{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:59:46Z","timestamp":1777373986446,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100011500","name":"Research Institute, Nationwide Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011500","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jcyt.2020.04.102","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T23:32:00Z","timestamp":1616801520000},"page":"411-422","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Splenic macrophage phagocytosis of intravenously infused mesenchymal stromal cells attenuates tumor localization"],"prefix":"10.1016","volume":"23","author":[{"given":"Suheyla","family":"Hasgur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Desbourdes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa","family":"Relation","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Overholt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph R.","family":"Stanek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J.","family":"Guess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pratik","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Roback","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Dominici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Otsuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin M.","family":"Horwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcyt.2020.04.102_bib0001","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12916-015-0426-0","article-title":"Mesenchymal stem\/stromal cells as a delivery platform in cell and gene therapies","volume":"13","author":"D'Souza","year":"2015","journal-title":"BMC medicine"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0002","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0003","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/gt.2008.39","article-title":"Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells","volume":"15","author":"Spaeth","year":"2008","journal-title":"Gene therapy"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0004","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1073\/pnas.042678299","article-title":"Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery","volume":"99","author":"Hofstetter","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0005","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1158\/0008-5472.CAN-04-1874","article-title":"Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas","volume":"65","author":"Nakamizo","year":"2005","journal-title":"Cancer research"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0006","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/jnci\/djh299","article-title":"Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents","volume":"96","author":"Studeny","year":"2004","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0007","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/jgm.2823","article-title":"Genetically engineered mesenchymal stromal cells producing TNF\u03b1 have tumour suppressing effect on human melanoma xenograft","volume":"17","author":"Wang","year":"2015","journal-title":"J Gene Med"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0008","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.addr.2011.06.010","article-title":"Mesenchymal stem cells engineered for cancer therapy","volume":"64","author":"Shah","year":"2012","journal-title":"Advanced drug delivery reviews"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0009","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jcyt.2012.10.003","article-title":"Tumor stroma engraftment of gene-modified mesenchymal stem cells as anti-tumor therapy against ovarian cancer","volume":"15","author":"Dembinski","year":"2013","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0010","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.3892\/or_00000796","article-title":"Chemokines mediate mesenchymal stem cell migration toward gliomas in vitro","volume":"23","author":"Xu","year":"2010","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0011","first-page":"3603","article-title":"Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors","volume":"62","author":"Studeny","year":"2002","journal-title":"Cancer research"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0012","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/stem.2614","article-title":"Concise Review: MSC Adhesion Cascade\u2014Insights into Homing and Transendothelial Migration","volume":"35","author":"Nitzsche","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0013","doi-asserted-by":"crossref","first-page":"e10088","DOI":"10.1371\/journal.pone.0010088","article-title":"A new mesenchymal stem cell (MSC) paradigm: polarization into a pro-inflammatory MSC1 or an immunosuppressive MSC2 phenotype","volume":"5","author":"Waterman","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0014","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000047856","article-title":"The dynamic in vivo distribution of bone marrow-derived mesenchymal stem cells after infusion","volume":"169","author":"Gao","year":"2001","journal-title":"Cells Tissues Organs"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0015","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/mt.2009.62","article-title":"Repair of tissues by adult stem\/progenitor cells (MSCs): controversies, myths, and changing paradigms","volume":"17","author":"Prockop","year":"2009","journal-title":"Molecular therapy: the journal of the American Society of Gene Therapy"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0016","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nbt.2816","article-title":"Mesenchymal stem cells: immune evasive, not immune privileged","volume":"32","author":"Ankrum","year":"2014","journal-title":"Nature biotechnology"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0017","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1002\/stem.187","article-title":"Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging","volume":"27","author":"Kidd","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0018","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1161\/CIRCRESAHA.108.187724","article-title":"Fate of culture-expanded mesenchymal stem cells in the microvasculature: in vivo observations of cell kinetics","volume":"104","author":"Toma","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0019","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/scd.2008.0253","article-title":"Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect","volume":"18","author":"Fischer","year":"2009","journal-title":"Stem cells and development"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0020","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1002\/stem.217","article-title":"Direct imaging of immune rejection and memory induction by allogeneic mesenchymal stromal cells","volume":"27","author":"Zangi","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0021","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","article-title":"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications","volume":"174","author":"Van Rooijen","year":"1994","journal-title":"Journal of immunological methods"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0022","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1182\/blood-2011-12-400085","article-title":"Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms","volume":"120","author":"Otsuru","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0023","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0024","first-page":"49","article-title":"The role of natural killer cells in adenovirus-mediated p53 gene therapy","volume":"1","author":"Carroll","year":"2001","journal-title":"Molecular cancer therapeutics"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0025","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.4049\/jimmunol.171.3.1148","article-title":"Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses","volume":"171","author":"Aichele","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0026","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1002\/eji.200939389","article-title":"Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control","volume":"39","author":"Fink","year":"2009","journal-title":"European journal of immunology"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0027","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/stem.2344","article-title":"Mesenchymal Stem Cells Induce Suppressive Macrophages Through Phagocytosis in a Mouse Model of Asthma","volume":"34","author":"Braza","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0028","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3389\/fimmu.2019.01191","article-title":"Immunomodulation by Mesenchymal Stem Cells (MSCs): Mechanisms of Action of Living, Apoptotic, and Dead MSCs","volume":"10","author":"Weiss","year":"2019","journal-title":"Frontiers in immunology"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0029","first-page":"91","article-title":"Crosstalk between mesenchymal stem cells and macrophages in inflammatory bowel disease and associated colorectal cancer","volume":"21","author":"Mao","year":"2017","journal-title":"Contemporary oncology"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cei.12929","article-title":"The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?","volume":"188","author":"Carty","year":"2017","journal-title":"Clinical and experimental immunology"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0031","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/stem.2369","article-title":"Mesenchymal Stromal Cells Induce Peculiar Alternatively Activated Macrophages Capable of Dampening Both Innate and Adaptive Immune Responses","volume":"34","author":"Chiossone","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0032","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/stem.2254","article-title":"Mesenchymal Stem Cell-Derived Interleukin 1 Receptor Antagonist Promotes Macrophage Polarization and Inhibits B Cell Differentiation","volume":"34","author":"Luz-Crawford","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0033","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00395-011-0221-9","article-title":"Mesenchymal stromal cells mediate a switch to alternatively activated monocytes\/macrophages after acute myocardial infarction","volume":"106","author":"Dayan","year":"2011","journal-title":"Basic research in cardiology"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0034","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/1240301","article-title":"CCR2 Positive Exosome Released by Mesenchymal Stem Cells Suppresses Macrophage Functions and Alleviates Ischemia\/Reperfusion-Induced Renal Injury","volume":"2016","author":"Shen","year":"2016","journal-title":"Stem cells international"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0035","doi-asserted-by":"crossref","first-page":"11002","DOI":"10.1073\/pnas.0704421104","article-title":"Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury","volume":"104","author":"Ortiz","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0036","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1073\/pnas.1522905113","article-title":"Mesenchymal stem\/stromal cells precondition lung monocytes\/macrophages to produce tolerance against allo- and autoimmunity in the eye","volume":"113","author":"Ko","year":"2016","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0037","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.5966\/sctm.2015-0020","article-title":"Skin-Derived Mesenchymal Stem Cells Alleviate Atherosclerosis via Modulating Macrophage Function","volume":"4","author":"Li","year":"2015","journal-title":"Stem cells translational medicine"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0038","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1007\/s11033-014-3364-6","article-title":"TGF-beta signaling-dependent alleviation of dextran sulfate sodium-induced colitis by mesenchymal stem cell transplantation","volume":"41","author":"Wang","year":"2014","journal-title":"Molecular biology reports"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0039","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2640746","article-title":"Pharmacological Inhibition of Gal-3 in Mesenchymal Stem Cells Enhances Their Capacity to Promote Alternative Activation of Macrophages in Dextran Sulphate Sodium-Induced Colitis","volume":"2016","author":"Simovic Markovic","year":"2016","journal-title":"Stem cells international"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0040","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/stem.2779","article-title":"Immunomodulation By Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered Through Phagocytosis of MSC By Monocytic Cells","volume":"36","author":"de Witte","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0041","doi-asserted-by":"crossref","first-page":"eaam7828","DOI":"10.1126\/scitranslmed.aam7828","article-title":"Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation","volume":"9","author":"Galleu","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0042","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.3389\/fimmu.2019.02249","article-title":"The Complement System Is Essential for the Phagocytosis of Mesenchymal Stromal Cells by Monocytes","volume":"10","author":"Gavin","year":"2019","journal-title":"Frontiers in immunology"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0043","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1084\/jem.20051921","article-title":"Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma","volume":"203","author":"Khakoo","year":"2006","journal-title":"The Journal of experimental medicine"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0044","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nm.1905","article-title":"Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production","volume":"15","author":"Nemeth","year":"2009","journal-title":"Nature medicine"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0045","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/4015039","article-title":"The Immunomodulatory Effects of Mesenchymal Stem Cell Polarization within the Tumor Microenvironment Niche","volume":"2017","author":"Rivera-Cruz","year":"2017","journal-title":"Stem cells international"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0046","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.omtm.2020.01.005","article-title":"Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery","volume":"16","author":"Almeida-Porada","year":"2020","journal-title":"Molecular therapy Methods & clinical development"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0047","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/stem.2801","article-title":"Intratumoral Delivery of Interferongamma-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo","volume":"36","author":"Relation","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0048","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fgene.2013.00261","article-title":"The role of mesenchymal stem cells in cancer development","volume":"4","author":"Yagi","year":"2013","journal-title":"Frontiers in genetics"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0049","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/xen.12000","article-title":"Do mesenchymal stem cells function across species barriers? Relevance for xenotransplantation","volume":"19","author":"Li","year":"2012","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0050","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nature reviews Immunology"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0051","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.4049\/jimmunol.1102997","article-title":"Innate NK cells and macrophages recognize and reject allogeneic nonself in vivo via different mechanisms","volume":"188","author":"Liu","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0052","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1182\/blood-2005-07-2775","article-title":"Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation","volume":"107","author":"Spaggiari","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0053","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13287-015-0271-2","article-title":"Biodistribution, migration and homing of systemically applied mesenchymal stem\/stromal cells","volume":"7","author":"Leibacher","year":"2016","journal-title":"Stem cell research & therapy"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0054","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.3727\/096368910X564076","article-title":"Human mesenchymal stem cells are susceptible to lysis by CD8(+) T cells and NK cells","volume":"20","author":"Crop","year":"2011","journal-title":"Cell transplantation"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0055","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1182\/blood-2005-11-011650","article-title":"Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting","volume":"108","author":"Nauta","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jcyt.2020.04.102_bib0056","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1182\/blood-2005-03-1004","article-title":"Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice","volume":"106","author":"Eliopoulos","year":"2005","journal-title":"Blood"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324920307490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324920307490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T01:42:27Z","timestamp":1761442947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324920307490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["S1465324920307490"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2020.04.102","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Splenic macrophage phagocytosis of intravenously infused mesenchymal stromal cells attenuates tumor localization","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2020.04.102","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc. on behalf of International Society for Cell & Gene Therapy.","name":"copyright","label":"Copyright"}]}}