{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:22:59Z","timestamp":1792333379012,"version":"4.4.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.jcv.2026.105969","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:34:57Z","timestamp":1782851697000},"page":"105969","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Predictive models for graft rejection and infections in renal transplant patients based on TTV viral load"],"prefix":"10.1016","volume":"185","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-7108","authenticated-orcid":false,"given":"Noelia Soledad","family":"Reyes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Adri\u00e1n","family":"Poletta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Jara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Boccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gervasio","family":"Soler Pujol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Hermida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Laham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Echavarria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2026.105969_bib1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1600-6143.2011.03840.x","article-title":"Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence","author":"Sellar\u00e9s","year":"2012","journal-title":"Am. Soc. Transplant."},{"key":"10.1016\/j.jcv.2026.105969_bib2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1034\/j.1600-6143.2002.21015.x","article-title":"Death after graft loss: an important late study endpoint in kidney transplantation","volume":"2","author":"Kaplan","year":"2002","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jcv.2026.105969_bib3","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.transproceed.2021.11.039","article-title":"Costs of treatment of acute antibody-mediated rejection in kidney transplant recipients","volume":"971","author":"Lab\u00fas","year":"2022","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.jcv.2026.105969_bib4","first-page":"1","article-title":"The Banff Working Group classification of definitive polyomavirus nephropathy: morphologic definitions and clinical correlations","author":"Nickeleit","year":"2017","journal-title":"J. Am. Sociaty Nephrol."},{"key":"10.1016\/j.jcv.2026.105969_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/ajt.12124","article-title":"Urinary tract infections in solid organ transplantation abbreviations","volume":"13","author":"Parasuraman","year":"2013","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jcv.2026.105969_bib6","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.jinf.2013.09.009","article-title":"BK and JC virus: a review","volume":"68","author":"Pinto","year":"2014","journal-title":"J. Infect."},{"key":"10.1016\/j.jcv.2026.105969_bib7","first-page":"1019","article-title":"An OPTN analysis of national registry data on treatment of BK virus allograft nephropathy in the United States","volume":"87","author":"Dharnidharka","year":"2009","journal-title":"Clin. Transl. Res."},{"key":"10.1016\/j.jcv.2026.105969_bib8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1681\/ASN.2014100985","article-title":"Surveillance of gd T cells predicts cytomegalovirus infection resolution in kidney transplants","volume":"27","author":"Kaminski","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jcv.2026.105969_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0189488","article-title":"Cytomegalovirus (CMV) immune monitoring with ELISPOTand QuantiFERON-CMV assay in seropositive kidney transplant recipients","volume":"12","author":"Lee","year":"2017","journal-title":"PLoS. One"},{"key":"10.1016\/j.jcv.2026.105969_bib10","doi-asserted-by":"crossref","DOI":"10.2215\/CJN.15971020","article-title":"Long-term infectious complications of kidney transplantation","volume":"17","author":"Agrawal","year":"2022","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.jcv.2026.105969_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.bj.2024.100719","article-title":"The epidemiology of invasive fungal infections in transplant recipients","volume":"47","author":"Elhaj Mahmoud","year":"2024","journal-title":"Biomed. J."},{"key":"10.1016\/j.jcv.2026.105969_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/TP.0000000000002019","article-title":"Chagas disease recommendations for solid-organ","volume":"102","author":"Pierrotti","year":"2018","journal-title":"Transplantation"},{"key":"10.1016\/j.jcv.2026.105969_bib13","doi-asserted-by":"crossref","first-page":"639","DOI":"10.2217\/fmb.12.28","article-title":"Invasive fungal infections in solid organ transplant recipients","author":"Shoham","year":"2012","journal-title":"Future Microbiol."},{"key":"10.1016\/j.jcv.2026.105969_bib14","doi-asserted-by":"crossref","unstructured":"Maggi, F. & Bendinelli, M. Immunobiology of the Torque Teno Viruses and Other Anelloviruses. in 35\u201337 (2009).","DOI":"10.1007\/978-3-540-70972-5_5"},{"key":"10.1016\/j.jcv.2026.105969_bib15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1128\/CMR.14.1.98-113.2001","article-title":"Molecular properties, biology, and clinical implications of TT virus, a recently identified widespread infectious agent of humans","volume":"14","author":"Bendinelli","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jcv.2026.105969_bib16","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1007\/s00705-021-05192-x","article-title":"Taxonomic update for mammalian anelloviruses (family Anelloviridae)","volume":"166","author":"Varsani","year":"2021","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jcv.2026.105969_bib17","first-page":"1","article-title":"Torque teno virus (TTV) in renal transplant recipients: species diversity and variability","author":"Reyes","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.jcv.2026.105969_bib18","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cmi.2020.01.011","article-title":"Assessment of prevalence and load of torquetenovirus viraemia in a large cohort of healthy blood donors","volume":"26","author":"Focosi","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.jcv.2026.105969_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0122975","article-title":"Pre-transplant plasma Torque Teno virus load and increase dynamics after lung transplantation","volume":"10","author":"G\u00f6rzer","year":"2015","journal-title":"PLoS. One"},{"key":"10.1016\/j.jcv.2026.105969_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2023.105501","article-title":"Prospective cohort study of Torque Teno Virus (TTV) viral load kinetics and the association with graft rejection in renal transplant patients","volume":"165","author":"Reyes","year":"2023","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.jcv.2026.105969_bib21","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.trre.2019.03.004","article-title":"Torque-Teno virus viral load as a potential endogenous marker of immune function in solid organ transplantation","volume":"33","author":"Rezahosseini","year":"2019","journal-title":"Transplant. Rev. J."},{"key":"10.1016\/j.jcv.2026.105969_bib22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41598-018-33909-7","article-title":"Early post-transplant torquetenovirus viremia predicts cytomegalovirus reactivations in solid organ transplant recipients","volume":"8","author":"Maggi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jcv.2026.105969_bib23","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/infdis\/jiy306","article-title":"Quantification of torque teno virus viremia as a prospective biomarker for infectious disease in kidney allograft recipients","volume":"218","author":"Strassl","year":"2018","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jcv.2026.105969_bib24","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1093\/infdis\/jiz039","article-title":"Torque teno virus for risk stratification of acute biopsyproven alloreactivity in kidney transplant recipients","volume":"219","author":"Strassl","year":"2019","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jcv.2026.105969_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2022.105348","article-title":"Validation of plasma Torque Teno viral load applying a CE-certified PCR for risk stratification of rejection and infection post kidney transplantation","volume":"158","author":"G\u00f6rzer","year":"2023","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.jcv.2026.105969_bib26","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1128\/JVI.77.4.2418-2425.2003","article-title":"TT virus in the nasal secretions of children with acute respiratory diseases: relations to viremia and disease severity","volume":"77","author":"Maggi","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2026.105969_bib27","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1600-6143.2010.03283.x","article-title":"Long-term renal allograft survival in the United States: a critical reappraisal","volume":"11","author":"Lamb","year":"2011","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jcv.2026.105969_bib28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nrneph.2012.81","article-title":"The impact of donor-specific anti-HLA antibodies on late kidney allograft failure","volume":"8","author":"Loupy","year":"2012","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.jcv.2026.105969_bib29","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/ajt.14208","article-title":"Infection in organ transplantation","volume":"17","author":"Fishman","year":"2017","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.jcv.2026.105969_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/ti.2022.10135","article-title":"Proposed definitions of T cell-mediated rejection and tubulointerstitial inflammation as clinical trial endpoints in kidney transplantation","volume":"35","author":"Seron","year":"2022","journal-title":"Transpl. Int."},{"key":"10.1016\/j.jcv.2026.105969_bib31","first-page":"1","article-title":"Acute rejection phenotypes in the current era of immunosuppression: a single-center analysis","author":"Wehmeier","year":"2017","journal-title":"Transplant. DIRECT"},{"key":"10.1016\/j.jcv.2026.105969_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/ti.2022.10140","article-title":"Proposed definitions of antibody-mediated rejection for use as a clinical trial endpoint in kidney transplantation","volume":"35","author":"Roufosse","year":"2022","journal-title":"Transpl. Int."},{"key":"10.1016\/j.jcv.2026.105969_bib33","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1159\/000495081","article-title":"Trends in the causes of death among kidney transplant recipients in the United States (1996-2014)","volume":"48","author":"Awan","year":"2019","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.jcv.2026.105969_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/ndt\/16.8.1545","article-title":"Causes of death after renal transplantation","author":"Briggs","year":"2001","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.jcv.2026.105969_bib35","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1053\/j.ajkd.2013.10.059","article-title":"Predicting 5-year risk of kidney transplant failure: a prediction instrument using data available at 1 year posttransplantation","volume":"63","author":"Shabir","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.jcv.2026.105969_bib36","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/ki.2010.232","article-title":"A clinical scoring system highly predictive of long-term kidney graft survival","author":"Foucher","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.jcv.2026.105969_bib37","first-page":"1","article-title":"Association of torque teno virus viremia with liver fibrosis in the first year after liver transplantation","author":"Engel","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jcv.2026.105969_bib38","first-page":"1","article-title":"Torque teno virus as a biomarker for infection risk in kidney transplant recipients: a machine learning-enabled cohort study","author":"Querido","year":"2025","journal-title":"Infect. Dis. Rep."},{"key":"10.1016\/j.jcv.2026.105969_bib39","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jinf.2019.05.010","article-title":"Torquetenovirus viremia for early prediction of graft rejection after kidney transplantation","volume":"79","author":"Solis","year":"2019","journal-title":"J. Infect."},{"key":"10.1016\/j.jcv.2026.105969_bib40","first-page":"1","article-title":"The association of acute rejection vs recurrent glomerular disease with graft outcomes after kidney transplantation","author":"Singh","year":"2019","journal-title":"Clin. Transplant."},{"key":"10.1016\/j.jcv.2026.105969_bib41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/iji.12294","article-title":"Clinical and immunological relevance of antibodies in solid organ transplantation","author":"Mehra","year":"2016","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.jcv.2026.105969_bib42","doi-asserted-by":"crossref","DOI":"10.1097\/MOT.0b013e3283636ddf","article-title":"Current role of human leukocyte antigen matching in kidney transplantation","author":"Susal","year":"2013","journal-title":"Curr. Opin. Organ. Transplant."},{"key":"10.1016\/j.jcv.2026.105969_bib43","first-page":"1","article-title":"Diabetes mellitus as a risk factor for complicated urinary tract infections in kidney transplant recipients","author":"Krohmals","year":"2025","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jcv.2026.105969_bib44","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.transproceed.2023.07.021","article-title":"Machine learning model to predict graft rejection after kidney transplantation","volume":"55","author":"dos Santos Minato","year":"2023","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.jcv.2026.105969_bib45","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2509785","article-title":"Development of BK polyomavirus-associated nephropathy risk prediction in kidney transplant recipients","volume":"47","author":"Yamauchi","year":"2025","journal-title":"Ren. Fail."}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653226000582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653226000582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:40:17Z","timestamp":1784806817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653226000582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":45,"alternative-id":["S1386653226000582"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2026.105969","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictive models for graft rejection and infections in renal transplant patients based on TTV viral load","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2026.105969","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105969"}}