{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:40:27Z","timestamp":1791499227473,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Foundation for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["celltherapyjournal.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cytotherapy"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jcyt.2025.10.008","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:13:09Z","timestamp":1761783189000},"page":"101998","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Brain on the mend: induced mesenchymal stem cell\u2212based therapies promote functional recovery in rats with neonatal hypoxic-ischemic brain injury"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-1599","authenticated-orcid":false,"given":"In\u00eas","family":"Serrenho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia C.","family":"Serra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio J.","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7942-0432","authenticated-orcid":false,"given":"Gra\u00e7a","family":"Baltazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jcyt.2025.10.008_bib0001","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-62544-8","article-title":"Advantages of pooling of human bone marrow-derived mesenchymal stromal cells from different donors versus single-donor MSCs","volume":"14","author":"Kannan","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0002","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s13287-015-0233-8","article-title":"A robust potency assay highlights significant donor variation of human mesenchymal stem\/progenitor cell immune modulatory capacity and extended radio-resistance","volume":"6","author":"Ketterl","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0003","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3389\/fcell.2020.00458","article-title":"Human mesenchymal stromal cell (MSC) characteristics vary among laboratories when manufactured from the same source material: a report by the cellular therapy team of the Biomedical Excellence for Safer Transfusion (BEST) collaborative","volume":"8","author":"Stroncek","year":"2020","journal-title":"Front Cell Dev Biol"},{"issue":"7","key":"10.1016\/j.jcyt.2025.10.008_bib0004","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1089\/scd.2012.0384","article-title":"The impact of cell source, culture methodology, culture location, and individual donors on gene expression profiles of bone marrow-derived and adipose-derived stromal cells","volume":"22","author":"Torensma","year":"2013","journal-title":"Stem Cells Dev"},{"issue":"1","key":"10.1016\/j.jcyt.2025.10.008_bib0005","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13287-023-03352-1","article-title":"Harmonised culture procedures minimise but do not eliminate mesenchymal stromal cell donor and tissue variability in a decentralised multicentre manufacturing approach","volume":"14","author":"Calcat","year":"2023","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"10.1016\/j.jcyt.2025.10.008_bib0006","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41419-021-03644-5","article-title":"Eradication of specific donor-dependent variations of mesenchymal stem cells in immunomodulation to enhance therapeutic values","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.jcyt.2025.10.008_bib0007","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13287-019-1209-x","article-title":"Human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation signature","volume":"10","author":"Spitzhorn","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0008","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41413-019-0069-4","article-title":"Human iPSC-derived iMSCs improve bone regeneration in mini-pigs","volume":"7","author":"Jungbluth","year":"2019","journal-title":"Bone Res"},{"issue":"14","key":"10.1016\/j.jcyt.2025.10.008_bib0009","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1089\/scd.2013.0554","article-title":"Mesenchymal stem cell population derived from human pluripotent stem cells displays potent immunomodulatory and therapeutic properties","volume":"23","author":"Kimbrel","year":"2014","journal-title":"Stem Cells Dev"},{"issue":"9","key":"10.1016\/j.jcyt.2025.10.008_bib0010","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1161\/CIRCULATIONAHA.109.898312","article-title":"Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice","volume":"121","author":"Lian","year":"2010","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.jcyt.2025.10.008_bib0011","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1038\/s41591-020-1050-x","article-title":"Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study","volume":"26","author":"Bloor","year":"2020","journal-title":"Nat Med"},{"issue":"22","key":"10.1016\/j.jcyt.2025.10.008_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242216544","article-title":"Secretome as a tool to treat neurological conditions: are we ready?","volume":"24","author":"da Silva","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.jcyt.2025.10.008_bib0013","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/stmcls\/sxad060","article-title":"Mesenchymal stromal cell secretome is affected by tissue source and donor age","volume":"41","author":"Turlo","year":"2023","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/j.jcyt.2025.10.008_bib0014","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s12015-022-10453-6","article-title":"Cellular aging secretes: a comparison of bone-marrow-derived and induced mesenchymal stem cells and their secretome over long-term culture","volume":"19","author":"Marote","year":"2023","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.716907","article-title":"Induced pluripotent stem cell-derived mesenchymal stem cells hold lower heterogeneity and great promise in biological research and clinical applications","volume":"9","author":"Zhang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.717772","article-title":"Human induced pluripotent stem cell-derived mesenchymal stem cells acquire rejuvenation and reduced heterogeneity","volume":"9","author":"Wruck","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"7","key":"10.1016\/j.jcyt.2025.10.008_bib0017","article-title":"Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"issue":"149","key":"10.1016\/j.jcyt.2025.10.008_bib0018","doi-asserted-by":"crossref","DOI":"10.3791\/59878","article-title":"Low-cost gait analysis for behavioral phenotyping of mouse models of neuromuscular disease","author":"Wertman","year":"2019","journal-title":"J Vis Exp"},{"issue":"1","key":"10.1016\/j.jcyt.2025.10.008_bib0019","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24010257","article-title":"Hypothermia does not boost the neuroprotection promoted by umbilical cord blood cells in a neonatal hypoxia-ischemia rat model","volume":"24","author":"Serrenho","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.jcyt.2025.10.008_bib0020","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"1","key":"10.1016\/j.jcyt.2025.10.008_bib0021","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"issue":"suppl 1","key":"10.1016\/j.jcyt.2025.10.008_bib0022","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/pr.2013.206","article-title":"Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990","volume":"74","author":"Lee","year":"2013","journal-title":"Pediatr Res"},{"issue":"6","key":"10.1016\/j.jcyt.2025.10.008_bib0023","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22063142","article-title":"Stem cell therapy for neonatal hypoxic-ischemic encephalopathy: a systematic review of preclinical studies","volume":"22","author":"Serrenho","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.jcyt.2025.10.008_bib0024","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1089\/scd.2018.0132","article-title":"Human Wharton's jelly mesenchymal stem cells show unique gene expression compared with bone marrow mesenchymal stem cells using single-cell RNA-sequencing","volume":"28","author":"Barrett","year":"2019","journal-title":"Stem Cells Dev"},{"issue":"2","key":"10.1016\/j.jcyt.2025.10.008_bib0025","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00018-020-03600-0","article-title":"Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses","volume":"78","author":"Costa","year":"2021","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"10.1016\/j.jcyt.2025.10.008_bib0026","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/stcltm\/szad027","article-title":"A pilot phase I trial of allogeneic umbilical cord tissue-derived mesenchymal stromal cells in neonates with hypoxic-ischemic encephalopathy","volume":"12","author":"Cotten","year":"2023","journal-title":"Stem Cells Transl Med"},{"issue":"3","key":"10.1016\/j.jcyt.2025.10.008_bib0027","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbi.2009.10.017","article-title":"Mesenchymal stem cell treatment after neonatal hypoxic-ischemic brain injury improves behavioral outcome and induces neuronal and oligodendrocyte regeneration","volume":"24","author":"van Velthoven","year":"2010","journal-title":"Brain Behav Immun"},{"issue":"5","key":"10.1016\/j.jcyt.2025.10.008_bib0028","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1161\/STROKEAHA.111.000326","article-title":"Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke","volume":"44","author":"van Velthoven","year":"2013","journal-title":"Stroke"},{"issue":"5","key":"10.1016\/j.jcyt.2025.10.008_bib0029","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3171\/2018.5.PEDS1845","article-title":"Functional recovery after the systemic administration of mesenchymal stem cells in a rat model of neonatal hypoxia-ischemia","volume":"22","author":"Sakai","year":"2018","journal-title":"J Neurosurg Pediatr"},{"issue":"10","key":"10.1016\/j.jcyt.2025.10.008_bib0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20102449","article-title":"Intranasal delivery of mesenchymal stromal cells protects against neonatal hypoxic(-)ischemic brain injury","volume":"20","author":"McDonald","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.jcyt.2025.10.008_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073031","article-title":"Mesenchymal stem cells induce T-cell tolerance and protect the preterm brain after global hypoxia-ischemia","volume":"8","author":"Jellema","year":"2013","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.jcyt.2025.10.008_bib0032","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/sctm.17-0074","article-title":"Long-term recovery after endothelial colony-forming cells or human umbilical cord blood cells administration in a rat model of neonatal hypoxic-ischemic encephalopathy","volume":"6","author":"Grandvuillemin","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0033","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuroscience.2017.05.006","article-title":"Intravenous injection of umbilical cord-derived mesenchymal stromal cells attenuates reactive gliosis and hypomyelination in a neonatal intraventricular hemorrhage model","volume":"355","author":"Mukai","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0034","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbr.2019.01.012","article-title":"Umbilical cord mesenchymal stem cells and umbilical cord blood mononuclear cells improve neonatal rat memory after hypoxia-ischemia","volume":"362","author":"Zhang","year":"2019","journal-title":"Behav Brain Res"},{"issue":"11","key":"10.1016\/j.jcyt.2025.10.008_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112339","article-title":"Intranasal administration of human MSC for ischemic brain injury in the mouse: in vitro and in vivo neuroregenerative functions","volume":"9","author":"Donega","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jcyt.2025.10.008_bib0036","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.ejcb.2009.02.001","article-title":"Intranasal delivery of cells to the brain","volume":"88","author":"Danielyan","year":"2009","journal-title":"Eur J Cell Biol"},{"issue":"7","key":"10.1016\/j.jcyt.2025.10.008_bib0037","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.addr.2011.11.002","article-title":"Intranasal delivery of biologics to the central nervous system","volume":"64","author":"Lochhead","year":"2012","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"10.1016\/j.jcyt.2025.10.008_bib0038","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41582-022-00736-4","article-title":"Cell-based therapies for neurological disorders - the bioreactor hypothesis","volume":"19","author":"Savitz","year":"2023","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0039","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fbioe.2019.00294","article-title":"Bone marrow mesenchymal stem cells' secretome exerts neuroprotective effects in a parkinson's disease rat model","volume":"7","author":"Mendes-Pinheiro","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fnmol.2019.00088","article-title":"Mechanism and treatment related to oxidative stress in neonatal hypoxic-ischemic encephalopathy","volume":"12","author":"Qin","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0041","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainres.2011.09.003","article-title":"Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation","volume":"1419","author":"Oyagi","year":"2011","journal-title":"Brain Res"},{"issue":"4","key":"10.1016\/j.jcyt.2025.10.008_bib0042","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1471-4159.2004.02350.x","article-title":"Comparative signaling pathways of insulin-like growth factor-1 and brain-derived neurotrophic factor in hippocampal neurons and the role of the PI3 kinase pathway in cell survival","volume":"89","author":"Zheng","year":"2004","journal-title":"J Neurochem"},{"issue":"6","key":"10.1016\/j.jcyt.2025.10.008_bib0043","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/glia.23939","article-title":"The impact of trophic and immunomodulatory factors on oligodendrocyte maturation: potential treatments for encephalopathy of prematurity","volume":"69","author":"Vaes","year":"2021","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.jcyt.2025.10.008_bib0044","doi-asserted-by":"crossref","first-page":"5480","DOI":"10.18632\/oncotarget.23869","article-title":"Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment","volume":"9","author":"Zhang","year":"2018","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.jcyt.2025.10.008_bib0045","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1136\/svn-2018-000198","article-title":"Basement membrane and blood-brain barrier","volume":"4","author":"Xu","year":"2019","journal-title":"Stroke Vasc Neurol"},{"issue":"1","key":"10.1016\/j.jcyt.2025.10.008_bib0046","doi-asserted-by":"crossref","first-page":"143","DOI":"10.7150\/thno.57234","article-title":"Human pluripotent stem cell-derived ectomesenchymal stromal cells promote more robust functional recovery than umbilical cord-derived mesenchymal stromal cells after hypoxic-ischaemic brain damage","volume":"12","author":"Huang","year":"2022","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.jcyt.2025.10.008_bib0047","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1634\/stemcells.2008-0333","article-title":"IFATS collection: the conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats","volume":"27","author":"Wei","year":"2009","journal-title":"Stem Cells"},{"issue":"6","key":"10.1016\/j.jcyt.2025.10.008_bib0048","doi-asserted-by":"crossref","first-page":"754","DOI":"10.5966\/sctm.2015-0197","article-title":"Mesenchymal stromal cell-derived extracellular vesicles protect the fetal brain after hypoxia-ischemia","volume":"5","author":"Ophelders","year":"2016","journal-title":"Stem Cells Transl Med"},{"issue":"8","key":"10.1016\/j.jcyt.2025.10.008_bib0049","doi-asserted-by":"crossref","DOI":"10.3390\/cells8080855","article-title":"Intranasally administered exosomes from umbilical cord stem cells have preventive neuroprotective effects and contribute to functional recovery after perinatal brain injury","volume":"8","author":"Thomi","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.jcyt.2025.10.008_bib0050","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bbi.2016.11.011","article-title":"Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury","volume":"60","author":"Drommelschmidt","year":"2017","journal-title":"Brain Behav Immun"}],"container-title":["Cytotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324925008758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1465324925008758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T07:19:17Z","timestamp":1780816757000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1465324925008758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1465324925008758"],"URL":"https:\/\/doi.org\/10.1016\/j.jcyt.2025.10.008","relation":{},"ISSN":["1465-3249"],"issn-type":[{"value":"1465-3249","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain on the mend: induced mesenchymal stem cell\u2212based therapies promote functional recovery in rats with neonatal hypoxic-ischemic brain injury","name":"articletitle","label":"Article Title"},{"value":"Cytotherapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jcyt.2025.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society for Cellular Therapy. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101998"}}