Cytomegalovirus (CMV) glycoprotein B genotype and CMV DNA load in the amniotic fluid of infected fetuses","volume":"24","author":"Picone","year":"2004","journal-title":"Prenat. Diagn."},{"issue":"3","key":"10.1016\/j.jcv.2025.105799_bib16","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1099\/vir.0.18704-0","article-title":"Human cytomegalovirus glycoprotein N (gpUL73-gN) genomic variants: Identification of a novel subgroup, geographical distribution and evidence of positive selective pressure","volume":"84","author":"Pignatelli","year":"2003","journal-title":"J. Gen. Virol."},{"issue":"11","key":"10.1016\/j.jcv.2025.105799_bib17","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1099\/0022-1317-82-11-2777","article-title":"gpUL73 (gN) genomic variants of human cytomegalovirus isolates are clustered into four distinct genotypes","volume":"82","author":"Pignatelli","year":"2001","journal-title":"J. Gen. Virol."},{"issue":"5","key":"10.1016\/j.jcv.2025.105799_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176160","article-title":"Human cytomegalovirus glycoprotein polymorphisms and increasing viral load in AIDS patients","volume":"12","author":"Jiang","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.jcv.2025.105799_bib19","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.virol.2003.09.036","article-title":"Linkage of human cytomegalovirus glycoprotein gO variant groups identified from worldwide clinical isolates with gN genotypes, implications for disease associations and evidence for N-terminal sites of positive selection","volume":"318","author":"Mattick","year":"2004","journal-title":"Virology"},{"issue":"5\u20136","key":"10.1016\/j.jcv.2025.105799_bib20","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.micinf.2005.01.016","article-title":"Monitoring for human cytomegalovirus infection in solid organ transplant recipients through antigenemia and glycoprotein N (gN) variants: evidence of correlation and potential prognostic value of gN genotypes","volume":"7","author":"Rossini","year":"2005","journal-title":"Microbes Infect."},{"issue":"2","key":"10.1016\/j.jcv.2025.105799_bib21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1099\/0022-1317-74-2-255","article-title":"Structure, composition and heparin binding properties of a human cytomegalovirus glycoprotein complex designated gC-II","volume":"74","author":"Kari","year":"1993","journal-title":"J. Gen. Virol."},{"issue":"4","key":"10.1016\/j.jcv.2025.105799_bib22","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1128\/JVI.79.4.2160-2170.2005","article-title":"Complex formation by glycoproteins M and N of human cytomegalovirus: structural and functional aspects","volume":"79","author":"Mach","year":"2005","journal-title":"J. Virol."},{"issue":"41","key":"10.1016\/j.jcv.2025.105799_bib23","first-page":"95","article-title":"BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume":"41","author":"Hall","year":"1999","journal-title":"Nucleic Acids Symp. Ser."},{"issue":"7","key":"10.1016\/j.jcv.2025.105799_bib24","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: molecular evolutionary genetics analysis version 11","volume":"38","author":"Tamura","year":"2021","journal-title":"Mol. Biol. Evol."},{"issue":"20","key":"10.1016\/j.jcv.2025.105799_bib25","doi-asserted-by":"crossref","first-page":"10960","DOI":"10.1128\/JVI.78.20.10960-10966.2004","article-title":"Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome","volume":"78","author":"Varnum","year":"2004","journal-title":"J. Virol."},{"issue":"11","key":"10.1016\/j.jcv.2025.105799_bib26","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1128\/jcm.29.11.2494-2502.1991","article-title":"Comparative sequence analysis of human cytomegalovirus strains","volume":"29","author":"Lehner","year":"1991","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.jcv.2025.105799_bib27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0168-1702(94)00117-U","article-title":"Identification and molecular characterization of the murine cytomegalovirus homolog of the human cytomegalovirus UL100 gene","volume":"36","author":"Li","year":"1995","journal-title":"Vir. Res."},{"issue":"1","key":"10.1016\/j.jcv.2025.105799_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0022-2836(82)90515-0","article-title":"A simple method for displaying the hydropathic character of a protein","volume":"157","author":"Kyte","year":"1982","journal-title":"J. Mol. Biol."},{"issue":"19","key":"10.1016\/j.jcv.2025.105799_bib29","doi-asserted-by":"crossref","first-page":"10316","DOI":"10.1128\/JVI.00375-07","article-title":"The cytoplasmic tail of glycoprotein M (gpUL100) expresses trafficking signals required for human cytomegalovirus assembly and replication","volume":"81","author":"Krzyzaniak","year":"2007","journal-title":"J. Virol."},{"issue":"14","key":"10.1016\/j.jcv.2025.105799_bib30","doi-asserted-by":"crossref","first-page":"7195","DOI":"10.1128\/JVI.00475-10","article-title":"Deep sequencing reveals highly complex dynamics of human cytomegalovirus genotypes in transplant patients over time","volume":"84","author":"Gorzer","year":"2010","journal-title":"J. Virol."},{"issue":"5","key":"10.1016\/j.jcv.2025.105799_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001344","article-title":"Extensive genome-wide variability of human cytomegalovirus in congenitally infected infants","volume":"7","author":"Renzette","year":"2011","journal-title":"PLoS Pathog."}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653225000411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653225000411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T21:20:32Z","timestamp":1749504032000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653225000411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":31,"alternative-id":["S1386653225000411"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2025.105799","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human cytomegalovirus (HCMV) glycoprotein M occurs in three distinct genotypes in laboratory strains and clinical isolates","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2025.105799","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105799"}}