{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:42:00Z","timestamp":1791236520112,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P40OD011050"],"award-info":[{"award-number":["P40OD011050"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.jcyt.2016.09.008","type":"journal-article","created":{"date-parts":[[2016,10,20]],"date-time":"2016-10-20T04:26:14Z","timestamp":1476937574000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":119,"title":["The exciting prospects of new therapies with mesenchymal stromal cells"],"prefix":"10.1016","volume":"19","author":[{"given":"Darwin J.","family":"Prockop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcyt.2016.09.008_bib0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.bi.64.070195.002155","article-title":"Collagens: molecular biology, diseases, and potentials for therapy","volume":"64","author":"Prockop","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jcyt.2016.09.008_bib0015","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mam.2016.01.001","article-title":"Pharmacological targeting of the HIF hydroxylases\u2013a new field in medicine development","volume":"47\u201348","author":"Chan","year":"2016","journal-title":"Mol Aspects Med"},{"issue":"12","key":"10.1016\/j.jcyt.2016.09.008_bib0020","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1002\/stem.1806","article-title":"Are clinical trials with mesenchymal stem\/progenitor cells too far ahead of the science? Lessons from experimental hematology","volume":"32","author":"Prockop","year":"2014","journal-title":"Stem Cells"},{"issue":"3","key":"10.1016\/j.jcyt.2016.09.008_bib0025","first-page":"381","article-title":"Osteogenesis in transplants of bone marrow cells","volume":"16","author":"Friedenstein","year":"1966","journal-title":"J Embryol Exp Morphol"},{"key":"10.1016\/j.jcyt.2016.09.008_bib0030","first-page":"42","article-title":"Stromal stem cells: marrow-derived osteogenic precursors","volume":"136","author":"Owen","year":"1988","journal-title":"Ciba Found Symp"},{"issue":"5309","key":"10.1016\/j.jcyt.2016.09.008_bib0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.276.5309.71","article-title":"Marrow stromal cells as stem cells for nonhematopoietic tissues","volume":"276","author":"Prockop","year":"1997","journal-title":"Science"},{"issue":"2\u20133","key":"10.1016\/j.jcyt.2016.09.008_bib0040","first-page":"315","article-title":"Haemopoietic stem cells and the problem of self-renewal","volume":"10","author":"Dexter","year":"1984","journal-title":"Blood Cells"},{"issue":"3","key":"10.1016\/j.jcyt.2016.09.008_bib0045","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1073\/pnas.95.3.1142","article-title":"Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta","volume":"95","author":"Pereira","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.jcyt.2016.09.008_bib0050","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/6529","article-title":"Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta","volume":"5","author":"Horwitz","year":"1999","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.jcyt.2016.09.008_bib0055","first-page":"557","article-title":"Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use","volume":"16","author":"Lazarus","year":"1995","journal-title":"Bone Marrow Transplant"},{"issue":"19","key":"10.1016\/j.jcyt.2016.09.008_bib0060","doi-asserted-by":"crossref","first-page":"10711","DOI":"10.1073\/pnas.96.19.10711","article-title":"Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains","volume":"96","author":"Kopen","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.jcyt.2016.09.008_bib0065","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1200\/JCO.2000.18.2.307","article-title":"Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy","volume":"18","author":"Ko\u00e7","year":"2000","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.jcyt.2016.09.008_bib0070","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1073\/pnas.0437997100","article-title":"Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma","volume":"100","author":"Spees","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"25","key":"10.1016\/j.jcyt.2016.09.008_bib0075","doi-asserted-by":"crossref","first-page":"9282","DOI":"10.1073\/pnas.0401558101","article-title":"Rat adult stem cells (marrow stromal cells) engraft and differentiate in chick embryos without evidence of cell fusion","volume":"101","author":"Pochampally","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9419","key":"10.1016\/j.jcyt.2016.09.008_bib0080","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0140-6736(04)16104-7","article-title":"Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells","volume":"363","author":"Le Blanc","year":"2004","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.jcyt.2016.09.008_bib0085","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1111\/j.1582-4934.2010.01151.x","article-title":"Evolving paradigms for repair of tissues by adult stem\/progenitor cells (MSCs)","volume":"14","author":"Prockop","year":"2010","journal-title":"J Cell Mol Med"},{"issue":"Suppl. 1","key":"10.1016\/j.jcyt.2016.09.008_bib0090","doi-asserted-by":"crossref","first-page":"11917","DOI":"10.1073\/pnas.1834138100","article-title":"One strategy for cell and gene therapy: harnessing the power of adult stem cells to repair tissues","volume":"100","author":"Prockop","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1\u20132","key":"10.1016\/j.jcyt.2016.09.008_bib0095","first-page":"7","article-title":"The relationship between the spleen colony-forming cell and the haemopoietic stem cell","volume":"4","author":"Schofield","year":"1978","journal-title":"Blood Cells"},{"issue":"2","key":"10.1016\/j.jcyt.2016.09.008_bib0100","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(00)81424-5","article-title":"Decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary","volume":"94","author":"Xie","year":"1998","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.jcyt.2016.09.008_bib0105","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2008.01.025","article-title":"Hematopoiesis: an evolving paradigm for stem cell biology","volume":"132","author":"Orkin","year":"2008","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jcyt.2016.09.008_bib0110","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.stem.2012.05.015","article-title":"Mesenchymal stromal cells: new directions","volume":"10","author":"Keating","year":"2012","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/j.jcyt.2016.09.008_bib0115","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.stem.2009.05.003","article-title":"Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6","volume":"5","author":"Lee","year":"2009","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/j.jcyt.2016.09.008_bib0120","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1073\/pnas.0510511103","article-title":"Mitochondrial transfer between cells can rescue aerobic respiration","volume":"103","author":"Spees","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.jcyt.2016.09.008_bib0125","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm.2736","article-title":"Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury","volume":"18","author":"Islam","year":"2012","journal-title":"Nat Med"},{"issue":"7","key":"10.1016\/j.jcyt.2016.09.008_bib0130","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.18632\/oncotarget.3211","article-title":"Extracellular vesicles from bone marrow mesenchymal stem\/stromal cells transport tumor regulatory microRNA, proteins, and metabolites","volume":"6","author":"Vallabhaneni","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcyt.2016.09.008_bib0135","doi-asserted-by":"crossref","first-page":"8472","DOI":"10.1038\/ncomms9472","article-title":"Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs","volume":"6","author":"Phinney","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jcyt.2016.09.008_bib0140","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1073\/pnas.1522297113","article-title":"Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI","volume":"113","author":"Kim","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.jcyt.2016.09.008_bib0145","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/trf.12421","article-title":"Mesenchymal stem or stromal cells: a review of clinical applications and manufacturing practices","volume":"54","author":"Sharma","year":"2014","journal-title":"Transfusion"},{"issue":"1","key":"10.1016\/j.jcyt.2016.09.008_bib0150","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.stem.2015.06.007","article-title":"Stem cell therapies in clinical trials: progress and challenges","volume":"17","author":"Trounson","year":"2015","journal-title":"Cell Stem Cell"},{"issue":"8","key":"10.1016\/j.jcyt.2016.09.008_bib0155","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.bbmt.2016.04.010","article-title":"Heterogeneity in studies of mesenchymal stromal cells to treat or prevent graft-versus-host disease: a scoping review of the evidence","volume":"22","author":"Rizk","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"10.1016\/j.jcyt.2016.09.008_bib0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/nyas.12984","article-title":"Unraveling mechanisms of mesenchymal stromal cell-mediated immunomodulation through patient monitoring and product characterization","volume":"1370","author":"Schepers","year":"2016","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.jcyt.2016.09.008_bib0165","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/(SICI)1097-4644(19991201)75:3<424::AID-JCB8>3.0.CO;2-8","article-title":"Donor variation in the growth properties and osteogenic potential of human marrow stromal cells","volume":"75","author":"Phinney","year":"1999","journal-title":"J Cell Biochem"},{"issue":"5","key":"10.1016\/j.jcyt.2016.09.008_bib0170","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/14653240701358460","article-title":"Differences in stem and progenitor cell yield in different subcutaneous adipose tissue depots","volume":"9","author":"Fraser","year":"2007","journal-title":"Cytotherapy"},{"issue":"6","key":"10.1016\/j.jcyt.2016.09.008_bib0175","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1634\/stemcells.20-6-530","article-title":"Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality","volume":"20","author":"Sekiya","year":"2002","journal-title":"Stem Cells"},{"issue":"5","key":"10.1016\/j.jcyt.2016.09.008_bib0180","doi-asserted-by":"crossref","first-page":"632","DOI":"10.5966\/sctm.2013-0203","article-title":"Should publications on mesenchymal stem\/progenitor cells include in-process data on the preparation of the cells?","volume":"3","author":"Reger","year":"2014","journal-title":"Stem Cells Transl Med"},{"issue":"10","key":"10.1016\/j.jcyt.2016.09.008_bib0185","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.exphem.2008.05.003","article-title":"Reversible commitment to differentiation by human multipotent stromal cells in single-cell-derived colonies","volume":"36","author":"Yl\u00f6stalo","year":"2008","journal-title":"Exp Hematol"},{"issue":"14","key":"10.1016\/j.jcyt.2016.09.008_bib0190","doi-asserted-by":"crossref","first-page":"7841","DOI":"10.1073\/pnas.141221698","article-title":"Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells","volume":"98","author":"Colter","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"10.1016\/j.jcyt.2016.09.008_bib0195","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/term.2051","article-title":"Low-density subculture: a technical note on the importance of avoiding cell-to-cell contact during mesenchymal stromal cell expansion","volume":"9","author":"Balint","year":"2015","journal-title":"J Tissue Eng Regen Med"},{"issue":"1","key":"10.1016\/j.jcyt.2016.09.008_bib0200","article-title":"Gene expression profiles of human adipose tissue-derived mesenchymal stem cells are modified by cell culture density","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jcyt.2016.09.008_bib0205","doi-asserted-by":"crossref","first-page":"920581","DOI":"10.1155\/2012\/920581","article-title":"Multipotent mesenchymal stromal stem cell expansion by plating whole bone marrow at a low cellular density: a more advantageous method for clinical use","volume":"2012","author":"Mareschi","year":"2012","journal-title":"Stem Cells Int"},{"issue":"1","key":"10.1016\/j.jcyt.2016.09.008_bib0210","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S2213-2600(14)70291-7","article-title":"Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial","volume":"3","author":"Wilson","year":"2015","journal-title":"Lancet Respir Med"},{"issue":"1","key":"10.1016\/j.jcyt.2016.09.008_bib0215","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/mt.2011.211","article-title":"Mesenchymal stem\/stromal cells (MSCs): role as guardians of inflammation","volume":"20","author":"Prockop","year":"2012","journal-title":"Mol Ther"},{"issue":"4","key":"10.1016\/j.jcyt.2016.09.008_bib0220","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"11","key":"10.1016\/j.jcyt.2016.09.008_bib0225","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1089\/scd.2013.0591","article-title":"Soliciting strategies for developing cell-based reference materials to advance mesenchymal stromal cell research and clinical translation","volume":"23","author":"Viswanathan","year":"2014","journal-title":"Stem Cells Dev"},{"issue":"2","key":"10.1016\/j.jcyt.2016.09.008_bib0230","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1073\/pnas.1423008112","article-title":"MSCs derived from iPSCs with a modified protocol are tumor-tropic but have much less potential to promote tumors than bone marrow MSCs","volume":"112","author":"Zhao","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"issue":"47","key":"10.1016\/j.jcyt.2016.09.008_bib0235","doi-asserted-by":"crossref","first-page":"16766","DOI":"10.1073\/pnas.1416121111","article-title":"TSG-6 as a biomarker to predict efficacy of human mesenchymal stem\/progenitor cells (hMSCs) in modulating sterile inflammation in vivo","volume":"111","author":"Lee","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"10.1016\/j.jcyt.2016.09.008_bib0240","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","article-title":"Exploring the full spectrum of macrophage activation","volume":"8","author":"Mosser","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcyt.2016.09.008_bib0245","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3389\/fimmu.2015.00370","article-title":"The many alternative faces of macrophage activation","volume":"6","author":"Hume","year":"2015","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jcyt.2016.09.008_bib0250","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ni.3306","article-title":"Molecular control of activation and priming in macrophages","volume":"17","author":"Glass","year":"2016","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.jcyt.2016.09.008_bib0255","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1073\/pnas.1522905113","article-title":"Mesenchymal stem\/stromal cells precondition lung monocytes\/macrophages to produce tolerance against allo- and autoimmunity in the eye","volume":"113","author":"Ko","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.jcyt.2016.09.008_bib0260","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0731-7085(89)80083-4","article-title":"Bio-assays for the analysis of insulin","volume":"7","author":"Trethewey","year":"1989","journal-title":"J Pharm Biomed Anal"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324916305229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324916305229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T22:24:30Z","timestamp":1761431070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324916305229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S1465324916305229"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2016.09.008","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The exciting prospects of new therapies with mesenchymal stromal cells","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2016.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}