{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:16:37Z","timestamp":1792804597426,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["304554\/2023-5"],"award-info":[{"award-number":["304554\/2023-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2022\/13268\\u20130"],"award-info":[{"award-number":["2022\/13268\\u20130"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/11487\\u20130"],"award-info":[{"award-number":["2023\/11487\\u20130"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2019\/26070\\u20131"],"award-info":[{"award-number":["2019\/26070\\u20131"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dentistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jdent.2025.106129","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T06:58:00Z","timestamp":1758697080000},"page":"106129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A new frontier in oral care with proteins and peptide infused in orally disintegrating film to prevent early dental erosion in vivo"],"prefix":"10.1016","volume":"163","author":[{"given":"Vin\u00edcius Taioqui","family":"Pel\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Cassalate","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3559-0564","authenticated-orcid":false,"given":"Mariana Miranda","family":"de Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Even Akemi","family":"Taira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Ruis","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2101-1350","authenticated-orcid":false,"given":"Talita Mendes Oliveira","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1469-5224","authenticated-orcid":false,"given":"Larissa Tercilia Grizzo","family":"Thomassian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3329-4597","authenticated-orcid":false,"given":"Fl\u00e1vio","family":"Henrique-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-0115","authenticated-orcid":false,"given":"Eduardo Pereira","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-1169","authenticated-orcid":false,"given":"Thiago Saads","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Soares da Costa","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5226-5009","authenticated-orcid":false,"given":"Karina","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8757-321X","authenticated-orcid":false,"given":"Reinaldo","family":"Marchetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Lussi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5985-3951","authenticated-orcid":false,"given":"Mar\u00edlia Afonso Rabelo","family":"Buzalaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdent.2025.106129_bib0001","article-title":"Bibliometric analysis of peer-reviewed literature on erosive tooth wear from 1945 to 2023","volume":"16","author":"Alghilan","year":"2024","journal-title":"Cureus."},{"key":"10.1016\/j.jdent.2025.106129_bib0002","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jdent.2014.10.012","article-title":"Estimated prevalence of erosive tooth wear in permanent teeth of children and adolescents: an epidemiological systematic review and meta-regression analysis","volume":"43","author":"Salas","year":"2015","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2025.106129_bib0003","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000359936","article-title":"The interactions between attrition, abrasion and erosion in tooth wear","volume":"25","author":"Shellis","year":"2014","journal-title":"Monogr. Oral Sci."},{"key":"10.1016\/j.jdent.2025.106129_bib0004","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1159\/000503308","article-title":"Terminology of erosive tooth wear: consensus report of a workshop organized by the ORCA and the Cariology Research Group of the IADR","volume":"54","author":"Schlueter","year":"2020","journal-title":"Caries Res."},{"key":"10.1016\/j.jdent.2025.106129_bib0005","first-page":"35","article-title":"Erosive tooth wear: prevalence, risk factors, and clinical consequences","volume":"40","author":"Ganss","year":"2012","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2025.106129_bib0006","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.140180.1","article-title":"Prevalence of tooth wear diseases in patients with diabetes and its impact on the quality of life in Dakshina Kannada population: a cross sectional study","volume":"12","author":"Sinha","year":"2023","journal-title":"F1000Res."},{"key":"10.1016\/j.jdent.2025.106129_bib0007","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/s41415-023-5624-0","article-title":"Epidemiology, aetiology and prevention of tooth wear","author":"Leven","year":"2023","journal-title":"Br. Dent. J."},{"key":"10.1016\/j.jdent.2025.106129_bib0008","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1590\/S1678-77572009000200002","article-title":"Insights into preventive measures for dental erosion","volume":"17","author":"Magalh\u00e3es","year":"2009","journal-title":"J. Appl. Oral Sci."},{"key":"10.1016\/j.jdent.2025.106129_bib0009","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1111\/jerd.13271","article-title":"Effectiveness and safety of biosilicate-enhanced bleaching gels on enamel with early erosion lesion","volume":"36","author":"Dascanio","year":"2024","journal-title":"J. Esthet. Restor. Dent."},{"key":"10.1016\/j.jdent.2025.106129_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2025.105812","article-title":"Dentin permeability and tubule occlusion of dentin treated with NaF and TiF(4) varnishes compared to Elmex Opti-namel and Biomin F toothpastes under simulated pulp pressure","volume":"159","author":"Mosquim","year":"2025","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2025.106129_bib0011","doi-asserted-by":"crossref","DOI":"10.1186\/s12903-020-01081-y","article-title":"In situ efcacy of an experimental toothpaste on enamel rehardening and prevention of demineralisation: a randomised, controlled trial","volume":"20","author":"Creeth","year":"2020","journal-title":"BMC. Oral Health"},{"key":"10.1016\/j.jdent.2025.106129_bib0012","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000542178","article-title":"Hydroxyapatite in oral care products: in vitro effects on erosion\/abrasion and analysis of formulation components","volume":"59","author":"Jung","year":"2025","journal-title":"Caries Res."},{"key":"10.1016\/j.jdent.2025.106129_bib0013","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1007\/s00784-023-05175-z","article-title":"Different vehicles containing CaneCPI-5 reduce erosive dentin wear in situ","volume":"9","author":"Pel\u00e1","year":"2023","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.jdent.2025.106129_bib0014","article-title":"Fluoride varnishes for preventing dental caries in children and adolescents","volume":"7","author":"Marinho","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jdent.2025.106129_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000350456","article-title":"An introduction to toothpaste - its purpose, history and ingredients","volume":"23","author":"Lippert","year":"2013","journal-title":"Monogr. Oral Sci."},{"key":"10.1016\/j.jdent.2025.106129_bib0016","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15020361","article-title":"Orodispersible Films\u2014Current State of the art, limitations, advances and future perspectives","volume":"15","author":"Ferlak","year":"2023","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.jdent.2025.106129_bib0017","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ejpb.2020.03.018","article-title":"Acceptability of an orodispersible film compared to syrup in neonates and infants: a randomized controlled trial","volume":"151","author":"Klingmann","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.jdent.2025.106129_bib0018","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115036","article-title":"Orodispersible films - recent developments and new applications in drug delivery and therapy","volume":"200","author":"Morath","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jdent.2025.106129_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2021.103612","article-title":"Acquired pellicle engineering with proteins\/peptides: mechanism of action on native human enamel surface","volume":"107","author":"Pel\u00e1","year":"2021","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2025.106129_bib0020","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1177\/00220345211011590","article-title":"Safety and In situ antierosive effect of CaneCPI-5 on dental enamel","volume":"100","author":"Pel\u00e1","year":"2021","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jdent.2025.106129_bib0021","doi-asserted-by":"crossref","DOI":"10.1590\/1678-7757-2024-0359","article-title":"Acquired pellicle engineering: a fascinating approach to prevent demineralization","volume":"33","author":"Ferrari","year":"2025","journal-title":"J. Appl. Oral Sci."},{"key":"10.1016\/j.jdent.2025.106129_bib0022","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1177\/0022034517712981","article-title":"A new sugarcane cystatin strongly binds to dental enamel and reduces erosion","volume":"96","author":"Santiago","year":"2017","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jdent.2025.106129_bib0023","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11051360","article-title":"Maquiberry cystatins: recombinant expression, characterization, and use to protect tooth dentin and enamel","volume":"11","author":"de Souza","year":"2023","journal-title":"Biomedicines."},{"key":"10.1016\/j.jdent.2025.106129_bib0024","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.ijbiomac.2020.02.280","article-title":"Recombinant expression, characterization and phylogenetic studies of novels cystatins like proteins of sweet orange (Citrus sinensis) and clementine (Citrus clementina)","volume":"152","author":"Schneider","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jdent.2025.106129_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2020.104890","article-title":"Statherin-derived peptide protects against intrinsic erosion","volume":"119","author":"Taira","year":"2020","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jdent.2025.106129_bib0026","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s00784-024-06040-3","article-title":"Designing mouthwash formulations with innovative molecular components to control initial dental erosion in vivo","volume":"28","author":"Pel\u00e1","year":"2024","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.jdent.2025.106129_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2020.103478","article-title":"Acquired pellicle protein-based engineering protects against erosive demineralization","volume":"102","author":"Carvalho","year":"2020","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2025.106129_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2024.106025","article-title":"Acquired pellicle and biofilm engineering with CaneCPI-5: insights from proteomic and microbiomics analysis","volume":"166","author":"Araujo","year":"2024","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jdent.2025.106129_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2023.104680","article-title":"Acquired pellicle engineering with the association of cystatin and vitamin E against enamel erosion","volume":"138","author":"de Oliveira","year":"2023","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2025.106129_bib0030","first-page":"141","article-title":"Use of reflectometer Optipen to assess the preventive effect of a sugarcane cystatin on initial dental erosion in vivo","author":"Pela","year":"2023","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jdent.2025.106129_bib0031","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jdent.2018.04.001","article-title":"Effect of an experimental mouth rinse containing NaF and TiF4 on tooth erosion and abrasion in situ","author":"de Souza","year":"2018","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2025.106129_bib0032","first-page":"15","article-title":"Preparation and evaluation of caffeine orodispersible films: the influence of hydrotropic substances and film-forming agent concentration on film properties","author":"Vlad","year":"2023","journal-title":"Polymers. (Basel)"},{"key":"10.1016\/j.jdent.2025.106129_bib0033","article-title":"Fluoride mouthrinses for preventing dental caries in children and adolescents","volume":"7","author":"Marinho","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jdent.2025.106129_bib0034","doi-asserted-by":"crossref","DOI":"10.1038\/srep25259","article-title":"A new handheld optical reflectometer to measure enamel erosion: correlation with surface hardness and calcium release","volume":"6","author":"Carvalho","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jdent.2025.106129_bib0035","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1007\/s00784-022-04600-z","article-title":"Preventive effect of chitosan gel containing CaneCPI-5 against enamel erosive wear in situ","volume":"26","author":"Pela","year":"2022","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.jdent.2025.106129_bib0036","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000260645","article-title":"A microanalytical procedure for the determination of calcium, phosphate and fluoride in enamel biopsy samples","volume":"17","author":"Vogel","year":"1983","journal-title":"Caries Res."},{"key":"10.1016\/j.jdent.2025.106129_bib0037","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000091121","article-title":"Effect of a calcium prerinse on salivary fluoride after a 228-ppm fluoride rinse","volume":"40","author":"Vogel","year":"2006","journal-title":"Caries Res."},{"key":"10.1016\/j.jdent.2025.106129_bib0038","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1007\/s13197-022-05589-9","article-title":"Oral disintegration films: applications and production methods","volume":"60","author":"Palezi","year":"2022","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.jdent.2025.106129_bib0039","article-title":"Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization","volume":"19","author":"Wang","year":"2021","journal-title":"J. Nanobiotechnology."},{"key":"10.1016\/j.jdent.2025.106129_bib0040","first-page":"98","article-title":"Statherin-derived peptide protects against intrinsic erosive enamel wear in situ","volume":"59","author":"Taira","year":"2025","journal-title":"Caries Res."},{"key":"10.1016\/j.jdent.2025.106129_bib0041","article-title":"Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children","volume":"12","author":"Tubert-Jeannin","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jdent.2025.106129_bib0042","first-page":"25","article-title":"Comparative analysis of the protective effects of fluoride compounds on dental erosion in mouse model","author":"Brox","year":"2025","journal-title":"BMC. Oral Health"},{"key":"10.1016\/j.jdent.2025.106129_bib0043","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000522490","article-title":"Acquired pellicle engineering using a combination of organic (Sugarcane Cystatin) and inorganic (Sodium Fluoride) components against dental erosion","volume":"56","author":"Pel\u00e1","year":"2022","journal-title":"Caries Res."},{"key":"10.1016\/j.jdent.2025.106129_bib0044","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3390\/pharmaceutics3040665","article-title":"Mucoadhesive gels designed for the controlled release of chlorhexidine in the oral cavity","volume":"3","author":"Fini","year":"2011","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.jdent.2025.106129_bib0045","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000331938","article-title":"Effect of salivary factors on the susceptibility of hydroxyapatite to early erosion","volume":"45","author":"Jager","year":"2011","journal-title":"Caries Res."},{"key":"10.1016\/j.jdent.2025.106129_bib0046","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042204","article-title":"Quantitative proteomic analysis of the effect of fluoride on the acquired enamel pellicle","volume":"7","author":"Siqueira","year":"2012","journal-title":"PLoS. One"}],"container-title":["Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571225005755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571225005755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T09:27:27Z","timestamp":1773134847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300571225005755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":46,"alternative-id":["S0300571225005755"],"URL":"https:\/\/doi.org\/10.1016\/j.jdent.2025.106129","relation":{},"ISSN":["0300-5712"],"issn-type":[{"value":"0300-5712","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new frontier in oral care with proteins and peptide infused in orally disintegrating film to prevent early dental erosion in vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Dentistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdent.2025.106129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106129"}}