{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:46:54Z","timestamp":1776559614150,"version":"3.51.2"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dentistry"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.jdent.2020.103330","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T18:47:46Z","timestamp":1586026066000},"page":"103330","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Maintaining pulpal vitality: Cost-effectiveness analysis on carious tissue removal and direct pulp capping"],"prefix":"10.1016","volume":"96","author":[{"given":"Ramy","family":"Emara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Krois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-1669","authenticated-orcid":false,"given":"Falk","family":"Schwendicke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jdent.2020.103330_bib0005","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/0022034513477425","article-title":"Incomplete caries removal: a systematic review and meta-analysis","volume":"92","author":"Schwendicke","year":"2013","journal-title":"J. Dent. Res."},{"issue":"5","key":"10.1016\/j.jdent.2020.103330_bib0010","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.joen.2010.12.004","article-title":"vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review","volume":"37","author":"Aguilar","year":"2011","journal-title":"J. Endod."},{"issue":"11","key":"10.1016\/j.jdent.2020.103330_bib0015","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/iej.12564","article-title":"Outcomes of direct pulp capping: interrogating an insurance database","volume":"49","author":"Raedel","year":"2016","journal-title":"Int. Endod. J."},{"issue":"2","key":"10.1016\/j.jdent.2020.103330_bib0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/0022034516639271","article-title":"Managing carious lesions: consensus recommendations on carious tissue removal","volume":"28","author":"Schwendicke","year":"2016","journal-title":"Adv. Dent. Res."},{"issue":"3","key":"10.1016\/j.jdent.2020.103330_bib0025","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/sj.bdj.2017.672","article-title":"Contemporary operative caries management: consensus recommendations on minimally invasive caries removal","volume":"223","author":"Banerjee","year":"2017","journal-title":"Br. Dent. J."},{"issue":"1","key":"10.1016\/j.jdent.2020.103330_bib0030","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joen.2009.09.006","article-title":"Mineral trioxide aggregate: a comprehensive literature review--part I: chemical, physical, and antibacterial properties","volume":"36","author":"Parirokh","year":"2010","journal-title":"J. Endod."},{"issue":"2","key":"10.1016\/j.jdent.2020.103330_bib0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/iej.12298","article-title":"Effect of biodentine and bioaggregate on odontoblastic differentiation via mitogen-activated protein kinase pathway in human dental pulp cells","volume":"48","author":"Jung","year":"2015","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.jdent.2020.103330_bib0040","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/08959374010150010201","article-title":"Enamel matrix derivative promotes reparative processes in the dental pulp","volume":"15","author":"Nakamura","year":"2001","journal-title":"Adv. Dent. Res."},{"issue":"5","key":"10.1016\/j.jdent.2020.103330_bib0045","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2341\/09-132-0","article-title":"Keys to clinical success with pulp capping: a review of the literature","volume":"34","author":"Hilton","year":"2009","journal-title":"Operative dentistry"},{"issue":"3","key":"10.1016\/j.jdent.2020.103330_bib0050","first-page":"155","article-title":"TNF-alpha release in monocytes after exposure to calcium hydroxide treated Escherichia coli LPS","volume":"30","author":"Barthel","year":"1997","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.jdent.2020.103330_bib0055","series-title":"Aktuelle empfehlungen zur vitalerhaltung der pulpa, DZZ Online","author":"Dammaschke","year":"2019"},{"issue":"12","key":"10.1016\/j.jdent.2020.103330_bib0060","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/j.joen.2015.08.019","article-title":"Calcium hydroxide versus mineral trioxide aggregate for direct pulp capping: a cost-effectiveness analysis","volume":"41","author":"Schwendicke","year":"2015","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2020.103330_bib0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1472-6831-14-153","article-title":"Cost-effectiveness of caries excavations in different risk groups - a micro-simulation study","volume":"14","author":"Schwendicke","year":"2014","journal-title":"BMC oral health"},{"issue":"10","key":"10.1016\/j.jdent.2020.103330_bib0070","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1177\/0022034513500792","article-title":"Cost-effectiveness of one- and two-step incomplete and complete excavation","volume":"92","author":"Schwendicke","year":"2013","journal-title":"J. Dent. Res."},{"issue":"2","key":"10.1016\/j.jdent.2020.103330_bib0075","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jval.2013.02.002","article-title":"Consolidated health economic evaluation reporting standards (CHEERS)--explanation and elaboration: a report of the ISPOR health economic evaluation publication guidelines good reporting practices task force","volume":"16","author":"Husereau","year":"2013","journal-title":"Value Health"},{"key":"10.1016\/j.jdent.2020.103330_bib0080","series-title":"Versicherungsverh\u00e4ltnisses in der Krankenversicherung","author":"Gesundheitsberichtserstattung","year":"2018"},{"key":"10.1016\/j.jdent.2020.103330_bib0085","series-title":"Gesundheitsberichterstattung des Bundes, Durchschnittliche Lebenserwartung im Alter von \u2026 Jahren je Person","year":"2020"},{"key":"10.1016\/j.jdent.2020.103330_bib0090","article-title":"Direct pulp capping following a carious exposure versus root canal treatment: a cost-effectiveness analysis","author":"Schwendicke","year":"2014","journal-title":"J. Endod. Accepted 40 (11)"},{"key":"10.1016\/j.jdent.2020.103330_bib0095","series-title":"Mundgesundheitsstudie, K\u00f6ln","author":"Jordan","year":"2016"},{"issue":"9","key":"10.1016\/j.jdent.2020.103330_bib0100","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1902\/jop.2015.150071","article-title":"Preventing and treating peri-implantitis: a cost-effectiveness analysis","volume":"86","author":"Schwendicke","year":"2015","journal-title":"J. Periodontol."},{"issue":"4","key":"10.1016\/j.jdent.2020.103330_bib0105","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jrsm.1054","article-title":"Automating network meta-analysis","volume":"3","author":"van Valkenhoef","year":"2012","journal-title":"Res. Synth. Methods"},{"issue":"3","key":"10.1016\/j.jdent.2020.103330_bib0110","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-051X.2011.01844.x","article-title":"A bayesian network meta-analysis on comparisons of enamel matrix derivatives, guided tissue regeneration and their combination therapies","volume":"39","author":"Tu","year":"2012","journal-title":"J. Clin. Periodontol."},{"issue":"10","key":"10.1016\/j.jdent.2020.103330_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical tools for network meta-analysis in STATA","volume":"8","author":"Chaimani","year":"2013","journal-title":"PloS one"},{"issue":"2","key":"10.1016\/j.jdent.2020.103330_bib0120","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinepi.2010.03.016","article-title":"Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial","volume":"64","author":"Salanti","year":"2011","journal-title":"J. Clin. Epidemiol."},{"issue":"9","key":"10.1016\/j.jdent.2020.103330_bib0125","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1007\/s00784-017-2084-4","article-title":"Four-year outcomes of restored posterior tooth surfaces-a massive data analysis","volume":"21","author":"Raedel","year":"2017","journal-title":"Clin. Oral Investig."},{"issue":"10","key":"10.1016\/j.jdent.2020.103330_bib0130","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1177\/0022034513500792","article-title":"Cost-effectiveness of one- and two-step incomplete and complete excavations","volume":"90","author":"Schwendicke","year":"2013","journal-title":"J. Dent. Res."},{"issue":"4","key":"10.1016\/j.jdent.2020.103330_bib0135","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5014\/ajot.37.4.239","article-title":"Micro-costing analysis: a measure of accountability","volume":"37","author":"Mansfield","year":"1983","journal-title":"Am. J. Occupat. Therapy"},{"key":"10.1016\/j.jdent.2020.103330_bib0140","author":"IQWiG","year":"2009"},{"issue":"1","key":"10.1016\/j.jdent.2020.103330_bib0145","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1146\/annurev.publhealth.23.100901.140534","article-title":"Thinking outside the box: recent advances in the analysis and presentation of uncertainty in cost-effectiveness studies","volume":"23","author":"Briggs","year":"2002","journal-title":"Annu. Rev. Public Health"},{"key":"10.1016\/j.jdent.2020.103330_bib0150","series-title":"Methods for Economic Evaluation of Health Care Programmes","author":"Drummond","year":"2005"},{"issue":"5","key":"10.1016\/j.jdent.2020.103330_bib0155","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2012-001094","article-title":"Development of an economic model to assess the cost-effectiveness of hawthorn extract as an adjunct treatment for heart failure in Australia","volume":"2","author":"Ford","year":"2012","journal-title":"BMJ Open"},{"key":"10.1016\/j.jdent.2020.103330_bib0160","series-title":"Professional Application of Fluoride Gel or Varnish: Cost-Effectiveness and Expected Value of Perfect Information Analysis, Submitted","author":"Schwendicke","year":"2017"},{"issue":"3","key":"10.1016\/j.jdent.2020.103330_bib0165","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000128560","article-title":"Unrestored dentin caries and deep dentin restorations in Swedish adolescents","volume":"42","author":"Ridell","year":"2008","journal-title":"Caries Res."},{"issue":"6","key":"10.1016\/j.jdent.2020.103330_bib0170","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3109\/00016357.2014.971866","article-title":"Deep carious lesions and other consequences of caries among 18-year-olds at public dental health service in Northern Norway: a cross-sectional age cohort study","volume":"73","author":"Stangvaltaite","year":"2015","journal-title":"Acta Odontol. Scand."},{"issue":"7","key":"10.1016\/j.jdent.2020.103330_bib0175","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/iej.13080","article-title":"European society of endodontology position statement: management of deep caries and the exposed pulp","volume":"52","author":"Duncan","year":"2019","journal-title":"Int. Endod. J."},{"issue":"9","key":"10.1016\/j.jdent.2020.103330_bib0180","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/iej.12537","article-title":"Conventional treatment, Hall technique or immediate pulpotomy for carious primary molars: a cost-effectiveness analysis","volume":"49","author":"Schwendicke","year":"2016","journal-title":"Int. Endod. J."},{"issue":"11","key":"10.1016\/j.jdent.2020.103330_bib0185","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1177\/0022034510377790","article-title":"Does incomplete caries removal reduce strength of restored teeth?","volume":"89","author":"Hevinga","year":"2010","journal-title":"J. Dent. Res."},{"issue":"2","key":"10.1016\/j.jdent.2020.103330_bib0190","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jdent.2013.12.003","article-title":"Fracture resistance and cuspal deflection of incompletely excavated teeth","volume":"42","author":"Schwendicke","year":"2013","journal-title":"J. Dentistry"},{"key":"10.1016\/j.jdent.2020.103330_bib0195","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1472-6831-14-58","article-title":"Sealing versus partial caries removal in primary molars: a randomized clinical trial","volume":"14","author":"Hesse","year":"2014","journal-title":"BMC oral health"},{"issue":"1","key":"10.1016\/j.jdent.2020.103330_bib0200","doi-asserted-by":"crossref","first-page":"55","DOI":"10.14219\/jada.archive.1998.0022","article-title":"Ultraconservative and cariostatic sealed restorations: results at year 10","volume":"129","author":"Mertz-Fairhurst","year":"1998","journal-title":"J. Am. Dental Association"},{"issue":"7 Suppl","key":"10.1016\/j.jdent.2020.103330_bib0205","doi-asserted-by":"crossref","first-page":"20s","DOI":"10.1177\/0022034514537828","article-title":"Global burden of severe tooth loss: a systematic review and meta-analysis","volume":"93","author":"Kassebaum","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jdent.2020.103330_bib0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.joen.2019.11.009","article-title":"Long-term pulpal and restorative outcomes of pulpotomy in mature permanent teeth","author":"Tan","year":"2020","journal-title":"J. Endod."},{"issue":"4","key":"10.1016\/j.jdent.2020.103330_bib0215","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jdent.2012.11.021","article-title":"Longevity of posterior resin composite restorations in permanent teeth in public dental health service: a prospective 8 years follow up","volume":"41","author":"Pallesen","year":"2013","journal-title":"J. Dent."},{"issue":"4","key":"10.1016\/j.jdent.2020.103330_bib0220","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jdent.2015.01.013","article-title":"Three-year outcomes of root canal treatment: mining an insurance database","volume":"43","author":"Raedel","year":"2015","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2020.103330_bib0225","series-title":"Barmer Zahnreport 2019","author":"Barmer","year":"2019"},{"issue":"12","key":"10.1016\/j.jdent.2020.103330_bib0230","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/j.1365-2591.2008.01484.x","article-title":"Outcome of secondary root canal treatment: a systematic review of the literature","volume":"41","author":"Ng","year":"2008","journal-title":"Int. Endod. J."},{"issue":"7","key":"10.1016\/j.jdent.2020.103330_bib0235","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.joen.2009.04.023","article-title":"Outcomes of nonsurgical retreatment and endodontic surgery: a systematic review","volume":"35","author":"Torabinejad","year":"2009","journal-title":"J. Endod."},{"issue":"4","key":"10.1016\/j.jdent.2020.103330_bib0240","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1007\/s00784-017-2276-y","article-title":"How frequent does peri-implantitis occur? A systematic review and meta-analysis","volume":"22","author":"Rakic","year":"2018","journal-title":"Clin. Oral Investig."},{"issue":"Suppl 6","key":"10.1016\/j.jdent.2020.103330_bib0245","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1600-0501.2012.02547.x","article-title":"Systematic review of the survival rate and the incidence of biological, technical, and aesthetic complications of single crowns on implants reported in longitudinal studies with a mean follow-up of 5 years","volume":"23","author":"Jung","year":"2012","journal-title":"Clin. Oral Implants Res."},{"issue":"5","key":"10.1016\/j.jdent.2020.103330_bib0250","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.joen.2017.01.002","article-title":"Cost-effectiveness of different Post-retained restorations","volume":"43","author":"Schwendicke","year":"2017","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2020.103330_bib0255","doi-asserted-by":"crossref","DOI":"10.1111\/jcpe.12796","article-title":"Cost-comparison of prediction-based decision-making for periodontally affected molars","author":"Schwendicke","year":"2017","journal-title":"J. Clin. Periodontol."}],"container-title":["Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571220300695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571220300695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:31:59Z","timestamp":1759537919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300571220300695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":51,"alternative-id":["S0300571220300695"],"URL":"https:\/\/doi.org\/10.1016\/j.jdent.2020.103330","relation":{},"ISSN":["0300-5712"],"issn-type":[{"value":"0300-5712","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maintaining pulpal vitality: Cost-effectiveness analysis on carious tissue removal and direct pulp capping","name":"articletitle","label":"Article Title"},{"value":"Journal of Dentistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdent.2020.103330","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103330"}}