{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:44:00Z","timestamp":1790516640530,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jcyt.2020.12.003","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T12:48:14Z","timestamp":1610714894000},"page":"242-255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["1,25-dihydroxyvitamin D3 induces stable and reproducible therapeutic tolerogenic dendritic cells with specific epigenetic modifications"],"prefix":"10.1016","volume":"23","author":[{"given":"Kayleigh M.","family":"van Megen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette M.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Laban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap-Jan","family":"Zwaginga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Natarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Nikolic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart O.","family":"Roep","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcyt.2020.12.003_bib0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-immunol-100311-102839","article-title":"Decisions about dendritic cells: past, present, and future","volume":"30","author":"Steinman","year":"2012","journal-title":"Annual review of immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0002","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/annrheumdis-2015-208456","article-title":"Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis","volume":"76","author":"Bell","year":"2017","journal-title":"Annals of the rheumatic diseases"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0003","doi-asserted-by":"crossref","first-page":"290ra287","DOI":"10.1126\/scitranslmed.aaa9301","article-title":"Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients","volume":"7","author":"Benham","year":"2015","journal-title":"Science translational medicine"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0004","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.2337\/dc11-0472","article-title":"Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients","volume":"34","author":"Giannoukakis","year":"2011","journal-title":"Diabetes care"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0005","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/ecco-jcc\/jjv144","article-title":"Intraperitoneal administration of autologous tolerogenic dendritic cells for refractory Crohn's disease: a phase I study","volume":"9","author":"Jauregui-Amezaga","year":"2015","journal-title":"Journal of Crohn's and Colitis"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0006","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S2213-8587(18)30109-8","article-title":"Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine","volume":"7","author":"Roep","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0007","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-030309","article-title":"Tolerogenic dendritic cell-based treatment for multiple sclerosis (MS): a harmonised study protocol for two phase I clinical trials comparing intradermal and intranodal cell administration","volume":"9","author":"Willekens","year":"2019","journal-title":"BMJ open"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0008","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12974-016-0584-9","article-title":"Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients","volume":"13","author":"Mansilla","year":"2016","journal-title":"Journal of neuroinflammation"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0009","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","article-title":"Type 1 diabetes","volume":"383","author":"Atkinson","year":"2014","journal-title":"The Lancet"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0010","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1002\/eji.200839103","article-title":"Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1","volume":"39","author":"Unger","year":"2009","journal-title":"European journal of immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0011","first-page":"97","article-title":"Inducing tissue specific tolerance in autoimmune disease with tolerogenic dendritic cells","volume":"33","author":"Suwandi","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0012","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.tig.2008.12.005","article-title":"Genetics and epigenetics: stability and plasticity during cellular differentiation","volume":"25","author":"Mohn","year":"2009","journal-title":"Trends in Genetics"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0013","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11892-017-0916-x","article-title":"The role of epigenetics in type 1 diabetes","volume":"17","author":"Jerram","year":"2017","journal-title":"Current diabetes reports"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0014","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41581-019-0135-6","article-title":"Epigenetics and epigenomics in diabetic kidney disease and metabolic memory","volume":"15","author":"Kato","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0015","doi-asserted-by":"crossref","first-page":"18347","DOI":"10.1074\/jbc.R110.205286","article-title":"DNA methylation and demethylation in mammals","volume":"286","author":"Chen","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0016","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.mce.2017.04.018","article-title":"Vitamin D endocrinology on the cross-road between immunity and metabolism","volume":"453","author":"Vanherwegen","year":"2017","journal-title":"Molecular and cellular endocrinology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0017","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/gene.2017.18","article-title":"Differential transcriptome of tolerogenic versus inflammatory dendritic cells points to modulated T1D genetic risk and enriched immune regulation","volume":"18","author":"Nikolic","year":"2017","journal-title":"Genes and immunity"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0018","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.gde.2018.01.006","article-title":"Genetics of type 1 diabetes","volume":"50","author":"Robertson","year":"2018","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0019","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.celrep.2015.01.013","article-title":"Vitamin D3 induces tolerance in human dendritic cells by activation of intracellular metabolic pathways","volume":"10","author":"Ferreira","year":"2015","journal-title":"Cell reports"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0020","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.2337\/diabetes.51.7.2119","article-title":"Redirection of human autoreactive T-cells upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D3","volume":"51","author":"van Halteren","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0021","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.4049\/jimmunol.1000560","article-title":"Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells","volume":"185","author":"Kleijwegt","year":"2010","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0022","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1182\/blood-2002-10-3229","article-title":"Induction of CD4+\/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells","volume":"101","author":"Mahnke","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0023","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3389\/fimmu.2015.00528","article-title":"Gene Expression Profiling of Human Monocyte-derived Dendritic Cells\u2014Searching for Molecular Regulators of Tolerogenicity","volume":"6","author":"Schinnerling","year":"2015","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0024","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.192.9.1213","article-title":"Induction of interleukin 10\u2013producing, nonproliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells","volume":"192","author":"Jonuleit","year":"2000","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0025","doi-asserted-by":"crossref","first-page":"F5","DOI":"10.1084\/jem.193.2.F5","article-title":"Differentiation of T regulatory cells by immature dendritic cells","volume":"193","author":"Roncarolo","year":"2001","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0026","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1182\/blood-2002-10-3229","article-title":"Induction of CD4+\/CD25+regulatory T cells by targeting of antigens to immature dendritic cells","volume":"101","author":"Mahnke","year":"2003","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.jcyt.2020.12.003_bib0027","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S2213-8587(20)30104-2","article-title":"Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide\u2014for type 1 diabetes","volume":"8","author":"Nikolic","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0028","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1021\/pr200724e","article-title":"Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells","volume":"11","author":"Ferreira","year":"2012","journal-title":"Journal of proteome research"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0029","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0030","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0031","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0032","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome biology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0033","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"EdgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0034","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nature Protocols"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0036","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1\u03b1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nature genetics"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0037","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0038","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0092-8674(00)80693-5","article-title":"Identification of DC-SIGN, a novel dendritic cell\u2013specific ICAM-3 receptor that supports primary immune responses","volume":"100","author":"Geijtenbeek","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0039","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/79815","article-title":"DC-SIGN\u2013ICAM-2 interaction mediates dendritic cell trafficking","volume":"1","author":"Geijtenbeek","year":"2000","journal-title":"Nature immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0040","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.tig.2008.12.005","article-title":"Genetics and epigenetics: stability and plasticity during cellular differentiation","volume":"25","author":"Mohn","year":"2009","journal-title":"Trends Genet"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0041","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrg.2017.80","article-title":"The DNA methyltransferase family: a versatile toolkit for epigenetic regulation","volume":"19","author":"Lyko","year":"2017","journal-title":"Nature Reviews Genetics"},{"issue":"16","key":"10.1016\/j.jcyt.2020.12.003_bib0042","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.3389\/fimmu.2019.01112","article-title":"Multiplicity of Mesenchymal Stromal Cells: Finding the Right Route to Therapy","volume":"10","author":"Wilson","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0043","doi-asserted-by":"crossref","first-page":"e2300","DOI":"10.7717\/peerj.2300","article-title":"Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies","volume":"4","author":"Lord","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0044","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3389\/fimmu.2019.00079","article-title":"Cell based therapy for type 1 diabetes: should we take hyperglycemia into account?","volume":"10","author":"Palov\u00e1 Jel\u00ednkov\u00e1","year":"2019","journal-title":"Frontiers in immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0045","doi-asserted-by":"crossref","first-page":"729","DOI":"10.4049\/jimmunol.1600676","article-title":"Tolerogenic Dendritic Cells from Poorly Compensated Type 1 Diabetes Patients Have Decreased Ability To Induce Stable Antigen-Specific T Cell Hyporesponsiveness and Generation of Suppressive Regulatory T Cells","volume":"198","author":"D\u00e1\u0148ov\u00e1","year":"2017","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0046","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.4049\/jimmunol.180.5.3166","article-title":"Abnormal NF-\u03baB function characterizes human type 1 diabetes dendritic cells and monocytes","volume":"180","author":"Mollah","year":"2008","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0047","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0140-6736(95)90586-3","article-title":"Defective maturation and function of antigen-presenting cells in type 1 diabetes","volume":"345","author":"Jansen","year":"1995","journal-title":"The Lancet"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0048","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2337\/db08-0964","article-title":"Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture","volume":"58","author":"Allen","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0049","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2337\/db11-1549","article-title":"Peripheral blood monocyte gene expression profile clinically stratifies patients with recent-onset type 1 diabetes","volume":"61","author":"Irvine","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/cei.13332","article-title":"A study of 51 subtypes of peripheral blood immune cells in newly diagnosed young type 1 diabetes patients","volume":"198","author":"Oras","year":"2019","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1016\/j.jcyt.2020.12.003_bib0051","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/cei.13332","article-title":"A study of 51 subtypes of peripheral blood immune cells in newly diagnosed young type 1 diabetes patients","volume":"198","author":"Oras","year":"2019","journal-title":"Clinical & Experimental Immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0052","first-page":"E3002","article-title":"Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT\/EDIC type 1 diabetes cohort","volume":"113","author":"Chen","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0053","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1136\/ard.2009.126383","article-title":"Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis","volume":"69","author":"Harry","year":"2010","journal-title":"Annals of the rheumatic diseases"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0054","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/eji.201141835","article-title":"Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients","volume":"42","author":"Ra\u03cach-Regu\u00e9","year":"2012","journal-title":"European Journal of Immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0055","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0140-6736(01)06580-1","article-title":"Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study","volume":"358","author":"Hypp\u00f6nen","year":"2001","journal-title":"The Lancet"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0056","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1055\/s-2005-870578","article-title":"Low levels of 25-hydroxyvitamin D3 and 1, 25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes","volume":"37","author":"Pozzilli","year":"2005","journal-title":"Hormone and Metabolic Research"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0057","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1101\/gr.107920.110","article-title":"A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution","volume":"20","author":"Ramagopalan","year":"2010","journal-title":"Genome research"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0058","doi-asserted-by":"crossref","first-page":"E1678","DOI":"10.1073\/pnas.1615783114","article-title":"Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis\u202c","volume":"114","author":"Zeitelhofer","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0059","doi-asserted-by":"crossref","first-page":"16335","DOI":"10.1074\/jbc.M111.330373","article-title":"Profiles of epigenetic histone post-translational modifications at type 1 diabetes susceptible genes","volume":"287","author":"Miao","year":"2012","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jaut.2015.12.003","article-title":"Hypomethylation within gene promoter regions and type 1 diabetes in discordant monozygotic twins","volume":"68","author":"Elboudwarej","year":"2016","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0061","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.4049\/jimmunol.168.6.2634","article-title":"DC-SIGN (CD209) expression is IL-4 dependent and is negatively regulated by IFN, TGF-\u03b2, and anti-inflammatory agents","volume":"168","author":"Relloso","year":"2002","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0062","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1002\/eji.200838987","article-title":"Semi-mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen-induced arthritis mice","volume":"39","author":"Lim","year":"2009","journal-title":"European journal of immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0063","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3389\/fimmu.2015.00528","article-title":"Gene Expression Profiling of Human Monocyte-derived Dendritic Cells\u2014Searching for Molecular Regulators of Tolerogenicity","volume":"6","author":"Schinnerling","year":"2015","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0064","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1021\/pr200724e","article-title":"Differential protein pathways in 1,25-dihydroxyvitamin D3 and dexamethasone modulated tolerogenic human dendritic cells","volume":"11","author":"Ferreira","year":"2011","journal-title":"Journal of proteome research"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0065","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10787-013-0177-5","article-title":"The multiple faces of CCL13 in immunity and inflammation","volume":"21","author":"Mendez-Enriquez","year":"2013","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0066","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.imlet.2007.11.006","article-title":"Expression of cytokine-associated genes in dendritic cells (DCs): comparison between adult peripheral blood- and umbilical cord blood-derived DCs by cDNA microarray","volume":"116","author":"Koga","year":"2008","journal-title":"Immunology Letters"},{"key":"10.1016\/j.jcyt.2020.12.003_bib0067","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1756-8935-7-21","article-title":"DNA methylation dynamics during ex vivo differentiation and maturation of human dendritic cells","volume":"7","author":"Zhang","year":"2014","journal-title":"Epigenetics & chromatin"},{"issue":"14","key":"10.1016\/j.jcyt.2020.12.003_bib0068","first-page":"6938","article-title":"Gene activation precedes DNA demethylation in response to infection in human dendritic cells","volume":"116","author":"Pacis","year":"2018","journal-title":"bioRxiv"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324920309658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324920309658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T01:42:54Z","timestamp":1761442974000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324920309658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":68,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S1465324920309658"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2020.12.003","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"1,25-dihydroxyvitamin D3 induces stable and reproducible therapeutic tolerogenic dendritic cells with specific epigenetic modifications","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2020.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society for Cell & Gene Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}