{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:21:34Z","timestamp":1771863694727,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jcyt.2018.10.005","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T09:16:56Z","timestamp":1541409416000},"page":"107-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Autologous bone marrow\u2013derived CD133 cells with core decompression as a novel treatment method for femoral head osteonecrosis: a pilot study"],"prefix":"10.1016","volume":"21","author":[{"given":"MOHSEN","family":"EMADEDIN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SHAHEDEH","family":"KARIMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ALIASGHAR","family":"KARIMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NARGES","family":"LABIBZADEH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARYAM","family":"NIKNEJADI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HOSSEIN","family":"BAHARVAND","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5390-7878","authenticated-orcid":false,"given":"NASSER","family":"AGHDAMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jcyt.2018.10.005_bib0001","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5312\/wjo.v3.i5.49","article-title":"Osteonecrosis of the femoral head: An update in year 2012","volume":"3","author":"Kaushik","year":"2012","journal-title":"World J Orthop"},{"issue":"3","key":"10.1016\/j.jcyt.2018.10.005_bib0002","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12178-015-9277-8","article-title":"Pathophysiology and risk factors for osteonecrosis","volume":"8","author":"Shah","year":"2015","journal-title":"Current reviews in musculoskeletal medicine"},{"issue":"3","key":"10.1016\/j.jcyt.2018.10.005_bib0003","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2106\/00004623-199503000-00018","article-title":"Non-traumatic avascular necrosis of the femoral head","volume":"77","author":"Mont","year":"1995","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.jcyt.2018.10.005_bib0004","first-page":"337","article-title":"Osteonecrosis of the hip: management in the 21st century","volume":"52","author":"Lieberman","year":"2003","journal-title":"Instr Course Lect"},{"issue":"21","key":"10.1016\/j.jcyt.2018.10.005_bib0005","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.4103\/0366-6999.168017","article-title":"Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey","volume":"128","author":"Zhao","year":"2015","journal-title":"Chin Med J (Engl)"},{"issue":"2","key":"10.1016\/j.jcyt.2018.10.005_bib0006","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s11999-013-3220-3","article-title":"Treatment of femoral head osteonecrosis in the United States: 16-year analysis of the Nationwide Inpatient Sample","volume":"472","author":"Johnson","year":"2014","journal-title":"Clin Orthop Relat Res"},{"issue":"6","key":"10.1016\/j.jcyt.2018.10.005_bib0007","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3928\/01477447-20130523-26","article-title":"Tantalum rod implantation and vascularized iliac grafting for osteonecrosis of the femoral head","volume":"36","author":"Zhao","year":"2013","journal-title":"Orthopedics"},{"issue":"7","key":"10.1016\/j.jcyt.2018.10.005_bib0008","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1517\/13543784.10.7.1309","article-title":"Anticoagulant therapy for osteonecrosis associated with heritable hypofibrinolysis and thrombophilia","volume":"10","author":"Glueck","year":"2001","journal-title":"Expert Opin Investig Drugs"},{"issue":"Suppl 1","key":"10.1016\/j.jcyt.2018.10.005_bib0009","first-page":"39","article-title":"Aseptic osteonecrosis of the hip in the adult: current evidence on conservative treatment","volume":"12","author":"Klumpp","year":"2015","journal-title":"Clin Cases Miner Bone Metab"},{"issue":"4","key":"10.1016\/j.jcyt.2018.10.005_bib0010","doi-asserted-by":"crossref","first-page":"250","DOI":"10.5371\/hp.2015.27.4.250","article-title":"Osteonecrosis of Femoral Head Treated with Extracorporeal Shock Wave Therapy: Analysis of Short-term Clinical Outcomes of Treatment with Radiologic Staging","volume":"27","author":"Lee","year":"2015","journal-title":"Hip Pelvis"},{"issue":"6","key":"10.1016\/j.jcyt.2018.10.005_bib0011","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1089\/ten.teb.2012.0672","article-title":"The key regulatory roles of the PI3K\/Akt signaling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration","volume":"19","author":"Chen","year":"2013","journal-title":"Tissue Eng Part B Rev"},{"issue":"405","key":"10.1016\/j.jcyt.2018.10.005_bib0012","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/00003086-200212000-00003","article-title":"Treatment of osteonecrosis with autologous bone marrow grafting","author":"Hernigou","year":"2002","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"10.1016\/j.jcyt.2018.10.005_bib0013","first-page":"3127","article-title":"Application of bone marrow mesenchymal stem cells to the treatment of osteonecrosis of the femoral head","volume":"8","author":"Wang","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.jcyt.2018.10.005_bib0014","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1471-2474-15-156","article-title":"Stem cell therapy for the treatment of early stage avascular necrosis of the femoral head: a systematic review","volume":"15","author":"Lau","year":"2014","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.jcyt.2018.10.005_bib0015","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13287-015-0105-2","article-title":"Efficacy of autologous stem cell-based therapy for osteonecrosis of the femoral head in sickle cell disease: a five-year follow-up study","volume":"6","author":"Daltro","year":"2015","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"10.1016\/j.jcyt.2018.10.005_bib0016","doi-asserted-by":"crossref","first-page":"232","DOI":"10.7150\/ijbs.16951","article-title":"Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis","volume":"13","author":"Liu","year":"2017","journal-title":"Int J Biol Sci"},{"issue":"4","key":"10.1016\/j.jcyt.2018.10.005_bib0017","first-page":"6902","article-title":"Bone Marrow Aspirate Concentrate in Combination With Intravenous Iloprost Increases Bone Healing in Patients With Avascular Necrosis of the Femoral Head: A Matched Pair Analysis","volume":"8","author":"Pilge","year":"2016","journal-title":"Orthop Rev (Pavia)"},{"issue":"1","key":"10.1016\/j.jcyt.2018.10.005_bib0018","first-page":"6162","article-title":"Core Decompression and Autologous Bone Marrow Concentrate for Treatment of Femoral Head Osteonecrosis: A Randomized Prospective Study","volume":"8","author":"Pepke","year":"2016","journal-title":"Orthop Rev (Pavia)"},{"issue":"4","key":"10.1016\/j.jcyt.2018.10.005_bib0019","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1582-4934.2004.tb00474.x","article-title":"Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance","volume":"8","author":"Hristov","year":"2004","journal-title":"J Cell Mol Med"},{"issue":"2","key":"10.1016\/j.jcyt.2018.10.005_bib0020","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.phrs.2008.07.008","article-title":"Endothelial progenitor cells in vascular repair and remodeling","volume":"58","author":"Hristov","year":"2008","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.jcyt.2018.10.005_bib0021","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2162-3619-2-17","article-title":"CD133: a stem cell biomarker and beyond","volume":"2","author":"Li","year":"2013","journal-title":"Experimental hematology & oncology"},{"issue":"5","key":"10.1016\/j.jcyt.2018.10.005_bib0022","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.3892\/mmr.2016.5745","article-title":"Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: A three-year follow-up study","volume":"14","author":"Chen","year":"2016","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.jcyt.2018.10.005_bib0023","first-page":"34","article-title":"A quantitative system for staging avascular necrosis","volume":"77","author":"Steinberg","year":"1995","journal-title":"Bone & Joint Journal"},{"issue":"4","key":"10.1016\/j.jcyt.2018.10.005_bib0024","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/rheumatology\/16.4.257","article-title":"Measurement of functional capacity with visual analogue scales","volume":"16","author":"Scott","year":"1977","journal-title":"Rheumatology and rehabilitation"},{"issue":"4","key":"10.1016\/j.jcyt.2018.10.005_bib0025","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2106\/00004623-196951040-00012","article-title":"Traumatic arthritis of the hip afer dislocation and acetabular fractures: treatment by mold arthroplasty. An end result study using a new method of result evaluation","volume":"51","author":"Harrris","year":"1969","journal-title":"J Bone Joint Surg [Am]"},{"issue":"11","key":"10.1016\/j.jcyt.2018.10.005_bib0026","first-page":"2635","article-title":"Minimal perceptible clinical improvement with the Western Ontario and McMaster Universities osteoarthritis index questionnaire and global assessments in patients with osteoarthritis","volume":"27","author":"Ehrich","year":"2000","journal-title":"The Journal of rheumatology"},{"key":"10.1016\/j.jcyt.2018.10.005_bib0027","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cbi.2018.03.002","article-title":"Naringin enhances endothelial progenitor cell (EPC) proliferation and tube formation capacity through the CXCL12\/CXCR4\/PI3K\/Akt signaling pathway","volume":"286","author":"Zhao","year":"2018","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.jcyt.2018.10.005_bib0028","doi-asserted-by":"crossref","first-page":"951","DOI":"10.12659\/MSM.906116","article-title":"Resveratrol Improves Endothelial Progenitor Cell Function through miR-138 by Targeting Focal Adhesion Kinase (FAK) and Promotes Thrombus Resolution In Vivo","volume":"24","author":"Zhang","year":"2018","journal-title":"Med Sci Monit"},{"issue":"4","key":"10.1016\/j.jcyt.2018.10.005_bib0029","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/CIRCRESAHA.116.309009","article-title":"Effects of Transendocardial Delivery of Bone Marrow-Derived CD133(+) Cells on Left Ventricle Perfusion and Function in Patients With Refractory Angina: Final Results of Randomized, Double-Blinded, Placebo-Controlled REGENT-VSEL Trial","volume":"120","author":"Wojakowski","year":"2017","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.jcyt.2018.10.005_bib0030","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/ijc.31349","article-title":"Endothelial progenitor cells contribute to neovascularization of non-small cell lung cancer via HDAC7 mediated cytoskeleton regulation and angiogenic genes transcription","volume":"143","author":"Wei","year":"2018","journal-title":"Int J Cancer"},{"key":"10.1016\/j.jcyt.2018.10.005_bib0031","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jns.2017.12.028","article-title":"Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics","volume":"385","author":"Sargento-Freitas","year":"2018","journal-title":"J Neurol Sci"},{"issue":"5","key":"10.1016\/j.jcyt.2018.10.005_bib0032","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/humrep\/dew042","article-title":"Autologous cell therapy with CD133+ bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy: a pilot cohort study","volume":"31","author":"Santamaria","year":"2016","journal-title":"Hum Reprod"},{"issue":"4","key":"10.1016\/j.jcyt.2018.10.005_bib0033","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1161\/STROKEAHA.117.019346","article-title":"Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion","volume":"49","author":"Maki","year":"2018","journal-title":"Stroke"},{"issue":"49","key":"10.1016\/j.jcyt.2018.10.005_bib0034","doi-asserted-by":"crossref","first-page":"86188","DOI":"10.18632\/oncotarget.21036","article-title":"Natural compound bavachalcone promotes the differentiation of endothelial progenitor cells and neovascularization through the RORalpha-erythropoietin-AMPK axis","volume":"8","author":"Ling","year":"2017","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.jcyt.2018.10.005_bib0035","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1002\/2211-5463.12317","article-title":"Coculture of endothelial progenitor cells and mesenchymal stem cells enhanced their proliferation and angiogenesis through PDGF and Notch signaling","volume":"7","author":"Liang","year":"2017","journal-title":"FEBS Open Bio"},{"issue":"2","key":"10.1016\/j.jcyt.2018.10.005_bib0036","doi-asserted-by":"crossref","first-page":"179","DOI":"10.15283\/ijsc17019","article-title":"Stem Cell Therapy for Avascular Necrosis of Femoral Head in Sickle Cell Disease: Report of 11 Cases and Review of Literature","volume":"10","author":"Sadat-Ali","year":"2017","journal-title":"Int J Stem Cells"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324918306418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324918306418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T01:37:49Z","timestamp":1761442669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324918306418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1465324918306418"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2018.10.005","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autologous bone marrow\u2013derived CD133 cells with core decompression as a novel treatment method for femoral head osteonecrosis: a pilot study","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2018.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc. on behalf of International Society for Cellular Therapy.","name":"copyright","label":"Copyright"}]}}