{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:29:55Z","timestamp":1792798195113,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T00:00:00Z","timestamp":1690588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dentistry"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jdent.2023.104645","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T11:17:30Z","timestamp":1690629450000},"page":"104645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Salivary metabolomic profile associated with cariogenic risk in children"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-0063","authenticated-orcid":false,"given":"Oscar","family":"Musalem-Dominguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3952-7681","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Montiel-Company","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Ausina-M\u00e1rquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4404-6735","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Morales-Tatay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9605-3833","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Almerich-Silla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdent.2023.104645_bib0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000503309","article-title":"Terminology of dental caries and dental caries management: consensus report of a workshop organized by ORCA and cariology research group of IADR","volume":"54","author":"Machiulskiene","year":"2020","journal-title":"Caries Res."},{"key":"10.1016\/j.jdent.2023.104645_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/froh.2022.764479","article-title":"Understanding dental caries as a non-communicable and behavioral disease: management implications","volume":"3","author":"Giacaman","year":"2022","journal-title":"Front. Oral Health"},{"key":"10.1016\/j.jdent.2023.104645_bib0003","unstructured":"World Health Organization, Global Oral Health Status report: Towards Universal Health Coverage For Oral Health By 2030, Geneva, 2022."},{"key":"10.1016\/j.jdent.2023.104645_bib0004","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/cdoe.12279","article-title":"Oral health-related quality-of-life scores differ by socioeconomic status and caries experience","volume":"45","author":"Chaffee","year":"2017","journal-title":"Community Dent. Oral Epidemiol."},{"key":"10.1016\/j.jdent.2023.104645_bib0005","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2019.1710953","article-title":"Integrated hypothesis of dental caries and periodontal diseases","volume":"12","author":"Nyvad","year":"2020","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.jdent.2023.104645_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2022.105471","article-title":"Metabolic differences of the oral microbiome related to dental caries \u2013 A pilot study","volume":"141","author":"Wang","year":"2022","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.jdent.2023.104645_bib0007","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/prd.12116","article-title":"The physiology of salivary secretion","volume":"70","author":"Proctor","year":"2016","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.jdent.2023.104645_bib0008","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/joor.12664","article-title":"Salivary secretion in health and disease","volume":"45","author":"Pedersen","year":"2018","journal-title":"J. Oral Rehabil."},{"key":"10.1016\/j.jdent.2023.104645_bib0009","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-981-13-2925-8_5","article-title":"Metabolomics","author":"Sengupta","year":"2018","journal-title":"Omics Approaches, Technologies and Applications: Integrative Approaches For Understanding OMICS Data"},{"key":"10.1016\/j.jdent.2023.104645_bib0010","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jmr.2019.07.013","article-title":"NMR metabolomics: a look ahead","volume":"306","author":"Wishart","year":"2019","journal-title":"J. Magnetic Resonance"},{"key":"10.1016\/j.jdent.2023.104645_bib0011","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/metabo9070123","article-title":"NMR spectroscopy for metabolomics research","volume":"9","author":"Emwas","year":"2019","journal-title":"Metabolites"},{"key":"10.1016\/j.jdent.2023.104645_bib0012","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1039\/B906712B","article-title":"Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy","volume":"40","author":"Dunn","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.jdent.2023.104645_bib0013","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jbiosc.2013.01.004","article-title":"Current metabolomics: technological advances","volume":"116","author":"Putri","year":"2013","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.jdent.2023.104645_bib0014","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.4155\/bio.11.155","article-title":"Advances in metabolite identification","volume":"3","author":"Wishart","year":"2011","journal-title":"Bioanalysis"},{"key":"10.1016\/j.jdent.2023.104645_bib0015","first-page":"6795","article-title":"Potential role of nuclear magnetic resonance spectroscopy to identify salivary metabolite alterations in patients with head and neck cancer","volume":"16","author":"Mikkonen","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jdent.2023.104645_bib0016","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3233\/JAD-161226","article-title":"Diagnostic biomarkers of alzheimer's disease as identified in saliva using 1H NMR-based metabolomics","volume":"58","author":"Yilmaz","year":"2017","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.jdent.2023.104645_bib0017","doi-asserted-by":"crossref","unstructured":"G. Setti, V. Righi, A. Mucci, L. Panari, G. Bernardelli, E. Tarentini, A. Gambini, U. Consolo, L. Generali, C. Magnoni, M. Meleti, G. Sandri, P. Bellini, Metabolic Profile of Whole Unstimulated Saliva in Patients with Sj\u00f6gren's Syndrome, Metabolites. 13 (2023) 348. 10.3390\/metabo13030348.","DOI":"10.3390\/metabo13030348"},{"key":"10.1016\/j.jdent.2023.104645_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0188710","article-title":"Using NMR in saliva to identify possible biomarkers of glioblastoma and chronic periodontitis","volume":"13","author":"Garc\u00eda-Villaescusa","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jdent.2023.104645_bib0019","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.21873\/invivo.11587","article-title":"Metabolomic status of the oral cavity in chronic periodontitis","volume":"33","author":"Gawron","year":"2019","journal-title":"In Vivo (Brooklyn)"},{"key":"10.1016\/j.jdent.2023.104645_bib0020","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s11306-012-0484-7","article-title":"Salivary metabolite signatures of children with and without dental caries lesions","volume":"9","author":"Fidalgo","year":"2013","journal-title":"Metabolomics"},{"key":"10.1016\/j.jdent.2023.104645_bib0021","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s11306-014-0717-z","article-title":"Longitudinal evaluation of salivary profile from children with dental caries before and after treatment","volume":"11","author":"Fidalgo","year":"2015","journal-title":"Metabolomics"},{"key":"10.1016\/j.jdent.2023.104645_bib0022","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/odi.13117","article-title":"Saliva NMR metabolomics: analytical issues in pediatric oral health research","volume":"25","author":"Pereira","year":"2019","journal-title":"Oral Dis."},{"key":"10.1016\/j.jdent.2023.104645_bib0023","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1021\/acs.jproteome.7b00847","article-title":"Developing and standardizing a protocol for quantitative proton Nuclear Magnetic Resonance (1H NMR) spectroscopy of saliva","volume":"17","author":"Gardner","year":"2018","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.jdent.2023.104645_bib0024","unstructured":"World Health Organization, Oral Health Surveys: Basic Methods, 5th ed., Geneva, 2013."},{"key":"10.1016\/j.jdent.2023.104645_bib0025","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0213-9111(89)70948-1","article-title":"Propuesta de un indicador de la \u00abclase social\u00bb basado en la ocupaci\u00f3n","volume":"3","author":"Domingo Salvany","year":"1989","journal-title":"Gac. Sanit."},{"key":"10.1016\/j.jdent.2023.104645_bib0026","unstructured":"International Caries Detection and Assessment System (ICDAS) Coordinating Committee, Criteria Manual: International Caries Detection and Assessment System (ICDAS II), Baltimore, Maryland, 2011."},{"key":"10.1016\/j.jdent.2023.104645_bib0027","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/s41598-020-57531-8","article-title":"Targeted metabolomics of pellicle and saliva in children with different caries activity","volume":"10","author":"Schulz","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jdent.2023.104645_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2021.716493","article-title":"Bacterial composition and metabolomics of dental plaque from adolescents","volume":"11","author":"Havsed","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"10.1016\/j.jdent.2023.104645_bib0029","series-title":"Fisiopatolog\u00eda De Las Gl\u00e1ndulas Salivales","first-page":"67","article-title":"Cap\u00edtulo 5. T\u00e9cnicas de exploraci\u00f3n salival: sialometr\u00eda","author":"L\u00f3pez Jornet","year":"2010"},{"key":"10.1016\/j.jdent.2023.104645_bib0030","first-page":"149","article-title":"Methods of collection of saliva - a review","volume":"3","author":"Priya","year":"2017","journal-title":"Int. J. Oral Health Dentistry"},{"key":"10.1016\/j.jdent.2023.104645_bib0031","doi-asserted-by":"crossref","first-page":"D622","DOI":"10.1093\/nar\/gkab1062","article-title":"HMDB 5.0: the human metabolome database for 2022","volume":"50","author":"Wishart","year":"2022","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.jdent.2023.104645_bib0032","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12903-023-02722-8","article-title":"Salivary microbiome and metabolome analysis of severe early childhood caries","volume":"23","author":"Li","year":"2023","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.jdent.2023.104645_bib0033","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/metabo13030356","article-title":"Identification of a biomarker panel for diagnosis of early childhood caries using salivary metabolic profile","volume":"13","author":"Kim","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.jdent.2023.104645_bib0034","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2019.1617014","article-title":"Determining bacterial and host contributions to the human salivary metabolome","volume":"11","author":"Gardner","year":"2019","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.jdent.2023.104645_bib0035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF01611399","article-title":"Intra-oral lactic acid production during clearance of different foods containing various carbohydrates","volume":"36","author":"Linke","year":"1997","journal-title":"Z. Ernahrungswiss."},{"key":"10.1016\/j.jdent.2023.104645_bib0036","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1007\/s11306-015-0840-5","article-title":"The human saliva metabolome","volume":"11","author":"Dame","year":"2015","journal-title":"Metabolomics"},{"key":"10.1016\/j.jdent.2023.104645_bib0037","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.archoralbio.2008.07.011","article-title":"Association of free amino acids with caries experience and mutans streptococci levels in whole saliva of children with early childhood caries","volume":"54","author":"Fonteles","year":"2009","journal-title":"Arch. Oral. Biol."},{"key":"10.1016\/j.jdent.2023.104645_bib0038","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/00220345590380021401","article-title":"Amino acid composition of proteins of human dentin","volume":"38","author":"Hughston","year":"1959","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jdent.2023.104645_bib0039","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/(SICI)1099-1492(199910)12:6<345::AID-NBM580>3.0.CO;2-C","article-title":"1H-NMR analysis of microbial-derived organic acids in primary root carious lesions and saliva","volume":"12","author":"Silwood","year":"1999","journal-title":"NMR Biomed."},{"key":"10.1016\/j.jdent.2023.104645_bib0040","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2021.1886748","article-title":"The bacterial microbiome and metabolome in caries progression and arrest","volume":"13","author":"da Costa Rosa","year":"2021","journal-title":"J. Oral Microbiol."},{"key":"10.1016\/j.jdent.2023.104645_bib0041","doi-asserted-by":"crossref","first-page":"115","DOI":"10.5650\/jos.57.115","article-title":"Lipids in human parotid saliva with regard to caries experience","volume":"57","author":"Tomita","year":"2008","journal-title":"J. Oleo Sci."},{"key":"10.1016\/j.jdent.2023.104645_bib0042","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s11745-013-3822-2","article-title":"Fatty acid profile of the initial oral biofilm (Pellicle): an in-situ study","volume":"48","author":"Reich","year":"2013","journal-title":"Lipids"},{"key":"10.1016\/j.jdent.2023.104645_bib0043","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.1038\/s41598-017-06418-2","article-title":"The basal free fatty acid concentration in human saliva is related to salivary lipolytic activity","volume":"7","author":"Neyraud","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jdent.2023.104645_bib0044","first-page":"34","article-title":"Las curvas ROC en la evaluaci\u00f3n de las pruebas diagn\u00f3sticas","volume":"108","author":"Burgue\u00f1o","year":"1995","journal-title":"Med. Clin. (Barc)"}],"container-title":["Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571223002312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571223002312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T15:15:11Z","timestamp":1736349311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300571223002312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":44,"alternative-id":["S0300571223002312"],"URL":"https:\/\/doi.org\/10.1016\/j.jdent.2023.104645","relation":{},"ISSN":["0300-5712"],"issn-type":[{"value":"0300-5712","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salivary metabolomic profile associated with cariogenic risk in children","name":"articletitle","label":"Article Title"},{"value":"Journal of Dentistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdent.2023.104645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104645"}}