{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T05:12:21Z","timestamp":1760332341867,"version":"build-2065373602"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jdsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.jdermsci.2012.04.007","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T17:08:26Z","timestamp":1335373706000},"page":"15-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["New insights into therapy by mathematical analysis: Recalcitrant granulated improved more than sclerotic venous leg ulcers with amelogenin treatment"],"prefix":"10.1016","volume":"67","author":[{"given":"Regina","family":"Renner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan C.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2012.04.007_bib0005","first-page":"116","article-title":"Etiology of chronic leg ulcers in 31,619 patients in Germany analyzed by an expert survey","volume":"9","author":"K\u00f6rber","year":"2011","journal-title":"J Dtsch Dermatol Ges"},{"issue":"6 Part 1","key":"10.1016\/j.jdermsci.2012.04.007_bib0010","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/0190-9622(91)70295-D","article-title":"Continuing medical education: leg ulcers","volume":"25","author":"Phillips","year":"1991","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0015","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/1534734607301394","article-title":"The extracellular matrix in wound healing: a closer look at therapeutics for chronic wounds","volume":"6","author":"Agren","year":"2007","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0020","first-page":"239","article-title":"Therapierefrakt\u00e4res ven\u00f6ses Ulcus cruris: Amelogenin als neue Therapieoption","volume":"4","author":"Renner","year":"2008","journal-title":"ZfW"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0025","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1006\/jsbi.1999.4130","article-title":"The structural biology of the developing dental enamel matrix","volume":"126","author":"Fincham","year":"1999","journal-title":"J Struct Biol"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0030","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/154405910208100713","article-title":"Amelogenin is a cell adhesion protein","volume":"81","author":"Hoang","year":"2002","journal-title":"J Dent Res"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0035","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1524-475X.2004.tb00001.x","article-title":"Effects of a topical enamel matrix derivative on skin wound healing","volume":"12","author":"Mirastschijski","year":"2004","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0040","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1365-2133.2004.06243.x","article-title":"Procollagen type I gene expression and cell proliferation are increased in lipodermatosclerosis","volume":"152","author":"Degiorgio-Miller","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0045","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/1534734602001002002","article-title":"Dermal changes in the lower leg skin of patients with venous hypertension","volume":"1","author":"Herrick","year":"2002","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0050","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1524-475X.2010.00627.x","article-title":"Mathematical analysis of wound healing trajectories as objective evaluation basis of different treatment options of chronic wounds using the example of single autologous keratinocyte transplantation","volume":"18","author":"Renner","year":"2010","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0055","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1523-1747.2000.00044.x","article-title":"Defective extracellular matrix reorganization by chronic wound fibroblasts is associated with alterations in TIMP-1, TIMP-2, and MMP-2 activity","volume":"115","author":"Cook","year":"2000","journal-title":"J Invest Dermatol"},{"issue":"17\u201318","key":"10.1016\/j.jdermsci.2012.04.007_bib0060","first-page":"20","article-title":"Effect of amelogenin extracellular matrix protein and compression on hard-to-heal venous leg ulcers: follow-up data","volume":"17","author":"Romanelli","year":"2008","journal-title":"J Wound Care"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0065","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3892\/ijmm_00000275","article-title":"Inhibition of angiogenesis in lipodermatosclerosis: implication for venous ulcer formation","volume":"24","author":"Herouy","year":"2009","journal-title":"Int J Mol Med"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0070","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2147\/CIA.S1846","article-title":"Amelogenin, an extracellular matrix protein, in the treatment of venous leg ulcers and other hard-to-heal wounds: experimental and clinical evidence","volume":"3","author":"Romanelli","year":"2008","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0075","series-title":"European Wound Management Association conference","article-title":"Amelogenins (Xelma\u00ae) in hard-to-heal venous leg ulcers, an open regime investigation [poster]","author":"Romanelli","year":"2006"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0080","series-title":"European Wound Management Association conference","article-title":"Experience with the use of an amelogenin-based extracellular matrix substitute in the management of a variety of complex hard-to-heal chronic wounds [poster]","author":"Vowden","year":"2007"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0085","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1742-481X.2007.00404.x","article-title":"Mathematical model for wound healing following autologous keratinocyte transplantation","volume":"5","author":"Renner","year":"2008","journal-title":"Int Wound J"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0090","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1743-6109.2006.00117.x","article-title":"The effect of amelogenins (Xelma\u00ae) on hard-to-heal venous leg ulcers","volume":"14","author":"Vowden","year":"2006","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.jdermsci.2012.04.007_bib0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.12968\/jowc.2007.16.5.27043","article-title":"Effect of amelogenin extracellular matrix protein and compression on hard-to-heal venous leg ulcers","volume":"16","author":"Vowden","year":"2007","journal-title":"J Wound Care"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181112001399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181112001399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T04:47:32Z","timestamp":1760330852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181112001399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0923181112001399"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2012.04.007","relation":{},"ISSN":["0923-1811"],"issn-type":[{"type":"print","value":"0923-1811"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New insights into therapy by mathematical analysis: Recalcitrant granulated improved more than sclerotic venous leg ulcers with amelogenin treatment","name":"articletitle","label":"Article Title"},{"value":"Journal of Dermatological Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jdermsci.2012.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Japanese Society for Investigative Dermatology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}