{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:39:55Z","timestamp":1786991995099,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100005326","name":"Yale University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005946","name":"Jackson Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.jdermsci.2011.04.012","type":"journal-article","created":{"date-parts":[[2011,5,10]],"date-time":"2011-05-10T02:17:56Z","timestamp":1304993876000},"page":"148-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes"],"prefix":"10.1016","volume":"63","author":[{"given":"Yanhua","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Sundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2011.04.012_bib0005","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1016\/j.jaad.2005.04.033","article-title":"Involving the patient: impact of inflammatory skin disease and patient-focused care","volume":"53","author":"Feldman","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1258\/rsmsmj.53.2.30","article-title":"Recent advances in inflammatory skin diseases","volume":"53","author":"Thind","year":"2008","journal-title":"Scott Med J"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0015","first-page":"972","article-title":"A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice","volume":"143","author":"HogenEsch","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0020","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.4049\/jimmunol.162.7.3890","article-title":"Absence of Peyer's patches and abnormal lymphoid architecture in chronic proliferative dermatitis (cpdm\/cpdm) mice","volume":"162","author":"HogenEsch","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0025","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1354\/vp.43-4-401","article-title":"Abnormal lymphoid organ development in immunodeficient mutant mice","volume":"43","author":"Seymour","year":"2006","journal-title":"Vet Pathol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0030","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/sj.jid.5700807","article-title":"Mouse models of psoriasis","volume":"127","author":"Gudjonsson","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0035","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1046\/j.1523-1747.1999.00538.x","article-title":"Animal models of psoriasis \u2013 what can we learn from them?","volume":"112","author":"Schon","year":"1999","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0040","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1600-0625.2008.00751.x","article-title":"Animal models of psoriasis: a critical appraisal","volume":"17","author":"Schon","year":"2008","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000028050","article-title":"Changes in keratin and filaggrin expression in the skin of chronic proliferative dermatitis (cpdm) mutant mice","volume":"67","author":"HogenEsch","year":"1999","journal-title":"Pathobiology"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0050","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/1521-4141(200103)31:3<734::AID-IMMU734>3.0.CO;2-9","article-title":"Increased expression of type 2 cytokines in chronic proliferative dermatitis (cpdm) mutant mice and resolution of inflammation following treatment with IL-12","volume":"31","author":"HogenEsch","year":"2001","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0055","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/sj.gene.6364403","article-title":"Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis","volume":"8","author":"Seymour","year":"2007","journal-title":"Genes Immun"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0060","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1006\/mcne.2000.0940","article-title":"Sharpin, a novel postsynaptic density protein that directly interacts with the shank family of proteins","volume":"17","author":"Lim","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0065","doi-asserted-by":"crossref","first-page":"D237","DOI":"10.1093\/nar\/gkl951","article-title":"CDD: a conserved domain database for interactive domain family analysis","volume":"35","author":"Marchler-Bauer","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0070","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/01913129509014610","article-title":"Ultrastructure of epidermis of mice with chronic proliferative dermatitis","volume":"19","author":"Gijbels","year":"1995","journal-title":"Ultrastruct Pathol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0075","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/jid.2003.11","article-title":"Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function","volume":"120","author":"Behne","year":"2003","journal-title":"J Invest Dermatol"},{"issue":"Suppl. 2","key":"10.1016\/j.jdermsci.2011.04.012_bib0080","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1038\/sj.cdd.4401722","article-title":"Death penalty for keratinocytes: apoptosis versus cornification","volume":"12","author":"Lippens","year":"2005","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0085","first-page":"19","article-title":"Apoptosis: the skin from a new perspective","volume":"1","author":"Polakowska","year":"1994","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0090","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/sj.cdd.4400785","article-title":"Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing","volume":"7","author":"Lippens","year":"2000","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0095","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature03098","article-title":"Intrinsic tumour suppression","volume":"432","author":"Lowe","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0100","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.cdd.4401186","article-title":"The CD95(APO-1\/Fas) DISC and beyond","volume":"10","author":"Peter","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0105","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nrm2153","article-title":"The apoptosome: signalling platform of cell death","volume":"8","author":"Riedl","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0110","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1093\/emboj\/16.10.2794","article-title":"FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)","volume":"16","author":"Medema","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0115","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0120","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nprot.2008.50","article-title":"Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice","volume":"3","author":"Lichti","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0125","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1006\/jsbi.2000.4254","article-title":"Review: nuclear events in apoptosis","volume":"129","author":"Robertson","year":"2000","journal-title":"J Struct Biol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0130","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2353\/ajpath.2009.080332","article-title":"Senescent keratinocytes die by autophagic programmed cell death","volume":"174","author":"Gosselin","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0076-6879(08)01401-8","article-title":"Analyzing morphological and ultrastructural features in cell death","volume":"442","author":"Tinari","year":"2008","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0140","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/sj.jid.5700008","article-title":"Keratinocyte apoptosis in epidermal development and disease","volume":"126","author":"Raj","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0145","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.311","article-title":"Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways","volume":"41","author":"Nair","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ng.310","article-title":"Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21","volume":"41","author":"Zhang","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jdermsci.2011.04.012_bib0155","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ymeth.2007.11.006","article-title":"Morphological assessment of apoptosis","volume":"44","author":"Doonan","year":"2008","journal-title":"Methods"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181111001459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181111001459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:47:37Z","timestamp":1760330857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181111001459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0923181111001459"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2011.04.012","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2011.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}