{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:17:42Z","timestamp":1780082262773,"version":"3.54.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1016\/j.jdermsci.2011.03.007","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T10:28:56Z","timestamp":1302863336000},"page":"10-16","source":"Crossref","is-referenced-by-count":32,"title":["Apigenin attenuates dopamine-induced apoptosis in melanocytes via oxidative stress-related p38, c-Jun NH2-terminal kinase and Akt signaling"],"prefix":"10.1016","volume":"63","author":[{"given":"Mao","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-shan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao-xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yi","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao-Qiang","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-xia","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2011.03.007_bib0005","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2165\/00128071-200203050-00001","article-title":"Vitiligo: a manifestation of apoptosis?","volume":"3","author":"Huang","year":"2002","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0010","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/sj.jid.5700700","article-title":"Membrane lipid alterations as a possible basis for melanocyte degeneration in vitiligo","volume":"127","author":"Dell\u2019Anna","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0015","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1111\/1523-1747.ep12492612","article-title":"Low catalase levels in the epidermis of patients with vitiligo","volume":"97","author":"Schallreuter","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/sj.jidsp.5640189","article-title":"In vivo and in vitro evidence for hydrogen peroxide (H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase","volume":"4","author":"Schallreuter","year":"1999","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jdermsci.2009.02.004","article-title":"Ultrastructural and functional alterations of mitochondria in perilesional vitiligo skin","volume":"54","author":"Prignano","year":"2009","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0030","first-page":"24","article-title":"The effects of vitamin E on the skin lipid peroxidation and the clinical improvement in vitiligo patients treated with PUVA","volume":"12","author":"Akyol","year":"2002","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1600-0749.2004.00149.x","article-title":"Study on the antioxidant status of vitiligo patients of different age groups in Baroda","volume":"17","author":"Agrawal","year":"2004","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0040","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2230.2004.01524.x","article-title":"Oxidant\u2013antioxidant enzymes and lipid peroxidation in generalized vitiligo","volume":"29","author":"Koca","year":"2004","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0045","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/sj.jid.5700257","article-title":"Estrogens can contribute to hydrogen peroxide generation and quinone-mediated DNA damage in peripheral blood lymphocytes from patients with vitiligo","volume":"126","author":"Schallreuter","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0050","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jdermsci.2007.03.009","article-title":"Glutathione prevented dopamine-induced apoptosis of melanocytes and its signaling","volume":"47","author":"Park","year":"2007","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0055","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1529-8019.2010.01328.x","article-title":"Oral minocycline in the treatment of vitiligo \u2013 a preliminary study","volume":"23","author":"Parsad","year":"2010","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0060","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease","volume":"65","author":"Blum","year":"2001","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0065","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/sj.bjp.0704982","article-title":"Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by l-3,4-dihydroxyphenylalanine (l-DOPA) and dopamine","volume":"137","author":"Pedrosa","year":"2002","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0070","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/j.1365-2133.2006.07293.x","article-title":"Dopamine-induced apoptosis in human melanocytes involves generation of reactive oxygen species","volume":"154","author":"Chu","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0075","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0749.1992.tb00003.x","article-title":"Catecholamines and vitiligo","volume":"5","author":"Morrone","year":"1992","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0080","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1034\/j.1600-0749.2000.130106.x","article-title":"Higher plasma catecholamine and metabolite levels in the early phase of nonsegmental vitiligo","volume":"13","author":"Cucchi","year":"2000","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0085","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1034\/j.1600-0749.2003.00015.x","article-title":"Catecholamines increase in the urine of non-segmental vitiligo especially during its active phase","volume":"16","author":"Cucchi","year":"2003","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0090","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4161\/oxim.3.3.12114","article-title":"Potential redox-sensitive Akt activation by dopamine activates Bad and promotes cell death in melanocytes","volume":"3","author":"Choi","year":"2010","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0095","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuint.2010.05.006","article-title":"Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis","volume":"57","author":"Choi","year":"2010","journal-title":"Neurochem Int"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0100","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s11095-010-0089-7","article-title":"Apigenin: a promising molecule for cancer prevention","volume":"27","author":"Shukla","year":"2010","journal-title":"Pharm Res"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jdermsci.2010.10.016","article-title":"The flavonoids apigenin and luteolin suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and AP-1-dependent signaling in HaCaT cells","volume":"61","author":"Hwang","year":"2011","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0110","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1017\/S000711459900080X","article-title":"Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects","volume":"81","author":"Nielsen","year":"1999","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0115","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1600-0749.2004.00130.x","article-title":"On the etiology of contact\/occupational vitiligo","volume":"17","author":"Boissy","year":"2004","journal-title":"Pigment Cell Res."},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0120","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-0-387-74911-2_20","article-title":"Antioxidants reduce consequences of radiation exposure","volume":"614","author":"Okunieff","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jdermsci.2011.03.007_bib0125","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1385\/MN:31:1-3:283","article-title":"Natural antioxidants for neurodegenerative diseases","volume":"31","author":"Zhao","year":"2005","journal-title":"Mol Neurobiol"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181111000934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181111000934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T15:23:03Z","timestamp":1543850583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181111000934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["S0923181111000934"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2011.03.007","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}