{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:38:30Z","timestamp":1790249910456,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1016\/j.jcyt.2013.10.008","type":"journal-article","created":{"date-parts":[[2013,12,21]],"date-time":"2013-12-21T20:45:23Z","timestamp":1387658723000},"page":"631-639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["A study of the immune properties of human umbilical cord lining epithelial cells"],"prefix":"10.1016","volume":"16","author":[{"given":"Yi-Jun","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tak-Yeung","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Burd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcyt.2013.10.008_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/14653249.2010.509578","article-title":"Stem cell-like properties of human umbilical cord lining epithelial cells and the potential for epidermal reconstitution","volume":"13","author":"Huang","year":"2011","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2013.10.008_bib2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2217\/imt.11.2","article-title":"Immune recognition and rejection of allogeneic skin grafts","volume":"3","author":"Benichou","year":"2011","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jcyt.2013.10.008_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11373-004-8183-7","article-title":"T\u00a0cell responses to allogeneic human mesenchymal stem cells: immunogenicity, tolerance, and suppression","volume":"12","author":"Klyushnenkova","year":"2005","journal-title":"J\u00a0Biomed Sci"},{"key":"10.1016\/j.jcyt.2013.10.008_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.athoracsur.2008.03.038","article-title":"Myocardial regenerative therapy: immunologic basis for the potential \u201cuniversal donor cells\u201d","volume":"86","author":"Atoui","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.jcyt.2013.10.008_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/cmi.2008.30","article-title":"Intracellular signals of T cell costimulation","volume":"5","author":"Song","year":"2008","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.jcyt.2013.10.008_bib6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0952-7915(97)80043-X","article-title":"The CD40 pathway in allograft rejection, acceptance, and tolerance","volume":"9","author":"Larsen","year":"1997","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jcyt.2013.10.008_bib7","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1634\/stemcells.2007-1028","article-title":"Immune properties of human umbilical cord Wharton's jelly-derived cells","volume":"26","author":"Weiss","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2013.10.008_bib8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/14653240310003611","article-title":"Immunomodulatory effects of fetal and adult mesenchymal stem cells","volume":"5","author":"Le Blanc","year":"2003","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2013.10.008_bib9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1634\/stemcells.2007-0491","article-title":"Human amnion mesenchyme harbors cells with allogeneic T-cell suppression and stimulation capabilities","volume":"26","author":"Magatti","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2013.10.008_bib10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00441-007-0504-5","article-title":"Human-placenta-derived mesenchymal stem cells inhibit proliferation and function of allogeneic immune cells","volume":"330","author":"Li","year":"2007","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.jcyt.2013.10.008_bib11","doi-asserted-by":"crossref","first-page":"899","DOI":"10.3727\/096368909X471314","article-title":"Amniotic mesenchymal tissue cells inhibit dendritic cell differentiation of peripheral blood and amnion resident monocytes","volume":"18","author":"Magatti","year":"2009","journal-title":"Cell Transplant"},{"issue":"9 Suppl","key":"10.1016\/j.jcyt.2013.10.008_bib12","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1097\/TP.0b013e3181a2a4b3","article-title":"HLA-G is a crucial immunosuppressive molecule secreted by adult human mesenchymal stem cells","volume":"87","author":"Selmani","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.jcyt.2013.10.008_bib13","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1182\/blood-2007-12-127662","article-title":"Beyond the increasing complexity of the immunomodulatory HLA-G molecule","volume":"111","author":"Carosella","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jcyt.2013.10.008_bib14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/35869","article-title":"HLA-E binds to natural killer cell receptors CD94\/NKG2A, B and C","volume":"391","author":"Braud","year":"1998","journal-title":"Nature"},{"issue":"1 Suppl","key":"10.1016\/j.jcyt.2013.10.008_bib15","doi-asserted-by":"crossref","first-page":"25S","DOI":"10.1038\/jid.1995.6","article-title":"Direct and indirect control of T-cell activation by keratinocytes","volume":"105","author":"Nickoloff","year":"1995","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jcyt.2013.10.008_bib16","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1365-2567.1996.tb00007.x","article-title":"Alloantigen-specific T-cell anergy induced by human keratinocytes is abrogated upon loss of cell-cell contact","volume":"88","author":"Otten","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/j.jcyt.2013.10.008_bib17","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/eji.1830200904","article-title":"Antigen presentation by keratinocytes induces tolerance in human T cells","volume":"20","author":"Bal","year":"1990","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jcyt.2013.10.008_bib18","doi-asserted-by":"crossref","first-page":"e29942","DOI":"10.1371\/journal.pone.0029942","article-title":"Functional characterization of cultured keratinocytes after acute cutaneous burn injury","volume":"7","author":"Gauglitz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2013.10.008_bib19","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1524-475X.2006.00190.x","article-title":"A\u00a0comparative study of the cytotoxicity of silver-based dressings in monolayer cell, tissue explant, and animal models","volume":"15","author":"Burd","year":"2007","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jcyt.2013.10.008_bib20","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.3727\/096368910X564085","article-title":"Characterization of human umbilical cord lining derived epithelial cells and transplantation potential","volume":"20","author":"Zhou","year":"2011","journal-title":"Cell Transplant"},{"issue":"Suppl 1","key":"10.1016\/j.jcyt.2013.10.008_bib21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-2184.2010.00729.x","article-title":"The umbilical cord: a rich and ethical stem cell source to advance regenerative medicine","volume":"44","author":"Forraz","year":"2011","journal-title":"Cell Prolif"},{"key":"10.1016\/j.jcyt.2013.10.008_bib22","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1046\/j.1523-1755.2003.00104.x","article-title":"Ten-year survival of second kidney transplants: impact of immunologic factors and renal function at 12 months","volume":"64","author":"Coupel","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.jcyt.2013.10.008_bib23","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1097\/01.tp.0000261108.27421.bc","article-title":"Simpler and equitable allocation of kidneys from postmortem donors primarily based on full HLA-DR compatibility","volume":"83","author":"Doxiadis","year":"2007","journal-title":"Transplantation"},{"key":"10.1016\/j.jcyt.2013.10.008_bib24","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/00007890-198705000-00013","article-title":"Substantial benefits of tissue matching in renal transplantation","volume":"43","author":"Gilks","year":"1987","journal-title":"Transplantation"},{"key":"10.1016\/j.jcyt.2013.10.008_bib25","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1006\/jsre.1998.5278","article-title":"Host priming, not target antigen type, decides rejection rate in mice primed with MHC II \u201cknockout\u201d cultured keratinocytes","volume":"76","author":"Hunt","year":"1998","journal-title":"J\u00a0Surg Res"},{"key":"10.1016\/j.jcyt.2013.10.008_bib26","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3727\/096368908786576507","article-title":"Comparative characterization of cultured human term amnion epithelial and mesenchymal stromal cells for application in cell therapy","volume":"17","author":"Bilic","year":"2008","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jcyt.2013.10.008_bib27","doi-asserted-by":"crossref","first-page":"e26136","DOI":"10.1371\/journal.pone.0026136","article-title":"Changes in culture expanded human amniotic epithelial cells: implications for potential therapeutic applications","volume":"6","author":"Pratama","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2013.10.008_bib28","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1634\/stemcells.2005-0330","article-title":"Human umbilical cord matrix stem cells: preliminary characterization and effect of transplantation in a rodent model of Parkinson's disease","volume":"24","author":"Weiss","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2013.10.008_bib29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0923-2494(96)80253-7","article-title":"T-cell costimulation via CD28-CD80\/CD86 and CD40-CD40 ligand interactions","volume":"146","author":"Somoza","year":"1995","journal-title":"Res Immunol"},{"issue":"4 Pt 2","key":"10.1016\/j.jcyt.2013.10.008_bib30","doi-asserted-by":"crossref","first-page":"S164","DOI":"10.1164\/ajrccm.162.supplement_3.15tac5","article-title":"Costimulation of T cells","volume":"162","author":"Bugeon","year":"2000","journal-title":"Am J Respir\u00a0Crit Care Med"},{"key":"10.1016\/j.jcyt.2013.10.008_bib31","first-page":"1","article-title":"HLA-G: from fetal tolerance to a regulatory molecule in inflammatory diseases","volume":"6","author":"Veit","year":"2010","journal-title":"Curr Immunol Rev"},{"key":"10.1016\/j.jcyt.2013.10.008_bib32","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1038\/jid.2010.120","article-title":"Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis","volume":"130","author":"Aden","year":"2010","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jcyt.2013.10.008_bib33","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/er.2002-0003","article-title":"Genetic analysis of the mammalian transforming growth factor-beta superfamily","volume":"23","author":"Chang","year":"2002","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jcyt.2013.10.008_bib34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0163-7258(03)00035-4","article-title":"Genealogy, expression, and cellular function of transforming growth factor-beta","volume":"98","author":"Govinden","year":"2003","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jcyt.2013.10.008_bib35","first-page":"127","article-title":"TGF-beta function in immune suppression","volume":"350","author":"Yoshimura","year":"2011","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.jcyt.2013.10.008_bib36","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1098\/rstb.2004.1475","article-title":"Scar-free healing: from embryonic mechanisms to adult therapeutic intervention","volume":"359","author":"Ferguson","year":"2004","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.jcyt.2013.10.008_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1524-475X.2005.00081.x","article-title":"The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing","volume":"14","author":"Conway","year":"2006","journal-title":"Wound Rep Reg"},{"key":"10.1016\/j.jcyt.2013.10.008_bib38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/path.1502","article-title":"Hypertrophic scar formation is associated with an increased number of epidermal Langerhans cells","volume":"202","author":"Niessen","year":"2004","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.jcyt.2013.10.008_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcyt.2013.10.008_bib40","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/labinvest.3780141","article-title":"Implication of interleukin-4 in wound healing","volume":"80","author":"Salmon-Ehr","year":"2000","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcyt.2013.10.008_bib41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/cmi.2011.64","article-title":"Human allograft rejection in humanized mice: a historical perspective","volume":"9","author":"Brehm","year":"2012","journal-title":"Cell Mol Immunol"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324913007548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324913007548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T22:19:17Z","timestamp":1761430757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324913007548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["S1465324913007548"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2013.10.008","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A study of the immune properties of human umbilical cord lining epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2013.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}