{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T08:33:49Z","timestamp":1789893229149,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.jdermsci.2007.08.008","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T22:07:50Z","timestamp":1196114870000},"page":"153-161","source":"Crossref","is-referenced-by-count":84,"title":["Serum levels of IgE anti-BP180 and anti-BP230 autoantibodies in patients with bullous pemphigoid"],"prefix":"10.1016","volume":"49","author":[{"given":"Nobuko","family":"Ishiura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kuwano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihito","family":"Yazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Echigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Okochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiko","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2007.08.008_bib1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1001\/jama.200.9.751","article-title":"Basement zone antibodies in bullous pemphigoid","volume":"200","author":"Jordon","year":"1967","journal-title":"JAMA"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1001\/archderm.110.3.378","article-title":"IgE levels in sera of patients with pemphigus or bullous pemphigoid","volume":"110","author":"Arbesman","year":"1974","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib3","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.4049\/jimmunol.157.8.3642","article-title":"IgE autoantibodies directed against the major bullous pemphigoid antigen in patients with a severe form of pemphigoid","volume":"157","author":"Delaporte","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/1523-1747.ep12274684","article-title":"A pool of bullous pemphigoid antigen(s) is intracellular and associated with the basal cell cytoskeleton-hemidesmosome complex","volume":"84","author":"Mutasim","year":"1985","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib5","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.4049\/jimmunol.136.4.1231","article-title":"Molecular heterogeneity of the bullous pemphigoid antigens as detected by immunoblotting","volume":"136","author":"Labib","year":"1986","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib6","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1172\/JCI113803","article-title":"Isolation of complementary DNA for bullous pemphigoid antigen by use of patients\u2019 autoantibodies","volume":"82","author":"Stanley","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib7","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1172\/JCI114812","article-title":"Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome","volume":"86","author":"Diaz","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/1523-1747.ep12616580","article-title":"Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180","volume":"99","author":"Giudice","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib9","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.4049\/jimmunol.151.10.5742","article-title":"Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain","volume":"151","author":"Giudice","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib10","first-page":"37","article-title":"BP180 (type XVII collagen) and its role in cutaneous biology and disease","volume":"19","author":"Van den Bergh","year":"2003","journal-title":"Adv Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib11","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1172\/JCI116856","article-title":"A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180","volume":"92","author":"Liu","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib12","doi-asserted-by":"crossref","first-page":"5449","DOI":"10.4049\/jimmunol.155.11.5449","article-title":"Molecular mapping of a pathogenically relevant BP180 epitope associated with experimentally induced murine bullous pemphigoid","volume":"155","author":"Liu","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib13","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1046\/j.1523-1747.1998.00126.x","article-title":"Detection of IgG autoantibodies in the sera of patients with bullous and gestational pemphigoid: ELISA studies utilizing a baculovirus-encoded form of bullous pemphigoid antigen 2","volume":"110","author":"Haase","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib14","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1001\/archderm.136.2.174","article-title":"Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid","volume":"136","author":"Schmidt","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/1523-1747.ep12337492","article-title":"Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies","volume":"109","author":"Zillikens","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib16","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0959-437X(97)80154-2","article-title":"The plakin family: versatile organizers of cytoskeletal architecture","volume":"7","author":"Ruhrberg","year":"1997","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0092-8674(95)90333-X","article-title":"Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration","volume":"81","author":"Guo","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib18","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1523-1747.1999.00546.x","article-title":"Structure and function of hemidesmosomes: more than simple adhesion complexes","volume":"112","author":"Borradori","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2004.09.007","article-title":"Experimental bullous pemphigoid generated in mice with an antigenic epitope of the human hemidesmosomal protein BP230","volume":"24","author":"Kiss","year":"2005","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib20","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nm1496","article-title":"Humanization of autoantigen","volume":"13","author":"Nishie","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib21","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1172\/JCI117826","article-title":"The role of complement in experimental bullous pemphigoid","volume":"95","author":"Liu","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib22","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1172\/JCI119639","article-title":"A major role for neutrophils in experimental bullous pemphigoid","volume":"100","author":"Liu","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib23","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1084\/jem.188.3.475","article-title":"Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid","volume":"188","author":"Liu","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1172\/JCI3693","article-title":"A critical role for neutrophil elastase in experimental bullous pemphigoid","volume":"105","author":"Liu","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib25","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1172\/JCI17891","article-title":"Role of different pathways of the complement cascade in experimental bullous pemphigoid","volume":"116","author":"Nelson","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib26","first-page":"193","article-title":"Immunopathology of bullous pemphigoid. Basement membrane deposition of IgE, alternate pathway components and fibrin","volume":"18","author":"Provost","year":"1974","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib27","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0190-9622(00)90168-3","article-title":"IgG4 and IgE are the major immunoglobulins targeting the NC16A domain of BP180 in bullous pemphigoid: serum levels of these immunoglobulins reflect disease activity","volume":"42","author":"Dopp","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib28","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1046\/j.1523-1747.2003.12146.x","article-title":"Identification of a potential effector function for IgE autoantibodies in the organ-specific autoimmune disease bullous pemphigoid","volume":"120","author":"Dimson","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib29","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/j.1365-2133.1992.tb11833.x","article-title":"Serum IgE antibodies bind to the epidermal side of the basement membrane zone splits in bullous pemphigoid","volume":"126","author":"Parodi","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2133.1993.tb00193.x","article-title":"IgE and its related phenomena in bullous pemphigoid","volume":"128","author":"Soh","year":"1993","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib31","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.0022-202X.2005.23853.x","article-title":"Mapping the binding sites of anti-BP180 immunoglobulin E autoantibodies in bullous pemphigoid","volume":"125","author":"Fairley","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib32","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1023\/A:1020531005776","article-title":"IgE antibodies in sera from patients with bullous pemphigoid are autoantibodies preferentially directed against the 230-kDa epidermal antigen (BP230)","volume":"18","author":"Ghohestani","year":"1998","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib33","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/1523-1747.ep12338088","article-title":"A highly sensitive enzyme-linked immunosorbent assay for the detection of circulating anti-BP180 autoantibodies in patients with bullous pemphigoid","volume":"109","author":"Zillikens","year":"1997","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib34","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jdermsci.2004.10.007","article-title":"Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid","volume":"37","author":"Tsuji-Abe","year":"2005","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib35","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1034\/j.1600-0625.2001.100405.x","article-title":"Bullous pemphigoid sera react specifically with various domains of BP230, most frequently with C-terminal domain, by immunoblot analyses using bacterial recombinant proteins covering the entire molecule","volume":"10","author":"Hamada","year":"2001","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib36","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/1523-1747.ep12358276","article-title":"Rabbits immunized with a peptide encoded for by the 230-kD bullous pemphigoid antigen cDNA develop an enhanced inflammatory response to UVB irradiation: a potential animal model for bullous pemphigoid","volume":"101","author":"Hall","year":"1993","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib37","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4049\/jimmunol.132.1.462","article-title":"Role of IgE receptors in effector function of human eosinophils","volume":"132","author":"Capron","year":"1984","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib38","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/0091-6749(94)90334-4","article-title":"The high-affinity IgE receptor on eosinophils: from allergy to parasites or from parasites to allergy?","volume":"94","author":"Gounni","year":"1994","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib39","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1189\/jlb.0603275","article-title":"The mast cell: an antenna of the microenvironment that directs the immune response","volume":"75","author":"Frossi","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib40","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/08916939008998433","article-title":"Demonstration of IgE antibodies to nucleic acid antigens in patients with SLE","volume":"8","author":"Nagpal","year":"1990","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib41","first-page":"489","article-title":"Rheumatoid arthritis with monoclonal IgE rheumatoid factor","volume":"20","author":"Burastero","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0161-6420(92)31964-5","article-title":"Correlation of serum immunoglobulin E elevations with clinical stages of dysthyroid orbitopathy","volume":"99","author":"Raikow","year":"1992","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib43","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/clin.1996.4297","article-title":"Thyroid peroxidase autoantibodies of IgE class in thyroid autoimmunity","volume":"82","author":"Guo","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib44","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1210\/jc.84.10.3602","article-title":"A possible role of immunoglobulin E in patients with hyperthyroid Graves\u2019 disease","volume":"84","author":"Sato","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib45","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/ni1477","article-title":"IgE(b) immune complexes activate macrophages through Fcgamma RIV binding","volume":"8","author":"Hirano","year":"2007","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1087-0024.2004.00841.x","article-title":"Bullous pemphigoid: using animal models to study the immunopathology","volume":"9","author":"Liu","year":"2004","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib47","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0091-6749(91)90099-A","article-title":"Release of granule proteins by eosinophils from allergic and nonallergic patients with eosinophilia on immunoglobulin-dependent activation","volume":"88","author":"Tomassini","year":"1991","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.jdermsci.2007.08.008_bib48","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.4049\/jimmunol.137.5.1659","article-title":"Role of specific IgE antibodies in peroxidase (EPO) release from human eosinophils","volume":"137","author":"Khalife","year":"1986","journal-title":"J Immunol"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092318110700309X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092318110700309X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T23:13:49Z","timestamp":1684106029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092318110700309X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S092318110700309X"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2007.08.008","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}