{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:30:18Z","timestamp":1777415418664,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007292","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.jcyt.2020.01.008","type":"journal-article","created":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T18:01:30Z","timestamp":1581616890000},"page":"166-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Efficacy and toxicity for CD22\/CD19 chimeric antigen receptor T-cell therapy in patients with relapsed\/refractory aggressive B-cell lymphoma involving the gastrointestinal tract"],"prefix":"10.1016","volume":"22","author":[{"given":"Chen","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3210-2522","authenticated-orcid":false,"given":"Jiali","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-7133","authenticated-orcid":false,"given":"Chunrui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9948-4783","authenticated-orcid":false,"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0049-4122","authenticated-orcid":false,"given":"Yaoyao","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9790-859X","authenticated-orcid":false,"given":"Xiaoxi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jcyt.2020.01.008_bib0001","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1056\/NEJMoa011795","article-title":"CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma","volume":"346","author":"Coiffier","year":"2002","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.jcyt.2020.01.008_bib0002","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1470-2045(08)70002-0","article-title":"Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60)","volume":"9","author":"Pfreundschuh","year":"2008","journal-title":"Lancet Oncol"},{"issue":"5","key":"10.1016\/j.jcyt.2020.01.008_bib0003","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1200\/JCO.2002.20.5.1288","article-title":"Rituximab and CHOP induction therapy for newly diagnosed mantle-cell lymphoma: molecular complete responses are not predictive of progression-free survival","volume":"20","author":"Howard","year":"2002","journal-title":"J Clin Oncol"},{"issue":"14","key":"10.1016\/j.jcyt.2020.01.008_bib0004","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1200\/JCO.2010.32.7577","article-title":"Transformation of indolent B-cell lymphomas","volume":"29","author":"Montoto","year":"2011","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1016\/j.jcyt.2020.01.008_bib0005","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1182\/blood-2010-03-276246","article-title":"Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d\u2019Etudes des Lymphomes de l\u2019Adulte","volume":"116","author":"Coiffier","year":"2010","journal-title":"Blood"},{"issue":"16","key":"10.1016\/j.jcyt.2020.01.008_bib0006","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1182\/blood-2017-03-769620","article-title":"Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study","volume":"130","author":"Crump","year":"2017","journal-title":"Blood"},{"issue":"26","key":"10.1016\/j.jcyt.2020.01.008_bib0007","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1056\/NEJMoa1707447","article-title":"Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma","volume":"377","author":"Neelapu","year":"2017","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jcyt.2020.01.008_bib0008","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1056\/NEJMoa1804980","article-title":"Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma","volume":"380","author":"Schuster","year":"2019","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.jcyt.2020.01.008_bib0009","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/0277-5379(89)90416-1","article-title":"Primary extranodal and nodal non-Hodgkin's lymphoma. A survey of a population-based registry","volume":"25","author":"Otter","year":"1989","journal-title":"Eur J Cancer Clin Oncol"},{"issue":"10","key":"10.1016\/j.jcyt.2020.01.008_bib0010","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/0277-5379(91)90081-N","article-title":"Clinicopathological features and prognostic factors in extranodal non-Hodgkin lymphomas. Danish LYFO Study Group","volume":"27","author":"d\u2019Amore","year":"1991","journal-title":"Eur J Cancer (Oxford, England: 1990)"},{"issue":"6","key":"10.1016\/j.jcyt.2020.01.008_bib0011","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3748\/wjg.v17.i6.697","article-title":"Primary gastrointestinal lymphoma","volume":"17","author":"Ghimire","year":"2011","journal-title":"World J Gastroenterology"},{"issue":"6","key":"10.1016\/j.jcyt.2020.01.008_bib0012","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/gut.2010.224949","article-title":"EGILS consensus report. Gastric extranodal marginal zone B-cell lymphoma of MALT","volume":"60","author":"Ruskone-Fourmestraux","year":"2011","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.jcyt.2020.01.008_bib0013","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cgh.2009.07.017","article-title":"Effects of Helicobacter pylori Eradication on Early Stage Gastric Mucosa\u2013Associated Lymphoid Tissue Lymphoma","volume":"8","author":"Zullo","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"10.1016\/j.jcyt.2020.01.008_bib0014","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1136\/gutjnl-2011-300495","article-title":"Long-term clinical outcome of gastric MALT lymphoma after eradication ofHelicobacter pylori: a multicentre cohort follow-up study of 420 patients in Japan","volume":"61","author":"Nakamura","year":"2012","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.jcyt.2020.01.008_bib0015","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1080\/1042819042000219476","article-title":"Conservative management of gastric lymphoma: the treatment option of choice","volume":"45","author":"Schmidt","year":"2004","journal-title":"Leuk Lymphoma"},{"issue":"26","key":"10.1016\/j.jcyt.2020.01.008_bib0016","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1200\/JCO.2005.05.018","article-title":"State-of-the-art therapeutics: marginal-zone lymphoma","volume":"23","author":"Bertoni","year":"2005","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.jcyt.2020.01.008_bib0017","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1245\/s10434-006-9069-x","article-title":"Bleeding,obstruction, and perforation in a series of patients with aggressive gastric lymphoma treated with primary chemotherapy","volume":"13","author":"Spectre","year":"2006","journal-title":"Ann Surg Oncol"},{"issue":"9","key":"10.1016\/j.jcyt.2020.01.008_bib0018","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1093\/annonc\/mdt188","article-title":"Bowel perforation in intestinal lymphoma: incidence and clinical features","volume":"24","author":"Vaidya","year":"2013","journal-title":"Ann Oncol"},{"issue":"7","key":"10.1016\/j.jcyt.2020.01.008_bib0019","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1200\/JCO.1988.6.7.1125","article-title":"Non-Hodgkin\u2019s lymphoma of the gastrointestinal tract: an analysis of clinical and pathologic features affecting outcome","volume":"6","author":"List","year":"1988","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1016\/j.jcyt.2020.01.008_bib0020","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1080\/10428190903147629","article-title":"Clinical outcome in patients with small-intestinal non-Hodgkin lymphoma","volume":"50","author":"Kako","year":"2009","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"10.1016\/j.jcyt.2020.01.008_bib0021","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s12032-010-9783-x","article-title":"Clinical prognostic analysis of 116 patients with primary intestinal non-Hodgkin lymphoma","volume":"29","author":"Gou","year":"2012","journal-title":"Med Oncol"},{"issue":"1","key":"10.1016\/j.jcyt.2020.01.008_bib0022","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1182\/blood.2019000017","article-title":"Efficacy and safety of CAR19\/22 T-cell cocktail therapy in patients with refractory\/relapsed B-cell malignancies","volume":"135","author":"Wang","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jcyt.2020.01.008_bib0024","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cryobiol.2018.06.007","article-title":"Effects of cryopreservation on chimeric antigen receptor T cell functions","volume":"83","author":"Xu","year":"2018","journal-title":"Cryobiology"},{"issue":"27","key":"10.1016\/j.jcyt.2020.01.008_bib0025","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1200\/JCO.2013.54.8800","article-title":"Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification","volume":"32","author":"Cheson","year":"2014","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.jcyt.2020.01.008_bib0026","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.bbmt.2018.12.758","article-title":"ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells","volume":"25","author":"Lee","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jcyt.2020.01.008_bib0027","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE), version 5.0. Available at: https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/docs\/CTCAE_v5_Quick_Reference_8.5x11.pdf. November 27, 2017."},{"issue":"1","key":"10.1016\/j.jcyt.2020.01.008_bib0028","doi-asserted-by":"crossref","first-page":"152","DOI":"10.21147\/j.issn.1000-9604.2019.01.10","article-title":"Clinical features and outcomes of diffuse large B-cell lymphoma based on nodal or extranodal primary sites of origin: Analysis of 1,085 WHO classified cases in a single institution in China","volume":"31","author":"Shi","year":"2019","journal-title":"Chin J Cancer Res"},{"issue":"6","key":"10.1016\/j.jcyt.2020.01.008_bib0029","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1023\/A:1008389119525","article-title":"Extended Rituximab (anti-CD20 monoclonal antibody) therapy for relapsed or refractory low-grade or follicular non-Hodgkin\u2019s lymphoma","volume":"10","author":"Piro","year":"1999","journal-title":"Ann Oncol"},{"issue":"6","key":"10.1016\/j.jcyt.2020.01.008_bib0030","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/annonc\/mdu135","article-title":"Incidence of bowel perforation in gastrointestinal lymphomas by location and histology","volume":"25","author":"Vaidya","year":"2014","journal-title":"Ann Oncol"},{"issue":"4","key":"10.1016\/j.jcyt.2020.01.008_bib0031","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1093\/cid\/cir073","article-title":"Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america","volume":"52","author":"Freifeld","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"8","key":"10.1016\/j.jcyt.2020.01.008_bib0032","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1086\/378297","article-title":"Stenotrophomonas maltophilia intestinal colonization in hospitalized oncology patients with diarrhea","volume":"37","author":"Apisarnthanarak","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jcyt.2020.01.008_bib0033","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijid.2016.02.014","article-title":"Emerging role of Raoultella ornithinolytica in human infections: a series of cases and review of the literature","volume":"45","author":"Seng","year":"2016","journal-title":"Int J Infect Dis"},{"issue":"1","key":"10.1016\/j.jcyt.2020.01.008_bib0034","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1128\/CMR.3.1.46","article-title":"The life and times of the Enterococcus","volume":"3","author":"Murray","year":"1990","journal-title":"Clin Microbiol Rev"},{"issue":"11","key":"10.1016\/j.jcyt.2020.01.008_bib0035","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.jcyt.2020.01.008_bib0036","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1017\/ice.2014.3","article-title":"Frequency, risk factors, and outcomes of vancomycin-resistant Enterococcus colonization and infection in patients with newly diagnosed acute leukemia: different patterns in patients with acute myelogenous and acute lymphoblastic leukemia","volume":"36","author":"Ford","year":"2015","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"4","key":"10.1016\/j.jcyt.2020.01.008_bib0037","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1086\/502197","article-title":"Risk factors for Stenotrophomonas maltophilia bacteremia in oncology patients: a case-control study","volume":"24","author":"Apisarnthanarak","year":"2003","journal-title":"Infect Control Hosp Epidemiol"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324920300116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324920300116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T01:39:19Z","timestamp":1761442759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324920300116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1465324920300116"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2020.01.008","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and toxicity for CD22\/CD19 chimeric antigen receptor T-cell therapy in patients with relapsed\/refractory aggressive B-cell lymphoma involving the gastrointestinal tract","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2020.01.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society for Cell and Gene Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}