{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:43:39Z","timestamp":1773891819166,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000377","name":"Dunhill Medical Trust","doi-asserted-by":"publisher","award":["R459\/0216"],"award-info":[{"award-number":["R459\/0216"]}],"id":[{"id":"10.13039\/501100000377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005045","name":"Ministry of Finance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005045","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jcyt.2021.11.005","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T08:18:48Z","timestamp":1644999528000},"page":"489-499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Treatment with outgrowth endothelial cells protects cerebral barrier against ischemic injury"],"prefix":"10.1016","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9435-9767","authenticated-orcid":false,"given":"Rais Reskiawan A.","family":"Kadir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6795-5256","authenticated-orcid":false,"given":"Mansour","family":"Alwjwaj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulvi","family":"Bayraktutan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10159","key":"10.1016\/j.jcyt.2021.11.005_bib0001","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Roth","year":"2018","journal-title":"The Lancet"},{"issue":"10159","key":"10.1016\/j.jcyt.2021.11.005_bib0002","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/S0140-6736(18)32335-3","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Kyu","year":"2018","journal-title":"The Lancet"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.005_bib0003","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10571-019-00737-w","article-title":"Urokinase Plasminogen Activator: A Potential Thrombolytic Agent for Ischaemic Stroke","volume":"40","author":"Kadir","year":"2020","journal-title":"Cellular and Molecular Neurobiology"},{"key":"10.1016\/j.jcyt.2021.11.005_bib0004","article-title":"MicroRNA: An Emerging Predictive, Diagnostic, Prognostic and Therapeutic Strategy in Ischaemic Stroke","author":"Kadir","year":"2020","journal-title":"Cellular and Molecular Neurobiology"},{"issue":"6","key":"10.1016\/j.jcyt.2021.11.005_bib0005","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.apsb.2016.06.013","article-title":"The fate of medications evaluated for ischemic stroke pharmacotherapy over the period 1995-2015","volume":"6","author":"Chen","year":"2016","journal-title":"Acta Pharm Sin B"},{"issue":"13 Suppl 1","key":"10.1016\/j.jcyt.2021.11.005_bib0006","first-page":"S207","article-title":"Stem cell therapy in ischemic stroke: role of IV and intra-arterial therapy","volume":"79","author":"Misra","year":"2012","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0007","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s13287-020-01762-z","article-title":"Stem cell-based therapies for ischemic stroke: a systematic review and meta-analysis of clinical trials","volume":"11","author":"Li","year":"2020","journal-title":"Stem Cell Research & Therapy"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.005_bib0008","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s13311-011-0040-6","article-title":"Investigational therapies for ischemic stroke: neuroprotection and neurorecovery","volume":"8","author":"Sahota","year":"2011","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jcyt.2021.11.005_bib0009","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.phrs.2019.04.017","article-title":"Endothelial progenitor cells: Potential novel therapeutics for ischemic stroke","volume":"144","author":"Bayraktutan","year":"2019","journal-title":"Pharmacological Research"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40478-019-0671-0","article-title":"Endothelial edema precedes blood\u2013brain barrier breakdown in early time points after experimental focal cerebral ischemia","volume":"7","author":"Krueger","year":"2019","journal-title":"Acta Neuropathologica Communications"},{"key":"10.1016\/j.jcyt.2021.11.005_bib0011","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pneurobio.2017.10.001","article-title":"Blood-brain barrier dysfunction and recovery after ischemic stroke","volume":"163-164","author":"Jiang","year":"2018","journal-title":"Prog Neurobiol"},{"issue":"6","key":"10.1016\/j.jcyt.2021.11.005_bib0012","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.4103\/1673-5374.269029","article-title":"Outgrowth endothelial cells form a functional cerebral barrier and restore its integrity after damage","volume":"15","author":"Abdulkadir","year":"2020","journal-title":"Neural Regen Res"},{"issue":"11","key":"10.1016\/j.jcyt.2021.11.005_bib0013","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/dom.12120","article-title":"Hyperglycaemia promotes cerebral barrier dysfunctionthrough activation of protein kinase C-\u03b2","volume":"15","author":"Shao","year":"2013","journal-title":"Diabetes Obes Metab"},{"issue":"7","key":"10.1016\/j.jcyt.2021.11.005_bib0014","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s11011-021-00810-8","article-title":"Therapeutic hypothermia augments the restorative effects of PKC-\u03b2 and Nox2 inhibition on an in vitro model of human blood\u2013brain barrier","volume":"36","author":"Kadir","year":"2021","journal-title":"Metabolic Brain Disease"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.005_bib0015","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.scr.2014.03.001","article-title":"Glycosaminoglycan mimetic improves enrichment and cell functions of human endothelial progenitor cell colonies","volume":"12","author":"Chevalier","year":"2014","journal-title":"Stem Cell Research"},{"key":"10.1016\/j.jcyt.2021.11.005_bib0016","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.mcn.2014.06.002","article-title":"NADPH oxidase mediates TNF-\u03b1-evoked in vitro brain barrier dysfunction: roles of apoptosis and time","volume":"61","author":"Abdullah","year":"2014","journal-title":"Mol Cell Neurosci"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0017","doi-asserted-by":"crossref","first-page":"12562","DOI":"10.1038\/s41598-020-69548-0","article-title":"Apoptotic exosome-like vesicles regulate endothelial gene expression, inflammatory signaling, and function through the NF-\u03baB signaling pathway","volume":"10","author":"Migneault","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/j.jcyt.2021.11.005_bib0018","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mcn.2015.11.003","article-title":"Inhibition of TNF-\u03b1 protects in vitro brain barrier from ischemic damage","volume":"69","author":"Abdullah","year":"2015","journal-title":"Molecular and Cellular Neuroscience"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0019","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbadis.2015.10.016","article-title":"Increases in intracellular calcium perturb blood\u2013brain barrier via protein kinase C-alpha and apoptosis","volume":"1862","author":"Rakkar","year":"2016","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"issue":"11","key":"10.1016\/j.jcyt.2021.11.005_bib0020","doi-asserted-by":"crossref","first-page":"5906","DOI":"10.1167\/iovs.09-4951","article-title":"Outgrowth Endothelial Cells: Characterization and Their Potential for Reversing Ischemic Retinopathy","volume":"51","author":"Medina","year":"2010","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"6","key":"10.1016\/j.jcyt.2021.11.005_bib0021","first-page":"1","article-title":"Disrupted Endothelial Cell Layer and Exposed Extracellular Matrix Proteins Promote Capture of Late Outgrowth Endothelial Progenitor Cells","author":"Zhao","year":"2016","journal-title":"Stem Cells Int"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0022","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.hest.2019.12.004","article-title":"The blood brain barrier in cerebral ischemic injury \u2013 Disruption and repair","volume":"1","author":"Zhang","year":"2020","journal-title":"Brain Hemorrhages"},{"issue":"8","key":"10.1016\/j.jcyt.2021.11.005_bib0023","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.4103\/1673-5374.303012","article-title":"The secretome of endothelial progenitor cells: a potential therapeutic strategy for ischemic stroke","volume":"16","author":"Alwjwaj","year":"2021","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jcyt.2021.11.005_bib0024","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.3389\/fneur.2020.594672","article-title":"Pathophysiology of Blood\u2013Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery","volume":"11","author":"Bernardo-Castro","year":"2020","journal-title":"Frontiers in Neurology"},{"issue":"3","key":"10.1016\/j.jcyt.2021.11.005_bib0025","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1007\/s12015-020-10064-z","article-title":"Characterization and Functional Assessment of Endothelial Progenitor Cells in Ischemic Stroke Patients","volume":"17","author":"Kukumberg","year":"2021","journal-title":"Stem Cell Reviews and Reports"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0026","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12015-010-9157-y","article-title":"Transplanted late outgrowth endothelial progenitor cells as cell therapy product for stroke","volume":"7","author":"Moubarik","year":"2011","journal-title":"Stem Cell Rev Rep"},{"issue":"11","key":"10.1016\/j.jcyt.2021.11.005_bib0027","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1161\/01.ATV.0000142810.27849.8f","article-title":"Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase","volume":"24","author":"He","year":"2004","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"12","key":"10.1016\/j.jcyt.2021.11.005_bib0028","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1182\/blood-2003-12-4103","article-title":"Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress","volume":"104","author":"Dernbach","year":"2004","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.jcyt.2021.11.005_bib0029","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1182\/blood.V93.9.2928.409k25_2928_2935","article-title":"Hematopoietic growth factors signal through the formation of reactive oxygen species","volume":"93","author":"Sattler","year":"1999","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0030","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/sctm.17-0187","article-title":"Preclinical Evaluation and Optimization of a Cell Therapy Using Human Cord Blood-Derived Endothelial Colony-Forming Cells for Ischemic Retinopathies","volume":"7","author":"Reid","year":"2018","journal-title":"Stem Cells Transl Med"},{"issue":"9","key":"10.1016\/j.jcyt.2021.11.005_bib0031","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1002\/jps.23575","article-title":"Quantitative atlas of blood\u2013brain barrier transporters, receptors, and tight junction proteins in rats and common marmoset","volume":"102","author":"Hoshi","year":"2013","journal-title":"J Pharm Sci"},{"issue":"5","key":"10.1016\/j.jcyt.2021.11.005_bib0032","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1177\/1747493017711814","article-title":"Enhancing the alignment of the preclinical and clinical stroke recovery research pipeline: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable translational working group","volume":"12","author":"Corbett","year":"2017","journal-title":"Int J Stroke"},{"issue":"6","key":"10.1016\/j.jcyt.2021.11.005_bib0033","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1747-4949.2009.00387.x","article-title":"Oxidative stress and its role in the pathogenesis of ischemic stroke","volume":"4","author":"Allen","year":"2009","journal-title":"Int J Stroke"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0034","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.brainres.2006.11.023","article-title":"Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat","volume":"1132","author":"Nagel","year":"2007","journal-title":"Brain Res"},{"issue":"12","key":"10.1016\/j.jcyt.2021.11.005_bib0035","doi-asserted-by":"crossref","first-page":"e82823","DOI":"10.1371\/journal.pone.0082823","article-title":"Moderate hypoxia followed by reoxygenation results in blood\u2013brain barrier breakdown via oxidative stress-dependent tight-junction protein disruption","volume":"8","author":"Zehendner","year":"2013","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.jcyt.2021.11.005_bib0036","doi-asserted-by":"crossref","first-page":"e1000479","DOI":"10.1371\/journal.pbio.1000479","article-title":"Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration","volume":"8","author":"Kleinschnitz","year":"2010","journal-title":"PLoS Biol"},{"issue":"2","key":"10.1016\/j.jcyt.2021.11.005_bib0037","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.neuroscience.2008.03.090","article-title":"Apocynin improves outcome in experimental stroke with a narrow dose range","volume":"154","author":"Tang","year":"2008","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0038","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3892\/ijmm.2012.1180","article-title":"Transplantation of bone marrow-derived endothelial progenitor cells attenuates cerebral ischemia and reperfusion injury by inhibiting neuronal apoptosis, oxidative stress and nuclear factor-\u03baB expression","volume":"31","author":"Qiu","year":"2013","journal-title":"Int J Mol Med"},{"issue":"4","key":"10.1016\/j.jcyt.2021.11.005_bib0039","first-page":"375","article-title":"Superoxide is a potential culprit of caspase-3 dependent endothelial cell death induced by lysophosphatidylcholine","volume":"61","author":"Park","year":"2010","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.jcyt.2021.11.005_bib0040","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2563764","article-title":"Norepinephrine Induces Lung Microvascular Endothelial Cell Death by NADPH Oxidase-Dependent Activation of Caspase-3","volume":"2020","author":"Chignalia","year":"2020","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"10.1016\/j.jcyt.2021.11.005_bib0041","doi-asserted-by":"crossref","first-page":"695","DOI":"10.21037\/cdt-20-329","article-title":"Exogenous endothelial progenitor cells reached the deficient region of acute cerebral ischemia rats to improve functional recovery via Bcl-2","volume":"10","author":"Hong","year":"2020","journal-title":"Cardiovasc Diagn Ther"},{"issue":"8","key":"10.1016\/j.jcyt.2021.11.005_bib0042","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/stem.1414","article-title":"Ex Vivo Expansion of Human outgrowth Endothelial Cells Leads to IL-8-Mediated Replicative Senescence and Impaired Vasoreparative Function","volume":"31","author":"Medina","year":"2013","journal-title":"STEM CELLS"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0043","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/cells8010019","article-title":"Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest","volume":"8","author":"Coluzzi","year":"2019","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0044","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/sctm.18-0012","article-title":"Autologous Endothelial Progenitor Cells Transplantation for Acute Ischemic Stroke: A 4-Year Follow-Up Study","volume":"8","author":"Fang","year":"2019","journal-title":"Stem Cells Transl Med"},{"issue":"9","key":"10.1016\/j.jcyt.2021.11.005_bib0045","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1161\/01.ATV.0000237750.44469.88","article-title":"Number and Function of Endothelial Progenitor Cells as a Marker of Severity for Diabetic Vasculopathy","volume":"26","author":"Fadini Gian","year":"2006","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"22","key":"10.1016\/j.jcyt.2021.11.005_bib0046","doi-asserted-by":"crossref","first-page":"5680","DOI":"10.3390\/ijms20225680","article-title":"The Importance of HLA Assessment in \"Off-the-Shelf\" Allogeneic Mesenchymal Stem Cells Based-Therapies","volume":"20","author":"Kot","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"19","key":"10.1016\/j.jcyt.2021.11.005_bib0047","doi-asserted-by":"crossref","first-page":"7406","DOI":"10.3390\/ijms21197406","article-title":"Therapeutic Potential of Endothelial Colony-Forming Cells in Ischemic Disease: Strategies to Improve their Regenerative Efficacy","volume":"21","author":"Faris","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"26","key":"10.1016\/j.jcyt.2021.11.005_bib0048","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1182\/blood-2008-09-181362","article-title":"Humanized large-scale expanded endothelial colony\u2013forming cells function in vitro and in vivo","volume":"113","author":"Reinisch","year":"2009","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jcyt.2021.11.005_bib0049","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13287-020-01687-7","article-title":"Cord blood-endothelial colony forming cells are immunotolerated and participate at post-ischemic angiogenesis in an original dorsal chamber immunocompetent mouse model","volume":"11","author":"Proust","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"7","key":"10.1016\/j.jcyt.2021.11.005_bib0050","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1177\/0963689718821686","article-title":"Clinical Assessment of Intravenous Endothelial Progenitor Cell Transplantation in Dogs","volume":"28","author":"Lee","year":"2019","journal-title":"Cell Transplant"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324922000032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324922000032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T01:45:41Z","timestamp":1761443141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324922000032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S1465324922000032"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2021.11.005","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment with outgrowth endothelial cells protects cerebral barrier against ischemic injury","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2021.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}