{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:38:52Z","timestamp":1793093932140,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271628"],"award-info":[{"award-number":["82271628"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7232148"],"award-info":[{"award-number":["7232148"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jcyt.2023.12.006","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T03:58:17Z","timestamp":1705636697000},"page":"311-316","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Predictive factors that influence the clinical efficacy of umbilical cord\u2013derived mesenchymal stromal cells in the treatment of type 2 diabetes mellitus"],"prefix":"10.1016","volume":"26","author":[{"given":"Yuepeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiejie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saichun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.jcyt.2023.12.006_bib0001","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176275","article-title":"Pathophysiology of type 2 diabetes mellitus","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.jcyt.2023.12.006_bib0002","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41574-021-00489-y","article-title":"Novel therapies with precision mechanisms for type 2 diabetes mellitus","volume":"17","author":"Perreault","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.jcyt.2023.12.006_bib0003","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13098-017-0233-1","article-title":"Mesenchymal stem cell therapy in type 2 diabetes mellitus","volume":"9","author":"Zang","year":"2017","journal-title":"Diabetol Metab Syndr"},{"key":"10.1016\/j.jcyt.2023.12.006_bib0004","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.intimp.2018.04.051","article-title":"The homing of human umbilical cord-derived mesenchymal stem cells and the subsequent modulation of macrophage polarization in type 2 diabetic mice","volume":"60","author":"Yin","year":"2018","journal-title":"Int Immunopharmacol"},{"issue":"5","key":"10.1016\/j.jcyt.2023.12.006_bib0005","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3727\/096368915X689622","article-title":"Clinical trials with mesenchymal stem cells: an update","volume":"25","author":"Squillaro","year":"2016","journal-title":"Cell Transplant."},{"issue":"2","key":"10.1016\/j.jcyt.2023.12.006_bib0006","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/scrt446","article-title":"A preliminary evaluation of efficacy and safety of Wharton's jelly mesenchymal stem cell transplantation in patients with type 2 diabetes mellitus","volume":"5","author":"Liu","year":"2014","journal-title":"Stem Cell Res Ther"},{"issue":"27","key":"10.1016\/j.jcyt.2023.12.006_bib0007","doi-asserted-by":"crossref","first-page":"4893","DOI":"10.2174\/13816128113199990326","article-title":"Treatment of foot disease in patients with type 2 diabetes mellitus using human umbilical cord blood mesenchymal stem cells: response and correction of immunological anomalies","volume":"19","author":"Li","year":"2013","journal-title":"Curr Pharm Des"},{"issue":"5","key":"10.1016\/j.jcyt.2023.12.006_bib0008","doi-asserted-by":"crossref","first-page":"e38189","DOI":"10.1371\/journal.pone.0038189","article-title":"Human mesenchymal stem cells protect human islets from pro-inflammatory cytokines","volume":"7","author":"Yeung","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jcyt.2023.12.006_bib0009","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jcyt.2021.01.005","article-title":"Reversion of early- and late-stage \u03b2-cell dedifferentiation by human umbilical cord-derived mesenchymal stem cells in type 2 diabetic mice","volume":"23","author":"Li","year":"2021","journal-title":"Cytotherapy"},{"issue":"46","key":"10.1016\/j.jcyt.2023.12.006_bib0010","doi-asserted-by":"crossref","first-page":"17438","DOI":"10.1073\/pnas.0608249103","article-title":"Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD\/scid mice","volume":"103","author":"Lee","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.jcyt.2023.12.006_bib0011","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/stem.3134","article-title":"Optimizing beta cell function through mesenchymal stromal cell-mediated mitochondria transfer","volume":"38","author":"Rackham","year":"2020","journal-title":"Stem Cells"},{"issue":"7","key":"10.1016\/j.jcyt.2023.12.006_bib0012","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41419-018-0801-9","article-title":"Human umbilical cord-derived mesenchymal stem cells direct macrophage polarization to alleviate pancreatic islets dysfunction in type 2 diabetic mice","volume":"9","author":"Yin","year":"2018","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.jcyt.2023.12.006_bib0013","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s13287-017-0668-1","article-title":"Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats","volume":"8","author":"Sun","year":"2017","journal-title":"Stem Cell Res Ther"},{"issue":"8","key":"10.1016\/j.jcyt.2023.12.006_bib0014","doi-asserted-by":"crossref","first-page":"7613","DOI":"10.1021\/acsnano.7b07643","article-title":"Human mesenchymal stem cell derived exosomes alleviate type 2 diabetes mellitus by reversing peripheral insulin resistance and relieving \u03b2-cell destruction","volume":"12","author":"Sun","year":"2018","journal-title":"ACS Nano"},{"issue":"3","key":"10.1016\/j.jcyt.2023.12.006_bib0015","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00441-021-03461-4","article-title":"Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach","volume":"385","author":"Gomes","year":"2021","journal-title":"Cell Tissue Res"},{"issue":"1","key":"10.1016\/j.jcyt.2023.12.006_bib0016","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13287-021-02342-5","article-title":"Efficacy of mesenchymal stem cell transplantation therapy for type 1 and type 2 diabetes mellitus: a meta-analysis","volume":"12","author":"Li","year":"2021","journal-title":"Stem Cell Res Ther"},{"issue":"9","key":"10.1016\/j.jcyt.2023.12.006_bib0017","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.2337\/dc14-2830","article-title":"Allogeneic mesenchymal precursor cells in type 2 diabetes: a randomized, placebo-controlled, dose-escalation safety and tolerability pilot study","volume":"38","author":"Skyler","year":"2015","journal-title":"Diabetes Care"},{"issue":"12","key":"10.1016\/j.jcyt.2023.12.006_bib0018","first-page":"1969","article-title":"Umbilical cord mesenchymal stem cell transfusion ameliorated hyperglycemia in patients with type 2 diabetes mellitus","volume":"60","author":"Kong","year":"2014","journal-title":"Clin Lab"},{"issue":"9","key":"10.1016\/j.jcyt.2023.12.006_bib0019","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3727\/096368913X665576","article-title":"Efficacy and safety of autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes mellitus: a randomized placebo-controlled study","volume":"23","author":"Bhansali","year":"2014","journal-title":"Cell Transplant"},{"issue":"3","key":"10.1016\/j.jcyt.2023.12.006_bib0020","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.3892\/etm.2016.3544","article-title":"Long term effect and safety of Wharton's jelly-derived mesenchymal stem cells on type 2 diabetes","volume":"12","author":"Hu","year":"2016","journal-title":"Exp Ther Med"},{"issue":"1","key":"10.1016\/j.jcyt.2023.12.006_bib0021","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13287-022-02848-6","article-title":"Efficacy and safety of umbilical cord-derived mesenchymal stem cells in Chinese adults with type 2 diabetes: a single-center, double-blinded, randomized, placebo-controlled phase II trial","volume":"13","author":"Zang","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2023.12.006_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.631463","article-title":"Stem cell-based clinical trials for diabetes mellitus","volume":"12","author":"de Klerk","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"22","key":"10.1016\/j.jcyt.2023.12.006_bib0023","first-page":"3622","article-title":"Autologous bone marrow stem cell transplantation for the treatment of type 2 diabetes mellitus","volume":"124","author":"Wang","year":"2011","journal-title":"Chin Med J (Engl)"},{"issue":"9","key":"10.1016\/j.jcyt.2023.12.006_bib0024","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/sctm.20-0506","article-title":"Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow\u2013derived mesenchymal stem\/stromal cells","volume":"10","author":"Nguyen","year":"2021","journal-title":"Stem Cells Transl Med"},{"issue":"6","key":"10.1016\/j.jcyt.2023.12.006_bib0025","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.2337\/db11-1141","article-title":"Infusion of mesenchymal stem cells ameliorates hyperglycemia in type 2 diabetic rats: identification of a novel role in improving insulin sensitivity","volume":"61","author":"Si","year":"2012","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/j.jcyt.2023.12.006_bib0026","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/sctm.20-0303","article-title":"Therapeutic potential of stem cells from human exfoliated deciduous teeth infusion into patients with type 2 diabetes depends on basal lipid levels and islet function","volume":"10","author":"Li","year":"2021","journal-title":"Stem Cells Transl Med"},{"issue":"5","key":"10.1016\/j.jcyt.2023.12.006_bib0027","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jcyt.2013.01.005","article-title":"Adipose tissue-derived mesenchymal stromal cells efficiently differentiate into insulin-producing cells in pancreatic islet microenvironment both in vitro and in vivo","volume":"15","author":"Karaoz","year":"2013","journal-title":"Cytotherapy"},{"issue":"5","key":"10.1016\/j.jcyt.2023.12.006_bib0028","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.bbamcr.2013.01.007","article-title":"Suppression of androgen receptor enhances the self-renewal of mesenchymal stem cells through elevated expression of EGFR","volume":"1833","author":"Huang","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"10.1016\/j.jcyt.2023.12.006_bib0029","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1002\/jcb.23098","article-title":"Body composition changes and inhibition of fat development in vivo implicates androgen in regulation of stem cell lineage allocation","volume":"112","author":"Semirale","year":"2011","journal-title":"J Cell Biochem"},{"issue":"6 Pt 1","key":"10.1016\/j.jcyt.2023.12.006_bib0030","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-2605.2010.01117.x","article-title":"Type 2 diabetes mellitus and testosterone: a meta-analysis study","volume":"34","author":"Corona","year":"2011","journal-title":"Int J Androl"},{"issue":"4","key":"10.1016\/j.jcyt.2023.12.006_bib0031","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1093\/biolre\/ioy017","article-title":"Elevated androgen levels induce hyperinsulinemia through increase in Ins1 transcription in pancreatic beta cells in female rats","volume":"98","author":"Mishra","year":"2018","journal-title":"Biol Reprod"},{"issue":"8","key":"10.1016\/j.jcyt.2023.12.006_bib0032","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrendo.2014.58","article-title":"Hyperinsulinaemic androgen excess in adolescent girls","volume":"10","author":"Ib\u00e1\u00f1ez","year":"2014","journal-title":"Nat Rev Endocrinol"},{"issue":"6","key":"10.1016\/j.jcyt.2023.12.006_bib0033","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s12015-021-10196-w","article-title":"Can autologous adipose-derived mesenchymal stem cell transplantation improve sexual function in people with sexual functional deficiency?","volume":"17","author":"Nguyen Thanh","year":"2021","journal-title":"Stem Cell Rev Rep"},{"issue":"10","key":"10.1016\/j.jcyt.2023.12.006_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164269","article-title":"The effect of gender on mesenchymal stem cell (MSC) efficacy in neonatal hyperoxia-induced lung injury","volume":"11","author":"Sammour","year":"2016","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.jcyt.2023.12.006_bib0035","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2337\/db15-1439","article-title":"Hypothyroidism impairs human stem cell-derived pancreatic progenitor cell maturation in mice","volume":"65","author":"Bruin","year":"2016","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.jcyt.2023.12.006_bib0036","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2014.09.040","article-title":"Generation of functional human pancreatic \u03b2 cells in vitro","volume":"159","author":"Pagliuca","year":"2014","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.jcyt.2023.12.006_bib0037","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1210\/jc.2015-2632","article-title":"MAFA and T3 drive maturation of both fetal human islets and insulin-producing cells differentiated from hESC","volume":"100","author":"Aguayo-Mazzucato","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1016\/j.jcyt.2023.12.006_bib0038","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nbt1259","article-title":"Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells","volume":"24","author":"D'Amour","year":"2006","journal-title":"Nat Biotechnol"},{"issue":"3","key":"10.1016\/j.jcyt.2023.12.006_bib0039","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.bbrc.2007.03.049","article-title":"Insulin-like growth factor 1 enhances the migratory capacity of mesenchymal stem cells","volume":"356","author":"Li","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.jcyt.2023.12.006_bib0040","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1210\/en.2013-1842","article-title":"Low-oxygen tension and IGF-I promote proliferation and multipotency of placental mesenchymal stem cells (PMSCs) from different gestations via distinct signaling pathways","volume":"155","author":"Youssef","year":"2014","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.jcyt.2023.12.006_bib0041","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2337\/db16-1356","article-title":"Glucocorticoids reprogram \u03b2-cell signaling to preserve insulin secretion","volume":"67","author":"Fine","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.jcyt.2023.12.006_bib0042","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3389\/fimmu.2020.00993","article-title":"Allogenic adipose tissue-derived stromal\/stem cells and vitamin d supplementation in patients with recent-onset type 1 diabetes mellitus: a 3-month follow-up pilot study","volume":"11","author":"Araujo","year":"2020","journal-title":"Front Immunol"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324924000021?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324924000021?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T01:52:00Z","timestamp":1761443520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324924000021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1465324924000021"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2023.12.006","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predictive factors that influence the clinical efficacy of umbilical cord\u2013derived mesenchymal stromal cells in the treatment of type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2023.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}