{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T23:31:16Z","timestamp":1774222276176,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,4,1]],"date-time":"2014-04-01T00:00:00Z","timestamp":1396310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2014,4]]},"DOI":"10.1016\/j.jcyt.2013.11.007","type":"journal-article","created":{"date-parts":[[2014,1,11]],"date-time":"2014-01-11T15:31:15Z","timestamp":1389454275000},"page":"523-534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Human amniotic epithelial stem cells inhibit microglia activation through downregulation of tumor necrosis factor-\u03b1, interleukin-1\u03b2 and\u00a0matrix metalloproteinase-12 in vitro and in a rat model of intracerebral hemorrhage"],"prefix":"10.1016","volume":"16","author":[{"given":"Hongsheng","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aili","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enxi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangtong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcyt.2013.11.007_bib1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11481-006-9015-5","article-title":"Microglia biology in health and disease","volume":"1","author":"Garden","year":"2006","journal-title":"J\u00a0Neuroimmune Pharmacol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1385\/NCC:3:1:077","article-title":"Contribution of extracellular proteolysis and microglia to intracerebral hemorrhage","volume":"3","author":"Wang","year":"2005","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.jcyt.2013.11.007_bib3","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/978-3-211-09469-3_13","article-title":"Microglial activation and brain injury after intracerebral hemorrhage","volume":"105","author":"Wu","year":"2008","journal-title":"Acta Neurochir Suppl"},{"key":"10.1016\/j.jcyt.2013.11.007_bib4","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/ana.10553","article-title":"Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases","volume":"53","author":"Power","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib5","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/sj.jcbfm.9600403","article-title":"Inflammation after intracerebral hemorrhage","volume":"27","author":"Wang","year":"2007","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"key":"10.1016\/j.jcyt.2013.11.007_bib6","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.STR.0000155729.12931.8f","article-title":"Tuftsin fragment 1\u20133 is beneficial when delivered after the induction of intracerebral hemorrhage","volume":"36","author":"Wang","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jcyt.2013.11.007_bib7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.expneurol.2007.06.025","article-title":"Minocycline protects the blood-brain barrier and reduces edema following intracerebral hemorrhage in the rat","volume":"207","author":"Wasserman","year":"2007","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1179\/174313209X385680","article-title":"Minocycline reduces intracerebral hemorrhage-induced brain injury","volume":"31","author":"Wu","year":"2009","journal-title":"Neurol Res"},{"key":"10.1016\/j.jcyt.2013.11.007_bib9","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1634\/stemcells.2004-0357","article-title":"Stem cell characteristics of amniotic epithelial cells","volume":"23","author":"Miki","year":"2005","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2013.11.007_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1254\/jphs.CR0070034","article-title":"The potential of amniotic membrane\/amnion-derived cells for regeneration of various tissues","volume":"105","author":"Toda","year":"2007","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.jcyt.2013.11.007_bib11","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1042\/CBI20090248","article-title":"Treatment of intracerebral haemorrhage in rats with intraventricular transplantation of human amniotic epithelial cells","volume":"34","author":"Dong","year":"2010","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.jcyt.2013.11.007_bib12","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/TP.0b013e318195742e","article-title":"Therapeutic effect of human umbilical cord multipotent mesenchymal stromal cells in a rat model of stroke","volume":"87","author":"Liao","year":"2009","journal-title":"Transplantation"},{"key":"10.1016\/j.jcyt.2013.11.007_bib13","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1161\/hs1101.098367","article-title":"Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.jcyt.2013.11.007_bib14","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.jcyt.2013.11.007_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3109\/08820139.2010.532266","article-title":"Amniotic Membrane is an immunosuppressor of peripheral blood mononuclear cells","volume":"40","author":"Garfias","year":"2011","journal-title":"Immunol Invest"},{"key":"10.1016\/j.jcyt.2013.11.007_bib16","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/00003226-200005000-00018","article-title":"Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane","volume":"19","author":"Hao","year":"2000","journal-title":"Cornea"},{"key":"10.1016\/j.jcyt.2013.11.007_bib17","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/BF01420301","article-title":"The role of the coagulation cascade in brain edema formation after intra-cerebral\u00a0hemorrhage","volume":"138","author":"Lee","year":"1996","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.jcyt.2013.11.007_bib18","article-title":"Isolation of amniotic epithelial stem cells","volume":"1","author":"Miki","year":"2010","journal-title":"Curr Protoc Stem Cell Biol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib19","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1083\/jcb.85.3.890","article-title":"Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue","volume":"85","author":"McCarthy","year":"1980","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/0471140856.tx1217s43","article-title":"Neonatal rat primary microglia: isolation, culturing and selected applications","author":"Ni","year":"2010","journal-title":"Curr Protoc Toxicol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib21","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/brain\/awm306","article-title":"Anti-inflammatory mechanish of intravascular neural stem cell transplantation in haemorrhagic stroke","volume":"131","author":"Lee","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.jcyt.2013.11.007_bib22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000233255","article-title":"Therapeutic benefit of human umbilical cord derived mesenchymal stromal cells in intracerebral hemorrhage rat: implications of anti-inflammation and angiogenesis","volume":"24","author":"Liao","year":"2009","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.jcyt.2013.11.007_bib23","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1212\/WNL.58.4.624","article-title":"Molecular signatures of brain injury after intracerebral hemorrhage","volume":"58","author":"Castillo","year":"2002","journal-title":"Neurology"},{"key":"10.1016\/j.jcyt.2013.11.007_bib24","first-page":"680","article-title":"Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist","volume":"95","author":"Masada","year":"2001","journal-title":"J\u00a0Neurosurg"},{"key":"10.1016\/j.jcyt.2013.11.007_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1460-9568.2004.03829.x","article-title":"Matrix metalloproteinase-12 expression has a negative impact on sensorimotor function following intracerebral haemorrhage in mice","volume":"21","author":"Wells","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jcyt.2013.11.007_bib26","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1179\/174313208X341102","article-title":"Matrix metalloproteinases in intracerebral hemorrhage","volume":"30","author":"Xue","year":"2008","journal-title":"Neurol Res"},{"key":"10.1016\/j.jcyt.2013.11.007_bib27","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/brain\/awm095","article-title":"Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage","volume":"130","author":"Wang","year":"2007","journal-title":"Brain"},{"key":"10.1016\/j.jcyt.2013.11.007_bib28","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0167-5699(99)01573-X","article-title":"Tumor necrosis factor: a master-regulator of leukocyte movement","volume":"21","author":"Sedgwick","year":"2000","journal-title":"Immunol Today"},{"key":"10.1016\/j.jcyt.2013.11.007_bib29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.tvjl.2003.10.016","article-title":"CNS injury: the role of the cytokine IL-1","volume":"168","author":"Gibson","year":"2004","journal-title":"Vet J"},{"key":"10.1016\/j.jcyt.2013.11.007_bib30","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0006-8993(02)02292-8","article-title":"The use of flow cytometry to evaluate temporal changes in inflammatory cells following focal cerebral ischemia in mice","volume":"932","author":"Stevens","year":"2002","journal-title":"Brain Res"},{"key":"10.1016\/j.jcyt.2013.11.007_bib31","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1096\/fj.05-5106com","article-title":"Deficiency of TNF receptors suppresses microglia activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-\u03b1","volume":"20","author":"Sriram","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.jcyt.2013.11.007_bib32","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0166-2236(00)01661-1","article-title":"Interleukin 1 in the brain: biology, pathology and therapeutic target","volume":"23","author":"Rothwell","year":"2000","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.jcyt.2013.11.007_bib33","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/ana.10519","article-title":"Interleukin-1beta promotes oligodendrocyte death through glutamate excitotoxicity","volume":"53","author":"Takahashi","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1161\/01.STR.32.1.240","article-title":"Antisense oligodeoxynucleotide inhibition of tumor necrosis factor-alpha expression is neuroprotective after intracerebral hemorrhage","volume":"32","author":"Mayne","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.jcyt.2013.11.007_bib35","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35081571","article-title":"Metalloproteinases in biology and pathology of the nervous system","volume":"2","author":"Yong","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.jcyt.2013.11.007_bib36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/glia.10108","article-title":"Matrix metalloproteinases in neuroinflammation","volume":"39","author":"Rosenberg","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.jcyt.2013.11.007_bib37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0165-5728(98)00046-0","article-title":"Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS","volume":"87","author":"Anthony","year":"1998","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib38","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0002-9440(10)65551-4","article-title":"Expression and localization of matrix metalloproteinase-12 in the aorta of cholesterol-fed rabbits: relationship to lesion development","volume":"153","author":"Matsumoto","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib39","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1164\/rccm.200212-1396OC","article-title":"Macrophage metalloelastase mediates acute cigarette smoke\u2013induced inflammation via tumor necrosis factor-\u03b1 release","volume":"167","author":"Churg","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcyt.2013.11.007_bib40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/bbrc.1996.1677","article-title":"Macrophage metalloelastase degrades matrix and myelin proteins and processes a tumour necrosis factor-alpha fusion protein","volume":"228","author":"Chandler","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcyt.2013.11.007_bib41","doi-asserted-by":"crossref","first-page":"e4952","DOI":"10.1371\/journal.pone.0004952","article-title":"Matrix metalloproteinase proteolysis of the myelin basic protein isoforms is a source of immunogenic peptides in autoimmune multiple sclerosis","volume":"4","author":"Shiryaev","year":"2009","journal-title":"Plos One"},{"key":"10.1016\/j.jcyt.2013.11.007_bib42","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1126\/science.1073634","article-title":"S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death","volume":"297","author":"Gu","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jcyt.2013.11.007_bib43","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1093\/brain\/124.11.2203","article-title":"T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases","volume":"124","author":"Newman","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.jcyt.2013.11.007_bib44","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1002\/glia.20689","article-title":"A\u00a0novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia","volume":"56","author":"Crocker","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.jcyt.2013.11.007_bib45","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/ana.10750","article-title":"Protective role of tuftsin fragment 1\u20133 in an animal model of intracerebral hemorrhage","volume":"54","author":"Wang","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib46","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/molehr\/7.6.573","article-title":"Production of secretory leukocyte protease inhibitor by human amniotic membranes and regulation of its concentration in amniotic fluid","volume":"7","author":"Zhang","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.jcyt.2013.11.007_bib47","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.ajog.2004.07.010","article-title":"Genome-wide expression profiling of fetal membranes reveals a deficient expression of proteinase inhibitor 3 in premature rupture of membranes","volume":"191","author":"Tromp","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib48","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1084\/jem.174.5.1209","article-title":"Interleukin 10 inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes","volume":"174","author":"de Waal Malefyt","year":"1991","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jcyt.2013.11.007_bib49","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1172\/JCI118286","article-title":"IL-10 inhibits metalloproteinase and stimulates TIMP-1 production in human mononuclear phagocytes","volume":"96","author":"Lacraz","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcyt.2013.11.007_bib50","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1172\/JCI119254","article-title":"Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases","volume":"99","author":"Zhang","year":"1997","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jcyt.2013.11.007_bib51","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0002-9440(10)65270-4","article-title":"Inhibition of NF-kappaB activation and augmentation of IkappaBbeta by secretory leukocyte protease inhibitor during lung inflammation","volume":"154","author":"Lentsch","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib52","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jneuroim.2005.01.015","article-title":"Autocrine activation of microglia by tumor necrosis factor-alpha","volume":"162","author":"Kuno","year":"2005","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.jcyt.2013.11.007_bib53","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.2174\/092986707780597961","article-title":"Microglia activation and its implications in the brain diseases","volume":"14","author":"Dheen","year":"2007","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.jcyt.2013.11.007_bib54","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ana.22455","article-title":"Inflammation after trauma: microglial activation and traumatic brain injury","volume":"70","author":"Ramlackhansingh","year":"2011","journal-title":"Ann Neurol"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324913007809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324913007809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T22:18:35Z","timestamp":1761430715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324913007809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["S1465324913007809"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2013.11.007","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2014,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human amniotic epithelial stem cells inhibit microglia activation through downregulation of tumor necrosis factor-\u03b1, interleukin-1\u03b2 and\u00a0matrix metalloproteinase-12 in vitro and in a rat model of intracerebral hemorrhage","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2013.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}