{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:53:56Z","timestamp":1786121636436,"version":"build-2736575974"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004909","name":"Universidade Federal do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dentistry"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jdent.2026.106889","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:09:33Z","timestamp":1783627773000},"page":"106889","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Organic complex based on cryomilled particles and doxycycline-laden electrospun fibers to improve the performance of a universal dental adhesive"],"prefix":"10.1016","volume":"174","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-0097","authenticated-orcid":false,"given":"Eliseu Aldrighi","family":"M\u00fcnchow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1978-0193","authenticated-orcid":false,"given":"Bianca Tatsch","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Tereza Pedrosa","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana da Silva","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane Kuhn","family":"Rutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evandro","family":"Piva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-2464","authenticated-orcid":false,"given":"Marco C\u00edcero","family":"Bottino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdent.2026.106889_bib0001","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.cden.2017.06.001","article-title":"An overview of Dental adhesive systems and the dynamic tooth\u2013Adhesive interface","volume":"61","author":"Bedran-Russo","year":"2017","journal-title":"Dent. Clin. North Am."},{"key":"10.1016\/j.jdent.2026.106889_bib0002","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.1016\/j.dental.2019.05.023","article-title":"Impact of shelf-life simulation on bonding performance of universal adhesive systems","volume":"35","author":"Cuevas-Su\u00e1rez","year":"2019","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/jicd.12234","article-title":"Effect of an extra layer of hydrophobic resin on the microleakage of Cl V composite resin restorations with a universal adhesive system","volume":"8","author":"Bahari","year":"2017","journal-title":"J. Investig. Clin. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0004","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.jdent.2015.03.004","article-title":"Bonding of universal adhesives to dentine-old wine in new bottles?","volume":"43","author":"Chen","year":"2015","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0005","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.dental.2024.05.004","article-title":"Bond strength and marginal adaptation of resin composites and correlations with clinical results","volume":"40","author":"Peutzfeldt","year":"2024","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0006","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1007\/s00784-019-03052-2","article-title":"Thirty-six-month clinical evaluation of different adhesive strategies of a universal adhesive","volume":"24","author":"Atalay","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.jdent.2026.106889_bib0007","doi-asserted-by":"crossref","first-page":"e503","DOI":"10.1016\/j.dental.2021.08.017","article-title":"Is clinical behavior of composite restorations placed in non-carious cervical lesions influenced by the application mode of universal adhesives? A systematic review and meta-analysis","volume":"37","author":"Josic","year":"2021","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/1678-7757-2018-0358","article-title":"Twenty-four-month clinical performance of different universal adhesives in etch-and-rinse, selective etching and self-etch application modes in NCCL - a randomized controlled clinical trial","volume":"27","author":"Oz","year":"2019","journal-title":"J. Appl. Oral Sci."},{"key":"10.1016\/j.jdent.2026.106889_bib0009","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.dental.2016.07.012","article-title":"Experimental primers containing synthetic and natural compounds reduce enzymatic activity at the dentin\u2013adhesive interface under cyclic loading","volume":"32","author":"Silva Sousa","year":"2016","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0010","first-page":"10793","article-title":"Morphological effects of MMPs inhibitors on the dentin bonding","volume":"8","author":"Li","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.jdent.2026.106889_bib0011","doi-asserted-by":"crossref","first-page":"10797","DOI":"10.1039\/D0TB02058C","article-title":"Development of an antibacterial and anti-metalloproteinase dental adhesive for long-lasting resin composite restorations","volume":"8","author":"M\u00fcnchow","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jdent.2026.106889_bib0012","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.dental.2025.05.005","article-title":"Doxycycline-laden fibrous microparticles as a therapeutic ingredient for etch-and-rinse adhesive systems: effects on optical, physical and bonding properties to dentin","volume":"41","author":"Silveira","year":"2025","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0013","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1177\/0022034514549997","article-title":"Doxycycline-encapsulated nanotube-modified dentin adhesives","volume":"93","author":"Feitosa","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jdent.2026.106889_bib0014","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jdsr.2022.09.004","article-title":"Incorporation of MMP inhibitors into dental adhesive systems and bond strength of coronal composite restorations: a systematic review and meta-analysis of in vitro studies","volume":"58","author":"Yaghmoor","year":"2022","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"10.1016\/j.jdent.2026.106889_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2022.105551","article-title":"Effect of dentin biomodification using natural collagen cross-linkers on the durability of the resin-dentin bond and demineralized dentin stiffness","volume":"138","author":"El Gindy","year":"2023","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0016","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.dental.2021.12.024","article-title":"Proanthocyanidin encapsulation for sustained bioactivity in dentin bioadhesion: a two-year study","volume":"38","author":"Alania","year":"2022","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0017","doi-asserted-by":"crossref","first-page":"E251","DOI":"10.2341\/20-016-L","article-title":"Mechanical stability and proteolytic activity of resin-dentin bonds using the cross-linked dry bonding technique","volume":"46","author":"Citta","year":"2021","journal-title":"Oper. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0018","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jdent.2012.08.015","article-title":"Effect of natural cross-linkers incorporation in a self-etching primer on dentine bond strength","volume":"40","author":"Islam","year":"2012","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0019","doi-asserted-by":"crossref","first-page":"e714","DOI":"10.4317\/jced.60729","article-title":"Influence of the incorporation of titanium dioxide nanofibers net on bond strength and morphology of a total etching adhesive system","volume":"15","author":"Klein","year":"2023","journal-title":"J. Clin. Exp. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0020","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3390\/jfb13040303","article-title":"Development and characterization of novel orthodontic adhesive containing PCL\u2013Gelatin\u2013AgNPs fibers","volume":"13","author":"Yuan","year":"2022","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.jdent.2026.106889_bib0021","doi-asserted-by":"crossref","first-page":"6069","DOI":"10.1021\/am405136s","article-title":"Polymer\/Carbon nanotube nano composite fibers\u2212a review","volume":"6","author":"Liu","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.jdent.2026.106889_bib0022","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jmbbm.2014.06.019","article-title":"Electrospun polyurethane\/hydroxyapatite bioactive scaffolds for bone tissue engineering: the role of solvent and hydroxyapatite particles","volume":"39","author":"Tetteh","year":"2014","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0023","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jmbbm.2015.03.019","article-title":"Effect of random\/aligned nylon-6\/MWCNT fibers on dental resin composite reinforcement","volume":"48","author":"Borges","year":"2015","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0024","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/jbm.b.33342","article-title":"Physicomechanical and antibacterial properties of experimental resin-based dental sealants modified with nylon-6 and chitosan nanofibers","volume":"103","author":"Hamilton","year":"2015","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.jdent.2026.106889_bib0025","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.dental.2016.01.002","article-title":"Use of dental adhesives as modeler liquid of resin composites","volume":"32","author":"M\u00fcnchow","year":"2016","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40430-019-1887-4","article-title":"Physico-mechanical characterization and fracture reliability of dental resin composites for enamel restoration","volume":"41","author":"de Almeida","year":"2019","journal-title":"J. Braz. Soc. Mech. Sci. Eng."},{"key":"10.1016\/j.jdent.2026.106889_bib0027","first-page":"257","article-title":"Effect of diamond bur grit size on composite repair","volume":"17","author":"Valente","year":"2015","journal-title":"J. Adhes. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0028","first-page":"221","article-title":"Replacing HEMA with alternative dimethacrylates in dental adhesive systems: evaluation of polymerization kinetics and physicochemical properties","volume":"16","author":"M\u00fcnchow","year":"2014","journal-title":"J. Adhes. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0029","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.dental.2024.12.011","article-title":"Bonding performance of universal adhesive systems to enamel \u2013 Effects of the acidic composition","volume":"41","author":"do","year":"2025","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0030","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.3390\/ijms25137061","article-title":"Engineering interfacial integrity with hydrolytic-resistant, self-reinforcing dentin adhesive","volume":"25","author":"Demirel","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jdent.2026.106889_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijadhadh.2021.102889","article-title":"Use of the adhesive layer as a controlled release platform for doxycycline, as promising advancement for longer durability of dentin adhesion","volume":"108","author":"de Menezes","year":"2021","journal-title":"Int. J. Adhes. Adhes."},{"key":"10.1016\/j.jdent.2026.106889_bib0032","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.joen.2015.03.005","article-title":"Antimicrobial effects of novel triple antibiotic paste-mimic scaffolds on Actinomyces naeslundii biofilm","volume":"41","author":"Albuquerque","year":"2015","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2026.106889_bib0033","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.joen.2011.06.018","article-title":"A new noninvasive model to study the effectiveness of dentin disinfection by using confocal laser scanning microscopy","volume":"37","author":"Ma","year":"2011","journal-title":"J. Endod."},{"key":"10.1016\/j.jdent.2026.106889_bib0034","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1016\/S0021-9258(19)67762-8","article-title":"Isolation and characterization of a 70-kDa metalloprotease (gelatinase) that is elevated in Rous sarcoma virus-transformed chicken embryo fibroblasts","volume":"266","author":"Chen","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jdent.2026.106889_bib0035","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00784-011-0551-x","article-title":"Addition of zinc methacrylate in dental polymers: MMP-2 inhibition and ultimate tensile strength evaluation","volume":"16","author":"Henn","year":"2012","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.jdent.2026.106889_bib0036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.archoralbio.2016.02.003","article-title":"Human neutrophil peptide-1 affects matrix metalloproteinase-2, -8 and -9 secretions of oral squamous cell carcinoma cell lines in vitro","volume":"66","author":"Musrati","year":"2016","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.jdent.2026.106889_bib0037","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/jemt.23401","article-title":"Effects of sodium hypochlorite as dentin deproteinizing agent and aging media on bond strength of two conventional adhesives","volume":"83","author":"Nima","year":"2020","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jdent.2026.106889_bib0038","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.jdent.2014.09.010","article-title":"Effects of different artificial ageing methods on the degradation of adhesive-dentine interfaces","volume":"42","author":"Deng","year":"2014","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0039","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.dental.2006.02.007","article-title":"A statistical evaluation of microtensile bond strength methodology for dental adhesives","volume":"23","author":"Eckert","year":"2007","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0040","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.msec.2017.03.093","article-title":"Modeling the permeability of multiaxial electrospun poly(\u03b5-caprolactone)-gelatin hybrid fibers for controlled doxycycline release","volume":"76","author":"Khalf","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jdent.2026.106889_bib0041","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.dental.2015.06.004","article-title":"Development and characterization of novel ZnO-loaded electrospun membranes for periodontal regeneration","volume":"31","author":"M\u00fcnchow","year":"2015","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0042","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s40496-017-0146-y","article-title":"Recent advances in adhesive bonding: the role of biomolecules, nanocompounds, and bonding strategies in enhancing resin bonding to dental substrates, curr","volume":"4","author":"M\u00fcnchow","year":"2017","journal-title":"Oral Health Rep."},{"key":"10.1016\/j.jdent.2026.106889_bib0043","doi-asserted-by":"crossref","first-page":"14188","DOI":"10.1021\/acsomega.4c11547","article-title":"Positive effect of isotropic components on the elongation at break of Mesophase pitch-based carbon fibers","volume":"10","author":"Liu","year":"2025","journal-title":"ACS. Omega"},{"key":"10.1016\/j.jdent.2026.106889_bib0044","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.msec.2016.03.103","article-title":"Osteogenic activity of cyclodextrin-encapsulated doxycycline in a calcium phosphate PCL and PLGA composite","volume":"64","author":"Trajano","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.jdent.2026.106889_bib0045","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.3390\/pharmaceutics14091865","article-title":"Dexamethasone and doxycycline doped nanoparticles increase the differentiation potential of Human bone marrow stem cells","volume":"14","author":"Toledano-Osorio","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.jdent.2026.106889_bib0046","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00008505-199200130-00005","article-title":"Fibroblastic growth and attachment on hydroxyapatite-coated titanium surfaces following the use of various detoxification modalities. Part I: noncontaminated hydroxyapatite","volume":"1","author":"Wittrig","year":"1992","journal-title":"ImPlant Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0047","doi-asserted-by":"crossref","first-page":"14687","DOI":"10.1021\/acsomega.4c08096","article-title":"Comparative analysis of electron microscopy techniques for Hydrogel microarchitecture characterization: SEM, Cryo-SEM, ESEM, and TEM","volume":"10","author":"Aigoin","year":"2025","journal-title":"ACS. Omega"},{"key":"10.1016\/j.jdent.2026.106889_bib0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00784-025-06443-w","article-title":"Effect of laser applications with different agents on dentin surface roughness, bacterial adhesion and tubule occlusion","volume":"29","author":"D\u00fcndar","year":"2025","journal-title":"Clin. Oral Investig."},{"key":"10.1016\/j.jdent.2026.106889_bib0049","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jdent.2015.11.009","article-title":"Ion release, fluoride charge of and adhesion of an orthodontic cement paste containing microcapsules","volume":"45","author":"Burbank","year":"2016","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0050","doi-asserted-by":"crossref","first-page":"24815","DOI":"10.1039\/D4RA02485K","article-title":"Fabrication and biocompatibility evaluation of hydroxyapatite-polycaprolactone-gelatin composite nanofibers as a bone scaffold","volume":"14","author":"Aminatun","year":"2024","journal-title":"RSC. Adv."},{"key":"10.1016\/j.jdent.2026.106889_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123789","article-title":"Cold atmospheric plasma modified polycaprolactone solution prior to electrospinning: a novel approach for improving quercetin-loaded nanofiber drug delivery systems","volume":"651","author":"Bulbul","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.jdent.2026.106889_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134109","article-title":"Antibiotic delivery in the presence of green AgNPs using multifunctional bilayer carrageenan nanofiber\/sodium alginate nanohydrogel for rapid control of wound infections","volume":"277","author":"Heidari","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.jdent.2026.106889_bib0053","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.dental.2025.08.013","article-title":"Marginal integrity produced by quaternary ammonium methacrylate-based dental adhesive tested under physiologically relevant models","volume":"41","author":"de Lucena","year":"2025","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0054","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3390\/jfb16110418","article-title":"Advances in bioactive dental adhesives for caries prevention: a State-of-the-art review","volume":"16","author":"Nizami","year":"2025","journal-title":"J. Funct. Biomater."},{"key":"10.1016\/j.jdent.2026.106889_bib0055","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1590\/0103-6440202305504","article-title":"Do different adhesives influence the color stability and fluorescence of composite restorations after aging?","volume":"34","author":"de Souza","year":"2023","journal-title":"Braz. Dent. J."},{"key":"10.1016\/j.jdent.2026.106889_bib0056","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.dental.2024.07.001","article-title":"Bis-EMA\/Bis-GMA ratio effects on resin-properties and impregnated fiber-bundles","volume":"40","author":"Hatamleh","year":"2024","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0057","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/jerd.12465","article-title":"Acceptability and perceptibility thresholds in dentistry: a comprehensive review of clinical and research applications","volume":"31","author":"Paravina","year":"2019","journal-title":"J. Esthet. Restor. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0058","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.dental.2024.03.004","article-title":"Toxicity and cytokine release from human dental pulp stem cells after exposure to universal dental adhesives cured by single peak and polywave LEDs","volume":"40","author":"Lima","year":"2024","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0059","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s10856-011-4541-y","article-title":"Effect of air-drying on the solvent evaporation, degree of conversion and water sorption\/solubility of dental adhesive models","volume":"23","author":"Bail","year":"2012","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.jdent.2026.106889_bib0060","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/jbm.b.31871","article-title":"A new approach in self-etching adhesive formulations: replacing HEMA for surfactant dimethacrylate monomers","volume":"99B","author":"Zanchi","year":"2011","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.jdent.2026.106889_bib0061","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1556\/1326.2021.00926","article-title":"High performance thin layer chromatography (HPTLC) method development and validation for determination of doxycycline hyclate in capsule and tablet formulations","volume":"34","author":"Kumssa","year":"2022","journal-title":"Acta Chromatogr."},{"key":"10.1016\/j.jdent.2026.106889_bib0062","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.dental.2010.03.011","article-title":"Effects of adhesive, base and diluent monomers on water sorption and conversion of experimental resins","volume":"26","author":"Dickens","year":"2010","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0063","doi-asserted-by":"crossref","first-page":"10960","DOI":"10.1039\/D5TB01248A","article-title":"Theoretical insights into adhesion mechanisms of dental adhesives on zirconia surfaces: effects of functional groups in adhesive monomers","volume":"13","author":"Sumiya","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.jdent.2026.106889_bib0064","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.actbio.2025.08.052","article-title":"Improvement of dentin bonding via adhesive monomers with multiple hydrogen bonding moieties","volume":"205","author":"Fu","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jdent.2026.106889_bib0065","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.actbio.2020.05.002","article-title":"Polymeric nanoparticles protect the resin-dentin bonded interface from cariogenic biofilm degradation: nanoparticles antidegradation activity at bonded dentin","volume":"111","author":"Toledano-Osorio","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.jdent.2026.106889_bib0066","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2019.103606","article-title":"Polymeric nanoparticles for endodontic therapy","volume":"103","author":"Toledano","year":"2020","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0067","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3390\/ijms23020971","article-title":"Engineering of injectable antibiotic-laden fibrous microparticles gelatin Methacryloyl hydrogel for endodontic infection ablation","volume":"23","author":"Ribeiro","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jdent.2026.106889_bib0068","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.dental.2020.03.007","article-title":"Chlorhexidine-modified nanotubes and their effects on the polymerization and bonding performance of a dental adhesive","volume":"36","author":"Kalagi","year":"2020","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0069","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.dental.2022.02.015","article-title":"Characterization of polymethylmethacrylate microspheres loaded with silver and doxycycline for dental materials applications","volume":"38","author":"De Morais","year":"2022","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0070","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1128\/AAC.00594-16","article-title":"rRNA binding sites and the molecular mechanism of action of the tetracyclines","volume":"60","author":"Chukwudi","year":"2016","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.jdent.2026.106889_bib0071","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3109\/13880209.2011.553625","article-title":"Antibacterial activity of essential oils from eucalyptus and of selected components against multidrug-resistant bacterial pathogens","volume":"49","author":"Mulyaningsih","year":"2011","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.jdent.2026.106889_bib0072","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.dental.2017.11.005","article-title":"Dentin bonding systems: from dentin collagen structure to bond preservation and clinical applications","volume":"34","author":"Breschi","year":"2018","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0073","doi-asserted-by":"crossref","DOI":"10.1111\/iej.12812","article-title":"The effects of 2-hydroxyethyl methacrylate on matrix metalloproteinases 2 and 9 in human pulp cells and odontoblast-like cells in vitro","volume":"51","author":"Sun","year":"2018","journal-title":"Int. Endod. J."},{"key":"10.1016\/j.jdent.2026.106889_bib0074","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/0022034513516465","article-title":"Carbodiimide inactivation of MMPs and effect on dentin bonding","volume":"93","author":"Mazzoni","year":"2014","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.jdent.2026.106889_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-23939-6","article-title":"Multi-functional nano-adhesive releasing therapeutic ions for MMP-deactivation and remineralization","volume":"8","author":"Jun","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jdent.2026.106889_bib0076","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1834-7819.2011.01294.x","article-title":"Current aspects on bonding effectiveness and stability in adhesive dentistry","volume":"56","author":"Cardoso","year":"2011","journal-title":"Aust. Dent. J."},{"key":"10.1016\/j.jdent.2026.106889_bib0077","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2025.105839","article-title":"The role of oral environmental factors in the degradation of resin-dentin interfaces: a comprehensive review","volume":"159","author":"Zhou","year":"2025","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0078","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jdent.2006.05.001","article-title":"NaOCl degradation of a HEMA-free all-in-one adhesive bonded to enamel and dentin following two air-blowing techniques","volume":"35","author":"De Munck","year":"2007","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0079","doi-asserted-by":"crossref","first-page":"464","DOI":"10.5005\/jp-journals-10024-1170","article-title":"Comparison of chemical aging and water immersion time on durability of resin-dentin interface produced by an etch-and-rinse adhesive","volume":"13","author":"Garbui","year":"2012","journal-title":"J. Contemp. Dent. Pract."},{"key":"10.1016\/j.jdent.2026.106889_bib0080","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jmbbm.2019.07.006","article-title":"Fracture behaviour of MOD restorations reinforced by various fibre-reinforced techniques \u2013 An in vitro study","volume":"98","author":"S\u00e1ry","year":"2019","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0081","doi-asserted-by":"crossref","first-page":"2662","DOI":"10.3390\/polym14132662","article-title":"Influence of stress level and fibre volume fraction on fatigue performance of glass fibre-reinforced polyester composites","volume":"14","author":"Zaghloul","year":"2022","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.jdent.2026.106889_bib0082","doi-asserted-by":"crossref","DOI":"10.1016\/j.polymertesting.2021.107460","article-title":"Stress-strain behavior and corresponding crystalline structures of four types of polyethylene under a wide range of strain rates","volume":"106","author":"Zhu","year":"2022","journal-title":"Polym. Test."},{"key":"10.1016\/j.jdent.2026.106889_bib0083","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.dental.2006.08.003","article-title":"Effect of fiber architecture on flexural characteristics and fracture of fiber-reinforced dental composites","volume":"23","author":"Karbhari","year":"2007","journal-title":"Dent. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0084","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2020.103550","article-title":"Physicochemical properties, metalloproteinases inhibition, and antibiofilm activity of doxycycline-doped dental adhesive","volume":"104","author":"Freitas","year":"2021","journal-title":"J. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0085","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1016\/j.biomaterials.2006.04.009","article-title":"The effect of PLGA doping of polycaprolactone films on the control of osteoblast adhesion and proliferation in vitro","volume":"27","author":"Tang","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.jdent.2026.106889_bib0086","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1016\/j.biomaterials.2004.09.052","article-title":"Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2","volume":"26","author":"Rai","year":"2005","journal-title":"Biomaterials"},{"key":"10.1016\/j.jdent.2026.106889_bib0087","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2026.107506","article-title":"Toward biomimetic direct restorations: a nanofiber-based interfacial strategy to approximate dentin\u2013enamel junction behavior","volume":"181","author":"Moreira","year":"2026","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.jdent.2026.106889_bib0088","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1017\/S143192761401366X","article-title":"Morphological and chemical comparative analysis of the Human and bovine dentin-adhesive layer","volume":"21","author":"Silva Soares","year":"2015","journal-title":"Microsc. Microanal."},{"key":"10.1016\/j.jdent.2026.106889_bib0089","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1590\/S1678-77572009000200004","article-title":"Influence of human and bovine substrate on the microleakage of two adhesive systems","volume":"17","author":"Almeida","year":"2009","journal-title":"J. Appl. Oral Sci."},{"key":"10.1016\/j.jdent.2026.106889_bib0090","first-page":"471","article-title":"Viability of bovine teeth as a substrate in bond strength tests: a systematic review and meta-analysis","volume":"20","author":"de Carvalho","year":"2018","journal-title":"J. Adhes. Dent."},{"key":"10.1016\/j.jdent.2026.106889_bib0091","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.dental.2016.09.019","article-title":"Bovine tooth is a substitute for human tooth on bond strength studies: a systematic review and meta-analysis of in vitro studies","volume":"32","author":"Soares","year":"2016","journal-title":"Dent. Mater."}],"container-title":["Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571226005592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300571226005592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T06:38:02Z","timestamp":1786084682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300571226005592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":91,"alternative-id":["S0300571226005592"],"URL":"https:\/\/doi.org\/10.1016\/j.jdent.2026.106889","relation":{},"ISSN":["0300-5712"],"issn-type":[{"value":"0300-5712","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Organic complex based on cryomilled particles and doxycycline-laden electrospun fibers to improve the performance of a universal dental adhesive","name":"articletitle","label":"Article Title"},{"value":"Journal of Dentistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdent.2026.106889","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106889"}}