{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:12:45Z","timestamp":1760548365707},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.jdermsci.2006.11.008","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T15:12:23Z","timestamp":1166627543000},"page":"121-126","source":"Crossref","is-referenced-by-count":29,"title":["Homocysteine: An activity marker in Beh\u00e7et's disease?"],"prefix":"10.1016","volume":"45","author":[{"given":"Tuncay","family":"Sarican","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice","family":"Ayabakan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sembol","family":"Turkmen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesile","family":"Kalaslioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fehmi","family":"Baran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Necati","family":"Yenice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2006.11.008_bib1","first-page":"1152","article-title":"Uber residivierende aphthose, durch ein virus verursachte geschwure am mund, am auge und an den genitalien","volume":"105","author":"Beh\u00e7et","year":"1937","journal-title":"Dermatol Wochenschr"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib2","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1056\/NEJM199910213411707","article-title":"Inaba G: Beh\u00e7et's disease","volume":"341","author":"Sakane","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0046-8177(85)80250-1","article-title":"Pathologic features of Beh\u00e7et's syndrom: a review of Japanese autopsy registry data","volume":"16","author":"Lakhanpal","year":"1985","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib4","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3109\/03009749509095184","article-title":"Plasma von Willebrand factor, tissue plasminogen activator, plasminogen activator inhibitor, and antithrombin III levels in Beh\u00e7et's disease","volume":"24","author":"Ozoran","year":"1995","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib5","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1055\/s-0038-1646409","article-title":"Coagulation and fibrinolytic activity in Beh\u00e7et's disease","volume":"66","author":"Hampton","year":"1991","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib6","first-page":"1544","article-title":"Overproduction of monocyte derived tumor necrosis factor alpha interleukin (IL) 6, IL-8 and increased neutrophil superoxide generation in Beh\u00e7et's disease: a comparative study with familial Mediterranean fever and healthy subjects","volume":"20","author":"Mege","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib7","first-page":"247","article-title":"Auto-oxidative damage in Beh\u00e7et's disease endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils","volume":"49","author":"Niwa","year":"1982","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib8","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1159\/000018029","article-title":"Oxidative stress in Adamantiades-Beh\u00e7et's disease","volume":"197","author":"Freitas","year":"1998","journal-title":"Dermatology"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib9","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/00015550310003782","article-title":"Lipid peroxidation and antioxidant defence system in patients with active or inactive Beh\u00e7et's disease","volume":"83","author":"Sandikci","year":"2003","journal-title":"Acta Derm Venerol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib10","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/jama.268.7.877","article-title":"A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians","volume":"268","author":"Stampfer","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib11","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1001\/jama.277.22.1775","article-title":"Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project","volume":"277","author":"Graham","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM199707243370403","article-title":"Plasma homocysteine levels and mortality in patients with coronary artery disease","volume":"337","author":"Nygard","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib13","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0140-6736(99)93019-2","article-title":"Plasma homocysteine concentrations and risk of coronary artery disease in UK Indian Asian and European men","volume":"355","author":"Chambers","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib14","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","article-title":"Homocysteine and atherothrombosis","volume":"338","author":"Welch","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib15","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/01.ATV.18.1.133","article-title":"Hyperhomocysteinaemia is associated with an increased risk of cardiovascular disease, espeially in non-insulin dependent diabetes mellitus: a population-based study","volume":"18","author":"Hoogeven","year":"1998","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib16","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0002-9149(00)80061-2","article-title":"Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients","volume":"75","author":"Glueck","year":"1995","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib17","first-page":"196","article-title":"Increased plasma homocysteine concentration in pat\u0130ents with chronic renal failure","volume":"18","author":"Chaureau","year":"1992","journal-title":"Miner Electrolyte Metab"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib18","first-page":"293","article-title":"Plasma homocysteine, a risk factor for premature vascular disease. Plasma levels in healthy persons; during pathologic conditions and drug therapy","volume":"104","author":"Ueland","year":"1989","journal-title":"Nord Med"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib19","first-page":"542","article-title":"High prevalance of hyperhomocysteinaemia in patients with inflammatory bowel disease: a pathogenic link with thromboembolic complications?","volume":"80","author":"Cattaneo","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib20","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1161\/01.CIR.99.9.1156","article-title":"Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia, an effect reversible with vitamin C therapy","volume":"99","author":"Chambers","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib21","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1161\/01.ATV.19.12.2922","article-title":"Physiological increments in plasma homocysteine induce vascular endothelial dysfunction in normal human subjects","volume":"19","author":"Chambers","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib22","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1161\/01.CIR.98.18.1848","article-title":"Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults","volume":"98","author":"Bellamy","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib23","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.100.11.1161","article-title":"Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans","volume":"100","author":"Kanani","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib24","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/rheumatology\/40.6.687","article-title":"Hyperhomocysteinaemia in Beh\u00e7et's disease","volume":"40","author":"Aksu","year":"2001","journal-title":"Rheumatol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib25","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/bjo.86.6.653","article-title":"Serum homocysteine level is increased and correlated with endothelin-1 and nitric oxide in Beh\u00e7et's disease","volume":"86","author":"Er","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib26","first-page":"1078","article-title":"Criteria for diagnosis of Beh\u00e7et's disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib27","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0002-9394(99)00476-6","article-title":"Hyperhomocysteinemia: a risk factor for central retinal vein occlusin","volume":"129","author":"Vine","year":"2000","journal-title":"Am J Ophtalmol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib28","first-page":"79","volume":"27","author":"Masaki","year":"1992","journal-title":"Endothelins Esseys Biochem"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib29","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0735-1097(00)01137-2","article-title":"Vascular endothelial function and oxidative stress mechanisms in patients with Beh\u00e7et's syndrome","volume":"37","author":"Chambers","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib30","first-page":"341","article-title":"Vascular involvement in Beh\u00e7et's disease: arterial and venous vessels of all sizes","volume":"19","author":"Lie","year":"1992","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0190-9622(99)70523-2","article-title":"Beh\u00e7ets disease and complex aphthosis","volume":"40","author":"Ghate","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(98)11058-9","article-title":"Homocysteine and vascular disease","volume":"354","author":"Hankey","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib33","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/bjo.84.2.154","article-title":"Raised plasma homocysteine as a risk factor for retinal vasclar occlusive disease","volume":"84","author":"Cahill","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib34","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/archinte.158.8.862","article-title":"Homocysteine and ischemic heart disease: results of a prospective study with implications regarding prevention","volume":"158","author":"Wald","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib35","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.1161\/01.CIR.96.8.2542","article-title":"Hyperhomocysteinaemia is a risk factor for arterial endothelial dysfunction in humans","volume":"96","author":"Woo","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib36","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1536\/jhj.40.729","article-title":"Plasma homocysteine levels in acute coronary syndromes","volume":"40","author":"Turgan","year":"1999","journal-title":"Jpn Herat J"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib37","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1136\/bjo.83.11.1287","article-title":"Hyperhomocycteinaemia in young patients with non-arteritic anterior ischaemic optic neuropathy","volume":"83","author":"Kawasaki","year":"1999","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib38","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0002-9394(14)73919-4","article-title":"Hyperhomocysteinaemia in retinal artery and retinal vein occlusion","volume":"115","author":"Wenzler","year":"1993","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib39","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/PL00014300","article-title":"The metabolism of homocysteine: pathways and regulation","volume":"157","author":"Finkelstein","year":"1998","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib40","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0002-9394(99)00184-1","article-title":"Factor V Leiden mutation is associated with ocular involvement in Beh\u00e7et's disease","volume":"128","author":"Verity","year":"1999","journal-title":"Am J Opthalmol"},{"key":"10.1016\/j.jdermsci.2006.11.008_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V90.1.1","article-title":"Homocysteine and thrombotic disease","volume":"90","author":"D\u2019Angelo","year":"1997","journal-title":"Blood"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181106003446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181106003446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T13:53:37Z","timestamp":1587304417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181106003446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S0923181106003446"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2006.11.008","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}