{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:44:50Z","timestamp":1792496690176,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jcyt.2021.11.003","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T08:17:57Z","timestamp":1644999477000},"page":"534-543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Marrow-Derived Autologous Stromal Cells for the Restoration of Salivary Hypofunction (MARSH): Study protocol for a phase 1 dose-escalation trial of patients with xerostomia after radiation therapy for head and neck cancer"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3178-3004","authenticated-orcid":false,"given":"Grace C.","family":"Blitzer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole M.","family":"Rogus-Pulia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan J.","family":"Mattison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomy","family":"Varghese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Ganz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-1996","authenticated-orcid":false,"given":"Jacques","family":"Galipeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"McDowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross O.","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany A.","family":"Glazer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8336-8000","authenticated-orcid":false,"given":"Randall J.","family":"Kimple","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jcyt.2021.11.003_bib0001","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.radonc.2013.11.010","article-title":"Intensity-modulated radiation therapy for head and neck cancer: systematic review and meta-analysis","volume":"110","author":"Marta","year":"2014","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.003_bib0002","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1742-1241.2009.02132.x","article-title":"Managing the patient presenting with xerostomia: a review","volume":"64","author":"Visvanathan","year":"2010","journal-title":"Int J Clin Pract"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.003_bib0003","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tripleo.2004.04.009","article-title":"Double-blind randomized, placebo-controlled study of pilocarpine to salvage salivary gland function during radiotherapy of patients with head and neck cancer","volume":"98","author":"Gornitsky","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"9","key":"10.1016\/j.jcyt.2021.11.003_bib0004","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1007\/s00296-011-2085-6","article-title":"Evaluation of the clinical efficacy of Biotene Oral Balance in patients with secondary Sjogren's syndrome: a pilot study","volume":"32","author":"Aliko","year":"2012","journal-title":"Rheumatol Int"},{"issue":"4","key":"10.1016\/j.jcyt.2021.11.003_bib0005","first-page":"319","article-title":"A double-blind, crossover study of Biotene Oralbalance and BioXtra systems as salivary substitutes in patients with post-radiotherapy xerostomia","volume":"14","author":"Shahdad","year":"2005","journal-title":"Eur J Cancer Care (Engl)"},{"key":"10.1016\/j.jcyt.2021.11.003_bib0006","first-page":"824","article-title":"The immune plasticity of mesenchymal stromal cells from mice and men: concordances and discrepancies","volume":"4","author":"Romieu-Mourez","year":"2012","journal-title":"Front Biosci (Elite Ed)"},{"issue":"5","key":"10.1016\/j.jcyt.2021.11.003_bib0007","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nri3209","article-title":"Multipotent mesenchymal stromal cells and the innate immune system","volume":"12","author":"Le Blanc","year":"2012","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"10.1016\/j.jcyt.2021.11.003_bib0008","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1001\/jama.299.8.925","article-title":"Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases","volume":"299","author":"Burt","year":"2008","journal-title":"Jama"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.003_bib0009","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.oooo.2013.11.496","article-title":"Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies","volume":"117","author":"Jensen","year":"2014","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol."},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.003_bib0010","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biocel.2010.09.023","article-title":"Bone marrow-derived cells rescue salivary gland function in mice with head and neck irradiation","volume":"43","author":"Sumita","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.003_bib0011","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.biocel.2010.10.010","article-title":"Bone marrow-derived cells: A potential approach for the treatment of xerostomia","volume":"43","author":"Tran","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.003_bib0012","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.ijrobp.2018.02.034","article-title":"Safety and Efficacy of Mesenchymal Stem Cells for Radiation-Induced Xerostomia: A Randomized, Placebo-Controlled Phase 1\/2 Trial (MESRIX)","volume":"101","author":"Gronhoj","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"9","key":"10.1016\/j.jcyt.2021.11.003_bib0013","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1002\/stem.2415","article-title":"Cryopreserved Mesenchymal Stromal Cells Are Susceptible to T-Cell Mediated Apoptosis Which Is Partly Rescued by IFNgamma Licensing","volume":"34","author":"Chinnadurai","year":"2016","journal-title":"Stem Cells"},{"issue":"11","key":"10.1016\/j.jcyt.2021.11.003_bib0014","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1182\/bloodadvances.2017006205","article-title":"Immune dysfunctionality of replicative senescent mesenchymal stromal cells is corrected by IFNgamma priming","volume":"1","author":"Chinnadurai","year":"2017","journal-title":"Blood Adv"},{"issue":"2","key":"10.1016\/j.jcyt.2021.11.003_bib0015","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jcyt.2015.11.008","article-title":"International Society for Cellular Therapy perspective on immune functional assays for mesenchymal stromal cells as potency release criterion for advanced phase clinical trials","volume":"18","author":"Galipeau","year":"2016","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2021.11.003_bib0016","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ebiom.2018.01.002","article-title":"Enhanced Immunosuppressive Properties of Human Mesenchymal Stem Cells Primed by Interferon-gamma","volume":"28","author":"Kim","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jcyt.2021.11.003_bib0017","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1479-5876-10-229","article-title":"Impact of passing mesenchymal stem cells through smaller bore size needles for subsequent use in patients for clinical or cosmetic indications","volume":"10","author":"Mamidi","year":"2012","journal-title":"J Transl Med"},{"issue":"6","key":"10.1016\/j.jcyt.2021.11.003_bib0018","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.jpainsymman.2010.08.016","article-title":"Studies comparing Numerical Rating Scales, Verbal Rating Scales, and Visual Analogue Scales for assessment of pain intensity in adults: a systematic literature review","volume":"41","author":"Hjermstad","year":"2011","journal-title":"J Pain Symptom Manage"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.003_bib0019","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0304-3959(94)90133-3","article-title":"What is the maximum number of levels needed in pain intensity measurement?","volume":"58","author":"Jensen","year":"1994","journal-title":"Pain"},{"key":"10.1016\/j.jcyt.2021.11.003_bib0020","doi-asserted-by":"crossref","first-page":"35s","DOI":"10.14219\/jada.archive.2008.0353","article-title":"Measuring salivary flow: challenges and opportunities","volume":"139","author":"Navazesh","year":"2008","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.jcyt.2021.11.003_bib0021","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1749-6632.1993.tb18343.x","article-title":"Methods for collecting saliva","volume":"694","author":"Navazesh","year":"1993","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.003_bib0022","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/0970-9290.42953","article-title":"Effects of radiation and alpha-tocopherol on saliva flow rate, amylase activity, total protein and electrolyte levels in oral cavity cancer","volume":"19","author":"Chitra","year":"2008","journal-title":"Indian J Dent Res"},{"issue":"2","key":"10.1016\/j.jcyt.2021.11.003_bib0023","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/adj.12608","article-title":"Xerostomia, salivary characteristics and gland volumes following intensity-modulated radiotherapy for nasopharyngeal carcinoma: a two-year follow up","volume":"63","author":"Sim","year":"2018","journal-title":"Aust Dent J"},{"issue":"7","key":"10.1016\/j.jcyt.2021.11.003_bib0024","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/odi.12686","article-title":"The effect of parotid gland-sparing intensitymodulated radiotherapy on salivary composition, flow rate and xerostomia measures","volume":"23","author":"Richards","year":"2017","journal-title":"Oral Dis."},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.003_bib0025","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0360-3016(93)90143-J","article-title":"Major salivary gland function in patients with radiation-induced xerostomia: flow rates and sialochemistry","volume":"25","author":"Valdez","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"6","key":"10.1016\/j.jcyt.2021.11.003_bib0026","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1034\/j.1399-302X.2001.160605.x","article-title":"amylase and mucin MUC5B and their relation to the oral microflora in hyposalivation of different origins","volume":"16","author":"Almstahl","year":"2001","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.jcyt.2021.11.003_bib0027","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1748-717X-7-91","article-title":"MUC5B levels in submandibular gland saliva of patients treated with radiotherapy for head-and-neck cancer: a pilot study","volume":"7","author":"Dijkema","year":"2012","journal-title":"Radiat Oncol"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.003_bib0028","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/S1368-8375(00)00063-4","article-title":"Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy","volume":"37","author":"Henson","year":"2001","journal-title":"Oral Oncol"},{"issue":"7","key":"10.1016\/j.jcyt.2021.11.003_bib0029","first-page":"870","article-title":"The development and validation of a dysphagia-specific quality-of-life questionnaire for patients with head and neck cancer: the M. D. Anderson dysphagia inventory","volume":"127","author":"Chen","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.003_bib0030","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1067\/moe.2001.111551","article-title":"Development of a Visual Analogue Scale questionnaire for subjective assessment of salivary dysfunction","volume":"91","author":"Pai","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod."},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.003_bib0031","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1148\/rg.263055024","article-title":"US of the major salivary glands: anatomy and spatial relationships, pathologic conditions, and pitfalls","volume":"26","author":"Bialek","year":"2006","journal-title":"Radiographics"},{"key":"10.1016\/j.jcyt.2021.11.003_bib0032","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.clinimag.2018.04.011","article-title":"Ultrasound elastography in assessment of salivary glands involvement in primary Sjogren's syndrome","volume":"50","author":"Cindil","year":"2018","journal-title":"Clin Imaging"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.003_bib0033","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.ultrasmedbio.2015.11.009","article-title":"Assessment of the Stiffness of Major Salivary Glands in Primary Sjogren's Syndrome through Quantitative Acoustic Radiation Force Impulse Imaging","volume":"42","author":"Zhang","year":"2016","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.jcyt.2021.11.003_bib0034","series-title":"The Prevention and Treatment of Missing Data in Clinical Trials","year":"2010"},{"issue":"14","key":"10.1016\/j.jcyt.2021.11.003_bib0035","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJMsr1203730","article-title":"The prevention and treatment of missing data in clinical trials","volume":"367","author":"Little","year":"2012","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jcyt.2021.11.003_bib0036","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.stem.2018.05.004","article-title":"Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities","volume":"22","author":"Galipeau","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/j.jcyt.2021.11.003_bib0037","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.bbmt.2015.01.014","article-title":"Bone Marrow Mesenchymal Stromal Cells from Patients with Acute and Chronic Graft-versus-Host Disease Deploy Normal Phenotype, Differentiation Plasticity, and Immune-Suppressive Activity","volume":"21","author":"Copland","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"issue":"2","key":"10.1016\/j.jcyt.2021.11.003_bib0038","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jcmgh.2015.12.004","article-title":"Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche","volume":"2","author":"Aoki","year":"2016","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.003_bib0039","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.stemcr.2015.11.009","article-title":"Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals","volume":"6","author":"Maimets","year":"2016","journal-title":"Stem Cell Reports"},{"issue":"8","key":"10.1016\/j.jcyt.2021.11.003_bib0040","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1172\/JCI74096","article-title":"Neurotrophic factor GDNF promotes survival of salivary stem cells","volume":"124","author":"Xiao","year":"2014","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jcyt.2021.11.003_bib0041","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3389\/fonc.2016.00111","article-title":"Xerostomia after Radiotherapy for Oral and Oropharyngeal Cancer: Increasing Salivary Flow with Tasteless Sugar-free Chewing Gum","volume":"6","author":"Kaae","year":"2016","journal-title":"Front Oncol"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324921008860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324921008860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T01:47:16Z","timestamp":1761443236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324921008860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S1465324921008860"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2021.11.003","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Marrow-Derived Autologous Stromal Cells for the Restoration of Salivary Hypofunction (MARSH): Study protocol for a phase 1 dose-escalation trial of patients with xerostomia after radiation therapy for head and neck cancer","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2021.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society for Cell &#38; Gene Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}