{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:02:44Z","timestamp":1769054564944,"version":"3.49.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Dermatological Science"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.jdermsci.2012.09.014","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T20:30:23Z","timestamp":1349296223000},"page":"164-171","source":"Crossref","is-referenced-by-count":26,"title":["Suppression of melanogenesis by a newly synthesized compound, MHY966 via the nitric oxide\/protein kinase G signaling pathway in murine skin"],"prefix":"10.1016","volume":"68","author":[{"given":"Yeon Ja","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Uehara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Wung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mi","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Min","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pusoon","family":"Chun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June Whan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung Ryong","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae Young","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jdermsci.2012.09.014_bib0005","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/372413a0","article-title":"DNA damage and melanogenesis","volume":"372","author":"Eller","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0010","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1152\/physrev.00044.2003","article-title":"Melanin pigmentation in mammalian skin and its hormonal regulation","volume":"84","author":"Slominski","year":"2004","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0015","doi-asserted-by":"crossref","first-page":"28052","DOI":"10.1074\/jbc.271.45.28052","article-title":"Ultraviolet B, radiation acts through the nitric oxide and cGMP signal transduction pathway to stimulate melanogenesis in human melanocytes","volume":"271","author":"Romero-Graillet","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0020","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1172\/JCI119206","article-title":"Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis","volume":"99","author":"Romero-Graillet","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0025","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1034\/j.1600-0749.2000.130509.x","article-title":"Involvement of nitric oxide in UVB-induced pigmentation in guinea pig skin","volume":"13","author":"Horikoshi","year":"2000","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0030","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1054-3589(08)60049-6","article-title":"Regulation of cytosolic guanylyl cyclase by nitric oxide: the NO-cyclic GMP signal transduction system","volume":"26","author":"Murad","year":"1994","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3181\/00379727-211-43950A","article-title":"Nitric oxide and cyclic GMP signaling","volume":"211","author":"McDonald","year":"1996","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0040","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1034\/j.1600-0749.2000.130406.x","article-title":"Up-regulation of tyrosinase gene by nitric oxide in human melanocytes","volume":"13","author":"Sasaki","year":"2000","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0045","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1034\/j.1600-0749.2001.140504.x","article-title":"BMP-2 stimulates tyrosinase gene expression and melanogenesis in differentiated melanocytes","volume":"14","author":"Bilodeau","year":"2001","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0050","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.bbagen.2012.03.018","article-title":"Evaluation of in vitro and in vivo anti-melanogenic activity of a newly synthesized strong tyrosinase inhibitor (E)-3-(2,4 dihydroxybenzylidene)pyrrolidine-2,5-dione (3-DBP)","volume":"1820","author":"Chung","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0055","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jdermsci.2011.03.012","article-title":"Comparison of the antimelanogenic effects of p-coumaric acid and its methyl ester and their skin permeabilities","volume":"63","author":"Song","year":"2011","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0060","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s11357-011-9235-3","article-title":"Attenuation of age-related changes in FOXO3a activity and the PI3K\/Akt pathway by short-term feeding of ferulate","volume":"34","author":"Choi","year":"2012","journal-title":"Age"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0065","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0070","doi-asserted-by":"crossref","unstructured":"Ha YM, Uehara Y, Park D, Jeong HO, Park JY, Park YJ, et al., Synthesis and preliminary in vitro biological evaluation of 5-chloro-2-(substituted phenyl)-benzo[d]thiazole derivatives designed as novel antimelanogenesis agents. Appl Biochem Biotechnol 2012, in press.","DOI":"10.1007\/s12010-012-9867-5"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0075","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1021\/jf0101206","article-title":"Peroxynitrite scavenging and cytoprotective activity of 2,3,6-tribromo-4,5-dihydroxybenzyl methyl ether from the marine alga Symphyocladia latiuscula","volume":"49","author":"Chung","year":"2001","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0080","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.niox.2004.04.005","article-title":"Nitric oxide function in the skin","volume":"10","author":"Cals-Grierson","year":"2004","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0085","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2230.2003.01365.x","article-title":"Nitric oxide: a key mediator in cutaneous physiology","volume":"28","author":"Weller","year":"2003","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0090","doi-asserted-by":"crossref","first-page":"21277","DOI":"10.1016\/S0021-9258(19)36601-3","article-title":"Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. Potential role for nitric oxide in the regulation of wound healing","volume":"267","author":"Heck","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0095","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s12272-011-0515-3","article-title":"Inhibition of UVA-mediated melanogenesis by ascorbic acid through modulation of antioxidant defense and nitric oxide system","volume":"34","author":"Panich","year":"2011","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0100","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1248\/bpb.32.1155","article-title":"Modulation of oxidative stress and melanogenesis by proanthocyanidins","volume":"32","author":"Kim","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0105","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1016\/j.fct.2008.04.002","article-title":"The anti-melanogenic effect of pycnogenol by its anti-oxidative actions","volume":"46","author":"Kim","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0110","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1755-148X.2011.00887.x","article-title":"2,4,6-Octatrienoic acid is a novel promoter of melanogenesis and antioxidant defence in normal human melanocytes via PPAR-gamma activation","volume":"24","author":"Flori","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0115","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1600-0625.2006.00521.x","article-title":"PPAR-gamma agonist, ciglitazone, increases pigmentation and migration of human melanocytes","volume":"16","author":"Lee","year":"2007","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0120","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/1523-1747.ep12470197","article-title":"The influence of stratum corneum morphology on water permeability","volume":"96","author":"Potts","year":"1991","journal-title":"J Invest Dermatol"},{"issue":"Suppl. 1","key":"10.1016\/j.jdermsci.2012.09.014_bib0125","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/S0923-1811(00)00137-7","article-title":"Influence of dry environment on epidermal function","volume":"24","author":"Denda","year":"2000","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jdermsci.2012.09.014_bib0130","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/j.1600-0749.2006.00334.x","article-title":"Hypopigmenting agents: an updated review on biological, chemical and clinical aspects","volume":"19","author":"Solano","year":"2006","journal-title":"Pigment Cell Res"}],"container-title":["Journal of Dermatological Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181112002939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0923181112002939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T23:32:54Z","timestamp":1643499174000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0923181112002939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0923181112002939"],"URL":"https:\/\/doi.org\/10.1016\/j.jdermsci.2012.09.014","relation":{},"ISSN":["0923-1811"],"issn-type":[{"value":"0923-1811","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}