{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:03:31Z","timestamp":1772895811080,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ministry of Science, ICT & Future Planning","award":["2017M3A9B3063636, 2017R1A2B4002861"],"award-info":[{"award-number":["2017M3A9B3063636, 2017R1A2B4002861"]}]},{"name":"Ministry of Science, ICT & Future Planning","award":["2017R1A2B4002611"],"award-info":[{"award-number":["2017R1A2B4002611"]}]},{"name":"Ministry of Health & Welfare, Republic of Korea","award":["HI16C-2207"],"award-info":[{"award-number":["HI16C-2207"]}]}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.jcyt.2018.06.008","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T10:06:22Z","timestamp":1532945182000},"page":"1013-1027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Double intratibial injection of human tonsil-derived mesenchymal stromal cells recovers postmenopausal osteoporotic bone mass"],"prefix":"10.1016","volume":"20","author":[{"given":"GYUNGAH","family":"KIM","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOON MI","family":"JIN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YEONSIL","family":"YU","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HA YEONG","family":"KIM","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANGMEE AHN","family":"JO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOON JEONG","family":"PARK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YOON SHIN","family":"PARK","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"INHO","family":"JO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcyt.2018.06.008_bib0001","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1016\/S0140-6736(06)68891-0","article-title":"Osteoporosis","volume":"367","author":"Sambrook","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0002","first-page":"135","article-title":"Compliance with treatment in osteoporosis patients\u2013an ongoing problem","volume":"35","author":"Sambrook","year":"2006","journal-title":"Aust Fam Physician"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0003","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s13770-017-0088-4","article-title":"Implantation of bone marrow stromal cell sheets derived from old donors supports bone tissue formation","volume":"15","author":"Akahane","year":"2018","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0004","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s13770-017-0061-2","article-title":"Co-culture of human dental pulp stem cells and endothelial cells using porous biopolymer microcarriers: a feasibility study for bone tissue engineering","volume":"14","author":"Jin","year":"2017","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13770-016-0001-6","article-title":"Artificial bone via bone tissue engineering: current scenario and challenges","volume":"14","author":"Kashte","year":"2017","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0006","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s13770-017-0022-9","article-title":"PCL\/beta-TCP composite scaffolds exhibit positive osteogenic differentiation with mechanical stimulation","volume":"14","author":"Park","year":"2017","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0007","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3109\/00365513.2011.624631","article-title":"Mechanisms for the bone anabolic effect of parathyroid hormone treatment in humans","volume":"72","author":"Aslan","year":"2012","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0008","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11914-014-0191-6","article-title":"Local strategies to prevent and treat osteoporosis","volume":"12","author":"Torstrick","year":"2014","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0009","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12891-016-1113-9","article-title":"Local pamidronate influences fracture healing in a rodent femur fracture model: an experimental study","volume":"17","author":"Menzdorf","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0010","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s13770-014-0070-3","article-title":"Healing of tibial and calvarial bone defect using Runx-2-transfected adipose stem cells","volume":"12","author":"Lee","year":"2014","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0011","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s13770-014-0001-3","article-title":"Adipose tissue-derived stem cells in the ovariectomy-induced postmenopausal osteoporosis rat model","volume":"12","author":"Jeong","year":"2014","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0012","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s13770-017-0069-7","article-title":"Chemokine receptors expression in mscs: comparative analysis in different sources and passages","volume":"14","author":"Heirani-Tabasi","year":"2017","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0013","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.3109\/14653249.2012.706708","article-title":"Tonsil-derived mesenchymal stromal cells: evaluation of biologic, immunologic and genetic factors for successful banking","volume":"14","author":"Ryu","year":"2012","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0014","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.biomaterials.2015.06.044","article-title":"Differentiated tonsil-derived mesenchymal stem cells embedded in Matrigel restore parathyroid cell functions in rats with parathyroidectomy","volume":"65","author":"Park","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0015","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.actbio.2016.03.003","article-title":"Scaffold-free parathyroid tissue engineering using tonsil-derived mesenchymal stem cells","volume":"35","author":"Park","year":"2016","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0016","doi-asserted-by":"crossref","first-page":"E1867","DOI":"10.3390\/ijms17111867","article-title":"Tonsil-derived mesenchymal stem cells differentiate into a schwann cell phenotype and promote peripheral nerve regeneration","volume":"17","author":"Jung","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0017","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3892\/ijmm.2016.2536","article-title":"Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration","volume":"37","author":"Park","year":"2016","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0018","doi-asserted-by":"crossref","first-page":"8616","DOI":"10.1038\/srep08616","article-title":"tonsil-derived mesenchymal stem cells ameliorate ccl4-induced liver fibrosis in mice via autophagy activation","volume":"5","author":"Park","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0019","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.yexcr.2014.06.007","article-title":"Tonsil-derived mesenchymal stem cells alleviate concanavalin A-induced acute liver injury","volume":"326","author":"Ryu","year":"2014","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0020","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2500\/ajra.2015.29.4216","article-title":"Immunomodulatory effect of tonsil-derived mesenchymal stem cells in a mouse model of allergic rhinitis","volume":"29","author":"Samivel","year":"2015","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0021","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1089\/scd.2016.0063","article-title":"Tonsil-derived mesenchymal stem cells promote bone mineralization and reduce marrow and visceral adiposity in a mouse model of senile osteoporosis","volume":"25","author":"Kim","year":"2016","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0022","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/joa.12229","article-title":"Characterization of long-term in vitro culture-related alterations of human tonsil-derived mesenchymal stem cells: role for CCN1 in replicative senescence-associated increase in osteogenic differentiation","volume":"225","author":"Yu","year":"2014","journal-title":"J Anat"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0023","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13770-017-0042-5","article-title":"Intracellular remodeling and accumulation of aberrant lysosomes in differentiation of tonsil-derived mesenchymal stem cells into parathyroid-like cells","volume":"14","author":"Jo","year":"2017","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0024","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.1016\/j.biomaterials.2012.05.024","article-title":"The effect of diminished osteogenic signals on reduced osteoporosis recovery in aged mice and the potential therapeutic use of adipose-derived stem cells","volume":"33","author":"Liu","year":"2012","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0025","first-page":"RC04","article-title":"Serum osteocalcin as a diagnostic biomarker for primary osteoporosis in women","volume":"9","author":"Singh","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0026","series-title":"The Mouse in biomedical research","author":"Foster","year":"1981"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0027","doi-asserted-by":"crossref","first-page":"E544","DOI":"10.3390\/ijerph13060544","article-title":"BMI and BMD: the potential interplay between obesity and bone fragility","volume":"13","author":"Palermo","year":"2016","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0028","first-page":"1629","article-title":"Divergent effects of obesity on fragility fractures","volume":"9","author":"Caffarelli","year":"2014","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0029","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5312\/wjo.v7.i3.171","article-title":"Major osteoporotic fragility fractures: Risk factor updates and societal impact","volume":"7","author":"Pisani","year":"2016","journal-title":"World J Orthop"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0030","doi-asserted-by":"crossref","first-page":"17114","DOI":"10.1038\/s41598-017-16788-2","article-title":"RNA sequencing reveals a transcriptomic portrait of human mesenchymal stem cells from bone marrow, adipose tissue, and palatine tonsils","volume":"7","author":"Cho","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0031","article-title":"Effect of stem cell therapy on bone mineral density: a meta-analysis of preclinical studies in animal models of osteoporosis","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0032","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3109\/03008201003597049","article-title":"Intra-bone marrow injection of mesenchymal stem cells improves the femur bone mass of osteoporotic female rats","volume":"51","author":"Ocarino Nde","year":"2010","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0033","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1634\/stemcells.20-6-542","article-title":"Prevention of senile osteoporosis in SAMP6 mice by intrabone marrow injection of allogeneic bone marrow cells","volume":"20","author":"Ichioka","year":"2002","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0034","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1634\/stemcells.2005-0068","article-title":"Treatment of senile osteoporosis in SAMP6 mice by intra-bone marrow injection of allogeneic bone marrow cells","volume":"24","author":"Takada","year":"2006","journal-title":"Stem Cells"},{"issue":"Suppl 1","key":"10.1016\/j.jcyt.2018.06.008_bib0035","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1007\/s40520-015-0423-3","article-title":"Femoral cortical index: an indicator of poor bone quality in patient\nwith hip fracture","volume":"27","author":"Feola","year":"2015","journal-title":"Aging Clin Exp Res"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0036","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/bonekey.2016.59","article-title":"Osteoporosis drug effects on cortical and trabecular bone microstructure: a review of HR-pQCT analyses","volume":"5","author":"Lespessailles","year":"2016","journal-title":"Bonekey Rep"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0037","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1089\/ten.tea.2015.0071","article-title":"The treatment efficacy of bone tissue engineering strategy for repairing segmental bone defects under osteoporotic conditions","volume":"21","author":"Wang","year":"2015","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0038","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1080\/14653240802071616","article-title":"Bone marrow stromal cell therapy improves femoral bone mineral density and mechanical strength in ovariectomized rats","volume":"10","author":"Uejima","year":"2008","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0039","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13287-016-0394-0","article-title":"Secreted trophic factors of mesenchymal stem cells support neurovascular and musculoskeletal therapies","volume":"7","author":"Hofer","year":"2016","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0040","doi-asserted-by":"crossref","first-page":"536","DOI":"10.5603\/FM.a2016.0013","article-title":"Assessment of femoral neck fractures in the elderly with respect to morphology and mineral density","volume":"75","author":"Sorkun","year":"2016","journal-title":"Folia Morphol (Warsz)"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0041","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1359\/jbmr.1997.12.4.641","article-title":"Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis","volume":"12","author":"Li","year":"1997","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0042","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s13770-016-0008-z","article-title":"Coculture effects on the osteogenic differentiation of human mesenchymal stromal cells","volume":"13","author":"Hayrapetyan","year":"2016","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0043","doi-asserted-by":"crossref","first-page":"7326","DOI":"10.1016\/j.biomaterials.2014.05.016","article-title":"Therapeutic potential of adipose-derived stromal cells in age-related osteoporosis","volume":"35","author":"Mirsaidi","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcyt.2018.06.008_bib0044","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1365-2796.2011.02443.x","article-title":"Body fat mass is a predictor of risk of osteoporotic fractures in women but not in men: a prospective population study","volume":"271","author":"Moayyeri","year":"2012","journal-title":"J Intern Med"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324918305504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324918305504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T01:36:01Z","timestamp":1761442561000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324918305504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1465324918305504"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2018.06.008","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Double intratibial injection of human tonsil-derived mesenchymal stromal cells recovers postmenopausal osteoporotic bone mass","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2018.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}