{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:03:02Z","timestamp":1790146982216,"version":"4.0.1"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Virology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jcv.2026.105999","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:26:36Z","timestamp":1789086396000},"page":"105999","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lenacapavir resistance surveillance in full-length HIV-1 proviral DNA and circulating RNA: Major RAMs are rare and absent in intact proviral DNA"],"prefix":"10.1016","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5987-3576","authenticated-orcid":false,"given":"Manuela","family":"Ceccarelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8273-5382","authenticated-orcid":false,"given":"Emmanuele","family":"Venanzi Rullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Spampinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Mallon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Nunnari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcv.2026.105999_bib1","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/s41586-020-2443-1","article-title":"Clinical targeting of HIV capsid protein with a long-acting small molecule","volume":"584","author":"Link","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jcv.2026.105999_bib2","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1093\/jac\/dkab503","article-title":"Phenotypic resistance to lenacapavir and monotherapy efficacy in a proof-of-concept clinical study","volume":"77","author":"Margot","year":"2022","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jcv.2026.105999_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02057-20","article-title":"Absence of Lenacapavir (GS-6207) phenotypic resistance in HIV Gag cleavage site mutants and in isolates with resistance to existing drug classes","volume":"65","author":"Margot","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.jcv.2026.105999_bib4","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/hiv.70092","article-title":"Natural occurrence of drug resistance mutations to the HIV-1 capsid inhibitor lenacapavir","volume":"26","author":"W\u00e4rnberg","year":"2025","journal-title":"HIV Med."},{"key":"10.1016\/j.jcv.2026.105999_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.854974","article-title":"HIV capsid protein genetic diversity across HIV-1 variants and impact on new capsid-inhibitor lenacapavir","volume":"13","author":"Troyano-Hern\u00e1ez","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jcv.2026.105999_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01749-23","article-title":"HIV-1 Gag, Pol, and Env diversified with limited adaptation since the 1980s","volume":"15","author":"Lewitus","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.jcv.2026.105999_bib7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/s41467-019-08431-7","article-title":"Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion","volume":"10","author":"Pinzone","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jcv.2026.105999_bib8","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133157","article-title":"Persistence of an intact HIV reservoir in phenotypically naive T cells","volume":"5","author":"Venanzi Rullo","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jcv.2026.105999_bib9","doi-asserted-by":"crossref","DOI":"10.1128\/cmr.00052-22","article-title":"Genotypic resistance testing of HIV-1 DNA in peripheral blood mononuclear cells","volume":"35","author":"Chu","year":"2022","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jcv.2026.105999_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcv.2026.105939","article-title":"HIV-1 gag genotypic resistance testing using short-read and long-read next-generation sequencing technologies","volume":"184","author":"Vellas","year":"2026","journal-title":"J. Clin. Virol."},{"key":"10.1016\/j.jcv.2026.105999_bib11","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.2147\/IDR.S484383","article-title":"Lack of resistance mutations to the novel HIV-1 capsid inhibitor lenacapavir among people living with HIV in Guangdong, China","volume":"17","author":"Lin","year":"2024","journal-title":"Infect. Drug. Resist."},{"key":"10.1016\/j.jcv.2026.105999_bib12","doi-asserted-by":"crossref","DOI":"10.1093\/jac\/dkag084","article-title":"Evaluation of HIV-1 transmitted drug-resistance among subtypes circulating from 2022 to 2024 in Italy: a refined analysis through next-generation sequencing","volume":"81","author":"Armenia","year":"2026","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Journal of Clinical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653226000910?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386653226000910?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T06:27:11Z","timestamp":1790144831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386653226000910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":12,"alternative-id":["S1386653226000910"],"URL":"https:\/\/doi.org\/10.1016\/j.jcv.2026.105999","relation":{},"ISSN":["1386-6532"],"issn-type":[{"value":"1386-6532","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lenacapavir resistance surveillance in full-length HIV-1 proviral DNA and circulating RNA: Major RAMs are rare and absent in intact proviral DNA","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcv.2026.105999","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105999"}}