{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:26:51Z","timestamp":1778297211803,"version":"3.51.4"},"reference-count":79,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,10]],"date-time":"2024-03-10T00:00:00Z","timestamp":1710028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","celltherapyjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jcyt.2024.03.004","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T08:05:47Z","timestamp":1710230747000},"page":"790-796","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Programmed spontaneously beating cardiomyocytes in regenerative cardiology"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0024-6472","authenticated-orcid":false,"given":"Keiko","family":"Inouye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Yeganyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4744-325X","authenticated-orcid":false,"given":"Kaelen","family":"Kay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7285-9808","authenticated-orcid":false,"given":"Finosh G.","family":"Thankam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcyt.2024.03.004_bib0001","unstructured":"Mechanic OJ, Gavin M, Grossman SA. Acute myocardial infarction. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459269\/ [accessed 08.11.23]."},{"key":"10.1016\/j.jcyt.2024.03.004_bib0002","doi-asserted-by":"crossref","first-page":"S144","DOI":"10.1038\/sj.cdd.4401544","article-title":"Functional and clinical repercussions of myocyte apoptosis in the multifaceted damage by ischemia\/reperfusion injury: old and new concepts after 10 years of contributions","volume":"11","author":"Scarabelli","year":"2004","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0003","doi-asserted-by":"crossref","first-page":"s008","DOI":"10.1007\/s003950050195","article-title":"Apoptosis and myocardial infarction","volume":"93","author":"Anversa","year":"1998","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0004","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1161\/01.CIR.96.5.1696","article-title":"Complex causes of fatal myocardial infarction","volume":"96","author":"James","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0005","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/01.CIR.95.2.320","article-title":"Apoptosis in human acute myocardial infarction","volume":"95","author":"Saraste","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0006","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1749-6632.1999.tb09255.x","article-title":"Apoptosis in myocardial ischemia-reperfusion","volume":"874","author":"Gottlieb","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0007","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/medicina44110107","article-title":"Cardiomyocyte remodeling in ischemic heart disease","volume":"44","author":"Pangonyt\u0117","year":"2008","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0008","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00125-003-1311-5","article-title":"Sustained cardiomyocyte apoptosis and left ventricular remodelling after myocardial infarction in experimental diabetes","volume":"47","author":"B\u00e4cklund","year":"2004","journal-title":"Diabetologia"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0009","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1161\/01.CIR.0000074225.62168.68","article-title":"Inhibition of granulation tissue cell apoptosis during the subacute stage of myocardial infarction improves cardiac remodeling and dysfunction at the chronic stage","volume":"108","author":"Hayakawa","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0010","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/01.CIR.97.3.276","article-title":"Attenuation of ischemia\/reperfusion injury in rats by a caspase inhibitor","volume":"97","author":"Yaoita","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2004.07.005","article-title":"Role of apoptosis in remodeling after myocardial infarction","volume":"104","author":"Takemura","year":"2004","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12717\/DR.2017.21.1.001","article-title":"Usage of human mesenchymal stem cells in cell-based therapy: advantages and disadvantages","volume":"21","author":"Kim","year":"2017","journal-title":"Dev Reprod"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0013","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13287-017-0483-8","article-title":"Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy","volume":"8","author":"Varghese","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0014","doi-asserted-by":"crossref","first-page":"41781","DOI":"10.1038\/srep41781","article-title":"Obtaining spontaneously beating cardiomyocyte-like cells from adipose-derived stromal vascular fractions cultured on enzyme-crosslinked gelatin hydrogels","volume":"7","author":"Yang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0015","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/s41598-020-80848-3","article-title":"Myocyte-specific enhancer factor 2c triggers transdifferentiation of adipose tissue-derived stromal cells into spontaneously beating cardiomyocyte-like cells","volume":"11","author":"Takashima","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0016","first-page":"280","article-title":"Cardiomyocyte senescence and cellular communications within myocardial microenvironments","volume":"11","author":"Tang","year":"2020"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0017","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/hh1101.091193","article-title":"Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness","volume":"88","author":"Pogwizd","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0018","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1152\/physrev.00006.2004","article-title":"Myocardial substrate metabolism in the normal and failing heart","volume":"85","author":"Stanley","year":"2005","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0019","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1056\/NEJMra063052","article-title":"The failing heart\u2014an engine out of fuel","volume":"356","author":"Neubauer","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0020","first-page":"364","article-title":"Comprehensive quantification of fuel use by the failing and nonfailing human heart","volume":"370","author":"Murashige","year":"2020","journal-title":"Science (1979)"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0021","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/cvr\/cvn280","article-title":"Mitochondrial oxidative stress and dysfunction in myocardial remodelling","volume":"81","author":"Tsutsui","year":"2009","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0022","first-page":"177","article-title":"Mitochondria and metabolic transitions in cardiomyocytes: lessons from development for stem cell-derived cardiomyocytes","volume":"12","author":"Garbern","year":"2021"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0023","first-page":"1086","article-title":"Cardiomyocyte maturation: new phase in development","volume":"126","author":"Guo","year":"2020"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0024","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/ajmg.a.35896","article-title":"Development of the human heart","volume":"164","author":"Sylva","year":"2014","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ajmg.c.31778","article-title":"Development of the human heart","volume":"184","author":"Buijtendijk","year":"2020","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0026","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1242\/dev.091538","article-title":"How to make a cardiomyocyte","volume":"141","author":"Sp\u00e4ter","year":"2014","journal-title":"Development (Cambridge)"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0027","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00246-010-9642-8","article-title":"Development of the endocardium","volume":"31","author":"Harris","year":"2010","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0028","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000501906","article-title":"The transitional heart: from early embryonic and fetal development to neonatal life","volume":"47","author":"Tan","year":"2020","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0029","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1006\/jmcc.1996.0163","article-title":"Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development","volume":"28","author":"Li","year":"1996","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0030","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/j.1582-4934.2010.01009.x","article-title":"Differentiation of human adipose-derived stem cells into beating cardiomyocytes","volume":"14","author":"Choi","year":"2010","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0031","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.3390\/cells12131727","article-title":"Human stem cells for cardiac disease modeling and preclinical and clinical applications\u2014are we on the road to success?","volume":"12","author":"Correia","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0032","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41421-022-00446-7","article-title":"Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells","volume":"8","author":"Li","year":"2022","journal-title":"Cell Discov"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0033","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nature11044","article-title":"In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes","volume":"485","author":"Qian","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0034","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/s13287-017-0681-4","article-title":"Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cells","volume":"8","author":"Schweizer","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0035","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1161\/01.RES.0000109792.43271.47","article-title":"Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells","volume":"94","author":"Planat-B\u00e9nard","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0036","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/scd.2010.0519","article-title":"5-azacytidine induces cardiac differentiation of human umbilical cord-derived mesenchymal stem cells by activating extracellular regulated kinase","volume":"21","author":"Qian","year":"2012","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0037","first-page":"1","article-title":"5-azacytidine-induced cardiomyocyte differentiation of very small embryonic-like stem cells","volume":"2020","author":"Sun","year":"2020","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0038","doi-asserted-by":"crossref","first-page":"11384","DOI":"10.1074\/jbc.M310822200","article-title":"Adult cardiac sca-1-positive cells differentiate into beating cardiomyocytes","volume":"279","author":"Matsuura","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0039","doi-asserted-by":"crossref","first-page":"9550","DOI":"10.1073\/pnas.152302499","article-title":"Oxytocin induces differentiation of P19 embryonic stem cells to cardiomyocytes","volume":"99","author":"Paquin","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0040","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3390\/nu13010275","article-title":"The potential properties of natural compounds in cardiac stem cell activation: their role in myocardial regeneration","volume":"13","author":"Carresi","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0041","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.yjmcc.2015.01.013","article-title":"Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells","volume":"81","author":"Kim","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0042","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200448","article-title":"Mitochondrial Ca2+ flux modulates spontaneous electrical activity in ventricular cardiomyocytes","volume":"13","author":"Xie","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0043","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.ceca.2015.02.003","article-title":"Regionally diverse mitochondrial calcium signaling regulates spontaneous pacing in developing cardiomyocytes","volume":"57","author":"Zhang","year":"2015","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0044","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1003684","article-title":"Stem cell-derived extracellular vesicles reduce the expression of molecules involved in cardiac hypertrophy\u2014in a model of human-induced pluripotent stem cell-derived cardiomyocytes","volume":"13","author":"Constantin","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0045","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/CIRCRESAHA.110.221531","article-title":"The multiple phases and faces of Wnt signaling during cardiac differentiation and development","volume":"107","author":"Gessert","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0046","doi-asserted-by":"crossref","first-page":"19389","DOI":"10.1038\/s41598-019-55620-x","article-title":"Deciphering role of Wnt signalling in cardiac mesoderm and cardiomyocyte differentiation from human iPSCs: four-dimensional control of Wnt pathway for hiPSC-CMs differentiation","volume":"9","author":"Zhao","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0047","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/stem.3106","article-title":"Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells","volume":"38","author":"Liang","year":"2020","journal-title":"Stem Cells (1981)"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0048","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.yjmcc.2007.06.012","article-title":"Non-canonical Wnt signaling enhances differentiation of Sca1+\/c-kit+ adipose-derived murine stromal vascular cells into spontaneously beating cardiac myocytes","volume":"43","author":"Palpant","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0049","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/cvr\/cvp267","article-title":"Spontaneously beating cardiomyocytes derived from white mature adipocytes","volume":"85","author":"Jumabay","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0050","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s12015-014-9564-6","article-title":"Robust generation of cardiomyocytes from human iPS cells requires precise modulation of BMP and WNT signaling","volume":"11","author":"Kadari","year":"2015","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0051","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijcard.2009.08.021","article-title":"Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin","volume":"147","author":"Wiese","year":"2011","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0052","doi-asserted-by":"crossref","first-page":"15014","DOI":"10.1038\/srep15014","article-title":"Directed differentiation of embryonic stem cells into cardiomyocytes by bacterial injection of defined transcription factors","volume":"5","author":"Bai","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0053","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41392-020-00413-2","article-title":"Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration","volume":"6","author":"Gong","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0054","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biocel.2015.06.008","article-title":"Gata4, Tbx5 and Baf60c induce differentiation of adipose tissue-derived mesenchymal stem cells into beating cardiomyocytes","volume":"66","author":"Li","year":"2015","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0055","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1161\/CIRCULATIONAHA.122.059713","article-title":"TBX20 improves contractility and mitochondrial function during direct human cardiac reprogramming","volume":"146","author":"Tang","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0056","doi-asserted-by":"crossref","first-page":"10312","DOI":"10.1038\/ncomms10312","article-title":"Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes","volume":"7","author":"Eng","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0057","doi-asserted-by":"crossref","DOI":"10.1002\/admt.202100669","article-title":"Effect of electrical stimulation on spontaneously beating dynamics of cardiac tissues: an analysis using digital image correlation","volume":"6","author":"Lou","year":"2021","journal-title":"Adv Mater Technol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0058","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/nmeth.2524","article-title":"Biowire: a platform for maturation of human pluripotent stem cell\u2013derived cardiomyocytes","volume":"10","author":"Nunes","year":"2013","journal-title":"Nat Methods"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0059","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.addr.2015.07.009","article-title":"Electrical and mechanical stimulation of cardiac cells and tissue constructs","volume":"96","author":"Stoppel","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0060","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1161\/CIRCRESAHA.108.192237","article-title":"Functional cardiomyocytes derived from human induced pluripotent stem cells","volume":"104","author":"Zhang","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0061","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1089\/ars.2016.6766","article-title":"Electrical stimulation enhances cardiac differentiation of human induced pluripotent stem cells for myocardial infarction therapy","volume":"28","author":"Ma","year":"2018","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0062","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/term.1870","article-title":"Advances in tissue engineering through stem cell-based co-culture","volume":"9","author":"Paschos","year":"2015","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0063","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1161\/01.CIR.0000068356.38592.68","article-title":"Differentiation of human embryonic stem cells to cardiomyocytes","volume":"107","author":"Mummery","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0064","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fmolb.2020.00014","article-title":"3D co-culture of hiPSC-derived cardiomyocytes with cardiac fibroblasts improves tissue-like features of cardiac spheroids","volume":"7","author":"Beauchamp","year":"2020","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0230966","article-title":"Co-culture of induced pluripotent stem cells with cardiomyocytes is sufficient to promote their differentiation into cardiomyocytes","volume":"15","author":"Chu","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0066","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1002\/jcb.23283","article-title":"Three-dimensional co-culture facilitates the differentiation of embryonic stem cells into mature cardiomyocytes","volume":"112","author":"Ou","year":"2011","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0067","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1161\/CIRCULATIONAHA.122.061736","article-title":"Combined treatment of human induced pluripotent stem cell\u2013derived cardiomyocytes and endothelial cells regenerate the infarcted heart in mice and non-human primates","volume":"148","author":"Cheng","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0068","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.653127","article-title":"Cardiac tissue engineering: inclusion of non-cardiomyocytes for enhanced features","volume":"9","author":"Munawar","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0069","doi-asserted-by":"crossref","first-page":"H771","DOI":"10.1152\/ajpheart.00110.2018","article-title":"Engineering cardiac microphysiological systems to model pathological extracellular matrix remodeling","volume":"315","author":"Ariyasinghe","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0070","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.actbio.2021.08.031","article-title":"Electroconductive biomaterials for cardiac tissue engineering","volume":"139","author":"Esmaeili","year":"2022","journal-title":"Acta Biomater"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0071","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1021\/nn305559j","article-title":"Carbon-nanotube-embedded hydrogel sheets for engineering cardiac constructs and bioactuators","volume":"7","author":"Shin","year":"2013","journal-title":"ACS Nano"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0072","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201803951","article-title":"Electroconductive biohybrid hydrogel for enhanced maturation and beating properties of engineered cardiac tissues","volume":"28","author":"Roshanbinfar","year":"2018","journal-title":"Adv Funct Mater"},{"issue":"Suppl 1","key":"10.1016\/j.jcyt.2024.03.004_bib0073","first-page":"71","article-title":"Differentiation of cardiomyocytes from human pluripotent stem cells using monolayer culture","volume":"10","author":"Batalov","year":"2015","journal-title":"Biomark Insights"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0074","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.ymthe.2018.02.026","article-title":"Pluripotent stem cell-derived cardiomyocytes as a platform for cell therapy applications: progress and hurdles for clinical translation","volume":"26","author":"Oikonomopoulos","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0075","doi-asserted-by":"crossref","first-page":"130ra47","DOI":"10.1126\/scitranslmed.3003552","article-title":"Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy","volume":"4","author":"Sun","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0076","article-title":"Advances in hypertrophic cardiomyopathy disease modeling using human iPSC-derived cardiomyocytes","author":"Dababneh","year":"2023","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0077","doi-asserted-by":"crossref","first-page":"eaaf2584","DOI":"10.1126\/scitranslmed.aaf2584","article-title":"High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells","volume":"9","author":"Sharma","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0078","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/scrt380","article-title":"Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening","volume":"4","author":"Sharma","year":"2013","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2024.03.004_bib0079","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3390\/bioengineering10020237","article-title":"The exciting realities and possibilities of iPS-derived cardiomyocytes","volume":"10","author":"Takahashi","year":"2023","journal-title":"Bioengineering"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324924000938?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324924000938?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T18:57:36Z","timestamp":1721674656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324924000938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":79,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1465324924000938"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2024.03.004","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Programmed spontaneously beating cardiomyocytes in regenerative cardiology","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2024.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Society for Cell & Gene Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}