{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:32:00Z","timestamp":1790371920665,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,7,1]],"date-time":"2009-07-01T00:00:00Z","timestamp":1246406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1016\/j.jdermsci.2009.02.015","type":"journal-article","created":{"date-parts":[[2009,4,18]],"date-time":"2009-04-18T04:58:29Z","timestamp":1240030709000},"page":"47-52","source":"Crossref","is-referenced-by-count":60,"title":["Increased interferon-\u03b3, interleukin-12p40 and IL-8 production in Propionibacterium acnes-treated peripheral blood mononuclear cells from patient with acne vulgaris"],"prefix":"10.1016","volume":"55","author":[{"given":"Hitomi","family":"Sugisaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Kakeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunitomo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban C.","family":"Gabazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Kurokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2009.02.015_bib1","series-title":"Acne & rosacea","author":"Plewig","year":"2002"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.0906-6705.2005.0285a.x","article-title":"What is the pathogenesis of acne?","volume":"14","author":"Zouboulis","year":"2005","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib3","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mjd.2003.618","article-title":"Management of acne: a report from a global alliance to improve outcomes in acne","volume":"49","author":"Gollnick","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000017862","article-title":"Modelling the infundibulum in acne","volume":"196","author":"Guy","year":"1998","journal-title":"Dermatol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib5","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/1523-1747.ep12477026","article-title":"Monoclonal antibody labeling for cytokeratins and filaggrin in the human pilosebaceous unit of normal, seborrhoeic and acne skin","volume":"91","author":"Kurokawa","year":"1988","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib6","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1365-2133.1997.tb14889.x","article-title":"Activity of type 1 5 Alpha-reductase is greater in the follicular infrainfundibulum compared with the epidermis","volume":"136","author":"Thiboutot","year":"1997","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib7","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1056\/NEJM199704173361607","article-title":"Therapy for acne vulgaris","volume":"336","author":"Leyden","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib8","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.4049\/jimmunol.169.3.1535","article-title":"Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses","volume":"169","author":"Kim","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1046\/j.1523-1747.2003.12321.x","article-title":"Inflammatory events are involved in acne lesion initiation","volume":"121","author":"Jeremy","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1600-0625.1998.tb00323.x","article-title":"Immunohistochemical investigation of evolving inflammation in lesions of acne vulgaris","volume":"7","author":"Layton","year":"1998","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jdermsci.2005.01.002","article-title":"Nadifloxacin, an antiacne quinolone antimicrobial, inhibits the production of proinflammatory cytokines by human peripheral blood mononuclear cells and normal human keratinocytes","volume":"38","author":"Kuwahara","year":"2005","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.0105-2896.2004.00205.x","article-title":"Induction of allergic inflammation by interleukin-18 in experimental animal models","volume":"202","author":"Tsutsui","year":"2004","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib13","doi-asserted-by":"crossref","first-page":"997","DOI":"10.4049\/jimmunol.165.2.997","article-title":"Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18","volume":"165","author":"Yamanaka","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000087011","article-title":"Review of the innate immune response in acne vulgaris: activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses","volume":"211","author":"Kim","year":"2005","journal-title":"Dermatol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib15","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1271\/bbb.70159","article-title":"Propionibacterium Acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells","volume":"71","author":"Jung","year":"2007","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1365-2249.1995.tb03864.x","article-title":"The influence of tetracyclines on T cell activation","volume":"102","author":"Kloppenburg","year":"1995","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib17","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.4049\/jimmunol.161.7.3400","article-title":"IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production","volume":"161","author":"Yoshimoto","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib18","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1046\/j.1523-1747.2003.12550_6.x","article-title":"Propionibacterium acnes-reactive T helper-1 cells in the skin of patients with acne vulgaris","volume":"121","author":"Mouser","year":"2003","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2009.02.015_bib19","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1128\/jcm.6.6.555-558.1977","article-title":"Enzymatic and hemolytic properties of Propionibacterium acnes and related bacteria","volume":"6","author":"Hoeffler","year":"1977","journal-title":"J Clin Microbiol"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181109000863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181109000863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T17:37:02Z","timestamp":1684949822000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181109000863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,7]]}},"alternative-id":["S0923181109000863"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2009.02.015","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1160285.620597","asserted-by":"object"}]},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}