{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:31:11Z","timestamp":1791361871206,"version":"4.3.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Shenzhen Science and Technology Innovation Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","celltherapyjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.jcyt.2024.03.008","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:22:58Z","timestamp":1710462178000},"page":"930-938","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Human embryonic stem cell\u2013derived mesenchymal stromal cells suppress inflammation in mouse models of rheumatoid arthritis and lung fibrosis by regulating T-cell function"],"prefix":"10.1016","volume":"26","author":[{"given":"Yan","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8509-0572","authenticated-orcid":false,"given":"Jingfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.jcyt.2024.03.008_bib0001","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"Jama"},{"issue":"4","key":"10.1016\/j.jcyt.2024.03.008_bib0002","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/rheumatology\/ker370","article-title":"Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing","volume":"51","author":"Li","year":"2012","journal-title":"Rheumatology (Oxford, England)"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0003","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41584-020-00541-7","article-title":"Persistent inflammatory and non-inflammatory mechanisms in refractory rheumatoid arthritis","volume":"17","author":"Buch","year":"2021","journal-title":"Nature reviews Rheumatology"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0004","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis","volume":"15","author":"Chen","year":"2019","journal-title":"Nature reviews Rheumatology"},{"issue":"10086","key":"10.1016\/j.jcyt.2024.03.008_bib0005","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel treatment strategies in rheumatoid arthritis","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102425","article-title":"Insights into the treatment of rheumatoid arthritis: a paradigm in medicine","volume":"110","author":"Smolen","year":"2020","journal-title":"Journal of autoimmunity"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0007","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/ard-2022-223356","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update","volume":"82","author":"Smolen","year":"2023","journal-title":"Annals of the rheumatic diseases"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0008","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41392-022-01134-4","article-title":"Stem cell-based therapy for human diseases","volume":"7","author":"Hoang","year":"2022","journal-title":"Signal transduction and targeted therapy"},{"issue":"30","key":"10.1016\/j.jcyt.2024.03.008_bib0009","doi-asserted-by":"crossref","first-page":"eaba6884","DOI":"10.1126\/sciadv.aba6884","article-title":"Shattering barriers toward clinically meaningful MSC therapies","volume":"6","author":"Levy","year":"2020","journal-title":"Science advances"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13287-021-02265-1","article-title":"Mesenchymal stem\/stromal cells as a valuable source for the treatment of immune-mediated disorders","volume":"12","author":"Markov","year":"2021","journal-title":"Stem cell research & therapy"},{"issue":"3","key":"10.1016\/j.jcyt.2024.03.008_bib0011","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2478\/jtim-2021-0037","article-title":"Repair of damaged pancreatic \u03b2 cells: new hope for a type 2 diabetes reversal?","volume":"9","author":"Wang","year":"2021","journal-title":"Journal of translational internal medicine"},{"issue":"4","key":"10.1016\/j.jcyt.2024.03.008_bib0012","doi-asserted-by":"crossref","first-page":"692","DOI":"10.14218\/JCTH.2021.00353","article-title":"Pluripotent stem cell-derived strategies to treat acute liver failure: current status and future directions","volume":"10","author":"Liu","year":"2022","journal-title":"Journal of clinical and translational hepatology"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0013","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41392-021-00754-6","article-title":"Mesenchymal stem cell therapy for severe COVID-19","volume":"6","author":"Shi","year":"2021","journal-title":"Signal transduction and targeted therapy"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0014","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2478\/jtim-2022-0028","article-title":"Mesenchymal stem cells and connective tissue diseases: from bench to bedside","volume":"11","author":"Shi","year":"2022","journal-title":"Journal of translational internal medicine"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0015","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1749-6632.2012.06551.x","article-title":"Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets","volume":"1266","author":"Sivasubramaniyan","year":"2012","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"7","key":"10.1016\/j.jcyt.2024.03.008_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17071164","article-title":"Senescence in human mesenchymal stem cells: functional changes and implications in stem cell-based therapy","volume":"17","author":"Turinetto","year":"2016","journal-title":"International journal of molecular sciences"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0017","doi-asserted-by":"crossref","first-page":"143","DOI":"10.7150\/thno.57234","article-title":"Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal stromal cells after hypoxic-ischaemic brain damage","volume":"12","author":"Huang","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0018","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s13287-020-01769-6","article-title":"Recovery of ovarian function by human embryonic stem cell-derived mesenchymal stem cells in cisplatin-induced premature ovarian failure in mice","volume":"11","author":"Yoon","year":"2020","journal-title":"Stem cell research & therapy"},{"issue":"11","key":"10.1016\/j.jcyt.2024.03.008_bib0019","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1136\/annrheumdis-2018-213511","article-title":"Maresin 1 improves the Treg\/Th17 imbalance in rheumatoid arthritis through miR-21","volume":"77","author":"Jin","year":"2018","journal-title":"Annals of the rheumatic diseases"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0020","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.572858","article-title":"Th17\/Treg-related transcriptional factor expression and cytokine profile in patients with rheumatoid arthritis","volume":"11","author":"Paradowska-Gorycka","year":"2020","journal-title":"Frontiers in immunology"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102376","article-title":"Treg cells in health and autoimmune diseases: new insights from single cell analysis","volume":"110","author":"Scheinecker","year":"2020","journal-title":"Journal of autoimmunity"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0022","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fmed.2020.00025","article-title":"Regulatory T cell suppressive activity predicts disease relapse during disease-modifying anti-rheumatic drug dose reduction in rheumatoid arthritis: a prospective cohort study","volume":"7","author":"Kanjana","year":"2020","journal-title":"Frontiers in medicine"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0023","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7262065","article-title":"Risk factors and changes of peripheral NK and T cells in pulmonary interstitial fibrosis of patients with rheumatoid arthritis","volume":"2019","author":"Lai","year":"2019","journal-title":"Canadian respiratory journal"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.scr.2020.102010","article-title":"Repair of acute liver damage with immune evasive hESC derived hepato-blasts","volume":"49","author":"Liu","year":"2020","journal-title":"Stem cell research"},{"issue":"5","key":"10.1016\/j.jcyt.2024.03.008_bib0025","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/stem.2964","article-title":"Concise review: mesenchymal stem cells derived from human pluripotent cells, an unlimited and quality-controllable source for therapeutic applications","volume":"37","author":"Jiang","year":"2019","journal-title":"Stem cells (Dayton, Ohio)"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153678","article-title":"Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc\/HIF-1\u03b1 pathway","volume":"91","author":"Liu","year":"2021","journal-title":"Phytomedicine : international journal of phytotherapy and phytopharmacology"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106063","article-title":"Novel isatin-based hybrids as potential anti-rheumatoid arthritis drug candidates: Synthesis and biological evaluation","volume":"128","author":"Chen","year":"2022","journal-title":"Bioorganic chemistry"},{"issue":"11","key":"10.1016\/j.jcyt.2024.03.008_bib0028","doi-asserted-by":"crossref","first-page":"4229","DOI":"10.1158\/0008-5472.CAN-07-5272","article-title":"Long-term in vitro expansion alters the biology of adult mesenchymal stem cells","volume":"68","author":"Izadpanah","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0029","article-title":"Mesenchymal stem cells promote the osteogenesis in collagen-induced arthritic mice through the inhibition of TNF-\u03b1","author":"Liu","year":"2018","journal-title":"Stem Cells Int"},{"issue":"10","key":"10.1016\/j.jcyt.2024.03.008_bib0030","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrrheum.2010.143","article-title":"The yin and yang of regulatory T cells and inflammation in RA","volume":"6","author":"Notley","year":"2010","journal-title":"Nature reviews Rheumatology"},{"issue":"9","key":"10.1016\/j.jcyt.2024.03.008_bib0031","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s13238-016-0297-y","article-title":"Obacunone activates the Nrf2-dependent antioxidant responses","volume":"7","author":"Xu","year":"2016","journal-title":"Protein Cell"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0032","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s13238-019-00665-x","article-title":"Functions of p53 in pluripotent stem cells","volume":"11","author":"Fu","year":"2020","journal-title":"Protein Cell"},{"issue":"11","key":"10.1016\/j.jcyt.2024.03.008_bib0033","doi-asserted-by":"crossref","first-page":"20801","DOI":"10.1002\/jcp.28686","article-title":"Norepinephrine protects against apoptosis of mesenchymal stem cells induced by high glucose","volume":"234","author":"Kong","year":"2019","journal-title":"J Cell Physiol"},{"issue":"4","key":"10.1016\/j.jcyt.2024.03.008_bib0034","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/14653249.2011.652735","article-title":"Dexamethasone has variable effects on mesenchymal stromal cells","volume":"14","author":"Wang","year":"2012","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.jcyt.2024.03.008_bib0035","doi-asserted-by":"crossref","first-page":"60","DOI":"10.5483\/BMBRep.2023-0113","article-title":"Highly efficient genome editing via CRISPR-Cas9 ribonucleoprotein (RNP) delivery in mesenchymal stem cells","volume":"57","author":"Han","year":"2024","journal-title":"BMB Rep"},{"issue":"39","key":"10.1016\/j.jcyt.2024.03.008_bib0036","doi-asserted-by":"crossref","first-page":"32338","DOI":"10.1074\/jbc.M112.383810","article-title":"A scalable approach to prevent teratoma formation of human embryonic stem cells","volume":"287","author":"Rong","year":"2012","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.jcyt.2024.03.008_bib0037","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/stem.2568","article-title":"A safety checkpoint to eliminate cancer risk of the immune evasive cells derived from human embryonic stem cells","volume":"35","author":"He","year":"2017","journal-title":"Stem Cells (Dayton, Ohio)"},{"issue":"4","key":"10.1016\/j.jcyt.2024.03.008_bib0038","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s13238-012-2922-8","article-title":"The genomic stability of induced pluripotent stem cells","volume":"3","author":"Chen","year":"2012","journal-title":"Protein Cell"},{"issue":"7350","key":"10.1016\/j.jcyt.2024.03.008_bib0039","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nature10135","article-title":"Immunogenicity of induced pluripotent stem cells","volume":"474","author":"Zhao","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.jcyt.2024.03.008_bib0040","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3389\/fimmu.2017.00645","article-title":"The immunogenicity and immune tolerance of pluripotent stem cell derivatives","volume":"8","author":"Liu","year":"2017","journal-title":"Frontiers in immunology"},{"issue":"5","key":"10.1016\/j.jcyt.2024.03.008_bib0041","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/stem.1066","article-title":"Concise review: Immune recognition of induced pluripotent stem cells","volume":"30","author":"Boyd","year":"2012","journal-title":"Stem cells (Dayton, Ohio)."},{"issue":"3","key":"10.1016\/j.jcyt.2024.03.008_bib0042","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tcb.2009.12.004","article-title":"p53 and stem cells: new developments and new concerns","volume":"20","author":"Zhao","year":"2010","journal-title":"Trends Cell Biol"},{"issue":"3","key":"10.1016\/j.jcyt.2024.03.008_bib0043","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.stem.2015.07.021","article-title":"Humanized mice reveal differential immunogenicity of cells derived from autologous induced pluripotent stem cells","volume":"17","author":"Zhao","year":"2015","journal-title":"Cell Stem Cell"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324924000963?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324924000963?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T14:57:22Z","timestamp":1721660242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324924000963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["S1465324924000963"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2024.03.008","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human embryonic stem cell\u2013derived mesenchymal stromal cells suppress inflammation in mouse models of rheumatoid arthritis and lung fibrosis by regulating T-cell function","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2024.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}