{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:57:27Z","timestamp":1784894247008,"version":"3.55.0"},"reference-count":132,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32002259"],"award-info":[{"award-number":["32002259"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["202300410198"],"award-info":[{"award-number":["202300410198"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jcyt.2021.07.013","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T04:57:34Z","timestamp":1632113854000},"page":"1045-1052","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Adenovirus vector-attributed hepatotoxicity blocks clinical application in gene therapy"],"prefix":"10.1016","volume":"23","author":[{"given":"Zeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jcyt.2021.07.013_bib0001","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1128\/AAC.50.4.1419-1424.2006","article-title":"Efficacy of Hospital Germicides against Adenovirus 8, a Common Cause of Epidemic Keratoconjunctivitis in Health Care Facilities","volume":"50","author":"Rutala","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"issue":"9","key":"10.1016\/j.jcyt.2021.07.013_bib0002","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.3390\/v2092134","article-title":"An Update on Canine Adenovirus Type 2 and Its Vectors","volume":"2","author":"Bru","year":"2010","journal-title":"Viruses-Basel"},{"key":"10.1016\/j.jcyt.2021.07.013_bib0003","doi-asserted-by":"crossref","first-page":"e13496","DOI":"10.1111\/tid.13496","article-title":"Detection of adenovirus hepatitis and acute liver failure in allogeneic hematopoietic stem cell transplant patients","volume":"23","author":"Onda","year":"2021","journal-title":"Transpl. Infect. Dis."},{"key":"10.1016\/j.jcyt.2021.07.013_bib0004","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1097\/PAS.0000000000000834","article-title":"Adenovirus Hepatitis: Clinicopathologic Analysis of 12 Consecutive Cases From a Single Institution","volume":"40","author":"Schaberg","year":"2017","journal-title":"Am. J. Surg. Pathol."},{"issue":"4","key":"10.1016\/j.jcyt.2021.07.013_bib0005","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1055\/s-0031-1283287","article-title":"Adenovirus","volume":"32","author":"Lynch","year":"2011","journal-title":"Semin. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0006","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/CMR.00116-13","article-title":"Adenovirus infections in immunocompetent and immunocompromised patients","volume":"27","author":"Lion","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"issue":"5","key":"10.1016\/j.jcyt.2021.07.013_bib0007","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1177\/1066896915587758","article-title":"Concurrent Acute Necrotizing Adenovirus Hepatitis and Enterocolitis in an Adult Patient After Double Cord Blood Stem Cell Transplant for Refractory Crohn's Disease","volume":"23","author":"Edward","year":"2015","journal-title":"Int. J. Surg. Pathol."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0008","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s15010-013-0527-7","article-title":"Fulminant hepatitis due to human adenovirus","volume":"42","author":"Ronan","year":"2013","journal-title":"Infection"},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0009","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/pbc.21120","article-title":"Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia","volume":"50","author":"Steiner","year":"2010","journal-title":"Pediatr. Blood Cancer"},{"issue":"11","key":"10.1016\/j.jcyt.2021.07.013_bib0010","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/sj.bmt.1701788","article-title":"Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy","volume":"23","author":"Chakrabarti","year":"1999","journal-title":"Bone Marrow Transplant"},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0011","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.4110\/in.2021.21.e6","article-title":"Adenovirus Vectors: Excellent Tools for Vaccine Development","volume":"21","author":"Chang","year":"2021","journal-title":"Immune Netw"},{"issue":"7830","key":"10.1016\/j.jcyt.2021.07.013_bib0012","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-020-2607-z","article-title":"Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques","volume":"586","author":"Mercado","year":"2020","journal-title":"Nature"},{"issue":"19","key":"10.1016\/j.jcyt.2021.07.013_bib0013","doi-asserted-by":"crossref","first-page":"8802","DOI":"10.1073\/pnas.91.19.8802","article-title":"An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3","volume":"91","author":"Bett","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.jcyt.2021.07.013_bib0014","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.3390\/v2081681","article-title":"Adenoviral producer cells","volume":"2","author":"Kovesdi","year":"2010","journal-title":"Viruses"},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0015","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1006\/viro.1997.8597","article-title":"Cloning and sequencing of the cellular\u2013viral junctions from the human adenovirus type 5 transformed 293 cell line","volume":"233","author":"Louis","year":"1997","journal-title":"Virology"},{"issue":"10","key":"10.1016\/j.jcyt.2021.07.013_bib0016","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1073\/pnas.91.10.4407","article-title":"Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy","volume":"91","author":"Yang","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.jcyt.2021.07.013_bib0017","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nm0696-714","article-title":"Second-generation adenovirus vectors","volume":"2","author":"Wang","year":"1996","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.jcyt.2021.07.013_bib0018","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1128\/jvi.69.4.2004-2015.1995","article-title":"Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses","volume":"69","author":"Yang","year":"1995","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.jcyt.2021.07.013_bib0019","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1089\/hum.1997.8.10-1195","article-title":"Liver-directed gene transfer in non-human primates","volume":"8","author":"Sullivan","year":"1997","journal-title":"Hum. Gene Ther."},{"issue":"5","key":"10.1016\/j.jcyt.2021.07.013_bib0020","first-page":"726","article-title":"Adenovirus induced acute hepatitis in non-human primates after liver-directed gene therapy","volume":"115","author":"Lu","year":"2002","journal-title":"Chin. Med. J."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0021","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.biotechadv.2008.10.003","article-title":"From the first to the third generation adenoviral vector: what parameters are governing the production yield?","volume":"27","author":"Dormond","year":"2009","journal-title":"Biotechnol. Adv."},{"issue":"8","key":"10.1016\/j.jcyt.2021.07.013_bib0022","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1089\/hum.2013.071","article-title":"Transgene expression up to 7 years in nonhuman primates following hepatic transduction with helper-dependent adenoviral vectors","volume":"24","author":"Brunetti-Pierri","year":"2013","journal-title":"Hum. Gene Ther."},{"issue":"8","key":"10.1016\/j.jcyt.2021.07.013_bib0023","doi-asserted-by":"crossref","first-page":"676","DOI":"10.4161\/cbt.8.8.7913","article-title":"A Phase I study of KH901, a conditionally replicating granulocyte-macrophage colony-stimulating factor: armed oncolytic adenovirus for the treatment of head and neck cancers","volume":"8","author":"Chang","year":"2009","journal-title":"Cancer Biol. Ther."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0024","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/sj.onc.1203251","article-title":"A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo","volume":"19","author":"Fueyo","year":"2000","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.jcyt.2021.07.013_bib0025","first-page":"A88","article-title":"Application of a novel mutant KRAS-regulated promoter in E1B-55kD-deleted oncolytic adenovirus for the therapy of pancreatic cancer","volume":"27","author":"Liu","year":"2016","journal-title":"Hum. Gene Ther."},{"issue":"8","key":"10.1016\/j.jcyt.2021.07.013_bib0026","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/sj.gt.3301669","article-title":"A novel bystander effect involving tumor cell-derived Fas and FasL interactions following Ad.HSV-tk and Ad.mIL-12 gene therapies in experimental prostate cancer","volume":"9","author":"Hall","year":"2002","journal-title":"Gene Ther"},{"issue":"4","key":"10.1016\/j.jcyt.2021.07.013_bib0027","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.3892\/or.2013.2663","article-title":"Co-transduction of ribosomal protein L23 enhances the therapeutic efficacy of adenoviral-mediated p53 gene transfer in human gastric cancer","volume":"30","author":"Zhang","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.jcyt.2021.07.013_bib0028","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3389\/fonc.2017.00195","article-title":"Oncolytic Viruses-Interaction of Virus and Tumor Cells in the Battle to Eliminate Cancer","volume":"7","author":"Howells","year":"2017","journal-title":"Front. Oncol."},{"issue":"1-2","key":"10.1016\/j.jcyt.2021.07.013_bib0029","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ymgme.2003.08.016","article-title":"Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer","volume":"80","author":"Raper","year":"2003","journal-title":"Mol. Genet. Metab."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0030","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/10430340152712692","article-title":"Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons","volume":"13","author":"Morral","year":"2002","journal-title":"Hum. Gene Ther."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0031","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/10430340460732445","article-title":"Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates","volume":"15","author":"Brunetti-Pierri","year":"2004","journal-title":"Hum. Gene Ther."},{"issue":"571","key":"10.1016\/j.jcyt.2021.07.013_bib0032","doi-asserted-by":"crossref","first-page":"eabc6659","DOI":"10.1126\/scitranslmed.abc6659","article-title":"Systemic cancer therapy with engineered adenovirus that evades innate immunity","volume":"12","author":"Atasheva","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0033","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2174\/1568009618666171129221503","article-title":"Oncorine, the World First Oncolytic Virus Medicine and its Update in China","volume":"18","author":"Liang","year":"2018","journal-title":"Curr. Cancer Drug Targets"},{"issue":"5","key":"10.1016\/j.jcyt.2021.07.013_bib0034","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/jnci\/djj111","article-title":"China approves world's first oncolytic virus therapy for cancer treatment","volume":"98","author":"Garber","year":"2006","journal-title":"J. Natl. Cancer Inst."},{"issue":"19","key":"10.1016\/j.jcyt.2021.07.013_bib0035","doi-asserted-by":"crossref","first-page":"11304","DOI":"10.1128\/JVI.00306-14","article-title":"Molecular characterization of a lizard adenovirus reveals the first atadenovirus with two fiber genes and the first adenovirus with either one short or three long fibers per penton","volume":"88","author":"P\u00e9nzes","year":"2014","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0036","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0168-1702(94)90054-X","article-title":"Human adenovirus type 41 contains two fibers","volume":"33","author":"Yeh","year":"1994","journal-title":"Virus Res"},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0037","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/viro.1993.1009","article-title":"Adenovirus type 40 virions contain two distinct fibers","volume":"192","author":"Kidd","year":"1993","journal-title":"Virology"},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0038","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.virol.2012.05.020","article-title":"Human adenovirus type 41 possesses different amount of short and long fibers in the virion","volume":"432","author":"Song","year":"2012","journal-title":"Virology"},{"issue":"10","key":"10.1016\/j.jcyt.2021.07.013_bib0039","doi-asserted-by":"crossref","first-page":"7909","DOI":"10.1128\/JVI.72.10.7909-7915.1998","article-title":"The coxsackievirus-adenovirus receptor protein can function as a cellular attachment protein for adenovirus serotypes from subgroups A, C, D, E, and F","volume":"72","author":"Roelvink","year":"1998","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.jcyt.2021.07.013_bib0040","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1002\/j.1460-2075.1983.tb01592.x","article-title":"Evidence for a repeating cross-beta sheet structure in the adenovirus fibre","volume":"2","author":"Green","year":"1983","journal-title":"The EMBO journal"},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0041","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/0042-6822(91)90547-O","article-title":"The amino terminus of the adenovirus fiber protein encodes the nuclear localization signal","volume":"185","author":"Hong","year":"1991","journal-title":"Virology"},{"issue":"5304","key":"10.1016\/j.jcyt.2021.07.013_bib0042","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1126\/science.275.5304.1320","article-title":"Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5","volume":"275","author":"Bergelson","year":"1997","journal-title":"Science (New York, N.Y.)"},{"issue":"4","key":"10.1016\/j.jcyt.2021.07.013_bib0043","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1128\/JVI.77.4.2512-2521.2003","article-title":"Reduction of natural adenovirus tropism to the liver by both ablation of fiber-coxsackievirus and adenovirus receptor interaction and use of replaceable short fiber","volume":"77","author":"Nakamura","year":"2003","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0044","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1089\/hum.2005.16.248","article-title":"Coxsackie and adenovirus receptor binding ablation reduces adenovirus liver tropism and toxicity","volume":"16","author":"Yun","year":"2005","journal-title":"Hum. Gene Ther"},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0045","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0042-6822(03)00238-1","article-title":"Shortening adenovirus type 5 fiber shaft decreases the efficiency of postbinding steps in CAR-expressing and nonexpressing cells","volume":"312","author":"Ambriovi\u0107-Ristov","year":"2003","journal-title":"Virology"},{"issue":"22","key":"10.1016\/j.jcyt.2021.07.013_bib0046","doi-asserted-by":"crossref","first-page":"10274","DOI":"10.1128\/JVI.74.22.10274-10286.2000","article-title":"Dependence of adenovirus infectivity on length of the fiber shaft domain","volume":"74","author":"Shayakhmetov","year":"2000","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0047","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/sj.gt.3301845","article-title":"Genetic manipulations of adenovirus type 5 fiber resulting in liver tropism attenuation","volume":"10","author":"Vigne","year":"2003","journal-title":"Gene Ther"},{"issue":"8","key":"10.1016\/j.jcyt.2021.07.013_bib0048","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1089\/104303403765255165","article-title":"Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice","volume":"14","author":"Smith","year":"2003","journal-title":"Hum. Gene Ther."},{"issue":"22","key":"10.1016\/j.jcyt.2021.07.013_bib0049","doi-asserted-by":"crossref","first-page":"14429","DOI":"10.1128\/JVI.79.22.14429-14436.2005","article-title":"CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7","volume":"79","author":"Marttila","year":"2005","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0050","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020732118","article-title":"Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46","volume":"118","author":"Persson","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0051","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nm.2270","article-title":"Desmoglein 2 is a receptor for adenovirus serotypes 3, 7, 11 and 14","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0052","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nm.2267","article-title":"The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis","volume":"17","author":"Nilsson","year":"2011","journal-title":"Nat. Med."},{"issue":"18","key":"10.1016\/j.jcyt.2021.07.013_bib0053","doi-asserted-by":"crossref","first-page":"E4264","DOI":"10.1073\/pnas.1716900115","article-title":"Polysialic acid is a cellular receptor for human adenovirus 52","volume":"115","author":"Lenman","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jcyt.2021.07.013_bib0054","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.virusres.2008.10.014","article-title":"Stability of the seven hexon hypervariable region sequences of adenovirus types 1-6 isolated in Yamagata, Japan between 1988 and 2007","volume":"140","author":"Mizuta","year":"2009","journal-title":"Virus Res"},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0055","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/mthe.1999.0001","article-title":"Type-specific epitope locations revealed by X-ray crystallographic study of adenovirus type 5 hexon","volume":"1","author":"Rux","year":"2000","journal-title":"Molecular therapy: the journal of the American Society of Gene Therapy"},{"issue":"17","key":"10.1016\/j.jcyt.2021.07.013_bib0056","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/sj.gt.3301515","article-title":"CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors","volume":"8","author":"Alemany","year":"2001","journal-title":"Gene Ther"},{"issue":"17","key":"10.1016\/j.jcyt.2021.07.013_bib0057","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1089\/104303403322542248","article-title":"Receptor interactions involved in adenoviral-mediated gene delivery after systemic administration in non-human primates","volume":"14","author":"Smith","year":"2003","journal-title":"Hum. Gene Ther."},{"issue":"14","key":"10.1016\/j.jcyt.2021.07.013_bib0058","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1073\/pnas.0711757105","article-title":"Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo","volume":"105","author":"Kalyuzhniy","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.jcyt.2021.07.013_bib0059","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001142","article-title":"Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X","volume":"6","author":"Bradshaw","year":"2010","journal-title":"PLoS Path"},{"issue":"5","key":"10.1016\/j.jcyt.2021.07.013_bib0060","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1182\/blood-2009-03-208835","article-title":"Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer","volume":"114","author":"Alba","year":"2009","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.jcyt.2021.07.013_bib0061","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1182\/blood-2009-12-260026","article-title":"Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors","volume":"116","author":"Alba","year":"2010","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0062","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004673","article-title":"Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo","volume":"11","author":"Ma","year":"2015","journal-title":"PLoS Path"},{"issue":"9","key":"10.1016\/j.jcyt.2021.07.013_bib0063","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1158\/1535-7163.MCT-10-0332","article-title":"Substitution of adenovirus serotype 3 hexon onto a serotype 5 oncolytic adenovirus reduces factor X binding, decreases liver tropism, and improves antitumor efficacy","volume":"9","author":"Short","year":"2010","journal-title":"Mol. Cancer Ther."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0064","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/gt.2011.87","article-title":"Coagulation factor X mediates adenovirus type 5 liver gene transfer in non-human primates (Microcebus murinus)","volume":"19","author":"Alba","year":"2012","journal-title":"Gene Ther"},{"issue":"4","key":"10.1016\/j.jcyt.2021.07.013_bib0065","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nm.3107","article-title":"Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement","volume":"19","author":"Xu","year":"2013","journal-title":"Nat. Med."},{"issue":"17","key":"10.1016\/j.jcyt.2021.07.013_bib0066","doi-asserted-by":"crossref","first-page":"9610","DOI":"10.1128\/JVI.01070-13","article-title":"Coagulation factor binding orientation and dimerization may influence infectivity of adenovirus-coagulation factor complexes","volume":"87","author":"Irons","year":"2013","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.jcyt.2021.07.013_bib0067","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1128\/JVI.02786-06","article-title":"Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D","volume":"81","author":"Parker","year":"2007","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0068","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s00284-020-02297-5","article-title":"The Inflammatory and Fibrotic Patterns of Hepatic Stellate Cells Following Coagulation Factors (VII or X)-Shielded Adenovirus Infection","volume":"78","author":"Shiri","year":"2021","journal-title":"Curr. Microbiol."},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0069","doi-asserted-by":"crossref","first-page":"199","DOI":"10.5114\/ceh.2020.99512","article-title":"The superior role of coagulation factor FX over FVII in adenoviral-mediated innate immune induction of the hepatocyte: an in vitro experiment","volume":"6","author":"Ghahestani","year":"2020","journal-title":"Clinical and Experimental Hepatology"},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0070","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1083\/jcb.127.1.257","article-title":"Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization","volume":"127","author":"Wickham","year":"1994","journal-title":"The Journal of cell biology"},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0071","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0092-8674(93)90231-E","article-title":"Integrins \u03b1v\u03b23 and \u03b1v\u03b25 promote adenovirus internalization but not virus attachment","volume":"73","author":"Wickham","year":"1993","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0072","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00430-019-00645-2","article-title":"Human adenovirus binding to host cell receptors: a structural view","volume":"209","author":"Stasiak","year":"2020","journal-title":"Med. Microbiol. Immunol."},{"issue":"11","key":"10.1016\/j.jcyt.2021.07.013_bib0073","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1007\/s00705-015-2579-8","article-title":"Beyond RGD: virus interactions with integrins","volume":"160","author":"Hussein","year":"2015","journal-title":"Arch. Virol."},{"issue":"18","key":"10.1016\/j.jcyt.2021.07.013_bib0074","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1111\/j.1742-4658.2006.05430.x","article-title":"Structural and biochemical characterization of a human adenovirus 2\/12 penton base chimera","volume":"273","author":"Zubieta","year":"2006","journal-title":"The FEBS journal"},{"issue":"23","key":"10.1016\/j.jcyt.2021.07.013_bib0075","doi-asserted-by":"crossref","first-page":"11284","DOI":"10.1128\/JVI.75.23.11284-11291.2001","article-title":"Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions","volume":"75","author":"Einfeld","year":"2001","journal-title":"J. Virol."},{"issue":"24","key":"10.1016\/j.jcyt.2021.07.013_bib0076","doi-asserted-by":"crossref","first-page":"13062","DOI":"10.1128\/JVI.77.24.13062-13072.2003","article-title":"Reduction of natural adenovirus tropism to mouse liver by fiber-shaft exchange in combination with both CAR- and alphav integrin-binding ablation","volume":"77","author":"Koizumi","year":"2003","journal-title":"J. Virol."},{"issue":"6","key":"10.1016\/j.jcyt.2021.07.013_bib0077","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1124\/mol.51.6.944","article-title":"Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1","volume":"51","author":"Koop","year":"1997","journal-title":"Mol. Pharmacol."},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0078","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/hep.510290335","article-title":"Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells","volume":"29","author":"Stachlewitz","year":"1999","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"4 Pt 1","key":"10.1016\/j.jcyt.2021.07.013_bib0079","first-page":"630","article-title":"Role of Kupffer cells in the pathogenesis of hepatic reperfusion injury","volume":"267","author":"Bremer","year":"1994","journal-title":"Am. J. Physiol."},{"issue":"11","key":"10.1016\/j.jcyt.2021.07.013_bib0080","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1128\/jvi.71.11.8798-8807.1997","article-title":"The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors","volume":"71","author":"Lieber","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.jcyt.2021.07.013_bib0081","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1099\/0022-1317-81-11-2605","article-title":"Blood clearance rates of adenovirus type 5 in mice","volume":"81","author":"Alemany","year":"2000","journal-title":"The Journal of general virology"},{"issue":"6","key":"10.1016\/j.jcyt.2021.07.013_bib0082","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1089\/10430349950018364","article-title":"Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo","volume":"10","author":"Muruve","year":"1999","journal-title":"Hum. Gene Ther."},{"issue":"10","key":"10.1016\/j.jcyt.2021.07.013_bib0083","doi-asserted-by":"crossref","first-page":"5368","DOI":"10.1128\/JVI.78.10.5368-5381.2004","article-title":"Analysis of adenovirus sequestration in the liver, transduction of hepatic cells, and innate toxicity after injection of fiber-modified vectors","volume":"78","author":"Shayakhmetov","year":"2004","journal-title":"J. Virol."},{"issue":"23","key":"10.1016\/j.jcyt.2021.07.013_bib0084","doi-asserted-by":"crossref","first-page":"11705","DOI":"10.1128\/JVI.01320-08","article-title":"Clearance of adenovirus by Kupffer cells is mediated by scavenger receptors, natural antibodies, and complement","volume":"82","author":"Xu","year":"2008","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0085","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1021\/mp8000974","article-title":"Scavenger receptor A: a new route for adenovirus 5","volume":"6","author":"Haisma","year":"2009","journal-title":"Mol. Pharm."},{"issue":"7","key":"10.1016\/j.jcyt.2021.07.013_bib0086","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1038\/mt.2011.71","article-title":"Generation of a Kupffer cell-evading adenovirus for systemic and liver-directed gene transfer","volume":"19","author":"Khare","year":"2011","journal-title":"Molecular therapy: the journal of the American Society of Gene Therapy"},{"issue":"4","key":"10.1016\/j.jcyt.2021.07.013_bib0087","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1189\/jlb.69.4.622","article-title":"Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-kappaB activation and cytokine production","volume":"69","author":"Wheeler","year":"2001","journal-title":"J. Leukocyte Biol."},{"issue":"7","key":"10.1016\/j.jcyt.2021.07.013_bib0088","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1172\/JCI9020","article-title":"NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease","volume":"106","author":"Kono","year":"2000","journal-title":"The Journal of clinical investigation"},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0089","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.4049\/jimmunol.181.3.2134","article-title":"Adenovirus vector-induced innate inflammatory mediators, MAPK signaling, as well as adaptive immune responses are dependent upon both TLR2 and TLR9 in vivo","volume":"181","author":"Appledorn","year":"2008","journal-title":"Journal of immunology (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.jcyt.2021.07.013_bib0090","first-page":"106","article-title":"Regulation of TNF-mediated cell death and inflammation by human adenoviruses","volume":"3","author":"Gooding","year":"1994","journal-title":"Infect. Agents Dis."},{"issue":"4","key":"10.1016\/j.jcyt.2021.07.013_bib0091","doi-asserted-by":"crossref","first-page":"C1173","DOI":"10.1152\/ajpcell.2001.281.4.C1173","article-title":"Roles of tumor necrosis factor p55 and p75 receptors in TNF-alpha-induced vascular permeability","volume":"281","author":"Ferrero","year":"2001","journal-title":"American journal of physiology. Cell physiology"},{"issue":"5","key":"10.1016\/j.jcyt.2021.07.013_bib0092","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jhep.2013.12.026","article-title":"Biomarkers of liver cell death","volume":"60","author":"Eguchi","year":"2014","journal-title":"J. Hepatol."},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0093","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/s41419-018-0377-4","article-title":"Kupffer cell-derived TNF-\u03b1 promotes hepatocytes to produce CXCL1 and mobilize neutrophils in response to necrotic cells","volume":"9","author":"Su","year":"2018","journal-title":"Cell Death Dis"},{"issue":"17","key":"10.1016\/j.jcyt.2021.07.013_bib0094","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1089\/104303403322542275","article-title":"A hemodynamic response to intravenous adenovirus vector particles is caused by systemic Kupffer cell-mediated activation of endothelial cells","volume":"14","author":"Schiedner","year":"2003","journal-title":"Hum. Gene Ther."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0095","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/mthe.2000.0227","article-title":"Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver","volume":"3","author":"Tao","year":"2001","journal-title":"Molecular therapy: the journal of the American Society of Gene Therapy"},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0096","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ymthe.2005.08.007","article-title":"Rapid Kupffer cell death after intravenous injection of adenovirus vectors","volume":"13","author":"Manickan","year":"2006","journal-title":"Molecular therapy: the journal of the American Society of Gene Therapy"},{"key":"10.1016\/j.jcyt.2021.07.013_bib0097","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2017.06.050","article-title":"Inflammation and mitochondrial dysfunction: a vicious circle in neurodegenerative disorders?","volume":"710","author":"van Horssen","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.jcyt.2021.07.013_bib0098","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3389\/fimmu.2020.01259","article-title":"Multiple Roles for Chemokines in Neutrophil Biology","volume":"11","author":"Capucetti","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.jcyt.2021.07.013_bib0099","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1074-7613(03)00263-2","article-title":"Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence","volume":"19","author":"Martin","year":"2003","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0100","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1084\/jem.184.3.1101","article-title":"A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)","volume":"184","author":"Bleul","year":"1996","journal-title":"The Journal of experimental medicine"},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0101","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00441-017-2722-9","article-title":"Neutrophil biology within hepatic environment","volume":"371","author":"Alvarenga","year":"2018","journal-title":"Cell Tissue Res"},{"issue":"6","key":"10.1016\/j.jcyt.2021.07.013_bib0102","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/hep.21175","article-title":"Neutrophil depletion protects against murine acetaminophen hepatotoxicity","volume":"43","author":"Liu","year":"2006","journal-title":"Hepatology (Baltimore, Md.)"},{"issue":"6","key":"10.1016\/j.jcyt.2021.07.013_bib0103","doi-asserted-by":"crossref","first-page":"G1083","DOI":"10.1152\/ajpgi.00568.2005","article-title":"Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions","volume":"290","author":"Jaeschke","year":"2006","journal-title":"American journal of physiology. Gastrointestinal and liver physiology"},{"issue":"3","key":"10.1016\/j.jcyt.2021.07.013_bib0104","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2567.2008.02950.x","article-title":"Neutrophil mobilization and clearance in the bone marrow","volume":"125","author":"Furze","year":"2008","journal-title":"Immunology"},{"issue":"20","key":"10.1016\/j.jcyt.2021.07.013_bib0105","doi-asserted-by":"crossref","first-page":"11703","DOI":"10.1074\/jbc.270.20.11703","article-title":"Signals and Receptors Involved in Recruitment of Inflammatory Cells","volume":"270","author":"Ben-Baruch","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.jcyt.2021.07.013_bib0106","doi-asserted-by":"crossref","first-page":"6552","DOI":"10.4049\/jimmunol.167.11.6552","article-title":"Role of p38 mitogen-activated protein kinase in chemokine-induced emigration and chemotaxis in vivo","volume":"167","author":"Cara","year":"2001","journal-title":"Journal of immunology (Baltimore, Md.: 1950)"},{"issue":"11","key":"10.1016\/j.jcyt.2021.07.013_bib0107","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.molimm.2004.06.011","article-title":"Complement: a unique innate immune sensor for danger signals","volume":"41","author":"Gasque","year":"2004","journal-title":"Mol. Immunol."},{"issue":"6","key":"10.1016\/j.jcyt.2021.07.013_bib0108","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1189\/jlb.72.6.1092","article-title":"Signal transduction during Fc receptor-mediated phagocytosis","volume":"72","author":"Garc\u00eda-Garc\u00eda","year":"2002","journal-title":"J. Leukocyte Biol."},{"issue":"23","key":"10.1016\/j.jcyt.2021.07.013_bib0109","doi-asserted-by":"crossref","first-page":"14622","DOI":"10.1128\/JVI.79.23.14622-14631.2005","article-title":"Neutrophils interact with adenovirus vectors via Fc receptors and complement receptor 1","volume":"79","author":"Cotter","year":"2005","journal-title":"J. Virol."},{"issue":"12","key":"10.1016\/j.jcyt.2021.07.013_bib0110","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1002\/1521-4141(200212)32:12<3443::AID-IMMU3443>3.0.CO;2-F","article-title":"The role of selectins and integrins in adenovirus vector-induced neutrophil recruitment to the liver","volume":"32","author":"Li","year":"2002","journal-title":"Eur. J. Immunol."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0111","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/hep.510290222","article-title":"Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress","volume":"29","author":"Jaeschke","year":"1999","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.jcyt.2021.07.013_bib0112","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3389\/fimmu.2018.01869","article-title":"Natural Killer Cells: Development, Maturation, and Clinical Utilization","volume":"9","author":"Abel","year":"2018","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0113","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.hemonc.2014.11.006","article-title":"Natural killer cells: in health and disease","volume":"8","author":"Mandal","year":"2015","journal-title":"Hematol. Oncol. Stem Cell Ther."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0114","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0022-1759(90)90407-M","article-title":"Isolation and flow cytometric analysis of the free lymphomyeloid cells present in murine liver","volume":"132","author":"Goossens","year":"1990","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.jcyt.2021.07.013_bib0115","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-020711-075005","article-title":"Controlling natural killer cell responses: integration of signals for activation and inhibition","volume":"31","author":"Long","year":"2013","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0116","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/smim.2000.0216","article-title":"Signaling pathways engaged by NK cell receptors: double concerto for activating receptors, inhibitory receptors and NK cells","volume":"12","author":"Tomasello","year":"2000","journal-title":"Semin. Immunol."},{"issue":"208","key":"10.1016\/j.jcyt.2021.07.013_bib0117","doi-asserted-by":"crossref","first-page":"208ra145","DOI":"10.1126\/scitranslmed.3006702","article-title":"Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry","volume":"5","author":"Horowitz","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0118","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/icb.2010.78","article-title":"Activating and inhibitory receptors of natural killer cells","volume":"89","author":"Pegram","year":"2011","journal-title":"Immunol. Cell Biol."},{"issue":"5","key":"10.1016\/j.jcyt.2021.07.013_bib0119","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1084\/jem.162.5.1645","article-title":"Widespread and selective induction of major histocompatibility complex-determined antigens in vivo by gamma interferon","volume":"162","author":"Skoskiewicz","year":"1985","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0120","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.immunol.16.1.359","article-title":"NK cell receptors","volume":"16","author":"Lanier","year":"1998","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0121","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/mthe.2002.0529","article-title":"Adenoviral vectors stimulate murine natural killer cell responses and demonstrate antitumor activities in the absence of transgene expression","volume":"5","author":"Ruzek","year":"2002","journal-title":"Molecular therapy: the journal of the American Society of Gene Therapy"},{"issue":"12","key":"10.1016\/j.jcyt.2021.07.013_bib0122","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.4049\/jimmunol.164.12.6480","article-title":"NK cells cause liver injury and facilitate the induction of T cell-mediated immunity to a viral liver infection","volume":"164","author":"Liu","year":"2000","journal-title":"Journal of immunology (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.jcyt.2021.07.013_bib0123","first-page":"83","article-title":"Interleukin-12: a cytokine at the interface of inflammation and immunity","author":"Giorgio","year":"1998","journal-title":"Adv. Immunol."},{"issue":"10","key":"10.1016\/j.jcyt.2021.07.013_bib0124","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1128\/JVI.75.10.4540-4550.2001","article-title":"Variation in adenovirus transgene expression between BALB\/c and C57BL\/6 mice is associated with differences in interleukin-12 and gamma interferon production and NK cell activation","volume":"75","author":"Peng","year":"2001","journal-title":"J. Virol."},{"issue":"2","key":"10.1016\/j.jcyt.2021.07.013_bib0125","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nri3384","article-title":"Six-of-the-best: unique contributions of \u03b3\u03b4 T cells to immunology","volume":"13","author":"Vantourout","year":"2013","journal-title":"Nature reviews. Immunology"},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0126","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.immuni.2011.04.018","article-title":"Skint-1 identifies a common molecular mechanism for the development of interferon-\u03b3-secreting versus interleukin-17-secreting \u03b3\u03b4 T cells","volume":"35","author":"Turchinovich","year":"2011","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.jcyt.2021.07.013_bib0127","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/ni.1717","article-title":"CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets","volume":"10","author":"Ribot","year":"2009","journal-title":"Nat. Immunol."},{"issue":"20","key":"10.1016\/j.jcyt.2021.07.013_bib0128","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.3748\/wjg.v26.i20.2559","article-title":"Role of \u03b3\u03b4T cells in liver diseases and its relationship with intestinal microbiota","volume":"26","author":"Zhou","year":"2020","journal-title":"World J. Gastroenterol."},{"issue":"19","key":"10.1016\/j.jcyt.2021.07.013_bib0129","doi-asserted-by":"crossref","first-page":"9564","DOI":"10.1128\/JVI.00927-08","article-title":"GammadeltaT cells initiate acute inflammation and injury in adenovirus-infected liver via cytokine-chemokine cross talk","volume":"82","author":"Ajuebor","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jcyt.2021.07.013_bib0130","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.coviro.2016.08.017","article-title":"Adenovirus sensing by the immune system","volume":"21","author":"Atasheva","year":"2016","journal-title":"Curr. Opin. Virol."},{"issue":"1","key":"10.1016\/j.jcyt.2021.07.013_bib0131","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/mt.2010.229","article-title":"Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells","volume":"19","author":"Prill","year":"2011","journal-title":"Molecular therapy: the journal of the American Society of Gene Therapy"},{"issue":"12","key":"10.1016\/j.jcyt.2021.07.013_bib0132","first-page":"4942","article-title":"Mutation in fiber of adenovirus serotype 5 gene therapy vector decreases liver tropism","volume":"7","author":"Wang","year":"2014","journal-title":"Int. J. Clin. Exp. Med."}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324921007507?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324921007507?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T01:44:51Z","timestamp":1761443091000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324921007507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":132,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1465324921007507"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2021.07.013","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adenovirus vector-attributed hepatotoxicity blocks clinical application in gene therapy","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2021.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society for Cell &#38; Gene Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}