{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:48:50Z","timestamp":1791398930486,"version":"4.3.3"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002332","name":"Semmelweis Egyetem","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["NKFIH K-147107"],"award-info":[{"award-number":["NKFIH K-147107"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dentistry"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.jdent.2025.106094","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:15:01Z","timestamp":1757031301000},"page":"106094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Association between systemic exposure to antibiotics in early childhood and molar-incisor hypomineralization (MIH): A systematic review and meta-analysis"],"prefix":"10.1016","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-4815","authenticated-orcid":false,"given":"\u00c9va","family":"Mlink\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalma","family":"T\u00e1bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-6524","authenticated-orcid":false,"given":"Bianca Golzio Navarro","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"V\u00e1g","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-4275","authenticated-orcid":false,"given":"Enik\u0151 Vaszin\u00e9","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi Katinka","family":"R\u00f3zsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5506-8198","authenticated-orcid":false,"given":"G\u00e1bor","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jdent.2025.106094_bib0001","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.adaj.2018.03.013","article-title":"Molar hypomineralization: what is the US experience?","volume":"149","author":"Hubbard","year":"2018","journal-title":"J. Am. Dent. Assoc"},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0002","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s40368-021-00646-x","article-title":"An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis","volume":"23","author":"Garot","year":"2022","journal-title":"Eur. Arch. Paediatr. Dent"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0003","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF03262713","article-title":"Aetiology of Molar-Incisor hypomineralisation: a systematic review","volume":"11","author":"Alaluusua","year":"2010","journal-title":"Eur. Arch. Paediatr. Dent"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0004","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF03262715","article-title":"Treatment modalities in children with teeth affected by molar-incisor enamel hypomineralisation (MIH): a systematic review","volume":"11","author":"Lygidakis","year":"2010","journal-title":"Eur. Arch. Paediatr. Dent"},{"issue":"5","key":"10.1016\/j.jdent.2025.106094_bib0005","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1159\/000047479","article-title":"Molar\u2013Incisor hypomineralisation","volume":"35","author":"Weerheijm","year":"2001","journal-title":"Caries. Res"},{"key":"10.1016\/j.jdent.2025.106094_bib0006","first-page":"110","article-title":"Judgement criteria for Molar Incisor hypomineralisation (MIH) in epidemiologic","author":"Weerheijm","year":"2003","journal-title":"Clin. Chem. -. CLIN. CHEM"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0007","first-page":"114","article-title":"Molar incisor hypomineralisation (MIH)","volume":"4","author":"Weerheijm","year":"2003","journal-title":"Eur. J. Paediatr. Dent"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0008","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF03262716","article-title":"Best clinical practice guidance for clinicians dealing with children presenting with Molar-Incisor-hypomineralisation (MIH): an EAPD policy document","volume":"11","author":"Lygidakis","year":"2010","journal-title":"Eur. Arch. Paediatr. Dent"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0009","doi-asserted-by":"crossref","DOI":"10.1111\/eos.12930","article-title":"Molar-incisor hypomineralisation in Norwegian children: prevalence and associated factors","volume":"131","author":"Haque Afzal","year":"2023","journal-title":"Eur. J. Oral. Sci"},{"issue":"5","key":"10.1016\/j.jdent.2025.106094_bib0010","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/00016357.2020.1863461","article-title":"Molar-incisor hypomineralization: an umbrella review","volume":"79","author":"Lopes","year":"2021","journal-title":"Acta. Odontol. Scand"},{"key":"10.1016\/j.jdent.2025.106094_bib0011","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jdent.2017.12.002","article-title":"Global burden of molar incisor hypomineralization","volume":"68","author":"Schwendicke","year":"2018","journal-title":"J. Dent"},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0012","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12903-023-03637-0","article-title":"Is there a rise of prevalence for Molar Incisor hypomineralization? A meta-analysis of published data","volume":"24","author":"Sluka","year":"2024","journal-title":"BMC. Oral. Health"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0013","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-263X.2007.00901.x","article-title":"Molar incisor hypomineralization: a study of aetiological factors in a group of UK children","volume":"18","author":"Whatling","year":"2008","journal-title":"Int. J. Paediatr. Dent"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0014","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/ipd.12327","article-title":"Exploring the association between genetic and environmental factors and molar incisor hypomineralization: evidence from a twin study","volume":"28","author":"Teixeira","year":"2018","journal-title":"Int. J. Paediatr. Dent."},{"issue":"6","key":"10.1016\/j.jdent.2025.106094_bib0015","doi-asserted-by":"crossref","first-page":"e799","DOI":"10.1016\/S2214-109X(20)30079-6","article-title":"Trends in reported antibiotic use among children under 5 years of age with fever, diarrhoea, or cough with fast or difficult breathing across low-income and middle-income countries in 2005-17: a systematic analysis of 132 national surveys from 73 countries","volume":"8","author":"Allwell-Brown","year":"2020","journal-title":"Lancet. Glob. Health"},{"issue":"10","key":"10.1016\/j.jdent.2025.106094_bib0016","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/archpedi.159.10.943","article-title":"Association of amoxicillin use during early childhood with developmental tooth enamel defects","volume":"159","author":"Hong","year":"2005","journal-title":"Arch. Pediatr. Adolesc. Med"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0017","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/imj.1963.12.4.325","article-title":"Tetracycline antibiotics and their effects on calcified and non-calcified tissues","volume":"12","author":"STOREY","year":"1963","journal-title":"Australas. Ann. Med"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0018","first-page":"130","article-title":"Effects of amoxicillin on the structure and mineralization of dental enamel and dentin in wistar rats","volume":"16","author":"Kameli","year":"2019","journal-title":"Front. Dent"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0019","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/ipd.12184","article-title":"Amoxicillin diminishes the thickness of the enamel matrix that is deposited during the secretory stage in rats","volume":"26","author":"de Souza","year":"2016","journal-title":"Int. J. Paediatr. Dent"},{"issue":"10","key":"10.1016\/j.jdent.2025.106094_bib0020","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.archoralbio.2013.04.012","article-title":"Association of amoxicillin use and molar incisor hypomineralization in piglets: visual and mineral density evaluation","volume":"58","author":"Kuscu","year":"2013","journal-title":"Arch. Oral. Biol"},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0021","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s40368-021-00677-4","article-title":"Effects of antibiotics on the developing enamel in neonatal mice","volume":"23","author":"Schmalfuss","year":"2022","journal-title":"Eur. Arch. Paediatr. Dent"},{"key":"10.1016\/j.jdent.2025.106094_bib0022","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.1590\/1807-3107bor-2020.vol34.0116","article-title":"The effect of amoxicillin on dental enamel development in vivo","volume":"34","author":"Feltrin-Souza","year":"2020","journal-title":"Braz. Oral. Res"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0023","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/00016351003752395","article-title":"Chemical, mechanical and morphological properties of hypomineralized enamel of permanent first molars","volume":"68","author":"Fagrell","year":"2010","journal-title":"Acta. Odontol. Scand"},{"issue":"10","key":"10.1016\/j.jdent.2025.106094_bib0024","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/sj.bdj.4811282","article-title":"3D X-ray microscopic study of the extent of variations in enamel density in first permanent molars with idiopathic enamel hypomineralisation","volume":"196","author":"Fearne","year":"2004","journal-title":"Br. Dent. J"},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0025","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1038\/s41598-022-05628-7","article-title":"Relationship between molar incisor hypomineralization, intrapartium medication and illnesses in the first year of life","volume":"12","author":"Acosta","year":"2022","journal-title":"Sci. Rep"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0026","first-page":"245","article-title":"Molar incisor hypomineralization: a study of prevalence and etiology in a group of Iranian children","volume":"22","author":"Ahmadi","year":"2012","journal-title":"Iran. J. Pediatr"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0027","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s40368-020-00555-5","article-title":"Molar-incisor hypomineralisation in Lebanon: association with prenatal, natal and postnatal factors","volume":"22","author":"Elzein","year":"2021","journal-title":"Eur. Arch. Paediatr. Dent"},{"key":"10.1016\/j.jdent.2025.106094_bib0028","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7584736","article-title":"Investigation of clinical characteristics and etiological factors in children with Molar Incisor hypomineralization","volume":"2018","author":"Giuca","year":"2018","journal-title":"Int. J. Dent"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0029","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s40368-015-0178-8","article-title":"A practical method for use in epidemiological studies on enamel hypomineralisation","volume":"16","author":"Ghanim","year":"2015","journal-title":"Eur. Arch. Paediatr. Dent"},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0030","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s40368-021-00665-8","article-title":"A case-controlled investigation of risk factors associated with molar incisor hypomineralization (MIH) in 8-12 year-old children living in Chandigarh, India","volume":"23","author":"Mariam","year":"2022","journal-title":"Eur. Arch. Paediatr. Dent"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0031","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF03262865","article-title":"Molar incisor hypomineralisation: possible aetiological factors in children from urban and rural areas","volume":"13","author":"Souza","year":"2012","journal-title":"Eur. Arch. Paediatr. Dent"},{"key":"10.1016\/j.jdent.2025.106094_bib0032","first-page":"41","article-title":"What are the systemic factors associated with the Molar- Incisor hypomineralization etiology?, Pesquisa Brasileira em Odontopediatria e","volume":"21","author":"Fonseca de Souza","year":"2021","journal-title":"Clin. Integr."},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0033","article-title":"Possible etiological factors for the development of molar incisor hypomineralization (MIH) in Austrian children","volume":"12","author":"Altner","year":"2024","journal-title":"Dent. J. (Basel)"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0034","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-263X.2008.00966.x","article-title":"Aetiology of molar-incisor hypomineralization: a critical review","volume":"19","author":"Crombie","year":"2009","journal-title":"Int. J. Paediatr. Dent"},{"issue":"5","key":"10.1016\/j.jdent.2025.106094_bib0035","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/cdoe.12467","article-title":"A systematic review and meta-analysis of systemic exposure associated with molar incisor hypomineralization","volume":"47","author":"Fatturi","year":"2019","journal-title":"Community. Dent. Oral. Epidemiol"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0036","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.adaj.2015.08.011","article-title":"Drugs related to the etiology of molar incisor hypomineralization: a systematic review","volume":"147","author":"Serna","year":"2016","journal-title":"J. Am. Dent. Assoc"},{"key":"10.1016\/j.jdent.2025.106094_bib0037","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Bmj"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0038","doi-asserted-by":"crossref","first-page":"276","DOI":"10.11613\/BM.2012.031","article-title":"Interrater reliability: the kappa statistic","volume":"22","author":"McHugh","year":"2012","journal-title":"Biochem. Med. (Zagreb)"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0039","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/00220345890680030201","article-title":"A modified DDE index for use in epidemiological studies of enamel defects","volume":"68","author":"Clarkson","year":"1989","journal-title":"J. Dent. Res"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0040","doi-asserted-by":"crossref","first-page":"280","DOI":"10.7326\/0003-4819-158-4-201302190-00009","article-title":"Assessing bias in studies of prognostic factors","volume":"158","author":"Hayden","year":"2013","journal-title":"Ann. Intern. Med"},{"key":"10.1016\/j.jdent.2025.106094_bib0041","series-title":"GRADE Handbook: Handbook for Grading Quality of Evidence and Strength of Recommendations","author":"Sch\u00fcnemann","year":"2013"},{"key":"10.1016\/j.jdent.2025.106094_bib0042","series-title":"R: A language and Environment For Statistical Computing","year":"2023"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0043","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: a practical tutorial","volume":"22","author":"Balduzzi","year":"2019","journal-title":"Evid. Based. Ment. Health"},{"key":"10.1016\/j.jdent.2025.106094_bib0044","series-title":"dmetar, dmetar: Companion R Package For The Guide 'Doing Meta-Analysis in R","author":"Harrer","year":"2019"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v036.i03","article-title":"Conducting meta-analyses in R with the metafor package","volume":"36","author":"Viechtbauer","year":"2010","journal-title":"J. Stat. Softw"},{"issue":"17","key":"10.1016\/j.jdent.2025.106094_bib0046","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1002\/sim.1482","article-title":"Improved tests for a random effects meta-regression with a single covariate","volume":"22","author":"Knapp","year":"2003","journal-title":"Stat. Med"},{"issue":"5","key":"10.1016\/j.jdent.2025.106094_bib0047","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/oxfordjournals.aje.a114447","article-title":"A general estimator for the variance of the Mantel-Haenszel odds ratio","volume":"124","author":"Robins","year":"1986","journal-title":"Am. J. Epidemiol"},{"key":"10.1016\/j.jdent.2025.106094_bib0048","series-title":"The Handbook of Research Synthesis and Meta-Analysis","author":"Cooper","year":"2009"},{"issue":"9","key":"10.1016\/j.jdent.2025.106094_bib0049","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/sim.1761","article-title":"What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data","volume":"23","author":"Sweeting","year":"2004","journal-title":"Stat. Med"},{"key":"10.1016\/j.jdent.2025.106094_bib0050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2288-14-25","article-title":"The Hartung-Knapp-Sidik-Jonkman method for random effects meta-analysis is straightforward and considerably outperforms the standard DerSimonian-Laird method","volume":"14","author":"IntHout","year":"2014","journal-title":"BMC. Med. Res. Methodol"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0051","doi-asserted-by":"crossref","first-page":"154","DOI":"10.20982\/tqmp.12.3.p154","article-title":"Fitting three-level meta-analytic models in R: A step-by-step tutorial","volume":"12","author":"Assink","year":"2016","journal-title":"Quant. Meth. Psych."},{"issue":"5","key":"10.1016\/j.jdent.2025.106094_bib0052","doi-asserted-by":"crossref","first-page":"377","DOI":"10.6028\/jres.087.022","article-title":"Consensus values and weighting factors","volume":"87","author":"Paule","year":"1977","journal-title":"J. Res. Natl. Bur. Stand"},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0053","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jrsm.1164","article-title":"Methods to estimate the between-study variance and its uncertainty in meta-analysis","volume":"7","author":"Veroniki","year":"2016","journal-title":"Res. Synth. Methods"},{"issue":"11","key":"10.1016\/j.jdent.2025.106094_bib0054","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat. Med"},{"key":"10.1016\/j.jdent.2025.106094_bib0055","doi-asserted-by":"crossref","unstructured":"M. Harrer, P. Cuijpers, T. Furukawa, D. Ebert, Doing Meta-Analysis with R: A Hands-On Guide, 2021.","DOI":"10.1201\/9781003107347"},{"issue":"6","key":"10.1016\/j.jdent.2025.106094_bib0056","article-title":"Etiology of molar-incisor hypomineralization (MIH): a cross-sectional study of Saudi children","volume":"8","author":"Alhowaish","year":"2021","journal-title":"Child. (Basel)"},{"key":"10.1016\/j.jdent.2025.106094_bib0057","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/234508","article-title":"Molar incisor hypomineralization, prevalence, and etiology","volume":"2014","author":"Allazzam","year":"2014","journal-title":"Int. J. Dent"},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0058","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.sdentj.2021.10.004","article-title":"Prevalence and possible aetiological factors of molar incisor hypomineralisation in Saudi children: a cross-sectional study","volume":"34","author":"Almuallem","year":"2022","journal-title":"Saudi. Dent. J"},{"issue":"6","key":"10.1016\/j.jdent.2025.106094_bib0059","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/ipd.12412","article-title":"Factors associated with molar-incisor hypomineralisation in schoolchildren aged 8-10 years: a case-control study","volume":"28","author":"Dantas-Neta","year":"2018","journal-title":"Int. J. Paediatr. Dent"},{"issue":"7","key":"10.1016\/j.jdent.2025.106094_bib0060","first-page":"513","article-title":"Epidemiologic study of molar-incisor hypomineralization in schoolchildren in north-eastern Brazil","volume":"37","author":"de Lima Mde","year":"2015","journal-title":"Pediatr. Dent"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0061","doi-asserted-by":"crossref","first-page":"297","DOI":"10.15644\/asc47\/4\/1","article-title":"Possible medical aetiological factors and characteristics of molar incisor hypomineralisation in a group of turkish children","volume":"47","author":"Durmus","year":"2013","journal-title":"Acta. Stomatol. Croat"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0062","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-263X.2012.01244.x","article-title":"Risk factors in the occurrence of molar-incisor hypomineralization amongst a group of Iraqi children","volume":"23","author":"Ghanim","year":"2013","journal-title":"Int. J. Paediatr. Dent"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0063","doi-asserted-by":"crossref","first-page":"211","DOI":"10.5005\/jp-journals-10005-1624","article-title":"Molar incisor hypomineralization-an emerging burden: a short study on prevalence and clinical characteristics in Central Delhi, India","volume":"12","author":"Goswami","year":"2019","journal-title":"Int. J. Clin. Pediatr. Dent"},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0064","first-page":"75","article-title":"Prevalence and aetiology of Molar-incisor hypomineralisation among children aged 8-10 years in Tirana, Albania","volume":"17","author":"Hysi","year":"2016","journal-title":"Eur. J. Paediatr. Dent"},{"key":"10.1016\/j.jdent.2025.106094_bib0065","doi-asserted-by":"crossref","first-page":"410","DOI":"10.5933\/JKAPD.2016.43.4.410","article-title":"Prevalence and etiology of molar incisor hypomineralization in children aged 8 - 9 years","volume":"43","author":"Kim","year":"2016","journal-title":"J. Korean. Acad. Pedtatric. Dent."},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0066","first-page":"134","article-title":"Factors associated with Molar-incisor hypomineralization: a population-based case-control study","volume":"42","author":"Lee","year":"2020","journal-title":"Pediatr. Dent"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0067","doi-asserted-by":"crossref","first-page":"167","DOI":"10.5005\/jp-journals-10005-1357","article-title":"Molar incisor hypomineralization: an epidemiological study with prevalence and etiological factors in Indian pediatric population","volume":"9","author":"Mishra","year":"2016","journal-title":"Int. J. Clin. Pediatr. Dent"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0068","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF03262595","article-title":"Molar incisor hypomineralisation in Bosnia and Herzegovina: aetiology and clinical consequences in medium caries activity population","volume":"8","author":"Muratbegovic","year":"2007","journal-title":"Eur. Arch. Paediatr. Dent"},{"key":"10.1016\/j.jdent.2025.106094_bib0069","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/ijpvm.IJPVM_459_18","article-title":"Could molar-incisor hypomineralization (MIH) existence be predictor of short stature?","volume":"11","author":"Owlia","year":"2020","journal-title":"Int. J. Prev. Med"},{"key":"10.1016\/j.jdent.2025.106094_bib0070","first-page":"1100","article-title":"Molar incisor hypomineralization prevalence in Arab children in UAE and its association with risk factors- A cross sectional study","volume":"14","author":"Padmanabhan","year":"2021","journal-title":"JIDMR"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0071","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/eos.12136","article-title":"Factors associated with molar incisor hypomineralization in Thai children","volume":"122","author":"Pitiphat","year":"2014","journal-title":"Eur. J. Oral. Sci"},{"key":"10.1016\/j.jdent.2025.106094_bib0072","first-page":"1","article-title":"Molar-incisor hypomineralization and associated factors: a CaseControl study, Pesquisa Brasileira em Odontopediatria e","volume":"18","author":"Portella","year":"2018","journal-title":"Cl\u00edn. Integr."},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0073","doi-asserted-by":"crossref","first-page":"280","DOI":"10.5005\/jp-journals-10005-2570","article-title":"Prevalence, severity and associated risk indicators of Molar Incisor hypomineralization amongst 8-13-year-old children of Vadodara District Gujarat: a cross-sectional study","volume":"16","author":"Shah","year":"2023","journal-title":"Int. J. Clin. Pediatr. Dent"},{"key":"10.1016\/j.jdent.2025.106094_bib0074","doi-asserted-by":"crossref","DOI":"10.1007\/s40368-013-0054-3","article-title":"Aetiology of molar-incisor hypomineralisation (MIH) in Brazilian children","author":"Souza","year":"2013","journal-title":"Eur. Arch. Paediatr. Dent"},{"key":"10.1016\/j.jdent.2025.106094_bib0075","doi-asserted-by":"crossref","first-page":"184","DOI":"10.2174\/1874210602115010184","article-title":"The prevalence and etiology of molar-incisor hypomineralization among female school children","volume":"15","author":"Sulaimani","year":"2021","journal-title":"Open. Dent. J"},{"issue":"6","key":"10.1016\/j.jdent.2025.106094_bib0076","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156332","article-title":"Association between Molar incisor hypomineralization in schoolchildren and both prenatal and postnatal factors: a population-based study","volume":"11","author":"Tourino","year":"2016","journal-title":"PLoS. One"},{"issue":"6","key":"10.1016\/j.jdent.2025.106094_bib0077","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/ipd.12655","article-title":"Use of asthma drugs and prevalence of molar incisor hypomineralization","volume":"30","author":"Wogelius","year":"2020","journal-title":"Int. J. Paediatr. Dent"},{"issue":"5","key":"10.1016\/j.jdent.2025.106094_bib0078","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3109\/00016357.2016.1172342","article-title":"Molar-incisor hypomineralization and the association with childhood illnesses and antibiotics in a group of Finnish children","volume":"74","author":"Wuollet","year":"2016","journal-title":"Acta. Odontol. Scand"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0079","doi-asserted-by":"crossref","first-page":"393","DOI":"10.12669\/pjms.302.4508","article-title":"Association of the use of bacterial cell wall synthesis inhibitor drugs in early childhood with the developmental defects of enamel","volume":"30","author":"Tariq","year":"2014","journal-title":"Pak. J. Med. Sci"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0080","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1034\/j.1600-0722.2001.00047.x","article-title":"Etiologic factors influencing the prevalence of demarcated opacities in permanent first molars in a group of Swedish children","volume":"109","author":"J\u00e4levik","year":"2001","journal-title":"Eur. J. Oral. Sci"},{"key":"10.1016\/j.jdent.2025.106094_bib0081","doi-asserted-by":"crossref","first-page":"714","DOI":"10.2174\/1745017901814010714","article-title":"Molar Incisor hypomineralization: prevalence and risk factors among 7-9 years old school children in Muradnagar, Ghaziabad","volume":"12","author":"Rai","year":"2018","journal-title":"Open. Dent. J"},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0082","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/0976-237X.177091","article-title":"Prevalence of molar incisor hypomineralization in 7-9-year-old children of Bengaluru City, India","volume":"7","author":"Subramaniam","year":"2016","journal-title":"Contemp. Clin. Dent"},{"issue":"5","key":"10.1016\/j.jdent.2025.106094_bib0083","doi-asserted-by":"crossref","first-page":"554","DOI":"10.5005\/jp-journals-10005-2429","article-title":"Correlation between aerosol therapy and other associated factors in early childhood with Molar incisor hypomineralization","volume":"15","author":"Shinde","year":"2022","journal-title":"Int. J. Clin. Pediatr. Dent"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0084","doi-asserted-by":"crossref","first-page":"393","DOI":"10.12669\/pjms.302.4508","article-title":"Association of the use of bacterial cell wall synthesis inhibitor drugs in early childhood with the developmental defects of enamel","volume":"30","author":"Tariq","year":"2014","journal-title":"Pak. J. Med. Sci"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0085","first-page":"153","article-title":"How serious is Molar Incisor Hypomineralisation (MIH) among 8- and 9-year-old children in Bosnia-Herzegovina? A clinical study","volume":"18","author":"Mulic","year":"2017","journal-title":"Eur. J. Paediatr. Dent."},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0086","article-title":"Molar-incisor hypomineralization and associated factors: a case-control study, Pesquisa Brasileira em Odontopediatriae","volume":"18","author":"Portella","year":"2018","journal-title":"Clin. Integr."},{"issue":"10","key":"10.1016\/j.jdent.2025.106094_bib0087","article-title":"Molar incisor hypomineralization and related risk factors among primary school children in Jeddah: a cross-sectional study","volume":"11","author":"Baghlaf","year":"2024","journal-title":"Child. (Basel)"},{"key":"10.1016\/j.jdent.2025.106094_bib0088","article-title":"What are the systemic factors associated with the molar-incisor hypomineralization etiology?, Pesquisa Brasileira em Odontopediatria e","volume":"21","author":"Fonseca-Souza","year":"2021","journal-title":"Clin. Integr."},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0089","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1186\/s12903-024-05065-0","article-title":"Influence of maternal health status during pregnancy and the child\u00b4s medical history on molar-incisor hypomineralization in a group of Spanish children (aged 6-14 years): a retrospective case-control study","volume":"24","author":"Mu\u00f1oz","year":"2024","journal-title":"BMC. Oral. Health"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0090","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/eos.12136","article-title":"Factors associated with molar incisor hypomineralization in Thai children","volume":"122","author":"Pitiphat","year":"2014","journal-title":"Eur. J. Oral. Sci"},{"issue":"4","key":"10.1016\/j.jdent.2025.106094_bib0091","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/BF03262865","article-title":"Molar incisor hypomineralisation: possible aetiological factors in children from urban and rural areas","volume":"13","author":"Souza","year":"2012","journal-title":"Eur. Arch. Paediatr. Dent."},{"issue":"6","key":"10.1016\/j.jdent.2025.106094_bib0092","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156332","article-title":"Association between molar incisor hypomineralization in schoolchildren and both prenatal and postnatal factors: a population-based study","volume":"11","author":"Tourino","year":"2016","journal-title":"PLoS. ONE"},{"issue":"3","key":"10.1016\/j.jdent.2025.106094_bib0093","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1365-263X.2007.00901.x","article-title":"Molar incisor hypomineralization: a study of aetiological factors in a group of UK children","volume":"18","author":"Whatling","year":"2008","journal-title":"Int. J. Paediatr. Dent."},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0094","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2023-061350","article-title":"Antibiotic exposure and dental health: a systematic review","volume":"152","author":"Ravindra","year":"2023","journal-title":"Pediatrics"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0095","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/0022034508328334","article-title":"Amoxicillin may cause molar incisor hypomineralization","volume":"88","author":"Laisi","year":"2009","journal-title":"J. Dent. Res"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0096","first-page":"153","article-title":"How serious is Molar Incisor Hypomineralisation (MIH) among 8- and 9-year-old children in Bosnia-Herzegovina? A clinical study","volume":"18","author":"Mulic","year":"2017","journal-title":"Eur. J. Paediatr. Dent"},{"issue":"1","key":"10.1016\/j.jdent.2025.106094_bib0097","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.4317\/medoral.18807","article-title":"Prenatal effects by exposing to amoxicillin on dental enamel in wistar rats","volume":"19","author":"Gottberg","year":"2014","journal-title":"Med. Oral. Patol. Oral. Cir. Bucal"},{"issue":"2","key":"10.1016\/j.jdent.2025.106094_bib0098","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/ipd.12327","article-title":"Exploring the association between genetic and environmental factors and molar incisor hypomineralization: evidence from a twin study","volume":"28","author":"Teixeira","year":"2018","journal-title":"Int. J. Paediatr. Dent"},{"issue":"8","key":"10.1016\/j.jdent.2025.106094_bib0099","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/s41591-021-01458-8","article-title":"Accelerating the translational medicine cycle: the Academia Europaea pilot","volume":"27","author":"Hegyi","year":"2021","journal-title":"Nat. Med"},{"issue":"5","key":"10.1016\/j.jdent.2025.106094_bib0100","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9051532","article-title":"Academia Europaea position Paper on Translational medicine: the cycle model for translating scientific results into community benefits","volume":"9","author":"Hegyi","year":"2020","journal-title":"J. Clin. Med"}],"container-title":["Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571225005408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571225005408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:56:20Z","timestamp":1789772180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300571225005408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":100,"alternative-id":["S0300571225005408"],"URL":"https:\/\/doi.org\/10.1016\/j.jdent.2025.106094","relation":{},"ISSN":["0300-5712"],"issn-type":[{"value":"0300-5712","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between systemic exposure to antibiotics in early childhood and molar-incisor hypomineralization (MIH): A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Dentistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdent.2025.106094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106094"}}