{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:55:03Z","timestamp":1785758103543,"version":"3.56.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","celltherapyjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.jcyt.2024.02.003","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T12:29:13Z","timestamp":1708000153000},"page":"490-497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of early cyclosporine A levels on acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation using in vivo T-cell depletion"],"prefix":"10.1016","volume":"26","author":[{"given":"Alexander","family":"Nikoloudis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Buxhofer-Ausch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Aichinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Hasengruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine","family":"Kaynak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Wipplinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Milanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Strassl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Stiefel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Machherndl-Spandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Petzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Weltermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-9706","authenticated-orcid":false,"given":"Johannes","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcyt.2024.02.003_bib0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0213913","article-title":"Cyclosporine A trough concentrations are associated with acute GvHD after non-myeloablative allogeneic hematopoietic cell transplantation","volume":"14","author":"de Kort","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0002","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/j.1432-2277.2012.01559.x","article-title":"The effect of cyclosporine initiation time on the outcome of matched allogeneic stem-cell transplantation following fludarabine-based conditioning","volume":"25","author":"Kedmi","year":"2012","journal-title":"Transpl Int"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0003","first-page":"305","article-title":"Assessment of cyclosporine serum concentrations on the incidence of acute graft versus host disease post hematopoietic stem cell transplantation","volume":"13","author":"Zeighami","year":"2014","journal-title":"Iran J Pharm Res"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0004","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbmt.2011.08.016","article-title":"Association between calcineurin inhibitor blood concentrations and outcomes after allogeneic hematopoietic cell transplantation","volume":"18","author":"Ram","year":"2012","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0005","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/bmt.2013.139","article-title":"Higher therapeutic CsA levels early post transplantation reduce risk of acute GVHD and improves survival","volume":"49","author":"Rogosheske","year":"2014","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0006","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbmt.2009.08.010","article-title":"Impact of cyclosporine-A concentration on the incidence of severe acute graft-versus-host disease after allogeneic stem cell transplantation","volume":"16","author":"Malard","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0007","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1007\/s00277-018-3577-1","article-title":"Cyclosporine levels >195 \u03bcg\/L on day 10 post-transplant was associated with significantly reduced acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation","volume":"98","author":"Bianchi","year":"2019","journal-title":"Ann Hematol"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0008","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1056\/NEJM198807143190201","article-title":"Serum cyclosporine concentration and risk of acute graft-versus-host disease after allogeneic marrow transplantation","volume":"319","author":"Yee","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0009","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41409-022-01598-6","article-title":"Optimized cyclosporine starting dose may reduce risk of acute GvHD after allogeneic hematopoietic cell transplantation: a single-center cohort study","volume":"57","author":"H\u00e9ritier","year":"2022","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0010","doi-asserted-by":"crossref","first-page":"e14732","DOI":"10.1111\/ctr.14732","article-title":"Toward optimization of cyclosporine concentration target to prevent acute graft-versus-host disease following myeloablative allogeneic stem cell transplant","volume":"36","author":"Kwan","year":"2022","journal-title":"Clin Transplant"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0011","doi-asserted-by":"crossref","first-page":"59892","DOI":"10.18632\/oncotarget.10988","article-title":"Blood concentration of cyclosporine during early post-transplant period may have influence on the occurrence of chronic graft versus host disease in patients who received allogeneic hematopoietic stem cell transplantation","volume":"7","author":"Park","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0012","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/bmt.2010.187","article-title":"Cyclosporine levels and rate of graft rejection following non-myeloablative conditioning for allogeneic hematopoietic SCT","volume":"46","author":"Gerull","year":"2011","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0013","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.bbmt.2016.06.001","article-title":"Analysis of cyclosporine A levels supports new dosing guidelines in adult double-unit cord blood transplant recipients to optimize immunosuppression early post-transplant","volume":"22","author":"Bhatt","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0014","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1016\/S2352-3026(19)30256-X","article-title":"Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation","volume":"7","author":"Penack","year":"2020","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0015","first-page":"825","article-title":"1994 consensus conference on acute GVHD grading","volume":"15","author":"Przepiorka","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0016","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0002-9343(80)90380-0","article-title":"Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients","volume":"69","author":"Shulman","year":"1980","journal-title":"Am J Med"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0017","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bbmt.2005.09.004","article-title":"National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report","volume":"11","author":"Filipovich","year":"2005","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0018","doi-asserted-by":"crossref","first-page":"686.e1","DOI":"10.1016\/j.jtct.2021.04.028","article-title":"Relapse protection following early cytomegalovirus reactivation after hematopoietic stem cell transplantation is limited to HLA-C killer cell immunoglobulin-like receptor ligand homozygous recipients","volume":"27","author":"Nikoloudis","year":"2021","journal-title":"Transplantation and Cellular Therapy"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0019","doi-asserted-by":"crossref","first-page":"22777","DOI":"10.1038\/s41598-023-50105-4","article-title":"Higher cyclosporine-A concentration increases the risk of relapse in AML following allogeneic stem cell transplantation from unrelated donors using anti-thymocyte globulin","volume":"13","author":"Lisak","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3390\/transplantology4010005","article-title":"Comparison of benefits and risks associated with anti-T-lymphocyte globulin (ATLG) serotherapy in methotrexate (MTX)- versus mycophenolate mofetil (MMF)-based hematopoietic stem cell transplantation","volume":"4","author":"Nikoloudis","year":"2023","journal-title":"Transplantology"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0021","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/sj.bmt.1704960","article-title":"Optimal initial dose of oral cyclosporine in relation to its toxicities for graft-versus-host disease prophylaxis following reduced-intensity stem cell transplantation in Japanese patients","volume":"35","author":"Kishi","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.jcyt.2024.02.003_bib0022","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00007890-198502000-00005","article-title":"Cyclosporine plasma levels in renal transplant patients. Association with renal toxicity and allograft rejection","volume":"39","author":"Klintmalm","year":"1985","journal-title":"Transplantation"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324924000495?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324924000495?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T13:39:37Z","timestamp":1714484377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324924000495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S1465324924000495"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2024.02.003","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of early cyclosporine A levels on acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation using in vivo T-cell depletion","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2024.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Society for Cell & Gene Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}