{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:08:05Z","timestamp":1793347685644,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dentistry"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1016\/j.jdent.2003.10.001","type":"journal-article","created":{"date-parts":[[2003,11,5]],"date-time":"2003-11-05T06:08:46Z","timestamp":1068012526000},"page":"133-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Mathematical coupling can undermine the statistical assessment of clinical research: illustration from the treatment of guided tissue regeneration"],"prefix":"10.1016","volume":"32","author":[{"given":"Yu-Kang","family":"Tu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"Maddick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth S.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Gilthorpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdent.2003.10.001_BIB1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1056\/NEJM198708133170706","article-title":"Statistical problems in the reporting of clinical trials. A survey of three medical journals","volume":"317","author":"Pocock","year":"1987","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.jdent.2003.10.001_BIB2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/bmj.308.6924.283","article-title":"The scandal of poor medical research","volume":"308","author":"Altman","year":"1994","journal-title":"British Medical Journal"},{"key":"10.1016\/j.jdent.2003.10.001_BIB3","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1002\/1097-0258(20001215)19:23<3275::AID-SIM626>3.0.CO;2-M","article-title":"Statistics in medical journals: some recent trends","volume":"19","author":"Altman","year":"2000","journal-title":"Statistics in Medicine"},{"key":"10.1016\/j.jdent.2003.10.001_BIB4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0021-9681(62)90116-9","article-title":"A note on the analysis of repeated measurements of the same subjects","volume":"15","author":"Oldham","year":"1962","journal-title":"Journal of Chronic Diseases"},{"key":"10.1016\/j.jdent.2003.10.001_BIB5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/00000658-198103000-00008","article-title":"Mathematical coupling: a common source of error","volume":"193","author":"Archie","year":"1981","journal-title":"Annals of Surgery"},{"key":"10.1016\/j.jdent.2003.10.001_BIB6","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1152\/jappl.1986.60.1.335","article-title":"Mathematical coupling of data: correction of a common error for linear calculations","volume":"60","author":"Moreno","year":"1986","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.jdent.2003.10.001_BIB7","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1152\/jappl.1987.62.5.2083","article-title":"Regression of calculated variables in the presence of shared measurement error","volume":"62","author":"Stratton","year":"1987","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.jdent.2003.10.001_BIB8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/sim.4780070903","article-title":"Methods for assessing whether change depends on initial value","volume":"7","author":"Hayes","year":"1988","journal-title":"Statistics in Medicine"},{"key":"10.1016\/j.jdent.2003.10.001_BIB9","series-title":"Methodological errors in medical research","author":"Andersen","year":"1990"},{"key":"10.1016\/j.jdent.2003.10.001_BIB10","first-page":"446","article-title":"Gastric bypass: analysis of weight loss and factors determining success","volume":"90","author":"Halverson","year":"1981","journal-title":"Surgery"},{"key":"10.1016\/j.jdent.2003.10.001_BIB11","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0140-6736(85)91219-X","article-title":"Relation between initial blood pressure and its fall with treatment","volume":"1","author":"Gill","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.jdent.2003.10.001_BIB12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1056\/NEJM198708133170701","article-title":"The effects of vasodilatation with prostacyclin on oxygen delivery and uptake in critically ill patients","volume":"317","author":"Bihari","year":"1987","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.jdent.2003.10.001_BIB13","first-page":"318","article-title":"Mathematical coupling explains dependence of oxygen consumption on oxygen delivery in ARDS","volume":"150","author":"Phang","year":"1994","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.jdent.2003.10.001_BIB14","first-page":"242","article-title":"Thoughts about judging dialysis treatment: mathematics and measurements, mirrors in the mind","volume":"16","author":"Lowrie","year":"1996","journal-title":"Seminars in Nephrology"},{"key":"10.1016\/j.jdent.2003.10.001_BIB15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/sim.4780010109","article-title":"Statistics in medical journals","volume":"1","author":"Altman","year":"1982","journal-title":"Statistics in Medicine"},{"key":"10.1016\/j.jdent.2003.10.001_BIB16","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/sim.4780101206","article-title":"Statistics in medical journals: developments in the 1980s","volume":"10","author":"Altman","year":"1991","journal-title":"Statistics in Medicine"},{"key":"10.1016\/j.jdent.2003.10.001_BIB17","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1159\/000013506","article-title":"Protein intake seems to respond to increase in Kt\/V despite baseline Kt\/V greater than 1.2","volume":"19","author":"Marcus","year":"1999","journal-title":"American Journal of Nephrology"},{"key":"10.1016\/j.jdent.2003.10.001_BIB18","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1034\/j.1399-6576.2001.045007863.x","article-title":"Changes in cardiac output and intrathoracic blood volume: a mathematical coupling of data?","volume":"45","author":"Buhre","year":"2001","journal-title":"Acta Anaesthesiologica Scandinavica"},{"key":"10.1016\/j.jdent.2003.10.001_BIB19","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/00003246-200105000-00006","article-title":"Mathematical coupling does not explain the relationship between right ventricular end-diastolic volume and cardiac output","volume":"29","author":"Nelson","year":"2001","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.jdent.2003.10.001_BIB20","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1097\/00003246-200105000-00044","article-title":"Right ventricular volumetric measurements: new tricks for an old dog","volume":"29","author":"Conrad","year":"2001","journal-title":"Critical Care Medicine"},{"key":"10.1016\/j.jdent.2003.10.001_BIB21","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1258\/0004563011900245","article-title":"Urea kinetic modelling: a measure of dialysis adequacy","volume":"38","author":"Kemp","year":"2001","journal-title":"Annals of Clinical Biochemistry"},{"key":"10.1016\/j.jdent.2003.10.001_BIB22","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1469-8986.1993.tb02076.x","article-title":"A simple test of the law of initial value","volume":"30","author":"Greenen","year":"1993","journal-title":"Psychophysiology"},{"key":"10.1016\/j.jdent.2003.10.001_BIB23","series-title":"Fundamental statistics in psychology and education","author":"Guilford","year":"1973"},{"key":"10.1016\/j.jdent.2003.10.001_BIB24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1037\/0033-2909.111.1.176","article-title":"Toward a reconceptualization of the law of initial value","volume":"111","author":"Jin","year":"1992","journal-title":"Psychological Bulletin"},{"key":"10.1016\/j.jdent.2003.10.001_BIB25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1600-0765.1991.tb01635.x","article-title":"A study of inter- and intra-examiner reliability of pocket depth and attachment level","volume":"26","author":"Fleiss","year":"1991","journal-title":"Journal of Periodontal Research"},{"key":"10.1016\/j.jdent.2003.10.001_BIB26","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/154405910308200310","article-title":"Unification of the \u2018burst\u2019 and \u2018linear\u2019 theories of periodontal disease progression: a multilevel manifestation of the same phenomena","volume":"82","author":"Gilthorpe","year":"2003","journal-title":"Journal of Dental Research"},{"key":"10.1016\/j.jdent.2003.10.001_BIB27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/jech.42.4.383","article-title":"Relationship of lung function loss to level of initial function: correcting for measurement error using reliability coefficient","volume":"42","author":"Irwig","year":"1988","journal-title":"Journal of Epidemiology and Community Health"},{"key":"10.1016\/j.jdent.2003.10.001_BIB28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1600-051X.1987.tb01510.x","article-title":"On the bias caused by regression toward the mean in studying the relation between change and initial value","volume":"14","author":"Blomqvist","year":"1986","journal-title":"Journal of Clinical Periodontology"},{"key":"10.1016\/j.jdent.2003.10.001_BIB29","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1177\/154405910208101013","article-title":"Is reduction of pocket probing depth correlated with the baseline value or is it \u2018mathematical coupling\u2019?","volume":"81","author":"Tu","year":"2002","journal-title":"Journal of Dental Research"}],"container-title":["Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571203001611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571203001611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:08:38Z","timestamp":1759536518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300571203001611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S0300571203001611"],"URL":"https:\/\/doi.org\/10.1016\/j.jdent.2003.10.001","relation":{},"ISSN":["0300-5712"],"issn-type":[{"value":"0300-5712","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mathematical coupling can undermine the statistical assessment of clinical research: illustration from the treatment of guided tissue regeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Dentistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdent.2003.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}