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Dermatol"},{"issue":"3","key":"10.1016\/j.jdcr.2026.08.007_bib11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1365-2133.2010.09834.x","article-title":"The neuropsychiatric phenotype in Darier disease","volume":"163","author":"Gordon-Smith","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jdcr.2026.08.007_bib12","unstructured":"A literature search was performed in PubMed\/MEDLINE, Embase, Scopus, Web of Science, and Goggle Scholar from database inception through April 26, 2026, using combinations of the terms \u201cDarier disease,\u201d \u201cDarier\u2019s disease,\u201d \u201ckeratosis follicularis,\u201d \u201croflumilast,\u201d \u201ctopical roflumilast,\u201d \u201cZoryve,\u201d \u201cphosphodiesterase-4,\u201d \u201cPDE-4 inhibitor,\u201d \u201capremilast,\u201d and topical PDE4 inhibitor.\u201d Published reports describing oral apremilast in Darier disease were identified, but no peer-reviewed case report specifically describing topical 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