{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:44:05Z","timestamp":1789512245113,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100019408","name":"The Marcus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019408","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007623","name":"School of Medicine, Emory University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007623","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012423","name":"Children&apos;s Healthcare of Atlanta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002378"],"award-info":[{"award-number":["UL1TR002378"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jcyt.2025.07.008","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:17:55Z","timestamp":1760541475000},"page":"101967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Single cell transcriptional profiling of monocytes from asthma patients show a predisposition for an inflammatory response"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-9998","authenticated-orcid":false,"given":"Kyndal","family":"Goss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-5889","authenticated-orcid":false,"given":"Melanie L.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokesh","family":"Guglani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik J.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2154-1162","authenticated-orcid":false,"given":"Cherish","family":"Caldwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-5926","authenticated-orcid":false,"given":"Anne M.","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3751-4027","authenticated-orcid":false,"given":"Edwin M.","family":"Horwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jcyt.2025.07.008_bib0001","first-page":"1","volume":"26","year":"2022","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0002","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1513\/AnnalsATS.202109-1068CME","article-title":"Asthma in the Americas: an update: a joint perspective from the Brazilian Thoracic Society, Canadian Thoracic Society, Latin American Thoracic Society, and American Thoracic Society","volume":"19","author":"Forno","year":"2022","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0003","article-title":"Biologic therapies targeting type 2 cytokines are effective at improving asthma symptoms and control-a systematic review and meta-analysis","volume":"4","author":"Bignold","year":"2025","journal-title":"J Allergy Clin Immunol Glob"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0004","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/17476348.2023.2226392","article-title":"Defining response to therapy with biologics in severe asthma: from global evaluation to super response and remission","volume":"17","author":"Papaioannou","year":"2023","journal-title":"Expert Rev Respir Med"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0005","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/14712598.2024.2302583","article-title":"Decoding treatment efficacy: uncovering response and failure dynamics to biologics in asthma","volume":"24","author":"Al Meslamani","year":"2024","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0006","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1042\/CS20220531","article-title":"M1\/M2 macrophages and their overlaps - myth or reality?","volume":"137","author":"Strizova","year":"2023","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0007","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.753940","article-title":"Diversity of macrophages in lung homeostasis and diseases","volume":"12","author":"Hou","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0008","doi-asserted-by":"crossref","first-page":"eabq6352","DOI":"10.1126\/sciimmunol.abq6352","article-title":"A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma","volume":"8","author":"Alladina","year":"2023","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0009","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1159\/000324297","article-title":"Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function","volume":"81","author":"Poliska","year":"2011","journal-title":"Respiration"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0010","unstructured":"Butler A, Darby C, Hao Y, Hartman A, Hoffman P, Molla G, et al. (2023). Azimuth: a shiny app demonstrating a query-reference mapping algorithm for single-cell data. Available online at https:\/\/github.com\/satijalab\/azimuth. [accessed 10.04.2025]."},{"key":"10.1016\/j.jcyt.2025.07.008_bib0011","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated analysis of multimodal single-cell data","volume":"184","author":"Hao","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0012","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.gpb.2020.07.004","article-title":"Evaluation of cell type annotation R packages on single-cell RNA-seq data","volume":"19","author":"Huang","year":"2021","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0013","article-title":"The Gene Ontology knowledgebase in 2023","volume":"224","author":"Gene Ontology","year":"2023","journal-title":"Genetics"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0014","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/gene.2009.83","article-title":"Regulation of major histocompatibility complex class II gene expression, genetic variation and disease","volume":"11","author":"Handunnetthi","year":"2010","journal-title":"Genes Immun"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1130214","article-title":"Utility of monocyte HLA-DR and rationale for therapeutic GM-CSF in sepsis immunoparalysis","volume":"14","author":"Joshi","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0017","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.3389\/fimmu.2019.01147","article-title":"The CD14(+)HLA-DR(lo\/neg) monocyte: an immunosuppressive phenotype that restrains responses to cancer immunotherapy","volume":"10","author":"Mengos","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.574027","article-title":"Insights into type I and III interferons in asthma and exacerbations","volume":"11","author":"Rich","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0019","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri.2017.28","article-title":"Monocyte differentiation and antigen-presenting functions","volume":"17","author":"Jakubzick","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0020","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/MOT.0000000000000313","article-title":"Role of monocytes and macrophages in regulating immune response following lung transplantation","volume":"21","author":"Chiu","year":"2016","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0021","doi-asserted-by":"crossref","first-page":"L350","DOI":"10.1152\/ajplung.00061.2004","article-title":"CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels","volume":"288","author":"Maus","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0022","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1371\/journal.pone.0000031","article-title":"Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes","volume":"1","author":"Nagaev","year":"2006","journal-title":"PLoS One"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0023","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/sji.12464","article-title":"Resistin gene expression is downregulated in CD4(+) T helper lymphocytes and CD14(+) monocytes in rheumatoid arthritis responding to TNF-alpha inhibition","volume":"84","author":"Nagaev","year":"2016","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0024","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jaip.2019.11.006","article-title":"T2-\"low\" asthma: overview and management strategies","volume":"8","author":"Fitzpatrick","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0025","doi-asserted-by":"crossref","DOI":"10.1111\/imr.70016","article-title":"Innate immunity and asthma exacerbations: insights from human models","volume":"330","author":"Alladina","year":"2025","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0026","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jaip.2022.01.006","article-title":"Rhinovirus infections and their roles in asthma: etiology and exacerbations","volume":"10","author":"Jackson","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0027","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12964-017-0177-y","article-title":"The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells","volume":"15","author":"Seif","year":"2017","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0028","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1016\/j.celrep.2015.11.055","article-title":"Type I interferon transcriptional signature in neutrophils and low-density granulocytes are associated with tissue damage in malaria","volume":"13","author":"Rocha","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0029","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/cea.13481","article-title":"Rhinovirus-16 induced temporal interferon responses in nasal epithelium links with viral clearance and symptoms","volume":"49","author":"Ravi","year":"2019","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0030","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jaci.2018.09.016","article-title":"Interferon-induced epithelial response to rhinovirus 16 in asthma relates to inflammation and FEV(1)","volume":"143","author":"Ravi","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0031","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1136\/thoraxjnl-2021-217389","article-title":"In vivo bronchial epithelial interferon responses are augmented in asthma on day 4 following experimental rhinovirus infection","volume":"77","author":"Farne","year":"2022","journal-title":"Thorax"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0032","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00006-2017","article-title":"IFN-alpha\/IFN-lambda responses to respiratory viruses in paediatric asthma","volume":"49","author":"Bergauer","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0033","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12931-021-01709-9","article-title":"Single-cell characterization of a model of poly I:C-stimulated peripheral blood mononuclear cells in severe asthma","volume":"22","author":"Chen","year":"2021","journal-title":"Respir Res"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0034","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1164\/rccm.201804-0715OC","article-title":"Personalized transcriptomics reveals heterogeneous immunophenotypes in children with viral bronchiolitis","volume":"199","author":"Jones","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0035","article-title":"Dysfunctional neutrophil type 1 interferon responses in preschool children with recurrent wheezing and IL-4-mediated aeroallergen sensitization","volume":"3","author":"Fitzpatrick","year":"2024","journal-title":"J Allergy Clin Immunol Glob"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0036","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.4049\/jimmunol.1800178","article-title":"Upper airway cell transcriptomics identify a major new immunological phenotype with strong clinical correlates in young children with acute wheezing","volume":"202","author":"Khoo","year":"2019","journal-title":"J Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0037","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11121293","article-title":"Personal network inference unveils heterogeneous immune response patterns to viral infection in children with acute wheezing","volume":"11","author":"Coleman","year":"2021","journal-title":"J Pers Med"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0038","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810144","article-title":"Differential regulation of interferon signaling pathways in CD4","volume":"22","author":"Alhamdan","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0039","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1016\/j.ymthe.2023.09.013","article-title":"Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma","volume":"31","author":"Hawthorne","year":"2023","journal-title":"Mol Ther"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0040","doi-asserted-by":"crossref","DOI":"10.3390\/cells13110916","article-title":"Ly6C(hi) monocytes are metabolically reprogrammed in the blood during inflammatory stimulation and require intact OxPhos for chemotaxis and monocyte to macrophage differentiation","volume":"13","author":"Purvis","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0041","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.4049\/jimmunol.1400580","article-title":"Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma","volume":"193","author":"Zaslona","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0042","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.4049\/jimmunol.1301828","article-title":"IDO-independent suppression of T cell effector function by IFN-gamma-licensed human mesenchymal stromal cells","volume":"192","author":"Chinnadurai","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0043","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1089\/scd.2013.0028","article-title":"IFN-gamma stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro","volume":"22","author":"Noone","year":"2013","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0044","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/sctm.16-0485","article-title":"Safety profile of good manufacturing practice manufactured interferon gamma-primed mesenchymal stem\/stromal cells for clinical trials","volume":"6","author":"Guess","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0045","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/stem.2801","article-title":"Intratumoral delivery of interferongamma-secreting mesenchymal stromal cells repolarizes tumor-associated macrophages and suppresses neuroblastoma proliferation in vivo","volume":"36","author":"Relation","year":"2018","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0046","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/stem.698","article-title":"Pretreatment with interferon-gamma enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis","volume":"29","author":"Duijvestein","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0047","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1398-9995.2010.02509.x","article-title":"Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells","volume":"66","author":"Kavanagh","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0048","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jdermsci.2014.10.004","article-title":"Bone marrow stromal cells as immunomodulators. A primer for dermatologists","volume":"77","author":"Nemeth","year":"2015","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0049","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1258\/ebm.2011.011221","article-title":"Suppression of allergic airway inflammation in a mouse model of asthma by exogenous mesenchymal stem cells","volume":"236","author":"Ou-Yang","year":"2011","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"Platanias","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0051","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jcyt.2020.07.003","article-title":"Identification and characterization of a large source of primary mesenchymal stem cells tightly adhered to bone surfaces of human vertebral body marrow cavities","volume":"22","author":"Johnstone","year":"2020","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0052","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0053","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0054","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0055","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0056","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0057","doi-asserted-by":"crossref","unstructured":"Valero-Mora PM (2010). ggplot2: elegant graphics for data analysis. https:\/\/ggplot2.tidyverse.org. [accessed 01.05.2025].","DOI":"10.18637\/jss.v035.b01"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0058","unstructured":"Yu G, Gao C-H (2024). enrichplot: Visualization of functional enrichment result. https:\/\/doi.org\/10.18129\/B9.bioc.enrichplot, R package version 1.30.1. https:\/\/www.bioconductor.org\/packages\/enrichplot. [accessed 01.05.2025]."},{"key":"10.1016\/j.jcyt.2025.07.008_bib0059","unstructured":"Blighe K, Rana S, Turkes E, Ostendorf B, Grioni A, and Lewis M (2023). EnhancedVolcano: publication-ready volcano plots with enhanced colouring and labeling. Blighe K, Rana S, Turkes E, Ostendorf B, Grioni A, Lewis M (2023). EnhancedVolcanoL Publication-ready volcano plots with enhanced coloring and labeling. R Package version 1.7.14. https:\/\/github.com\/kevinblighe\/EnhanceVolcano. [accessed 01.05.2025]."},{"key":"10.1016\/j.jcyt.2025.07.008_bib0060","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1093\/bioinformatics\/btv300","article-title":"GOplot: an R package for visually combining expression data with functional analysis","volume":"31","author":"Walter","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jcyt.2025.07.008_bib0061","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324925007893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324925007893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:45:01Z","timestamp":1773834301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324925007893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S1465324925007893"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2025.07.008","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single cell transcriptional profiling of monocytes from asthma patients show a predisposition for an inflammatory response","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2025.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society for Cell & Gene Therapy. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101967"}}