{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:05:59Z","timestamp":1789733159194,"version":"4.0.1"},"reference-count":12,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Damial Foundation"}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.jcyt.2016.08.007","type":"journal-article","created":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T20:39:12Z","timestamp":1476131952000},"page":"1476-1482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Clinical safety of intrathecal administration of mesenchymal stromal cell\u2013derived neural progenitors in multiple sclerosis"],"prefix":"10.1016","volume":"18","author":[{"given":"Violaine K.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Vyshkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saud A.","family":"Sadiq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jcyt.2016.08.007_bib0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2011.06.008","article-title":"The MSC: an injury drugstore","volume":"9","author":"Caplan","year":"2011","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.jcyt.2016.08.007_bib0015","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1089\/scd.2008.0068","article-title":"Derivation of neural stem cells from mesenchymal stemcells: evidence for a bipotential stem cell population","volume":"17","author":"Fu","year":"2008","journal-title":"Stem Cells Dev"},{"issue":"7","key":"10.1016\/j.jcyt.2016.08.007_bib0020","doi-asserted-by":"crossref","first-page":"536","DOI":"10.5966\/sctm.2012-0015","article-title":"Characterization of autologous mesenchymal stem cell-derived neural progenitors as a feasible source of stem cells for central nervous system applications in multiple sclerosis","volume":"1","author":"Harris","year":"2012","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jcyt.2016.08.007_bib0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jns.2011.08.036","article-title":"Clinical and pathological effects of intrathecal injection of mesenchymal stem cell\u2013derived neural progenitors in an experimental model of multiple sclerosis","volume":"313","author":"Harris","year":"2012","journal-title":"J Neurol Sci"},{"issue":"Pt 19","key":"10.1016\/j.jcyt.2016.08.007_bib0030","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1242\/jcs.01307","article-title":"Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells","volume":"117","author":"Hermann","year":"2004","journal-title":"J Cell Sci"},{"issue":"11","key":"10.1016\/j.jcyt.2016.08.007_bib0035","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.exphem.2006.06.020","article-title":"Neural differentiation of human mesenchymal stem cells: evidence for expression of neural markers and eag K+ channel types","volume":"34","author":"Mareschi","year":"2006","journal-title":"Exp Hematol"},{"issue":"4","key":"10.1016\/j.jcyt.2016.08.007_bib0040","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"1\u20132","key":"10.1016\/j.jcyt.2016.08.007_bib0045","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jns.2012.12.009","article-title":"Mesenchymal stem cell transplantation in multiple sclerosis","volume":"333","author":"Cohen","year":"2013","journal-title":"J Neurol Sci"},{"issue":"2","key":"10.1016\/j.jcyt.2016.08.007_bib0050","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S1474-4422(11)70305-2","article-title":"Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study","volume":"11","author":"Connick","year":"2012","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.1016\/j.jcyt.2016.08.007_bib0055","first-page":"50","article-title":"Does mesenchymal stem cell therapy help multiple sclerosis patients? Report of a pilot study","volume":"4","author":"Mohyeddin Bonab","year":"2007","journal-title":"Iran J Immunol"},{"issue":"1\u20132","key":"10.1016\/j.jcyt.2016.08.007_bib0060","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jneuroim.2010.07.013","article-title":"Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study","volume":"227","author":"Yamout","year":"2010","journal-title":"J Neuroimmunol"},{"issue":"10","key":"10.1016\/j.jcyt.2016.08.007_bib0065","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1001\/archneurol.2010.248","article-title":"Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis","volume":"67","author":"Karussis","year":"2010","journal-title":"Arch Neurol"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324916304960?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324916304960?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T22:22:52Z","timestamp":1761430972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324916304960"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":12,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1465324916304960"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2016.08.007","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical safety of intrathecal administration of mesenchymal stromal cell\u2013derived neural progenitors in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2016.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}