{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T15:40:22Z","timestamp":1768837222642,"version":"3.49.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014440","name":"Espana Ministerio de Ciencia e Innovacion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dentistry"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jdent.2024.105333","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T17:23:47Z","timestamp":1725038627000},"page":"105333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Efficacy of topical application of corticosteroids in the remineralization of dental pulp tissue. A systematic review of the literature"],"prefix":"10.1016","volume":"150","author":[{"given":"Marta","family":"Vallecillo-Rivas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Fern\u00e1ndez-Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"P\u00e9rez-Segura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Toledano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anisa","family":"Amar-Zetouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Toledano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Vallecillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdent.2024.105333_bib0001","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1039\/C5TB00482A","article-title":"Biomineralization on enzymatically cross-linked gelatin hydrogels in the absence of dexamethasone","volume":"3","author":"Bhatnagar","year":"2015","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jdent.2024.105333_bib0002","doi-asserted-by":"crossref","first-page":"6738","DOI":"10.1016\/j.biomaterials.2013.05.046","article-title":"Bioinspired intrafibrillar mineralization of human dentine by PAMAM dendrimer","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jdent.2024.105333_bib0003","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1016\/j.biomaterials.2013.03.053","article-title":"Hydroxyapatite-anchored dendrimer for in situ remineralization of human tooth enamel","volume":"34","author":"Wu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.jdent.2024.105333_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111011","article-title":"Electrospinning of dexamethasone\/cyclodextrin inclusion complex polymer fibers for dental pulp therapy","volume":"191","author":"Daghrery","year":"2020","journal-title":"Colloids. Surf. B Biointerfaces."},{"key":"10.1016\/j.jdent.2024.105333_bib0005","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s10266-019-00459-x","article-title":"Dexamethasone-loaded hollow hydroxyapatite microsphere promotes odontogenic differentiation of human dental pulp cells in vitro","volume":"108","author":"Zhang","year":"2020","journal-title":"Odontology."},{"key":"10.1016\/j.jdent.2024.105333_bib0006","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.pdpdt.2015.09.005","article-title":"Photodynamic antimicrobial chemotherapy and ultraconservative caries removal linked for management of deep caries lesions","volume":"12","author":"Melo","year":"2015","journal-title":"Photodiagnosis. Photodyn. Ther."},{"key":"10.1016\/j.jdent.2024.105333_bib0007","first-page":"6","article-title":"A review on vital pulp therapy in primary teeth","volume":"10","author":"Parisay","year":"2015","journal-title":"Iran. Endod. J."},{"key":"10.1016\/j.jdent.2024.105333_bib0008","doi-asserted-by":"crossref","first-page":"e3466","DOI":"10.1002\/jgm.3466","article-title":"Genome wide analysis of dexamethasone stimulated mineralization in human dental pulp cells by RNA sequencing","volume":"25","author":"Tang","year":"2023","journal-title":"J. Gene Med."},{"key":"10.1016\/j.jdent.2024.105333_bib0009","first-page":"123","article-title":"Mineralisation Influence of Betamethasone on Lipopolysaccharide-Stimulated Dental Pulp Cells","volume":"22","author":"Wang","year":"2019","journal-title":"Chin. J. Dent. Res."},{"key":"10.1016\/j.jdent.2024.105333_bib0010","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.joen.2012.09.012","article-title":"Fluocinolone acetonide promotes the proliferation and mineralization of dental pulp cells","volume":"39","author":"Liu","year":"2013","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2024.105333_bib0011","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s13577-011-0010-7","article-title":"Dentinogenic potential of human adult dental pulp cells during the extended primary culture","volume":"24","author":"Min","year":"2011","journal-title":"Hum. Cell"},{"key":"10.1016\/j.jdent.2024.105333_bib0012","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.archoralbio.2010.12.008","article-title":"Comparative analysis of in vitro osteo\/odontogenic differentiation potential of human dental pulp stem cells (DPSCs) and stem cells from the apical papilla (SCAP)","volume":"56","author":"Bakopoulou","year":"2011","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jdent.2024.105333_bib0013","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo","volume":"97","author":"Gronthos","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.jdent.2024.105333_bib0014","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1073\/pnas.0937635100","article-title":"SHED: stem cells from human exfoliated deciduous teeth","volume":"100","author":"Miura","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.jdent.2024.105333_bib0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jdent.2024.105333_bib0016","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.joen.2007.11.021","article-title":"Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study","volume":"34","author":"Sonoyama","year":"2008","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2024.105333_bib0017","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/cpr.12071","article-title":"10(-7) m 17\u03b2-oestradiol enhances odonto\/osteogenic potency of human dental pulp stem cells by activation of the NF-\u03baB pathway","volume":"46","author":"Wang","year":"2013","journal-title":"Cell Prolif."},{"key":"10.1016\/j.jdent.2024.105333_bib0018","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2121-11-32","article-title":"Differentiation potential of STRO-1+ dental pulp stem cells changes during cell passaging","volume":"11","author":"Yu","year":"2010","journal-title":"BMC. Cell Biol."},{"key":"10.1016\/j.jdent.2024.105333_bib0019","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/01.don.0000164138.49923.e5","article-title":"The application of tissue engineering to regeneration of pulp and dentin in endodontics","volume":"31","author":"Nakashima","year":"2005","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2024.105333_bib0020","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/nbt864","article-title":"The application of bone morphogenetic proteins to dental tissue engineering","volume":"21","author":"Nakashima","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jdent.2024.105333_bib0021","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1601-0825.2006.01346.x","article-title":"Stem cells and the dental pulp: potential roles in dentine regeneration and repair","volume":"13","author":"Sloan","year":"2007","journal-title":"Oral Dis."},{"key":"10.1016\/j.jdent.2024.105333_bib0022","first-page":"2557","article-title":"Delivery of dexamethasone from bioactive nanofiber matrices stimulates odontogenesis of human dental pulp cells through integrin\/BMP\/mTOR signaling pathways","volume":"11","author":"Lim","year":"2016","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.jdent.2024.105333_bib0023","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00441-005-1115-7","article-title":"Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures","volume":"321","author":"Alliot-Licht","year":"2005","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.jdent.2024.105333_bib0024","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1089\/ten.2006.12.3097","article-title":"Differentiation of dental pulp stem cells into regular-shaped dentin-pulp complex induced by tooth germ cell conditioned medium","volume":"12","author":"Yu","year":"2006","journal-title":"Tissue Eng."},{"key":"10.1016\/j.jdent.2024.105333_bib0025","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fphar.2019.00308","article-title":"Glucocorticoid-induced Leucine Zipper: a novel anti-inflammatory molecule","volume":"10","author":"Bereshchenko","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jdent.2024.105333_bib0026","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.joen.2007.05.007","article-title":"Different roles of dexamethasone on transforming growth factor-beta1-induced fibronectin and nerve growth factor expression in dental pulp cells","volume":"33","author":"Srisawasdi","year":"2007","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2024.105333_bib0027","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.rdc.2011.07.003","article-title":"Update on glucocorticoid-induced osteoporosis","volume":"37","author":"Maricic","year":"2011","journal-title":"Rheum. Dis. Clin. North Am."},{"key":"10.1016\/j.jdent.2024.105333_bib0028","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1006\/excr.2000.4909","article-title":"Human dentin production in vitro","volume":"258","author":"About","year":"2000","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.jdent.2024.105333_bib0029","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1163\/156856298X00127","article-title":"Role of synthetic extracellular matrix in development of engineered dental pulp","volume":"9","author":"Bohl","year":"1998","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.jdent.2024.105333_bib0030","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0142-9612(95)98280-R","article-title":"Response of odontoblast-like cells to hydroxyapatite ceramic granules","volume":"16","author":"Holtgrave","year":"1995","journal-title":"Biomaterials"},{"key":"10.1016\/j.jdent.2024.105333_bib0031","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/(SICI)1097-4636(1999)48:6<913::AID-JBM22>3.0.CO;2-0","article-title":"Stem cell technology and bioceramics: from cell to gene engineering","volume":"48","author":"Ohgushi","year":"1999","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.jdent.2024.105333_bib0032","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1021\/am5077759","article-title":"Osteoinductive fibrous scaffolds of biopolymer\/mesoporous bioactive glass nanocarriers with excellent bioactivity and long-term delivery of osteogenic drug","volume":"7","author":"El-Fiqi","year":"2015","journal-title":"ACS. Appl. Mater. Interfaces."},{"key":"10.1016\/j.jdent.2024.105333_bib0033","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.joen.2015.03.024","article-title":"Temporal-controlled dexamethasone releasing chitosan nanoparticle system enhances odontogenic differentiation of stem cells from apical papilla","volume":"41","author":"Shrestha","year":"2015","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2024.105333_bib0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"PRISMA-P Group, preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst. Rev."},{"key":"10.1016\/j.jdent.2024.105333_bib0035","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.jdent.2024.105333_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2022.104350","article-title":"RoBDEMAT: a risk of bias tool and guideline to support reporting of pre-clinical dental materials research and assessment of systematic reviews","volume":"127","author":"Delgado","year":"2022","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2024.105333_bib0037","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.bja.2019.08.015","article-title":"Use of the GRADE approach in systematic reviews and guidelines","volume":"123","author":"Granholm","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.jdent.2024.105333_bib0038","doi-asserted-by":"crossref","first-page":"331","DOI":"10.29252\/rbmb.9.3.331","article-title":"Comparison of osteogenic potential of phenytoin with dexamethasone in cultured dental pulp stem cells","volume":"9","author":"Asgharian-Rezaee","year":"2020","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"10.1016\/j.jdent.2024.105333_bib0039","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.joen.2015.09.016","article-title":"Pulpal responses to direct capping with betamethasone\/gentamicin cream and mineral trioxide aggregate: histologic and micro-computed tomography assessments","volume":"42","author":"AlShwaimi","year":"2016","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2024.105333_bib0040","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1752-7325.2005.tb02792.x","article-title":"Root canal filled versus non-root canal filled teeth: a retrospective comparison of survival times","volume":"65","author":"Caplan","year":"2005","journal-title":"J. Public Health Dent."},{"key":"10.1016\/j.jdent.2024.105333_bib0041","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00784-016-1802-7","article-title":"Different materials for direct pulp capping: systematic review and meta-analysis and trial sequential analysis","volume":"20","author":"Schwendicke","year":"2016","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.jdent.2024.105333_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2023.104447","article-title":"Dexamethasone-doped nanoparticles improve mineralization, crystallinity and collagen structure of human dentin","volume":"130","author":"Toledano","year":"2023","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2024.105333_bib0043","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1038\/cdd.2015.99","article-title":"miR-216a rescues dexamethasone suppression of osteogenesis, promotes osteoblast differentiation and enhances bone formation, by regulating c-Cbl-mediated PI3K\/AKT pathway","volume":"22","author":"Li","year":"2015","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.jdent.2024.105333_bib0044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10856-020-06475-6","article-title":"Effect of dexamethasone as osteogenic supplementation in in vitro osteogenic differentiation of stem cells from human exfoliated deciduous teeth","volume":"32","author":"Sordi","year":"2021","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.jdent.2024.105333_bib0045","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/(SICI)1097-4644(19960501)61:2<182::AID-JCB3>3.0.CO;2-Q","article-title":"Expression of bone matrix proteins during dexamethasone-induced mineralization of human bone marrow stromal cells","volume":"61","author":"Cheng","year":"1996","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.jdent.2024.105333_bib0046","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/jcb.10220","article-title":"Differential regulation of Cbfa1\/Runx2 and osteocalcin gene expression by vitamin-D3, dexamethasone, and local growth factors in primary human osteoblasts","volume":"86","author":"Viereck","year":"2002","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.jdent.2024.105333_bib0047","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1034\/j.1600-0722.2000.00765.x","article-title":"Molecular cloning of a human dentin sialophosphoprotein gene","volume":"108","author":"Gu","year":"2000","journal-title":"Eur. J. Oral Sci."},{"key":"10.1016\/j.jdent.2024.105333_bib0048","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/0006-291X(92)92287-8","article-title":"Clonal dental pulp cells (RDP4-1, RPC-C2A) synthesize and secrete osteopontin (SPP1, 2ar)","volume":"189","author":"Yokota","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jdent.2024.105333_bib0049","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1177\/0022034515584615","article-title":"Long-term fluoride release from dental resins affects STRO-1+ cell behavior","volume":"94","author":"Calarco","year":"2015","journal-title":"J. Dent. Res."}],"container-title":["Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571224005025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571224005025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T14:09:26Z","timestamp":1729519766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300571224005025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":49,"alternative-id":["S0300571224005025"],"URL":"https:\/\/doi.org\/10.1016\/j.jdent.2024.105333","relation":{},"ISSN":["0300-5712"],"issn-type":[{"value":"0300-5712","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of topical application of corticosteroids in the remineralization of dental pulp tissue. A systematic review of the literature","name":"articletitle","label":"Article Title"},{"value":"Journal of Dentistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdent.2024.105333","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105333"}}