{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:33:30Z","timestamp":1790858010106,"version":"4.1.0"},"reference-count":192,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jcyt.2021.06.004","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T01:41:49Z","timestamp":1628386909000},"page":"961-973","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Mesenchymal stromal cells in wound healing applications: role of the secretome, targeted delivery and impact on recessive dystrophic epidermolysis bullosa treatment"],"prefix":"10.1016","volume":"23","author":[{"given":"Julia","family":"Riedl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Popp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Eide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen","family":"Ebens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Tolar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcyt.2021.06.004_bib0001","first-page":"381","article-title":"Osteogenesis in transplants of bone marrow cells","volume":"16","author":"Friedenstein","year":"1966","journal-title":"J Embryol Exp Morphol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0002","first-page":"393","article-title":"The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells","volume":"3","author":"Friedenstein","year":"1970","journal-title":"Cell Tissue Kinet"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0003","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/jor.1100090504","article-title":"Mesenchymal stem cells","volume":"9","author":"Caplan","year":"1991","journal-title":"J Orthop Res"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0004","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0005","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1002\/stem.3356","article-title":"ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for recessive dystrophic epidermolysis bullosa treatment","volume":"39","author":"Riedl","year":"2021","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0006","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0007","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.jcyt.2019.08.002","article-title":"Mesenchymal stem versus stromal cells: International Society for Cell & Gene Therapy (ISCT(R)) Mesenchymal Stromal Cell committee position statement on nomenclature","volume":"21","author":"Viswanathan","year":"2019","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0008","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jocit.2014.12.001","article-title":"Mesenchymal stem cells: immunomodulatory capability and clinical potential in immune diseases","volume":"2","author":"Zhao","year":"2016","journal-title":"J Cell Immunother"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0009","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbmt.2014.09.030","article-title":"Immunomodulation effects of mesenchymal stromal cells on acute graft-versus-host disease after hematopoietic stem cell transplantation","volume":"21","author":"Zhao","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.yexcr.2005.04.029","article-title":"Functional studies of mesenchymal stem cells derived from adult human adipose tissue","volume":"308","author":"Dicker","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0011","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/j.0022-202X.2005.23734.x","article-title":"Cultured cells from the adult human hair follicle dermis can be directed toward adipogenic and osteogenic differentiation","volume":"124","author":"Richardson","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0012","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nprot.2008.221","article-title":"A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow","volume":"4","author":"Soleimani","year":"2009","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0013","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/stem.3016","article-title":"Concise Review: Mesenchymal Stem Cells: From Roots to Boost","volume":"37","author":"Andrzejewska","year":"2019","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0014","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3390\/cells8080886","article-title":"Mesenchymal Stem Cells for Regenerative Medicine","volume":"8","author":"Han","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0015","doi-asserted-by":"crossref","first-page":"e949","DOI":"10.1002\/term.2417","article-title":"Unbiased and quantitative proteomics reveals highly increased angiogenesis induction by the secretome of mesenchymal stromal cells isolated from fetal rather than adult skin","volume":"12","author":"Gaetani","year":"2018","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0016","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1001\/archderm.139.4.510","article-title":"Treatment of chronic wounds with bone marrow-derived cells","volume":"139","author":"Badiavas","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0017","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1089\/ten.2006.0278","article-title":"Autologous bone marrow-derived cultured mesenchymal stem cells delivered in a fibrin spray accelerate healing in murine and human cutaneous wounds","volume":"13","author":"Falanga","year":"2007","journal-title":"Tissue Eng"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0018","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/01.prs.0000299922.96006.24","article-title":"Wound therapy by marrow mesenchymal cell transplantation","volume":"121","author":"Yoshikawa","year":"2008","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0019","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6901983","article-title":"Mesenchymal Stromal Cells and Cutaneous Wound Healing: A Comprehensive Review of the Background, Role, and Therapeutic Potential","volume":"2018","author":"Hu","year":"2018","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0020","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1089\/scd.2009.0192","article-title":"Isolation and characterization of mesenchymal stem cells from the sub-amniotic human umbilical cord lining membrane","volume":"19","author":"Kita","year":"2010","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0021","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0047-6374(01)00224-X","article-title":"Stem cells and aging: expanding the possibilities","volume":"122","author":"Rao","year":"2001","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0022","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.biocel.2003.11.001","article-title":"Mesenchymal stem cells: clinical applications and biological characterization","volume":"36","author":"Barry","year":"2004","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0023","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/stem.677","article-title":"Debrided skin as a source of autologous stem cells for wound repair","volume":"29","author":"Natesan","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0024","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/107836","article-title":"Amniotic fluid and amniotic membrane stem cells: marker discovery","volume":"2012","author":"Roubelakis","year":"2012","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0025","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bbrc.2013.07.088","article-title":"Placenta mesenchymal stem cell accelerates wound healing by enhancing angiogenesis in diabetic Goto-Kakizaki (GK) rats","volume":"438","author":"Kong","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0026","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/scrt417","article-title":"Human Wharton's jelly mesenchymal stem cells promote skin wound healing through paracrine signaling","volume":"5","author":"Arno","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0027","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00383-013-3454-x","article-title":"Tissue engineering of skin: human tonsil-derived mesenchymal cells can function as dermal fibroblasts","volume":"30","author":"Bottcher-Haberzeth","year":"2014","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0028","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3727\/096368910X520065","article-title":"Locally administered adipose-derived stem cells accelerate wound healing through differentiation and vasculogenesis","volume":"20","author":"Nie","year":"2011","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0029","doi-asserted-by":"crossref","first-page":"136","DOI":"10.5021\/ad.2012.24.2.136","article-title":"Paracrine effects of adipose-derived stem cells on keratinocytes and dermal fibroblasts","volume":"24","author":"Lee","year":"2012","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0030","first-page":"1","article-title":"Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model","volume":"2017","author":"Kato","year":"2017","journal-title":"J Vis Exp"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0031","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/107632701300062859","article-title":"Multilineage cells from human adipose tissue: implications for cell-based therapies","volume":"7","author":"Zuk","year":"2001","journal-title":"Tissue Eng"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0032","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1097\/PRS.0b013e3181babbb6","article-title":"Improvement of the survival of human autologous fat transplantation by using VEGF-transfected adipose-derived stem cells","volume":"124","author":"Lu","year":"2009","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0033","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.jcyt.2015.04.001","article-title":"In vitro characterization of human hair follicle dermal sheath mesenchymal stromal cells and their potential in enhancing diabetic wound healing","volume":"17","author":"Ma","year":"2015","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0034","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1089\/scd.2011.0674","article-title":"Comparative analysis of paracrine factor expression in human adult mesenchymal stem cells derived from bone marrow, adipose, and dermal tissue","volume":"21","author":"Hsiao","year":"2012","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0035","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3892\/ijmm.2012.1199","article-title":"Direct comparison of the potency of human mesenchymal stem cells derived from amnion tissue, bone marrow and adipose tissue at inducing dermal fibroblast responses to cutaneous wounds","volume":"31","author":"Liu","year":"2013","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0036","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/wrr.12380","article-title":"Different wound healing properties of dermis, adipose, and gingiva mesenchymal stromal cells","volume":"24","author":"Boink","year":"2016","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0037","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jaad.2016.02.1161","article-title":"Hair follicle-containing punch grafts accelerate chronic ulcer healing: a randomized controlled trial","volume":"75","author":"Martinez","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0038","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1478-811X-9-12","article-title":"Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC","volume":"9","author":"Hass","year":"2011","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0039","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3892\/ijmm.2015.2413","article-title":"Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue","volume":"37","author":"Heo","year":"2016","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13287-015-0066-5","article-title":"Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy","volume":"6","author":"Li","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0041","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1634\/stemcells.2005-0342","article-title":"Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue","volume":"24","author":"Kern","year":"2006","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0042","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3727\/096368910X","article-title":"Mesenchymal stem cells","volume":"20","author":"Ding","year":"2011","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0043","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-019-0083-6","article-title":"Mesenchymal stem cell perspective: cell biology to clinical progress","volume":"4","author":"Pittenger","year":"2019","journal-title":"NPJ Regen Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0044","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.stem.2013.09.006","article-title":"Mesenchymal stromal cells: sensors and switchers of inflammation","volume":"13","author":"Bernardo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0045","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/156652412800619950","article-title":"Immunosuppressive properties of mesenchymal stem cells: advances and applications","volume":"12","author":"De Miguel","year":"2012","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0046","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1007\/s00018-020-03454-6","article-title":"Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy","volume":"77","author":"Fan","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0047","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.3390\/cells9051145","article-title":"Identifying the Therapeutic Significance of Mesenchymal Stem Cells","volume":"9","author":"Mishra","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0048","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ymthe.2017.09.023","article-title":"Stem Cell Secretome and Its Effect on Cellular Mechanisms Relevant to Wound Healing","volume":"26","author":"Park","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0049","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jdermsci.2016.11.005","article-title":"Mesenchymal stem cells: the roles and functions in cutaneous wound healing and tumor growth","volume":"86","author":"Motegi","year":"2017","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0050","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/wound.2012.0383","article-title":"Neutrophils and Wound Repair: Positive Actions and Negative Reactions","volume":"2","author":"Wilgus","year":"2013","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0051","doi-asserted-by":"crossref","first-page":"142","DOI":"10.5966\/sctm.2011-0018","article-title":"Concise review: role of mesenchymal stem cells in wound repair","volume":"1","author":"Maxson","year":"2012","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0052","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1634\/stemcells.2007-0226","article-title":"Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis","volume":"25","author":"Wu","year":"2007","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0053","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/cdd.2013.158","article-title":"Immunobiology of mesenchymal stem cells","volume":"21","author":"Ma","year":"2014","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0054","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/stem.3022","article-title":"Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist","volume":"37","author":"Vander Beken","year":"2019","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0055","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jdermsci.2016.03.003","article-title":"Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling","volume":"83","author":"Fang","year":"2016","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0056","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1016\/j.biochi.2013.05.010","article-title":"Mesenchymal stem cell secretome and regenerative therapy after cancer","volume":"95","author":"Zimmerlin","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0057","doi-asserted-by":"crossref","first-page":"e91574","DOI":"10.1371\/journal.pone.0091574","article-title":"Pro-inflammatory chemokine CCL2 (MCP-1) promotes healing in diabetic wounds by restoring the macrophage response","volume":"9","author":"Wood","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0058","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.3389\/fimmu.2018.02837","article-title":"Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning","volume":"9","author":"Ferreira","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0059","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.4049\/jimmunol.180.4.2581","article-title":"Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type","volume":"180","author":"Sasaki","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0060","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1172\/JCI43027","article-title":"Pivotal role of the CCL5\/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing","volume":"122","author":"Ishida","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0061","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1365-2133.2009.09528.x","article-title":"Granulocyte-macrophage colony-stimulating factor enhances wound healing in diabetes via upregulation of proinflammatory cytokines","volume":"162","author":"Fang","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0062","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fmolb.2020.00119","article-title":"Differential Wound Healing Capacity of Mesenchymal Stem Cell-Derived Exosomes Originated From Bone Marrow, Adipose Tissue and Umbilical Cord Under Serum- and Xeno-Free Condition","volume":"7","author":"Hoang","year":"2020","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0063","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3892\/etm.2011.402","article-title":"Influence of interleukin-8 (IL-8) and IL-8 receptors on the migration of human keratinocytes, the role of PLC-gamma and potential clinical implications","volume":"3","author":"Jiang","year":"2012","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0064","doi-asserted-by":"crossref","first-page":"e1886","DOI":"10.1371\/journal.pone.0001886","article-title":"Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing","volume":"3","author":"Chen","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0065","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.surg.2015.06.034","article-title":"Angiopoietin-1 improves endothelial progenitor cell-dependent neovascularization in diabetic wounds","volume":"158","author":"Balaji","year":"2015","journal-title":"Surgery"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0066","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1073\/pnas.0506352103","article-title":"COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model","volume":"103","author":"Cho","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0067","doi-asserted-by":"crossref","first-page":"6609","DOI":"10.1073\/pnas.1016753108","article-title":"PDGFRalpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia","volume":"108","author":"Tamai","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0068","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1083\/jcb.92.2.584","article-title":"Platelet-derived growth factor in chemotactic for fibroblasts","volume":"92","author":"Seppa","year":"1982","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0069","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/470418","article-title":"HGF accelerates wound healing by promoting the dedifferentiation of epidermal cells through beta1-integrin\/ILK pathway","volume":"2013","author":"Li","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0070","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3892\/mmr.2015.3409","article-title":"Conditioned medium from umbilical cord mesenchymal stem cells induces migration and angiogenesis","volume":"12","author":"Shen","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0071","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1089\/wound.2014.0581","article-title":"Metalloproteinases and Wound Healing","volume":"4","author":"Caley","year":"2015","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0072","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120225","article-title":"Combination of adrenomedullin with its binding protein accelerates cutaneous wound healing","volume":"10","author":"Idrovo","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0073","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/stem.2575","article-title":"Concise Review: MSC-Derived Exosomes for Cell-Free Therapy","volume":"35","author":"Phinney","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0074","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jcyt.2017.11.002","article-title":"MSC-exosome: a novel cell-free therapy for cutaneous regeneration","volume":"20","author":"Wu","year":"2018","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0075","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13287-018-0791-7","article-title":"Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine","volume":"9","author":"Keshtkar","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0076","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3390\/cells9040991","article-title":"Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications","volume":"9","author":"Tsiapalis","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0077","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fcell.2020.00149","article-title":"Mesenchymal Stem Cell-Derived Extracellular Vesicles: Challenges in Clinical Applications","volume":"8","author":"Gowen","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0078","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s41038-019-0178-8","article-title":"Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic tool for wound healing and cutaneous regeneration","volume":"7","author":"Hu","year":"2019","journal-title":"Burns Trauma"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0079","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1089\/scd.2016.0349","article-title":"Effect of the Microenvironment on Mesenchymal Stem Cell Paracrine Signaling: Opportunities to Engineer the Therapeutic Effect","volume":"26","author":"Kusuma","year":"2017","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0080","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/term.2966","article-title":"Understanding the multifaceted mechanisms of diabetic wound healing and therapeutic application of stem cells conditioned medium in the healing process","volume":"13","author":"Fui","year":"2019","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0081","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1574888X11666160714115926","article-title":"Role of Mesenchymal Stem Cells in Dermal Repair in Burns and Diabetic Wounds","volume":"12","author":"Maranda","year":"2017","journal-title":"Curr Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0082","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0140-6736(04)16104-7","article-title":"Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells","volume":"363","author":"Le Blanc","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0083","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1016\/j.transproceed.2007.08.103","article-title":"Favorable response to human adipose tissue-derived mesenchymal stem cells in steroid-refractory acute graft-versus-host disease","volume":"39","author":"Fang","year":"2007","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0084","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/bjh.12545","article-title":"Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid-refractory, grade III-IV acute graft-versus-host disease","volume":"163","author":"Ball","year":"2013","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0085","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bbmt.2013.11.033","article-title":"Treatment of graft versus host disease with mesenchymal stromal cells: a phase I study on 40 adult and pediatric patients","volume":"20","author":"Introna","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0086","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bbmt.2013.11.001","article-title":"Allogeneic human mesenchymal stem cell therapy (remestemcel-L, Prochymal) as a rescue agent for severe refractory acute graft-versus-host disease in pediatric patients","volume":"20","author":"Kurtzberg","year":"2014","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0087","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/jdv.13934","article-title":"Mesenchymal stromal cells: properties and role in management of cutaneous diseases","volume":"31","author":"Kim","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0088","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3390\/ijms18020244","article-title":"Mesenchymal Stem Cell Therapy for Inflammatory Skin Diseases: Clinical Potential and Mode of Action","volume":"18","author":"Shin","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0089","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2174\/1574888X13666180913123424","article-title":"The Clinical Trials of Mesenchymal Stem Cell Therapy in Skin Diseases: An Update and Concise Review","volume":"14","author":"Golchin","year":"2019","journal-title":"Curr Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0090","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3389\/fcell.2020.00326","article-title":"Mesenchymal Stem Cells and Atopic Dermatitis: A Review","volume":"8","author":"Daltro","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0091","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/ced.14269","article-title":"Mesenchymal stem cells for the treatment of psoriasis: a comprehensive review","volume":"45","author":"Paganelli","year":"2020","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0092","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/exd.12141","article-title":"Mesenchymal stem cell therapy in skin: why and what for?","volume":"22","author":"Khosrotehrani","year":"2013","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0093","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40257-013-0059-z","article-title":"Treatment of hereditary epidermolysis bullosa: updates and future prospects","volume":"15","author":"Hsu","year":"2014","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0094","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1080\/14712598.2020.1740678","article-title":"Leading edge: emerging drug, cell, and gene therapies for junctional epidermolysis bullosa","volume":"20","author":"Keith","year":"2020","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0095","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.cnur.2017.04.008","article-title":"Impairments in Skin Integrity","volume":"52","author":"Murphree","year":"2017","journal-title":"Nurs Clin North Am"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0096","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biologicals.2020.08.003","article-title":"Modulated mesenchymal stromal cells improve skin wound healing","volume":"67","author":"Liubaviciute","year":"2020","journal-title":"Biologicals"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0097","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13287-016-0303-6","article-title":"Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy","volume":"7","author":"Lee","year":"2016","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0098","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.yexcr.2010.02.026","article-title":"Mesenchymal stem cell-conditioned medium accelerates skin wound healing: an in vitro study of fibroblast and keratinocyte scratch assays","volume":"316","author":"Walter","year":"2010","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0099","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.yexcr.2009.08.001","article-title":"Mesenchymal stem cells induce dermal fibroblast responses to injury","volume":"316","author":"Smith","year":"2010","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0100","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1524-475X.2010.00636.x","article-title":"Mesenchymal stem cells' interaction with skin: wound-healing effect on fibroblast cells and skin tissue","volume":"18","author":"Jeon","year":"2010","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0101","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/exd.13668","article-title":"Inherited epidermolysis bullosa: New diagnostics and new clinical phenotypes","volume":"28","author":"Has","year":"2019","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0102","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.ajpath.2017.03.003","article-title":"Pathomechanisms of Altered Wound Healing in Recessive Dystrophic Epidermolysis Bullosa","volume":"187","author":"Cianfarani","year":"2017","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0103","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1172\/JCI68127","article-title":"Collagen VII plays a dual role in wound healing","volume":"123","author":"Nystrom","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0104","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jmg.2006.045302","article-title":"Epidermolysis bullosa. II. Type VII collagen mutations and phenotype-genotype correlations in the dystrophic subtypes","volume":"44","author":"Varki","year":"2007","journal-title":"J Med Genet"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0105","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.matbio.2018.01.016","article-title":"Injury- and inflammation-driven skin fibrosis: The paradigm of epidermolysis bullosa","volume":"68-69","author":"Nystrom","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0106","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/bjd.17858","article-title":"Bone marrow transplant with post-transplant cyclophosphamide for recessive dystrophic epidermolysis bullosa expands the related donor pool and permits tolerance of nonhaematopoietic cellular grafts","volume":"181","author":"Ebens","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0107","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1182\/blood-2008-06-161299","article-title":"Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells","volume":"113","author":"Tolar","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0108","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0140-6736(13)61897-8","article-title":"Allogeneic blood and bone marrow cells for the treatment of severe epidermolysis bullosa: repair of the extracellular matrix","volume":"382","author":"Tolar","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0109","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1056\/NEJMoa0910501","article-title":"Bone marrow transplantation for recessive dystrophic epidermolysis bullosa","volume":"363","author":"Wagner","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0110","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/mt.2015.47","article-title":"From marrow to matrix: novel gene and cell therapies for epidermolysis bullosa","volume":"23","author":"Webber","year":"2015","journal-title":"Mol Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0111","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.jcyt.2015.03.006","article-title":"Placenta-based therapies for the treatment of epidermolysis bullosa","volume":"17","author":"Nevala-Plagemann","year":"2015","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0112","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.biochi.2018.04.007","article-title":"Dual mechanism of type VII collagen transfer by bone marrow mesenchymal stem cell extracellular vesicles to recessive dystrophic epidermolysis bullosa fibroblasts","volume":"155","author":"McBride","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0113","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jdermsci.2018.06.004","article-title":"The development of induced pluripotent stem cell-derived mesenchymal stem\/stromal cells from normal human and RDEB epidermal keratinocytes","volume":"91","author":"Nakayama","year":"2018","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0114","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jid.2019.05.031","article-title":"Human Mesenchymal Stromal Cells Engineered to Express Collagen VII Can Restore Anchoring Fibrils in Recessive Dystrophic Epidermolysis Bullosa Skin Graft Chimeras","volume":"140","author":"Petrova","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0115","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3109\/14653249.2010.518609","article-title":"Gene expression signatures of mouse bone marrow-derived mesenchymal stem cells in the cutaneous environment and therapeutic implications for blistering skin disorder","volume":"13","author":"Alexeev","year":"2011","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0116","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/scrt511","article-title":"Preconditioning of mesenchymal stem cells for improved transplantation efficacy in recessive dystrophic epidermolysis bullosa","volume":"5","author":"Perdoni","year":"2014","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0117","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.4049\/jimmunol.1400914","article-title":"Transplanted bone marrow-derived circulating PDGFRalpha+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft","volume":"194","author":"Iinuma","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0118","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.celrep.2015.08.010","article-title":"ABCB5 Identifies Immunoregulatory Dermal Cells","volume":"12","author":"Schatton","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0119","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/labinvest.2017.85","article-title":"Rapid generation of Col7a1(\u2013\/\u2013) mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells","volume":"97","author":"Webber","year":"2017","journal-title":"Lab Invest"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0120","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jcyt.2020.08.012","article-title":"Ex vivo-expanded highly pure ABCB5(+) mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data","volume":"23","author":"Kerstan","year":"2021","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0121","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jaad.2019.11.038","article-title":"Phase I\/II open-label trial of intravenous allogeneic mesenchymal stromal cell therapy in adults with recessive dystrophic epidermolysis bullosa","volume":"83","author":"Rashidghamat","year":"2020","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0122","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/dth.12305","article-title":"Treatment of dystrophic epidermolysis bullosa with bone marrow non-hematopoeitic stem cells: a randomized controlled trial","volume":"29","author":"El-Darouti","year":"2016","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0123","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1038\/jid.2015.158","article-title":"Potential of Systemic Allogeneic Mesenchymal Stromal Cell Therapy for Children with Recessive Dystrophic Epidermolysis Bullosa","volume":"135","author":"Petrof","year":"2015","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0124","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3109\/14653241003587637","article-title":"Replenishment of type VII collagen and re-epithelialization of chronically ulcerated skin after intradermal administration of allogeneic mesenchymal stromal cells in two patients with recessive dystrophic epidermolysis bullosa","volume":"12","author":"Conget","year":"2010","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0125","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.burns.2011.06.005","article-title":"Epidemiology of burns throughout the world. Part I: Distribution and risk factors","volume":"37","author":"Peck","year":"2011","journal-title":"Burns"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0126","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.burns.2020.04.012","article-title":"Mesenchymal stem cell therapy of acute thermal burns: a systematic review of the effect on inflammation and wound healing","volume":"47","author":"Rangatchew","year":"2021","journal-title":"Burns"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0127","first-page":"23","article-title":"Role of cord blood and bone marrow mesenchymal stem cells in recent deep burn: a case-control prospective study","volume":"6","author":"Abo-Elkheir","year":"2017","journal-title":"Am J Stem Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0128","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s10517-005-0232-3","article-title":"First experience of the use bone marrow mesenchymal stem cells for the treatment of a patient with deep skin burns","volume":"139","author":"Rasulov","year":"2005","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0129","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s41038-015-0018-4","article-title":"Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns","volume":"3","author":"Mansilla","year":"2015","journal-title":"Burns Trauma"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0130","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3390\/ijms18071419","article-title":"Diabetes and Wound Angiogenesis","volume":"18","author":"Okonkwo","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0131","first-page":"62","article-title":"Mesenchymal Stem Cell Therapies for Skin Repair and Regeneration","volume":"1","author":"Lam","year":"2017","journal-title":"J Dermat Cosmetol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0132","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.ajpath.2020.03.017","article-title":"Mesenchymal Stem Cell\/Multipotent Stromal Cell Augmentation of Wound Healing: Lessons from the Physiology of Matrix and Hypoxia Support","volume":"190","author":"Sylakowski","year":"2020","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0133","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1524-475X.2009.00499.x","article-title":"Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF","volume":"17","author":"Lee","year":"2009","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0134","doi-asserted-by":"crossref","first-page":"e96161","DOI":"10.1371\/journal.pone.0096161","article-title":"Conditioned medium from hypoxic bone marrow-derived mesenchymal stem cells enhances wound healing in mice","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0135","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3390\/ijms15010605","article-title":"Hypoxic conditioned medium from human amniotic fluid-derived mesenchymal stem cells accelerates skin wound healing through TGF-beta\/SMAD2 and PI3K\/Akt pathways","volume":"15","author":"Jun","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0136","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/1534734615569053","article-title":"Mesenchymal stem cell-conditioned medium improves the proliferation and migration of keratinocytes in a diabetes-like microenvironment","volume":"14","author":"Li","year":"2015","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0137","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9328347","article-title":"Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer","volume":"2017","author":"Cao","year":"2017","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0138","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3727\/096368910X514170","article-title":"Cell therapy, a new standard in management of chronic critical limb ischemia and foot ulcer","volume":"19","author":"Prochazka","year":"2010","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0139","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/wound.2015.0627","article-title":"Mesenchymal Stem Cells in Chronic Wounds: The Spectrum from Basic to Advanced Therapy","volume":"5","author":"Otero-Vinas","year":"2016","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0140","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/stem.544","article-title":"Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37","volume":"28","author":"Krasnodembskaya","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0141","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s13287-020-01807-3","article-title":"Antimicrobial activity of mesenchymal stem cells against Staphylococcus aureus","volume":"11","author":"Yagi","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0142","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1099\/jmm.0.000861","article-title":"Human adipose tissue-derived mesenchymal stem\/stromal cells adhere to and inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa","volume":"67","author":"Wood","year":"2018","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0143","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/1753425919883932","article-title":"Human umbilical-cord mesenchymal stem cells inhibit bacterial growth and alleviate antibiotic resistance in neonatal imipenem-resistant Pseudomonas aeruginosa infection","volume":"26","author":"Ren","year":"2020","journal-title":"Innate Immun"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0144","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2172-5-7","article-title":"Up-regulation of the chemokine CCL21 in the skin of subjects exposed to irritants","volume":"5","author":"Eberhard","year":"2004","journal-title":"BMC Immunol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0145","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3171\/2008.9.JNS08158","article-title":"Intravenous mesenchymal stem cell therapy for traumatic brain injury","volume":"110","author":"Harting","year":"2009","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0146","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/scd.2008.0253","article-title":"Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect","volume":"18","author":"Fischer","year":"2009","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0147","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1586\/erd.09.57","article-title":"Recent advances in dermal wound healing: biomedical device approaches","volume":"7","author":"Rizzi","year":"2010","journal-title":"Expert Rev Med Devices"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0148","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1126\/science.7031899","article-title":"Wound tissue can utilize a polymeric template to synthesize a functional extension of skin","volume":"215","author":"Yannas","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0149","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1073\/pnas.86.3.933","article-title":"Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin","volume":"86","author":"Yannas","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120558","article-title":"Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy","volume":"268","author":"Shafiee","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0151","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1016\/j.biomaterials.2009.02.025","article-title":"Differentiation of bone marrow-derived mesenchymal stem cells into multi-layered epidermis-like cells in 3D organotypic coculture","volume":"30","author":"Ma","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0152","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1016\/j.biomaterials.2006.03.022","article-title":"Inducing hepatic differentiation of human mesenchymal stem cells in pellet culture","volume":"27","author":"Ong","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0153","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1021\/mp400573g","article-title":"Engineering anisotropic biomimetic fibrocartilage microenvironment by bioprinting mesenchymal stem cells in nanoliter gel droplets","volume":"11","author":"Gurkan","year":"2014","journal-title":"Mol Pharm"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0154","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-4939-8697-2_7","article-title":"3D Bioprinting and Stem Cells","volume":"1842","author":"Moore","year":"2018","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0155","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3390\/polym12030538","article-title":"Enhanced Biocompatibility of Multi-Layered, 3D Bio-Printed Artificial Vessels Composed of Autologous Mesenchymal Stem Cells","volume":"12","author":"Jang","year":"2020","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0156","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ymeth.2015.03.002","article-title":"Engineering mesenchymal stem cells for regenerative medicine and drug delivery","volume":"84","author":"Park","year":"2015","journal-title":"Methods"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0157","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1089\/hum.2010.165","article-title":"Genetic engineering of mesenchymal stem cells and its application in human disease therapy","volume":"21","author":"Hodgkinson","year":"2010","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0158","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4956063","article-title":"Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and Survival","volume":"2016","author":"Nowakowski","year":"2016","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0159","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.jcyt.2020.03.480","article-title":"Enhancing the therapeutic potential of mesenchymal stem cell-based therapy via CRISPR\/Cas9-based genome editing","volume":"20","author":"Lee","year":"2020","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0160","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/nm1504","article-title":"Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells","volume":"12","author":"Mavilio","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0161","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jid.2016.10.038","article-title":"Closure of a Large Chronic Wound through Transplantation of Gene-Corrected Epidermal Stem Cells","volume":"137","author":"Bauer","year":"2017","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0162","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature24487","article-title":"Regeneration of the entire human epidermis using transgenic stem cells","volume":"551","author":"Hirsch","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0163","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4103\/idoj.IDOJ_287_18","article-title":"Newer Treatment Modalities in Epidermolysis Bullosa","volume":"10","author":"Bruckner-Tuderman","year":"2019","journal-title":"Indian Dermatol Online J"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0164","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.stem.2018.05.004","article-title":"Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities","volume":"22","author":"Galipeau","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.aat2189","article-title":"Challenges for mesenchymal stromal cell therapies","volume":"11","author":"Martin","year":"2019","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0166","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41746-019-0079-z","article-title":"The reproducibility crisis in the age of digital medicine","volume":"2","author":"Stupple","year":"2019","journal-title":"NPJ Digit Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0168","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fimmu.2020.00243","article-title":"Editorial: Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies","volume":"11","author":"Moll","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0169","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12967-014-0260-8","article-title":"A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods","volume":"12","author":"Madrigal","year":"2014","journal-title":"J Transl Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2019.04.002","article-title":"The mesenchymal stem cell secretome: a new paradigm towards cell-free therapeutic mode in regenerative medicine","volume":"46","author":"L","year":"2019","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0171","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature06188","article-title":"Mesenchymal stem cells within tumour stroma promote breast cancer metastasis","volume":"449","author":"Karnoub","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0172","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nri2395","article-title":"Mesenchymal stem cells in health and disease","volume":"8","author":"Uccelli","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0173","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2119\/molmed.2010.00157","article-title":"Mesenchymal stromal cells promote tumor growth through the enhancement of neovascularization","volume":"17","author":"Suzuki","year":"2011","journal-title":"Mol Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0174","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/sctm.16-0204","article-title":"Systemically Infused Mesenchymal Stem Cells Show Different Homing Profiles in Healthy and Tumor Mouse Models","volume":"6","author":"Xie","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0175","doi-asserted-by":"crossref","first-page":"14508","DOI":"10.1038\/s41598-017-15155-5","article-title":"Passage-dependent accumulation of somatic mutations in mesenchymal stromal cells during in vitro culture revealed by whole genome sequencing","volume":"7","author":"Kim","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0176","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192445","article-title":"Clonal chromosomal and genomic instability during human multipotent mesenchymal stromal cells long-term culture","volume":"13","author":"Nikitina","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0177","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1089\/ten.teb.2019.0351","article-title":"Mesenchymal Stem Cells for Chronic Wound Healing: Current Status of Preclinical and Clinical Studies","volume":"26","author":"Huang","year":"2020","journal-title":"Tissue Eng Part B Rev"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0178","doi-asserted-by":"crossref","first-page":"L735","DOI":"10.1152\/ajplung.00347.2009","article-title":"Autocrine production of TGF-beta1 promotes myofibroblastic differentiation of neonatal lung mesenchymal stem cells","volume":"298","author":"Popova","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0179","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/cdd.2012.26","article-title":"Mesenchymal stem cells: a double-edged sword in regulating immune responses","volume":"19","author":"Li","year":"2012","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0180","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1016\/j.transproceed.2017.03.078","article-title":"Thromboembolism Induced by Umbilical Cord Mesenchymal Stem Cell Infusion: A Report of Two Cases and Literature Review","volume":"49","author":"Wu","year":"2017","journal-title":"Transplant Proc"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0181","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/sctm.17-0139","article-title":"Autologous Mesenchymal Stem Cell and Islet Cotransplantation: Safety and Efficacy","volume":"7","author":"Wang","year":"2018","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0182","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1097\/MIB.0000000000000441","article-title":"Human Placenta-derived Cells (PDA-001) for the Treatment of Moderate-to-severe Crohn's Disease: A Phase 1b\/2a Study","volume":"21","author":"Melmed","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0183","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/sctm.20-0213","article-title":"Mesenchymal stromal cells in human immunodeficiency virus-infected patients with discordant immune response: Early results of a phase I\/II clinical trial","volume":"10","author":"Trujillo-Rodriguez","year":"2021","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0184","doi-asserted-by":"crossref","first-page":"e42819","DOI":"10.1371\/journal.pone.0042819","article-title":"Bivalirudin in combination with heparin to control mesenchymal cell procoagulant activity","volume":"7","author":"Stephenne","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0185","doi-asserted-by":"crossref","first-page":"106","DOI":"10.7150\/thno.16911","article-title":"Heparin improves BMSC cell therapy: Anticoagulant treatment by heparin improves the safety and therapeutic effect of bone marrow-derived mesenchymal stem cell cytotherapy","volume":"7","author":"Liao","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0186","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12015-013-9492-x","article-title":"The size of mesenchymal stem cells is a significant cause of vascular obstructions and stroke","volume":"10","author":"Ge","year":"2014","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0187","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13287-020-1572-7","article-title":"Infusion-related thrombogenesis by liver-derived mesenchymal stem cells controlled by anticoagulant drugs in 11 patients with liver-based metabolic disorders","volume":"11","author":"Coppin","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0188","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/jcb.24661","article-title":"Human Wharton's jelly stem cells and its conditioned medium enhance healing of excisional and diabetic wounds","volume":"115","author":"Fong","year":"2014","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0189","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/0963689718807410","article-title":"The Healing Effects of Conditioned Medium Derived from Mesenchymal Stem Cells on Radiation-Induced Skin Wounds in Rats","volume":"28","author":"Sun","year":"2019","journal-title":"Cell Transplant"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0190","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3109\/14653241003649510","article-title":"GMP-manufactured density gradient media for optimized mesenchymal stromal\/stem cell isolation and expansion","volume":"12","author":"Grisendi","year":"2010","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0191","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.exphem.2016.02.004","article-title":"Evaluation of GMP-compliant culture media for in vitro expansion of human bone marrow mesenchymal stromal cells","volume":"44","author":"Wuchter","year":"2016","journal-title":"Exp Hematol"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0192","doi-asserted-by":"crossref","first-page":"e43255","DOI":"10.1371\/journal.pone.0043255","article-title":"GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC","volume":"7","author":"Fekete","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2021.06.004_bib0193","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/cyto.a.23242","article-title":"Isolation, cultivation, and characterization of human mesenchymal stem cells","volume":"93","author":"Mushahary","year":"2018","journal-title":"Cytometry A"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S146532492100712X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S146532492100712X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T01:45:10Z","timestamp":1761443110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S146532492100712X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":192,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S146532492100712X"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2021.06.004","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stromal cells in wound healing applications: role of the secretome, targeted delivery and impact on recessive dystrophic epidermolysis bullosa treatment","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2021.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society for Cell &#38; Gene Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}