{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:03:02Z","timestamp":1790146982470,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007606","name":"Aarhus Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jcv.2026.105986","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:45:10Z","timestamp":1785253510000},"page":"105986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Comparative evaluation of in-house PCR and commercial TTV R-GENE assays for Torque Teno Virus quantification: An agreement and reliability study"],"prefix":"10.1016","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1456-3746","authenticated-orcid":false,"given":"Maja","family":"N\u00f8rgaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Skougaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille","family":"Koefoed-Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jcv.2026.105986_bib1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/bbrc.1997.7765","article-title":"A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology","volume":"241","author":"Nishizawa","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jcv.2026.105986_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1168400","article-title":"Understanding torquetenovirus (TTV) as an immune marker","volume":"10","author":"Gore","year":"2023","journal-title":"Front. Med."},{"issue":"11","key":"10.1016\/j.jcv.2026.105986_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00705-023-05903-6","article-title":"Anelloviridae taxonomy update 2023","volume":"168","author":"Varsani","year":"2023","journal-title":"Arch. Virol."},{"key":"10.1016\/j.jcv.2026.105986_bib4","first-page":"65","article-title":"Immunobiology of the Torque Teno Viruses and other anelloviruses","volume":"331","author":"Maggi","year":"2009","journal-title":"Curr. Top. Microbiol. Immunol."},{"issue":"1","key":"10.1016\/j.jcv.2026.105986_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/rmv.524","article-title":"Torque teno virus (TTV): current status","volume":"17","author":"Hino","year":"2007","journal-title":"Rev. Med. Virol."},{"issue":"3","key":"10.1016\/j.jcv.2026.105986_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04928-22","article-title":"Human Anelloviruses: Influence of Demographic Factors, Recombination, and Worldwide Diversity. Rouzine IM, redakt\u00f8r","volume":"11","author":"Cebri\u00e1-Mendoza","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"10.1016\/j.jcv.2026.105986_bib7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s12879-018-3248-9","article-title":"Prevalence of human anelloviruses in Romanian healthy subjects and patients with common pathologies","volume":"18","author":"Spandole-Dinu","year":"2018","journal-title":"BMC Infect. Dis."},{"issue":"3","key":"10.1016\/j.jcv.2026.105986_bib8","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.trre.2019.03.004","article-title":"Torque-Teno virus viral load as a potential endogenous marker of immune function in solid organ transplantation","volume":"33","author":"Rezahosseini","year":"2019","journal-title":"Transplant. Rev."},{"issue":"14","key":"10.1016\/j.jcv.2026.105986_bib9","doi-asserted-by":"crossref","first-page":"7744","DOI":"10.3390\/ijms25147744","article-title":"Torque Teno Virus: A Promising Biomarker in Kidney Transplant Recipients","volume":"25","author":"Dal Lago","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.jcv.2026.105986_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2393","article-title":"Torque teno virus load as marker of rejection and infection in solid organ transplantation \u2013 A systematic review and meta-analysis","volume":"33","author":"Van Rijn","year":"2023","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.jcv.2026.105986_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/eci.70068","article-title":"Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review","author":"Medina","year":"2025","journal-title":"Eur. J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.jcv.2026.105986_bib12","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3390\/v17030334","article-title":"Torque Teno Virus: Lights and Shades","volume":"17","author":"Brani","year":"2025","journal-title":"Viruses"},{"issue":"12","key":"10.1016\/j.jcv.2026.105986_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2023.110720","article-title":"Kinetics of Torque Teno virus in heart transplant patients","volume":"84","author":"Berg","year":"2023","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jcv.2026.105986_bib14","unstructured":"Gramkow A.M. Monitoring of renal transplant recipients by use of complement factors, kidney-specific cell-free DNA, Torque Teno Virus, and HLA epitope matching: Investigation and application of biomarkers in kidney transplantation: From development to clinical and research relevance [Internet]. Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet; 2023 [henvist 2. december 2024]. Tilg\u00e6ngelig hos: https:\/\/portal.findresearcher.sdu.dk\/en\/publications\/monitoring-of-renal-transplant-recipients-by-use-of-complement-fa doi:10.21996\/X270-7E94."},{"issue":"4","key":"10.1016\/j.jcv.2026.105986_bib15","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1128\/JVI.77.4.2418-2425.2003","article-title":"TT Virus in the Nasal Secretions of Children with Acute Respiratory Diseases: Relations to Viremia and Disease Severity","volume":"77","author":"Maggi","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.jcv.2026.105986_bib16","unstructured":"Homepage (EN). QCMD [Internet]. [henvist 16. december 2025]. Tilg\u00e6ngelig hos: https:\/\/www.qcmd.org\/en\/."},{"issue":"2","key":"10.1016\/j.jcv.2026.105986_bib17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jcm.2016.02.012","article-title":"A Guideline of Selecting and Reporting Intraclass Correlation Coefficients for Reliability Research","volume":"15","author":"Koo","year":"2016","journal-title":"J. Chiropr. Med."},{"issue":"2","key":"10.1016\/j.jcv.2026.105986_bib18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jmv.25488","article-title":"Comparative evaluation of molecular methods for the quantitative measure of torquetenovirus viremia, the new surrogate marker of immune competence","volume":"94","author":"Macera","year":"2022","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.jcv.2026.105986_bib19","unstructured":"bioM\u00e9rieux Website [Internet]. [henvist 2. december 2024]. TTV R-GENE\u00ae. Tilg\u00e6ngelig hos: https:\/\/www.biomerieux.com\/corp\/en\/our-offer\/clinical-products\/ttv-r-gene.html."},{"key":"10.1016\/j.jcv.2026.105986_bib20","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jcv.2018.06.010","article-title":"Development of a standardized real time PCR for Torque teno viruses (TTV) viral load detection and quantification: A new tool for immune monitoring","volume":"105","author":"Kulifaj","year":"2018","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.jcv.2026.105986_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2022.105348","article-title":"Validation of plasma Torque Teno viral load applying a CE-certified PCR for risk stratification of rejection and infection post kidney transplantation","volume":"158","author":"G\u00f6rzer","year":"2023","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.jcv.2026.105986_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2023.105501","article-title":"Prospective cohort study of Torque Teno Virus (TTV) viral load kinetics and the association with graft rejection in renal transplant patients","volume":"165","author":"Reyes","year":"2023","journal-title":"J. Clin. Virol."},{"issue":"6","key":"10.1016\/j.jcv.2026.105986_bib23","doi-asserted-by":"crossref","first-page":"963","DOI":"10.3390\/v16060963","article-title":"Torquetenovirus Viremia Quantification Using Real-Time PCR Developed on a Fully Automated, Random-Access Platform","volume":"16","author":"Spezia","year":"2024","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.jcv.2026.105986_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2025.111348","article-title":"m.fl. Development of a novel qPCR test for monitoring immunosuppression levels by quantifying torque teno virus (TTV) in whole blood","volume":"86","author":"Alhadid","year":"2025","journal-title":"Hum. Immunol."},{"issue":"3","key":"10.1016\/j.jcv.2026.105986_bib25","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3390\/v16030432","article-title":"m.fl. Torque Teno Virus (TTV) in Renal Transplant Recipients: Species Diversity and Variability","volume":"16","author":"Reyes","year":"2024","journal-title":"Viruses"},{"issue":"4","key":"10.1016\/j.jcv.2026.105986_bib26","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/ajt.15145","article-title":"m.fl. Monitoring of alphatorquevirus DNA levels for the prediction of immunosuppression-related complications after kidney transplantation","volume":"19","author":"Fern\u00e1ndez-Ruiz","year":"2019","journal-title":"Am. J. Transplant."},{"issue":"5","key":"10.1016\/j.jcv.2026.105986_bib27","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/ajt.15194","article-title":"Torque teno virus monitoring in transplantation: The quest for standardization","volume":"19","author":"Focosi","year":"2019","journal-title":"Am. J. Transplant."},{"issue":"2","key":"10.1016\/j.jcv.2026.105986_bib28","doi-asserted-by":"crossref","DOI":"10.1111\/tid.13778","article-title":"Viruses, friends, and foes: The case of Torque Teno Virus and the net state of immunosuppression","volume":"24","author":"Redondo","year":"2022","journal-title":"Transpl. Infect. Dis."},{"issue":"7","key":"10.1016\/j.jcv.2026.105986_bib29","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/j.ekir.2025.04.033","article-title":"m.fl. Comparison of Torque Teno Virus DNA Load in Plasma and Whole Blood","volume":"10","author":"Truffot","year":"2025","journal-title":"Kidney Int. Rep."},{"issue":"10","key":"10.1016\/j.jcv.2026.105986_bib30","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.cmi.2020.01.011","article-title":"m.fl. Assessment of prevalence and load of torquetenovirus viraemia in a large cohort of healthy blood donors","volume":"26","author":"Focosi","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"issue":"5","key":"10.1016\/j.jcv.2026.105986_bib31","doi-asserted-by":"crossref","first-page":"9716","DOI":"10.1007\/s11357-014-9716-2","article-title":"TTV DNA plasma load and its association with age, gender, and HCMV IgG serostatus in healthy adults","volume":"36","author":"Haloschan","year":"2014","journal-title":"AGE"},{"issue":"3","key":"10.1016\/j.jcv.2026.105986_bib32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/00365590310008163","article-title":"Presence and significance of TT Virus in Danish patients on maintenance hemodialysis","volume":"37","author":"Boysen","year":"2003","journal-title":"Scand. J. Urol. Nephrol."},{"issue":"6","key":"10.1016\/j.jcv.2026.105986_bib33","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3390\/v14061277","article-title":"Torque Teno Virus primary infection kinetics in early childhood","volume":"14","author":"V\u00e4is\u00e4nen","year":"2022","journal-title":"Viruses"},{"issue":"12","key":"10.1016\/j.jcv.2026.105986_bib34","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1111\/trf.17140","article-title":"How do we decide how representative our donors are for public health surveillance?","volume":"62","author":"O\u2019Brien","year":"2022","journal-title":"Transfusion"}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653226000776?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653226000776?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:27:17Z","timestamp":1790144837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653226000776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":34,"alternative-id":["S1386653226000776"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2026.105986","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative evaluation of in-house PCR and commercial TTV R-GENE assays for Torque Teno Virus quantification: An agreement and reliability study","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2026.105986","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105986"}}