{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:52:55Z","timestamp":1792590775783,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1016\/j.jdermsci.2007.06.006","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T08:21:05Z","timestamp":1186647665000},"page":"87-101","source":"Crossref","is-referenced-by-count":59,"title":["Targeting TNF\u03b1 rapidly reduces density of dendritic cells and macrophages in psoriatic plaques with restoration of epidermal keratinocyte differentiation"],"prefix":"10.1016","volume":"48","author":[{"given":"Deborah J.","family":"Marble","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth B.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Nickoloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2007.06.006_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1067\/mjd.2002.120568","article-title":"The immunologic basis for the treatment of psoriasis with new biologic agents","volume":"46","author":"Krueger","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0738-081X(95)93817-8","article-title":"Altered keratinocyte growth and differentiation in psoriasis","volume":"13","author":"McKay","year":"1995","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib3","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1172\/JCI200422147","article-title":"Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities","volume":"113","author":"Nickoloff","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib4","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1046\/j.1523-1747.1999.00749.x","volume":"113","author":"Austin","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.it.2004.03.006","article-title":"Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and \u201cType 1\u201d inflammatory gene expression","volume":"25","author":"Lew","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib6","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/1523-1747.ep12371679","article-title":"The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response","volume":"101","author":"Uyemura","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib7","first-page":"129","article-title":"Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis","volume":"138","author":"Nickoloff","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/1568010043343903","article-title":"Targeting tumor necrosis factor-alpha in the therapy of psoriasis","volume":"3","author":"Gisondi","year":"2004","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1001\/archderm.140.2.218","article-title":"Potential of tumor necrosis factor inhibitors in psoriasis and psoriatic arthritis","volume":"140","author":"Krueger","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib10","first-page":"233","article-title":"Focus on biologics that affect therapeutic agents in dermatology","volume":"4","author":"Saripalli","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib11","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.4049\/jimmunol.175.4.2721","article-title":"TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques","volume":"175","author":"Gottlieb","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib12","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.jaad.2006.05.004","article-title":"Etanercept induces apoptosis of dermal dendritic cells in psoriatic plaques of responding patients","volume":"55","author":"Malaviya","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib13","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1136\/ard.2003.018085","article-title":"Early effects of tumour necrosis factor alpha blockade on skin and synovial tissue in patients with active psoriasis and psoriatic arthritis","volume":"63","author":"Goedkoop","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib14","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/1523-1747.ep12340429","article-title":"Evidence for an alternative pathway of keratinocyte maturation in psoriasis from an antigen found in psoriatic but not normal epidermis","volume":"83","author":"Mansbridge","year":"1984","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1159\/000081685","article-title":"Interferon-gamma-dependent in vitro model for the putative keratin 17 autoimmune loop in psoriasis: exploration of pharmaco- and gene-therapeutic effects","volume":"18","author":"Bockelmann","year":"2005","journal-title":"Skin Pharmacol Physiol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib16","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0022-202X.2004.22723.x","article-title":"Regulation of involucrin gene expression","volume":"123","author":"Eckert","year":"2004","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0923-1811(98)00016-4","article-title":"Epidermal signal transduction and transcription factor activation in activated keratinocytes","volume":"17","author":"Tomic-Canic","year":"1998","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib18","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1346-8138.2004.tb00672.x","article-title":"Unique keratinization process in psoriasis: late differentiation markers are abolished because of the premature cell death","volume":"31","author":"Iizuka","year":"2004","journal-title":"J Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/1523-1747.ep12665870","article-title":"Differences in involucrin immunolabeling within cornified cell envelopes in normal and psoriatic epidermis","volume":"104","author":"Ishida-Yamamoto","year":"1995","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib20","first-page":"119","article-title":"Epidermal pathogenesis of inflammatory dermatoses","volume":"10","author":"Elias","year":"1999","journal-title":"Am J Contact Dermat"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jdermsci.2004.05.004","article-title":"Epidermal desquamation","volume":"36","author":"Milstone","year":"2004","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nm0105-17","article-title":"Psoriasis: more than skin deep","volume":"11","author":"Pittelkow","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib23","doi-asserted-by":"crossref","first-page":"32633","DOI":"10.1074\/jbc.M400642200","article-title":"Effects of tumor necrosis factor-alpha (TNF alpha) in epidermal keratinocytes revealed using global transcriptional profiling","volume":"279","author":"Banno","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib24","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/j.1365-2133.2005.06816.x","article-title":"The tumour necrosis factor-alpha inhibitor adalimumab rapidly reverses the decrease in epidermal Langerhans cell density in psoriatic plaques","volume":"153","author":"Gordon","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/00000372-200204000-00004","article-title":"How specific is the TUNEL reaction? An account of a histochemical study on human skin","volume":"24","author":"Baima","year":"2002","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib26","first-page":"1465","article-title":"In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note","volume":"21","author":"Grasl-Kraupp","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1172\/JCI1165","article-title":"Sunlight-induced basal cell carcinoma tumor cells and ultraviolet-B-irradiated psoriatic plaques express Fas ligand (CD95L)","volume":"101","author":"Gutierrez-Steil","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib28","first-page":"1321","article-title":"Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin","volume":"151","author":"Wrone-Smith","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib29","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1038\/sj.onc.1205404","article-title":"Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes","volume":"21","author":"Qin","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1365-2249.1994.tb06244.x","article-title":"Elevated tumour necrosis factor-alpha (TNF-alpha) biological activity in psoriatic skin lesions","volume":"96","author":"Ettehadi","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib31","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.4049\/jimmunol.176.3.1431","article-title":"Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2","volume":"176","author":"Johansen","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib32","doi-asserted-by":"crossref","first-page":"19057","DOI":"10.1073\/pnas.0509736102","article-title":"Increase in TNF-{alpha} and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)","volume":"102","author":"Lowes","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib33","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1084\/jem.192.5.681","article-title":"Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells","volume":"192","author":"Abrams","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib34","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.jaad.2004.02.021","article-title":"Infliximab induction therapy for patients with severe plaque-type psoriasis: a randomized, double-blind, placebo-controlled trial","volume":"51","author":"Gottlieb","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib35","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/BF00387595","article-title":"Permeability barrier disruption alters the localization and expression of TNF alpha\/protein in the epidermis","volume":"286","author":"Tsai","year":"1994","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0190-9622(94)70059-1","article-title":"Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin","volume":"30","author":"Nickoloff","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib37","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1001\/archderm.1991.01680050115015","article-title":"The cytokine network in psoriasis","volume":"127","author":"Nickoloff","year":"1991","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib38","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1038\/sj.onc.1207796","article-title":"Defining the temporal requirements for Myc in the progression and maintenance of skin neoplasia","volume":"23","author":"Flores","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib39","first-page":"1079","article-title":"Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo","volume":"146","author":"Wrone-Smith","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib40","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/01.MIB.0000168371.87283.4b","article-title":"Hyperresponsiveness of the mucosal barrier in Crohn's disease is not tumor necrosis factor-dependent","volume":"11","author":"Suenaert","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.jdermsci.2007.06.006_bib41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/sj.jidsymp.5650010","article-title":"Lessons learned from psoriatic plaques concerning mechanisms of tissue repair, remodeling, and inflammation","volume":"11","author":"Nickoloff","year":"2006","journal-title":"J Investig Dermatol Symp Proc"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181107002216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181107002216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,5]],"date-time":"2019-01-05T02:52:31Z","timestamp":1546656751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181107002216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,11]]}},"alternative-id":["S0923181107002216"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2007.06.006","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}