{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:53:34Z","timestamp":1780552414919,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dentistry"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jdent.2025.105604","type":"journal-article","created":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T06:27:05Z","timestamp":1738477625000},"page":"105604","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDSCs), and periodontal ligament stem cells (PDLSCs) isolation, characterization and the effectiveness of allantoin as bioactive molecule for dental regeneration"],"prefix":"10.1016","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6198-132X","authenticated-orcid":false,"given":"Bet\u00fcl","family":"Mutlu \u00d6z\u00e7\u0131nar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"\u00d6z\u00fcko\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5166-2109","authenticated-orcid":false,"given":"Emrah","family":"T\u00fcrkmen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabia","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jdent.2025.105604_bib0001","doi-asserted-by":"crossref","first-page":"7114","DOI":"10.3390\/ijerph19127114","article-title":"Cherrez-Ojeda I. Individual, family, and socioeconomic contributors to dental caries in children from low-and middle-income countries","volume":"19","author":"Yousaf","year":"2022","journal-title":"Int J Environ Res Public Health N Hav"},{"issue":"16","key":"10.1016\/j.jdent.2025.105604_bib0002","doi-asserted-by":"crossref","first-page":"8991","DOI":"10.3390\/ijms22168991","article-title":"Functional dental pulp regeneration: basic research and clinical translation","volume":"22","author":"Xie","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jdent.2025.105604_bib0003","first-page":"454","article-title":"Role and application of stem cells in dental regeneration: a comprehensive overview","volume":"20","author":"Soudi","year":"2021","journal-title":"EXCLI. J."},{"issue":"9","key":"10.1016\/j.jdent.2025.105604_bib0004","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/j.joen.2020.06.022","article-title":"Scaffold-based and scaffold-free strategies in dental pulp regeneration","volume":"46","author":"Dissanayaka","year":"2020","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2025.105604_bib0005","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8864572","article-title":"Dental tissue-derived human mesenchymal stem cells and their potential in therapeutic application","volume":"2020","author":"Gan","year":"2020","journal-title":"Stem Cells Int."},{"issue":"9","key":"10.1016\/j.jdent.2025.105604_bib0006","doi-asserted-by":"crossref","first-page":"897","DOI":"10.4252\/wjsc.v12.i9.897","article-title":"Dental stem cells: the role of biomaterials and scaffolds in developing novel therapeutic strategies","volume":"12","author":"Granz","year":"2020","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.jdent.2025.105604_bib0007","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9978837","article-title":"Stem cells: a historical review about biological, religious, and ethical issues","volume":"2021","author":"Charitos","year":"2021","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.jdent.2025.105604_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13287-020-01683-x","article-title":"Promising advances in clinical trials of dental tissue-derived cell-based regenerative medicine","volume":"11","author":"Yamada","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jdent.2025.105604_bib0009","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5304860","article-title":"The role of epigenetic in dental and oral regenerative medicine by different types of dental stem cells: a comprehensive overview","volume":"2022","author":"Hussain","year":"2022","journal-title":"Stem Cells Int."},{"issue":"25","key":"10.1016\/j.jdent.2025.105604_bib0010","doi-asserted-by":"crossref","first-page":"13625","DOI":"10.1073\/pnas.240309797","article-title":"Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo","volume":"97","author":"Gronthos","year":"2000","journal-title":"Proc Natl Acad Sci"},{"issue":"2\u20133","key":"10.1016\/j.jdent.2025.105604_bib0011","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/term.71","article-title":"In vivo evaluation of human dental pulp stem cells differentiated towards multiple lineages","volume":"2","author":"Zhang","year":"2008","journal-title":"J. Tissue Eng. Regen. Med."},{"issue":"10","key":"10.1016\/j.jdent.2025.105604_bib0012","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1073\/pnas.0937635100","article-title":"SHED: stem cells from human exfoliated deciduous teeth","volume":"100","author":"Miura","year":"2003","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"10.1016\/j.jdent.2025.105604_bib0013","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1600-0765.2006.00870.x","article-title":"Stem cell properties of human periodontal ligament cells","volume":"41","author":"Nagatomo","year":"2006","journal-title":"J. Periodontal. Res."},{"issue":"7","key":"10.1016\/j.jdent.2025.105604_bib0014","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3727\/096368910X539128","article-title":"Promising cell-based therapy for bone regeneration using stem cells from deciduous teeth, dental pulp, and bone marrow","volume":"20","author":"Yamada","year":"2011","journal-title":"Cell TransPlant"},{"issue":"15","key":"10.1016\/j.jdent.2025.105604_bib0015","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1089\/scd.2019.0023","article-title":"A comparative analysis of the osteogenic potential of dental mesenchymal stem cells","volume":"28","author":"Winning","year":"2019","journal-title":"Stem Cells Dev."},{"issue":"8","key":"10.1016\/j.jdent.2025.105604_bib0016","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.3390\/ijms21082753","article-title":"The expression profile of dental pulp-derived stromal cells supports their limited capacity to differentiate into adipogenic cells","volume":"21","author":"Fracaro","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jdent.2025.105604_bib0017","doi-asserted-by":"crossref","DOI":"10.1100\/2012\/827149","article-title":"In vitro chondrogenesis transformation study of mouse dental pulp stem cells","volume":"2012","author":"Zainal Ariffin","year":"2012","journal-title":"Sci World J"},{"issue":"10","key":"10.1016\/j.jdent.2025.105604_bib0018","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.joen.2009.07.005","article-title":"Stem cell regulatory gene expression in human adult dental pulp and periodontal ligament cells undergoing odontogenic\/osteogenic differentiation","volume":"35","author":"Liu","year":"2009","journal-title":"J. Endod."},{"issue":"11","key":"10.1016\/j.jdent.2025.105604_bib0019","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.joen.2009.07.024","article-title":"Stem cell proliferation pathways comparison between human exfoliated deciduous teeth and dental pulp stem cells by gene expression profile from promising dental pulp","volume":"35","author":"Nakamura","year":"2009","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2025.105604_bib0020","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9980137","article-title":"Early osteogenic differentiation stimulation of dental pulp stem cells by calcitriol and curcumin","volume":"2021","author":"Samiei","year":"2021","journal-title":"Stem Cells Int."},{"issue":"1","key":"10.1016\/j.jdent.2025.105604_bib0021","first-page":"7","article-title":"Allantoin: synthesis and chemical properties","author":"Bakibaev","year":"2020","journal-title":"\u0412\u0435\u0441\u0442\u043d\u0438\u043a \u041a\u0430\u0440\u0430\u0433\u0430\u043d\u0434\u0438\u043d\u0441\u043a\u043e\u0433\u043e \u0443\u043d\u0438\u0432\u0435\u0440\u0441\u0438\u0442\u0435\u0442\u0430 \u0421\u0435\u0440\u0438\u044f: \u0425\u0438\u043c\u0438\u044f"},{"issue":"5","key":"10.1016\/j.jdent.2025.105604_bib0022","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/14786419.2017.1326492","article-title":"Proliferative and antioxidant activity of Symphytum officinale root extract","volume":"32","author":"Sowa","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.jdent.2025.105604_bib0023","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1590\/S0102-86502010000500014","article-title":"Profile of wound healing process induced by allantoin","volume":"25","author":"Ara\u00fajo","year":"2010","journal-title":"Acta Cir. Bras."},{"issue":"5","key":"10.1016\/j.jdent.2025.105604_bib0024","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1080\/00405000.2021.1903197","article-title":"Preparation of allantoin loaded liposome formulations and application for cosmetic textile production","volume":"113","author":"Say\u0131t","year":"2022","journal-title":"J Text Inst"},{"issue":"3","key":"10.1016\/j.jdent.2025.105604_bib0025","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5152\/iao.2021.8882","article-title":"The effect of allantoin on chronic perforation of rat tympanic membrane","volume":"17","author":"\u00dcnsal","year":"2021","journal-title":"J. Int. Adv. Otol."},{"issue":"18","key":"10.1016\/j.jdent.2025.105604_bib0026","doi-asserted-by":"crossref","first-page":"10170","DOI":"10.3390\/su131810170","article-title":"Allantoin from valuable Romanian animal and plant sources with promising anti-inflammatory activity as a nutricosmetic ingredient","volume":"13","author":"Dinica","year":"2021","journal-title":"Sustainability."},{"key":"10.1016\/j.jdent.2025.105604_bib0027","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jep.2018.07.005","article-title":"Aqueous extract of Sedum oxypetalum induces mineralization and osteogenic differentiation by human Periodontal Ligament-Derived cells","volume":"225","author":"Lara-Issasi","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.jdent.2025.105604_bib0028","doi-asserted-by":"crossref","first-page":"71","DOI":"10.26505\/DJM.18024981002","article-title":"Histological and Immunohistochemical Study of Osteocalcin to Evaluate The Effect of Local Application of Symphytum Officinale Oil on Bone Healing on Rat","volume":"18","author":"Khalel","year":"2020","journal-title":"Diyala J Med"},{"issue":"8","key":"10.1016\/j.jdent.2025.105604_bib0029","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/ptr.5356","article-title":"Comparative study of the biological activity of allantoin and aqueous extract of the comfrey root","volume":"29","author":"Savi\u0107","year":"2015","journal-title":"Phyther Res"},{"issue":"7","key":"10.1016\/j.jdent.2025.105604_bib0030","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S1357-2725(01)00166-2","article-title":"The hyaluronan receptor, CD44","volume":"34","author":"Isacke","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jdent.2025.105604_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112329","article-title":"Symphytum officinale augments osteogenesis in human bone marrow-derived mesenchymal stem cells in vitro as they differentiate into osteoblasts","volume":"248","author":"Dey","year":"2020","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.jdent.2025.105604_bib0032","doi-asserted-by":"crossref","first-page":"547","DOI":"10.3892\/mmr.2012.974","article-title":"Effects of total flavonoids from Drynaria fortunei on the proliferation and osteogenic differentiation of rat dental pulp stem cells","volume":"6","author":"Huang","year":"2012","journal-title":"Mol. Med. Rep."}],"container-title":["Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571225000508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571225000508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T23:43:32Z","timestamp":1740095012000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300571225000508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":32,"alternative-id":["S0300571225000508"],"URL":"https:\/\/doi.org\/10.1016\/j.jdent.2025.105604","relation":{},"ISSN":["0300-5712"],"issn-type":[{"value":"0300-5712","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHEDSCs), and periodontal ligament stem cells (PDLSCs) isolation, characterization and the effectiveness of allantoin as bioactive molecule for dental regeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Dentistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdent.2025.105604","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105604"}}